• Title/Summary/Keyword: elasticity

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Transdermal Delivery of Quercetin Using Elastic Liposomes: Preparation, Characterization and In Vitro Skin Permeation Study (탄성 리포좀을 사용한 쿼세틴의 경피 전달: 제조, 특성 그리고 In Vitro 피부 투과 연구)

  • Park, Soo Nam;Lim, Myoung Sun;Park, Min A;Kwon, Soon Sik;Han, Seat Byeol
    • Polymer(Korea)
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    • v.36 no.6
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    • pp.705-711
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    • 2012
  • In this study, the elastic liposome consisted of egg phospholipids and edge activator ($Tego^{(R)}$ care 450) was prepared in order to supplement the defect of the conventional liposome. We prepared elastic liposome containing quercetin, known as natural antioxidant, and evaluated the vesicles size, elasticity, loading efficiency, stability, and in vitro skin permeation. The mean diameter of quercetin loaded elastic liposome formulations ranged between 208.2~303.4 nm and loading efficiency was observed 64.1~87.5%. The highest loading efficiency (87.5%) and deformability (28.3) were observed at the optimal ratio of 90 : 10 (egg phospholipids : $Tego^{(R)}$ care 450) among 0.1% quercetin loaded elastic liposome formulations. The elastic liposome formulation was selected for further transdermal permeation study. The elastic liposome ($129.9{\mu}g/cm^2$) exhibited more skin permeability than general liposome ($114.8{\mu}g/cm^2$) and 1,3-butylene glycol ($75.1{\mu}g/cm^2$) solution. This results suggest that the elastic liposome formulation using $Tego^{(R)}$ care 450 as a major edge activator could be useful for the delivery of active ingredient through the skin transdermal.

The Effect of $Sa-Am$ Lung Sedating Acupuncture on Wrist Pulse in Healthy Human Subjects (폐승격(肺勝格) 자침이 촌관척(寸關尺) 맥파변화에 미치는 영향)

  • Kim, Seok-Joo;Lee, Hyun
    • Journal of Acupuncture Research
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    • v.29 no.2
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    • pp.43-57
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    • 2012
  • Objectives : The purpose of this study is to observe the effects of $Sa-Am$ lung sedating acupuncture (LS) on wrist pulse changes in healthy participants. Method : Forty healthy subjects participated in this study, and were divided into an acupuncture group and controlled group. Using a three-dimensional pulse imaging system (DMP-3000), wrist pulse was measured before, immediately after, 30 minutes after and 60 minutes after acupuncture in the acupuncture group, with the rest in controlled group. Sixteen parameters between the acupuncture group and the controlled group were analyzed at Cun, Guan and Chi in each time. Result : After LS acupuncture, wrist pulse sixteen parameters were changed significantly according to the time at each measuring region. 1. Heart rate significantly decreased in immediately after, 30 minutes after and 60 minutes after, Pulse period significantly increased in 30 minutes after and 60 minutes after. 2. T4 didn't significantly changed, T-T4 significantly increased in immediately after, 30 minutes after and 60 minutes after. T4/T, T4/(T-T4), T1/T, T5/T significantly decreased in immediately after, 30 minutes after and 60 minutes after. (T-T4)/T significantly decreased in immediately after, 30 minutes after and 60 minutes after. T5 significantly increased in 30 minutes after and 60 minutes after. 3. Modulus of elasticity significantly decreased in left Cun 60 minutes after, significantly increased in left Chi 30 minutes after. 4. Variance of Amplitude significantly increased in right Guan 60 minutes after. 5. Area of pulse significantly increased in left Cun 60 minutes after, left Chi 30 minutes after and right Cun 60 minutes after. Systolic pulse area significantly decreased left Chi 30 minutes after, right Cun immediately after, 30 minutes after and 60 minutes after, right Guan in immediately after. 6. Energy/min significantly decreased in left Chi 60 minutes after and right Cun immediately after. EIx significantly decreased in right Cun immediately after. 7. In both sides Cun, Guan, Chi wrist pulse, a lot of significant changes in right Cun and left Chi appeared, and then followed by the left Cun, right Guan. Conclusion : This study analyzed that the correlation between LS acupuncture and radial pulse(cun, guan, chi) is considered to be meaningful, hereafter clinical studies on this are needed.

Three-Dimensional Vibration Analysis of Solid and Hollow Hemispheres Having Varying Thickness (변두께를 갖는 두꺼운 반구형 쉘과 반구헝체의 3차원적 진동해석)

  • 심현주;장경호;강재훈
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.16 no.2
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    • pp.197-206
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    • 2003
  • A three-dimensional (3-D) method of analysis is presented for determining the free vibration frequencies and mode shapes of solid and hollow hemispherical shells of revolution of arbitrary wall thickness having arbitrary constraints on their boundaries. Unlike conventional shell theories, which are mathematically two-dimensional (2-D), the present method is based upon the 3-D dynamic equations of elasticity. Displacement components μ/sub Φ/, μ/sub z/, and μ/sub θ/ in the meridional, normal, and circumferential directions, respectively, are taken to be sinusoidal in time, periodic in θ, and algebraic polynomials in the Φ and z directions. Potential (strain) and kinetic energies of the hemispherical shells are formulated, and the Ritz method is used to solve the eigenvalue problem, thus yielding upper bound values of the frequencies obtained by minimizing the frequencies. As the degree of the polynomials is increased, frequencies converge to the exact values. Novel numerical results are presented for solid and hollow hemispheres with linear thickness variation. The effect on frequencies of a small axial conical hole is also discussed. Comparisons are made for the frequencies of completely free, thick hemispherical shells with uniform thickness from the present 3-D Ritz solutions and other 3-D finite element ones.

Multi-scale Analysis of Thin film Considering Surface Effects (표면효과를 고려한 박막구조의 멀티스케일 해석)

  • Cho, Maeng-Hyo;Choi, Jin-Bok;Jung, Kwang-Sub
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.20 no.3
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    • pp.287-292
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    • 2007
  • In general, the response of bulk material is independent of its size when it comes to considering classical elasticity theory. Because the surface to bulk ratio of the large solids is very small, the influence of surface can be negligible. But the surface effect plays important role as the surface to bulk ratio becomes larger, that is, the contribution of the surface effect must be considered in nano-size elements such as thin film or beam structure. Molecular dynamics computation has been a conventional way to analyze these ultra-thin structures but this method is limited to simulate on the order of $10^6{\sim}10^9$ atoms for a few nanoseconds, and besides, very time consuming. Analysis of structures in submicro to micro range(thin-film, wire etc.) is difficult with classical molecular dynamics due to the restriction of computing resources and time. Therefore, in this paper, the continuum-based method is considered to simulate the overall physical and mechanical properties of the structures in nano-scale, especially, for the thin-film.

Enterprise Human Resource Management using Hybrid Recognition Technique (하이브리드 인식 기술을 이용한 전사적 인적자원관리)

  • Han, Jung-Soo;Lee, Jeong-Heon;Kim, Gui-Jung
    • Journal of Digital Convergence
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    • v.10 no.10
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    • pp.333-338
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    • 2012
  • Human resource management is bringing the various changes with the IT technology. In particular, if HRM is non-scientific method such as group management, physical plant, working hours constraints, personal contacts, etc, the current enterprise human resources management(e-HRM) appeared in the individual dimension management, virtual workspace (for example: smart work center, home work, etc.), working time flexibility and elasticity, computer-based statistical data and the scientific method of analysis and management has been a big difference in the sense. Therefore, depending on changes in the environment, companies have introduced a variety of techniques as RFID card, fingerprint time & attendance systems in order to build more efficient and strategic human resource management system. In this paper, time and attendance, access control management system was developed using multi camera for 2D and 3D face recognition technology-based for efficient enterprise human resource management. We had an issue with existing 2D-style face-recognition technology for lighting and the attitude, and got more than 90% recognition rate against the poor readability. In addition, 3D face recognition has computational complexities, so we could improve hybrid video recognition and the speed using 3D and 2D in parallel.

Quality Characteristics and Antioxidative Activity of Mung Bean Starch Gels Added with Carrot, Spinach and Mulberry Juice (당근, 시금치, 오디즙 첨가 녹두전분 겔의 항산화 및 품질 특성)

  • Cha, Ye-Ji;Jung, Yeon-Sook;Kim, Jae-Won;Youn, Kwang-Sup
    • Journal of the East Asian Society of Dietary Life
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    • v.21 no.1
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    • pp.46-52
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    • 2011
  • This study was conducted to evaluate the quality characteristics of mung bean starch gel (MBSJ) containing carrot (CMBSJ), spinach (SMBSJ), and mulberry (MMBSJ) juice. The moisture contents of MBSJ, CMBSJ, SMBSJ and MMBSJ were not different significantly. The color of MBSJ was in good accordance with the $L^*$, $a^*$, $b^*$ values and hue angle of the material juices. The hardness levels of CMBSJ, SMBSJ, and MMBSJ were lower than that of MBSJ, but the springiness, cohesiveness, and chewiness of CMBSJ and SMBSJ were higer than those of MBSJ. Antioxidative activities of CMBSJ, SMBSJ, and MMBSJ were greatly increased compared to those of MBSJ. The syneresis and hardness of colored the MBSJ decreased during storage at $4^{\circ}C$. In the sensory evaluation, colored MBSJ scored the highest in taste, shine, elasticity, and overall acceptability. Based on the above results, we expect that mung bean starch gels with carrot, spinach and mulberry juice have good quality characteristics and antioxidant activity.

A Study of the Abalone Outlook Model Using by Partial Equilibrium Model Approach Based on DEEM System (부분균형모형을 이용한 전복 수급전망모형 구축에 관한 연구)

  • Han, Suk-Ho;Jang, Hee-Soo;Heo, Su-Jin;Lee, Nam-Su
    • The Journal of Fisheries Business Administration
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    • v.51 no.2
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    • pp.51-69
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    • 2020
  • The purpose of this study is to construct an outlook model that is consistent with the "Fisheries Outlook" monthly published by the Fisheries Outlook Center of the Korea Maritime Institute(KMI). In particular, it was designed as a partial equilibrium model limited to abalone items, but a model was constructed with a dynamic ecological equation model(DEEM) system taking into account biological breeding and shipping time. The results of this study are significant in that they can be used as basic data for model development of various items in the future. In this study, due to the limitation of monthly data, the market equilibrium price was calculated by using the recursive model construction method to be calculated directly as an inverse demand. A model was built in the form of a structural equation model that can explain economic causality rather than a conventional time series analysis model. The research results and implications are as follows. As a result of the estimation of the amount of young seashells planting, it was estimated that the coefficient of the amount of young seashells planting from the previous year was estimated to be 0.82 so that there was no significant difference in the amount of young seashells planting this year and last year. It is also meant to be nurtured for a long time after aquaculture license and limited aquaculture area(edge style) and implantation. The economic factor, the coefficient of price from last year was estimated at 0.47. In the case of breeding quantity, it was estimated that the longer the breeding period, the larger the coefficient of breeding quantity in the previous period. It was analyzed that the impact of shipments on the breeding volume increased. In the case of shipments, the coefficient of production price was estimated unelastically. As the period of rearing increased, the estimation coefficient decreased. Such result indicates that the expected price, which is an economic factor variable and that had less influence on the intention to shipments. In addition, the elasticity of the breeding quantity was estimated more unelastically as the breeding period increased. This is also correlated with the relative coefficient size of the expected price. The abalone supply and demand forecast model developed in this study is significant in that it reduces the prediction error than the existing model using the ecological equation modeling system and the economic causal model. However, there are limitations in establishing a system of simultaneous equations that can be linked to production and consumption between industries and items. This is left as a future research project.

Synthesis of Eco-Friendly High Solid Acrylic Resins and Curing Properties of Acrylic Urethane Resin Coatings (환경 친화형 하이솔리드 아크릴수지의 합성과 아크릴 우레탄 도료의 경화 특성)

  • Kim, Jin-Wook;Lee, Dong-Chan;Choi, Joong-So
    • Korean Chemical Engineering Research
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    • v.55 no.5
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    • pp.586-592
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    • 2017
  • In this study, acrylic resins with solids content of 75% were prepared by addition polymerization of n-butyl acrylate (BA), methyl methacrylate (MMA), 2-hydroxypropyl methacrylate (HPMA) and acetoacetoxyethyl methacrylate (AAEM) monomers. At this time, the glass transition temperature ($T_g$) of the acrylic resin was changed to 20, 30 and $40^{\circ}C$, and the hydroxyl value (OH value) was changed to 60, 90 and 120. As a result, the viscosity of acrylic resin increased with increasing $T_g$ and hydroxyl (OH) value. The synthesized acrylic resin was designed to have a high cross-link density to maintain high elasticity and high durability. The crosslinked acrylic resin was used to prepare an acrylic urethane clear coating by curing reaction with a block isocyanate (Desmodur BL-3175). The physical properties of the clear paints were analyzed by measuring viscosity, adhesion, pencil hardness and $60^{\circ}$ specular gloss. Acrylic urethane clear coatings were prepared as specimens and evaluated for various properties to be applied as top coatings for coil coating. The prepared coatings were excellent in adhesion, excellent in $60^{\circ}$ specular gloss and pencil hardness, and eco-friendly.

Optimization to Prepare SIS-SBS Modified Asphalt for Waterproof-sheet (SIS-SBS 개질아스팔트 방수시트재 물성 최적화)

  • Lim, Kwang-Hee
    • Korean Chemical Engineering Research
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    • v.55 no.5
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    • pp.690-697
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    • 2017
  • In this study, styrene-isoprene-styrene (SIS)-styrene-butadiene-styrene (SBS) modified asphalt was prepared for waterproof-sheet to measure its properties including softening point, penetration, low temperature flexibility, viscosity and adhesion. Then the properties of SIS-SBS modified asphalt imparted with self-healing were optimized to seek for optimal compositions of SIS and SBS versus asphalt according to response surface methodology (RSM). As the content of SBS or SIS was increased, both properties of softening point and viscosity, measured at high temperature, were increased with a statistical significance. However, the increments of softening point and viscosity per unit content of SBS added, were observed to be greater than those per unit content of SIS added, respectively. It was due to the difference of thermal properties of SBS and SIS at high temperature that the cross-linking degree of SBS was increased by gelation accompanied with the increase of viscosity, while chain-entanglement of SIS was relatively reduced owing to a chain scission of poly(isoprene) blocks causing the decrease of viscosity. To the contrary, SIS-SBS modified asphalt showed a behavior of the least elasticity resulting in both the maximum of penetration and adhesion, measured at room temperature, as well as the lowest low temperature flexibility at the composition of SIS, 4 g and SBS, 8.5 g based on asphalt, 63 g.

A Model-Fitting Approach of External Force on Electric Pole Using Generalized Additive Model (일반화 가법 모형을 이용한 전주 외력 모델링)

  • Park, Chul Young;Shin, Chang Sun;Park, Myung Hye;Lee, Seung Bae;Park, Jang Woo
    • KIPS Transactions on Computer and Communication Systems
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    • v.6 no.11
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    • pp.445-452
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    • 2017
  • Electric pole is a supporting beam used for power transmission/distribution which accelerometer are used for measuring a external force. The meteorological condition has various effects on the external forces of electric pole. One of them is the elasticity change of the aerial wire. It is very important to perform modelling. The acceleration sensor is converted into a pitch and a roll angle. The meteorological condition has a high correlation between variables, and selecting significant explanatory variables for modeling may result in the problem of over-fitting. We constructed high deviance explained model considering multicollinearity using the Generalized Additive Model which is one of the machine learning methods. As a result of the Variation Inflation Factor Test, we selected and fitted the significant variable as temperature, precipitation, wind speed, wind direction, air pressure, dewpoint, hours of daylight and cloud cover. It was noted that the Hours of daylight, cloud cover and air pressure has high explained value in explonatory variable. The average coefficient of determination (R-Squared) of the Generalized Additive Model was 0.69. The constructed model can help to predict the influence on the external forces of electric pole, and contribute to the purpose of securing safety on utility pole.