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Novel Early Predictor of Acute Kidney Injury after Open Heart Surgery under Cadiopulmonary Bypass Using Plasma Neutrophil Gelatinase-Associated Lipocalin

  • Kim, Jong Duk;Chee, Hyun Keun;Shin, Je Kyoun;Kim, Jun Seok;Lee, Song Am;Kim, Yo Han;Lee, Woo Surng;Kim, Hye Young
    • Journal of Chest Surgery
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    • v.47 no.3
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    • pp.240-248
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    • 2014
  • Background: Open heart surgery using cardiopulmonary bypass (CPB) is considered one of the most frequent surgical procedures in which acute kidney injury (AKI) is a frequent and serious complication. The aim of the present study was to evaluate the efficiency of neutrophil gelatinase-associated lipocalin (NGAL) as an early AKI biomarker after CPB in cardiac surgery (CS). Methods: Thirty-seven adult patients undergoing CS with CPB were included in this retrospective study. They had normal preoperative renal function, as assessed by the creatinine (Cr) level, NGAL level, and estimated glomerular filtration rate. Serial evaluation of serum NGAL and Cr levels was performed before, immediately after, and 24 hours after the operation. Patients were divided into two groups: those who showed normal immediate postoperative serum NGAL levels (group A, n=30) and those who showed elevated immediate postoperative serum NGAL levels (group B, n=7). Statistical analysis was performed using Statistical Package for the Social Sciences version 18. Results: Of the 37 patients, 6 (6/37, 16.2%) were diagnosed with AKI. One patient belonged to group A (1/30, 3.3%), and 5 patients belonged to group B (5/7, 71.4%). Two patients in group B (2/7, 28.5%) required further renal replacement therapy. Death occurred in only 1 patient (1/37, 2.7%), who belonged to group B. Conclusion: The results of this study suggest that postoperative plasma NGAL levels can be used as an early biomarker for the detection of AKI following CS using CPB. Further studies with a larger sample size are needed to confirm our results.

Strategies to Attract Transshipment Container Cargoes among Main Competitive Ports in North (East Asian Region) (동북아 경쟁항만간의 환적화물 유치전략 (부산항을 중심으로))

  • 정태원;곽규석
    • Journal of Korean Society of Transportation
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    • v.20 no.7
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    • pp.43-50
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    • 2002
  • Competition to attract the increasing container cargoes of North China and the West Japan in North-East Asia region is fairly intensed in recent days between the main ports of Korea, China, and Japan. Inducing a new container cargo make those countries possible to invest enormous fund to mordernize its port facilities, as well as to improve efficiency in Port operation and management. In this situation, Strategy to attract transshipment cargoes is of the immediate necessity, This study, therefore, aims to establish the feasible strategies to attract transshipment container cargoes in the North-East Asian region by empirical analysis, he major output of the research is as follows : First, Busan Port to attract transshipment cargoes is required to adjust port tariff and free storage period with flexibility for liner shipping companies and freight forwarder. Second, Price-Demand function of Busan port between main competitive ports in North-East Asian region that is derived from strategies to attract transshipment cargoes, helps marketing manager to fix scientifically port price as understanding the change of demand quantity.

A Study on the Function Overlap and Irrational Hierarchy System of Logistics Complexes of Inland Base: Focusing on the Case of the Integrated Freight Terminal in the Yeongnam Area (내륙 거점 물류단지 기능중첩 및 연계체계 불합리성에 관한 연구: 영남권 복합물류 터미널을 사례로)

  • JUNG, Jin Uk;PARK, Woonho;JOH, Chang-Hyeon;PARK, Dongjoo
    • Journal of Korean Society of Transportation
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    • v.34 no.4
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    • pp.304-317
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    • 2016
  • The advancement in technology including transportation and information communication has accelerated the flow of supplies, and the importance of the national logistics policy has increased following the expansion of the regional range of logistics to a national range. The rapid growth of the domestic logistics market results in the deficit of logistics facilities, inefficient operation of logistics facilities, and a complicated distribution structure. It has precipitated a plan aimed at efficiency improvement by building base logistics facilities, but this market is now undergoing difficulties due to low performance. Many studies on the revitalization of base logistics facilities have been conducted, but a causal analysis focusing on the function overlap of private logistics businesses has been absent. Therefore, this study has analyzed the function overlap of logistics facilities and the irrationality of the system, which resulted from the lost function of Inland Freight bases in the Yeongnam region. By suggesting the cause of disuse of base logistics complexes from the function overlap in the ground transportation of domestic freight, the study can provide the policy implication for the national logistics infrastructure.

Development of Bialaphos-Resistant Transgenic Rice Using Agrobacterium tumefaciens (Agrobacterium tumefaciens를 이용한 bialaphos 저항성 형질전환 벼의 개발)

  • 이효연;이춘환;김호일;한원동;최지은;김진호;임용표
    • Korean Journal of Plant Tissue Culture
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    • v.25 no.4
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    • pp.283-288
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    • 1998
  • The bialaphos is a potent inhibitor of glutamine synthease in higher plants and is used as a non-selective herbicide. We have used the bialaphos resistant gene(Bar) encoding for an acetyltransferase isolated from Streptomyces hygroscopicus SF1293. Callus derived from mature seeds of rice(Oryza sativa L. cv. Dong Jin) were co-cultivated with Agrobacterium tumefaciens EHA101 carring a plasmid pGPTV-HB containing genes for hygromycin resistance (HygR) and Bar. Transgenic plants showing in vitro resistance to 50 mg/L hygromycin and 10 mg/L bialaphos were obtained by using a two-step selection/regeneration procedure. Transformation efficiency of rice was about 30% which was as high as reported in other dicotyledons. Progenies ($\textrm{T}_{1}$ generation) derived from primary transformant of 17 lines were segregated with a 3 resistant : 1 sensitive ratio in medium containing hygromycin and bialaphos. Stable integration of Bar gene into chromosomal DNA was proven by Southern blot analysis of genomic DNA isolated from $\textrm{T}_{2}$ progenies. Transgenic plants ($\textrm{T}_{3}$) grown in the field were resistant to bialaphos (Basta) at a dosage lethal to wild type plants.

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Effects of osmoticum treatments and shooting chances on the improvement of particle gun-mediated transformation in Phalaenopsis (유전자총을 이용한 팔레놉시스 형질전환 효율향상에 삼투압 조절제 및 발사횟수차이가 미치는 영향)

  • Roh, Hee Sun;Kim, Jong Bo
    • Journal of Plant Biotechnology
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    • v.41 no.4
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    • pp.216-222
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    • 2014
  • This study was carried out to develop an efficient transformation protocol via particle bombardment with PLBs (protocorm-like bodies) in Phalaenopsis. To achieve this aim, osmoticum treatment and an increasing shooting chances in particle bombardment process were applied for this study. In addition, pCAMBIA3301: ORE7 vector which contains a herbicide-resistance bar gene as a selectable marker and ORE7 gene as a gene of interests were employed. With regard to the increasing chances of shooting in particle bombardment, double shooting was the best results with 1.5 ~ 2.5 times higher than those of a single or triple shooting treatment in the productioon of PPT (D-L-phosphinothricin)-resistant PLBs. However, regeneration rate of shoots in double shooting was not high as a single shooting. Further, double shooting showed 35 ~ 40% higher than that of a single shooting in the frequency of browning. Regarding effects of different osmotic treatments, combination of 0.2 M sorbitol with 0.2 M mannitol showed the best results in transformation efficiency, regeneration of transformants and reduction of browning. Putative transgenic Phalaenopsis plants were analyzed by PCR analysis and confirmed the presence of bar and ORE 7 gene. Also, real-time PCR was conducted by using 21 transgenic plants and showed only 4 plants had one copy of transgene; whereas, the other 17 plants had more than 2 copies of transgene. Transgenic phalaenopsis plants produced in this study were transferred to pots and flowered normally without morphological variations in flower and leaf.

Image Segmentation Algorithm Based on Geometric Information of Circular Shape Object (원형객체의 기하학적 정보를 이용한 영상분할 알고리즘)

  • Eun, Sung-Jong;WhangBo, Taeg-Keun
    • Journal of Internet Computing and Services
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    • v.10 no.6
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    • pp.99-111
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    • 2009
  • The result of Image segmentation, an indispensable process in image processing, significantly affects the analysis of an image. Despite the significance of image segmentation, it produces some problems when the variation of pixel values is large, or the boundary between background and an object is not clear. Also, these problems occur frequently when many objects in an image are placed very close by. In this paper, when the shape of objects in an image is circular, we proposed an algorithm which segment an each object in an image using the geometric characteristic of circular shape. The proposed algorithm is composed of 4 steps. First is the boundary edge extraction of whole object. Second step is to find the candidate points for further segmentation using the boundary edge in the first step. Calculating the representative circles using the candidate points is the third step. Final step is to draw the line connecting the overlapped points produced by the several erosions and dilations of the representative circles. To verify the efficiency of the proposed algorithm, the algorithm is compared with the three well-known cell segmentation algorithms. Comparison is conducted by the number of segmented region and the correctness of the inner segment line. As the result, the proposed algorithm is better than the well-known algorithms in both the number of segmented region and the correctness of the inner segment line by 16.7% and 21.8%, respectively.

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Driving Torque Analysis of Role Driving & Wrapping Arm Rotation Type Round Bale Wrapper (롤 구동 래핑암 회전식 원형베일래퍼의 구동 토크 분석)

  • Yu B. K;Kim H. J.;Oh K. Y.;Choe K. J.;Lee S. H.;Park H. J.;Kim B. K.
    • Journal of Animal Environmental Science
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    • v.11 no.1
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    • pp.11-16
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    • 2005
  • The round bale wrappers are generally used for rice straw after the harvesting of low land rice by combine harvester. In this situation, the bale wrappers should be well adapted under the travelling over raised borders and temporary ditches in soft soil of narrow rice fields. The study was conducted to improve the performance of bale wrapper through the new design for compact size, lowered gravity center and lowered power consumption. The prototype of round bale wrapper had been designed and assembled to tractor with three point hitch mounted. The machine type is one roll driving system with one roll for rotating and one roll for wrapping. The driving torque and work performance of the machines were measured and analysed. The torque requirement of the prototype and conventional type was 6kgf-m and 12kgf-m, respectively. The prototype shaved less friction resistance between bale driving roll and round bale. and the power requirement can also be reduced from 12kgf-m in the conventional to 6kgf-m in the prototype. The work efficiency of the new bale wrapper was $45\%$ higher than the conventional wrapper, and the working cost of the prototype can be reduced $17\%$ than that of the conventional.

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Unsupervised Change Detection for Very High-spatial Resolution Satellite Imagery by Using Object-based IR-MAD Algorithm (객체 기반의 IR-MAD 기법을 활용한 고해상도 위성영상의 무감독 변화탐지)

  • Jaewan, Choi
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.33 no.4
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    • pp.297-304
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    • 2015
  • The change detection algorithms, based on remotely sensed satellite imagery, can be applied to various applications, such as the hazard/disaster analysis and the land monitoring. However, unchanged areas sometimes detected as the changed areas due to various errors in relief displacements and noise pixels, included in the original multi-temporal dataset at the application of unsupervised change detection algorithm. In this research, the object-based changed detection for the high-spatial resolution satellite images is applied by using the IR-MAD (Iteratively Reweighted- Multivariate Alteration Detection), which is one of those representative change detection algorithms. In additionally, we tried to increase the accuracy of change detection results with using the additional information, based on the cross-sharpening method. In the experiment, we used the KOMPSAT-2 satellite sensor, and resulted in the object-based IR-MAD algorithm, representing higher changed detection accuracy than that by the pixel-based IR-MAD. Also, the object-based IR-MAD, focused on cross-sharpened images, increased in accuracy of changed detection, compared to the original object-based IR-MAD. Through these experiments, we could conclude that the land monitoring and the change detection with the high-spatial-resolution satellite imagery can be accomplished efficiency by using the object-based IR-MAD algorithm.

A Comparative Study of the Assay Methods Used to Quantify Fermentable Sugar in Makgeolli Sul-dut (막걸리 술덧의 발효성 당 분석방법 비교 연구)

  • Kim, Byong-Soo;Kim, Gye-Won;Shim, Jae-Yong
    • Korean Journal of Food Science and Technology
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    • v.48 no.1
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    • pp.48-53
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    • 2016
  • The objective of this study was to evaluate the accuracy and efficiency of different methods used for the fermentable sugar assay in the production of Makgeolli sul-dut. In the initial stage of fermentation, Ipguk treatment produced a higher alcohol content compared to the Nuruk treatment. However, the alcohol content was not significantly different between the two starters at the final stage of fermentation. Acidity in the Ipguk treatment was higher than that of Nuruk throughout the fermentation period. After analyzing the fermentable sugars using dinitrosalicylic acid (DNS), Fehling's method, refractometer, glucose kit, and high performance liquid chromatography (HPLC), it was confirmed that the HPLC method was the most accurate for fermentable sugar quantification. In both types of starters, DNS and Fehling's methods showed results comparable to HPLC in terms of fermentable sugar content, while the glucose kit and refractometer analyses showed relatively large discrepancies, indicating that the Fehling's method could also be effective for the analysis of fermentable sugars in the manufacture of Makgeolli.

Inheritance of Fruit Ripening Time in Oriental Pear (Pyrus pyrifolia var. culta Nakai) (동양배 과실 숙기형질의 유전분석)

  • Hwang, Hae-Sung;Byeon, Jae-Kyun;Kim, Whee-Cheon;Shin, Il-Sheob
    • Horticultural Science & Technology
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    • v.33 no.5
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    • pp.712-721
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    • 2015
  • To improve the breeding efficiency of oriental pear, heritability, correlation and frequency distribution of fruit ripening date were analyzed using 4,035 seedlings obtained from 15 families between 13 parental cultivars. Although variation of fruit ripening time was higher in most early-ripening parental cultivars than in late-ripening parental cultivars, according to analysis of average, standard deviation, and coefficient of ripening variation for ten years, fruit ripening time obtained from all parental cultivars was inherited narrower and more stable variation than others fruit trait, with 0.92-3.41 in coefficient of variation. The heritability of fruit ripening time was calculated to be over 0.8 in almost all crosses and average fruit ripening time of seedlings from cross combinations could be predicted based on that of the parental cultivars due to its superior heritability relative to other fruit traits. The average ripening time was earlier than the mid-parental value in families obtained from cross combinations using at least one late-ripening cultivar as parent, indicating that the early-ripening trait was more likely to be dominant compared to the late-ripening trait. By contrast, average ripening time was clustered in families of crosses not only between mid-season and early-season cultivars, but also between mid-season and mid-season cultivars. There was highly significant relationship (at 0.68) between mid-parental and progeny mean fruit ripening time. The correlation between fruit ripening time and fruit weight was also highly positive and thus, the mid-parental fruit ripening time could be a potent criterion for indirect selection of fruit weight.