• Title/Summary/Keyword: effective modification method

Search Result 315, Processing Time 0.035 seconds

Inhibitory Effects of Momordin I Derivatives on the Formation of Fos-Jun-AP-1 DNA Complex

  • Lee, Ju-hyung;Park, Chi-Hoon;Kim, Wook-Hwan;Hwang, Yun-Ha;Jeong, Kyung-chae;Yang, Chul-Hak
    • Bulletin of the Korean Chemical Society
    • /
    • v.27 no.4
    • /
    • pp.535-538
    • /
    • 2006
  • In our previous studies, we have observed that curcumin and momordin I isolated from Ampelopsis radix inhibit the formation of Fos-Jun-activation protein-1 (AP-1) DNA complex. We have screened more effective compounds which have a 5-membered ring framework like momordin I and have modified disaccharide or carboxylic acid portions in momordin I. We synthesized momordin I derivatives according to the published method with slight modification. Synthetic momordin I derivatives showed remarkable inhibitory activities on Fos-Jun-AP-1 DNA complex formation results in in vitro assays. The $IC_{50}$ values of momordin I derivatives were about 4.0 $\mu$M in an electrophoretic mobility shift assay (EMSA). This value is about 125 times higher than that of curcumin and about 12 times higher than that for curcumin derivative C1, and moreover about 30 times higher than that for momordin I. We found momordin I derivatives (a) and (b) are the strongest inhibitory compound for Fos-Jun-AP-1 DNA complex formation.

Effect of Nutrition Education Program in Obese Children and Their Parents(II) - Focus on Nutrition Knowledge, Eating Behaviors, Food Habit and Nutrient Intakes - (비만아동과 그 부모에 대한 영양교육 효과의 평가(II)-영양지식, 식행동, 식습관과 영양소섭취를상태를 중심으로-)

  • 신은경;이혜성;이연경
    • Korean Journal of Community Nutrition
    • /
    • v.9 no.5
    • /
    • pp.578-588
    • /
    • 2004
  • The present study was conducted to investigate the effect of nutrition education program on nutrition knowledge, eating behaviors, food habit, nutrient intakes in obese children and their parents who live in Gumi city. The subjects were 16 obese boys, 20 obese girls with obesity index over 130% and 36 of their parents. The nutrition education for the subjects was carried out by the professional personnel such as doctors, professors, and dietitians. The children were provided with well-balanced lunch meals and had 40 min-lectures on the reasonable weight management, 40 min-games and also had regular exercises (stretching, swimming) for 90 mins everyday during 2 weeks of the program. The parents had 90 min-lectures on childhood obesity, diet therapy, behavior modification, and exercise for 6 times. The nutrition knowledge, eating behaviors and food habits were surveyed by using questionnaires before and after the education. The nutrition intakes of the children were surveyed before and after the education by 3-day food record method. The nutrition intakes of the parents were surveyed before and after the education by using semi-quantity questionnaires. After the education, the mean nutrition knowledge scores were significantly improved compared with the pretest scores in both children and parents. After the education, all subjects' eating behaviors were significantly changed positively and calorie and carbohydrates intakes were significantly decreased and vit. C was significantly increased in obese children. The food habits of the parents were significantly improved after the education. These findings show that the well-designed nutrition education program for obese children and their parents can be an effective approach to help them to improve their nutrition knowledge and to establish desirable food habits and eating behaviors.

Effect of Adding Crosslinked Particles on Rheological and Electrical Properties of Polystyrene/Carbon Nanotube Nanocomposites (가교 입자 첨가가 폴리스티렌/탄소나노튜브 나노복합재료의 유변물성 및 전기적 물성에 미치는 영향)

  • Yeom, Hyo Yeol;Na, Hyo Yeol;Lee, Seong Jae
    • Polymer(Korea)
    • /
    • v.38 no.6
    • /
    • pp.767-773
    • /
    • 2014
  • Rheological and electrical properties of polystyrene (PS)/carbon nanotube (CNT) nanocomposites via coagulated precipitation were investigated. Chemical modification and surfactant wrapping of CNT to improve the dispersion of CNTs may reduce the intrinsic properties of pristine CNT. To avoid this problem, PS and CNTs were dissolved and dispersed in dimethylformamide and then PS/CNT nanocomposites were prepared by the coagulated precipitation of CNT-dispersed PS solution in water. The coagulated precipitation method was highly effective enhancing the electrical conductivity of nanocomposites. Furthermore, the effect of adding poly(styrene-co-divinylbenzene) crosslinked particles to PS matrix on the rheological and electrical properties was investigated. With the addition of the crosslinked particles, the electrical percolation threshold of CNT reduced to 0.25 wt% and electrical conductivity increased further. It is speculated that CNTs in the volume occupied by crosslinked particles helped electrical pathway formation.

A Study on the Apartment Residents' Awareness and Needs about Interior Coordination - Focused on the Apartment Residents in Pusan - (실내코디네이션에 대한 아파트 거주자들의 인식 및 요구조사 - 부산광역시 아파트 거주자를 중심으로 -)

  • Kim, Ji-Eun;Han, Jeong-Won
    • Korean Institute of Interior Design Journal
    • /
    • v.21 no.3
    • /
    • pp.103-110
    • /
    • 2012
  • Interior Coordination is the activity of making characteristic living space by planning and harmonizing various interior elements. In modern society, the taste and needs of the residents are getting varied and segmented, and the role of interior coordination is getting more important because that reflects cultural codes and trends and satisfies residents' needs. This study aims to investigate awareness and needs about interior coordination targeting apartment residents, and to provide fundamental data that could attribute to the planning of unique and diverse residential spaces. Methods of study include the literature research and the empirical study. Elements of interior coordination were extracted through the literature review, and the questionnaire was developed using these elements. And then a survey was carried out targeting apartment residents of Busan. The result shows that most of the residents were much interested in interior coordination, and they recognized it's importance. They wanted to plan and select the elements by themselves, but were passive in actual execution because of the difficulties in execution methods and economical conditions. There were certain differences between the styles of their own houses and the preferred styles, but they did not try actively to reconcile the differences. Therefore, various methods of interior coordination should be developed and proposed which are easy and effective for actual execution, and various media should be provided by which residents could easily get informations on design elements. Also, the concept and method of interior coordination should be considered from the very first stage of residential planning, and the replacement and modification of interior coordination could be easily done according to the change of life cycle and life styles.

  • PDF

Needle Stick Injuries and their Related Safety Measures among Nurses in a University Hospital, Shiraz, Iran

  • Jahangiri, Mehdi;Rostamabadi, Akbar;Hoboubi, Naser;Tadayon, Neda;Soleimani, Ali
    • Safety and Health at Work
    • /
    • v.7 no.1
    • /
    • pp.72-77
    • /
    • 2016
  • Background: This study aimed to determine the prevalence and factors related to needle stick injuries (NSIs) and to assess related safety measures among a sample of Iranian nurses. Methods: In this cross-sectional study, a random sample of 168 registered active nurses was selected from different wards of one of the hospitals of Shiraz University of Medical Sciences (SUMS). Data were collected by an anonymous questionnaire and a checklist based observational method among the 168 registered active nurses. Results: The prevalence of NSIs in the total of work experience and the last year was 76% and 54%, respectively. Hollow-bore needles were the most common devices involved in the injuries (85.5%). The majority of NSIs occurred in the morning shift (57.8%) and the most common activity leading to NSIs was recapping needles (41.4%). The rate of underreporting NSIs was 60.2% and the major reasons for not reporting the NSIs were heavy clinical schedule (46.7%) and perception of low risk of infection (37.7%). A statistically significant relationship was found between the occurrence of NSIs and sex, hours worked/week, and frequency of shifts/month. Conclusion: The study showed a high prevalence of NSIs among nurses. Supportive measures such as improving injection practices, modification of working schedule, planning training programs targeted at using personal protective equipment, and providing an adequate number of safety facilities such as puncture resistant disposal containers and engineered safe devices are essential for the effective prevention of NSI incidents among the studied nurses.

Superhydrophobic nano-hair mimicking for water strider leg using CF4 plasma treatment on the 2-D and 3-D PTFE patterned surfaces

  • Shin, Bong-Su;Moon, Myoung-Woon;Kim, Ho-Young;Lee, Kwang-Ryeol
    • Proceedings of the Korean Vacuum Society Conference
    • /
    • 2010.02a
    • /
    • pp.365-365
    • /
    • 2010
  • Similar to the superhydrophobic surfaces of lotus leaf, water strider leg is attributed to hierarchical structure of micro pillar and nano-hair coated with low surface energy materials, by which water strider can run and even jump on the water surface. In order to mimick its leg, many effort, especially, on the fabrication of nanohairs has been made using several methods such as a capillarity-driven molding and lithography using poly(urethane acrylate)(PUA). However most of those effort was not so effective to create the similar structure due to its difficulty in the fabrication of nanoscale hairy structures with hydrophobic surface. In this study, we have selected a low surface energy polymeric material of polytetrafluoroethylene (PTFE, or Teflon) assisted with surface modification of CF4 plasma treatment followed by hydrophobic surface coating with pre-cursor of hexamethyldisiloxane (HMDSO) using a plasma enhanced chemical vapor deposition (PE-CVD). It was found that the plasma energy and duration of CF4 treatment on PTFE polymer could control the aspect ratio of nano-hairy structure, which varying with high aspect ratio of more than 20 to 1, or height of over 1000nm but width of 50nm in average. The water contact angle on pristine PTFE surface was measured as approximately $115^{\circ}$. With nanostructures by CF4 plasma treatment and hydrophobic coating of HMDSO film, we made a superhydrophobic nano-hair structure with the wetting angle of over $160^{\circ}C$. This novel fabrication method of nanohairy structures has been applied not only on 2-D flat substrate but also on 3-D substrates like wire and cylinder, which is similarly mimicked the water strider's leg.

  • PDF

Synthesis of functional ZnO nanoparticles and their photocatalytic properties

  • Nam, Sang-Hun;Kim, Myoung-Hwa;Lee, Sang-Duck;Kim, Min-Hee;Boo, Jin-Hyo
    • Proceedings of the Korean Vacuum Society Conference
    • /
    • 2010.02a
    • /
    • pp.54-54
    • /
    • 2010
  • Zinc oxide is metal oxide semiconductor with the 3.37 eV bandgap energy. Zinc oxide is very attractive materials for many application fields. Zinc Oxide has many advantages such as high conductivity and good transmittance in visible region. Also it is cheaper than other semiconductor materials such as indium tin oxide (ITO). Therefore, ZnO is alternative material for ITO. ZnO is attracting attention for its application to transparent conductive oxide (TCO) films, surface acoustic wave (SAW), films bulk acoustic resonator (FBAR), piezoelectric materials, gas-sensing, solar cells and photocatalyst. In this study, we synthesized ZnO nanoparticles and defined their physical and chemical properties. Also we studied about the application of ZnO nanoparticles as a photocatalyst and try to find a enhancement photocatalytic activity of ZnO nanorticles.. We synthesized ZnO nanoparticles using spray-pyrolysis method and defined the physical and optical properties of ZnO nanoparticles in experiment I. When the ZnO are exposed to UV light, reduction and oxidation(REDOX) reaction will occur on the ZnO surface and generate ${O_2}^-$ and OH radicals. These powerful oxidizing agents are proven to be effective in decomposition of the harmful organic materials and convert them into $CO_2$ and $H_2O$. Therefore, we investigated that the photocatalytic activity was increased through the surface modification of synthesized ZnO nanoparticles. In experiment II, we studied on the stability of ZnO nanoparticles in water. It is well known that ZnO is unstable in water in comparison with $TiO_2$. $Zn(OH)_2$ was formed at the ZnO surface and ZnO become inactive as a photocatalyst when ZnO is present in the solution. Therefore, we prepared synthesized ZnO nanoparticles that were immersed in the water and dried in the oven. After that, we measured photocatalytic activities of prepared samples and find the cause of their photocatalytic activity changes.

  • PDF

Review of Clinical Studies of Herbal Medicine Retention Enema for Pediatric Diarrhea in Chinese Medicine (중의학에서 소아 설사에 적용하는 한약 보류관장요법에 대한 문헌 고찰)

  • Park, Beom Chan;Kim, Hee Yeon;Kim, Kibong;Cheon, Jin Hong
    • The Journal of Pediatrics of Korean Medicine
    • /
    • v.33 no.4
    • /
    • pp.47-59
    • /
    • 2019
  • Objectives The purpose of this study is to analyze recent Chinese randomized controlled trials on efficacy and safety of the retention enema with herbal medicine in pediatric diarrhea. Methods We searched the recent Chinese randomized controlled trials from the China National Knowledge Infrastructure (CNKI) by using key words; '保留灌腸', '小兒', '腹瀉' and '泄瀉' with data range from January $1^{st}$, 2010 to March $2^{nd}$, 2019. Year of the publication, demographic information, disease, intervention, outcome measure, results, adverse events and composition of herbal medicine were analyzed for this study. Results 19 out of 32 studies were selected and analyzed. The most commonly used herbal medicine was Galgeungeumlyeon-tang modification (葛根芩連湯加減), and the most widely used retention enema method was to retain for 15 minutes and administer twice a day for 3 days. In most of the studies, retention enema with herbal medicine in pediatric diarrhea showed significant efficacies. No adverse effects were reported from the studies. Conclusions The results of these studies from China showed that the retention enema with herbal medicine in pediatric diarrhea may be effective and safe.

A Study on Methods for Efficient Enterprise Software Patch Management

  • Kang, Chang-Hoon
    • Journal of the Korea Society of Computer and Information
    • /
    • v.27 no.12
    • /
    • pp.179-188
    • /
    • 2022
  • In this paper, we propose an efficient and procedural software patch management phases. Every year, organizations have tens of thousands of known vulnerabilities and spend tens of thousands of hours and millions of dollars or more patching them. Despite these efforts, research has shown that the time it takes for an exploit to appear for a given patched vulnerability is shortening. As various types of organizations such as companies and universities manage patches in inconsistent ways, problems such as security problems, system instability, information leakage and work delay due to patches occur. In this paper, we look at the basics required for software patch management and define the factors to be considered for patch management and the effective steps for patch management. Therefore, this study will be used as a method to efficiently and procedurally execute the organization's patch management policy in the process of updating and patching the software in the organization to a new version as a solution to software function modification and security vulnerability.

Improvement of Dimensional Stability of Tropical Light-Wood Ceiba pentandra (L) by Combined Alkali Treatment and Densification

  • Deded Sarip NAWAWI;Andita MARIA;Rizal Danang FIRDAUS;Istie Sekartining RAHAYU;Adesna FATRAWANA;Fadlan PRAMATANA;Pamona Silvia SINAGA;Widya FATRIASARI
    • Journal of the Korean Wood Science and Technology
    • /
    • v.51 no.2
    • /
    • pp.133-144
    • /
    • 2023
  • Densification is an effective method for improving the physical and mechanical properties of low-density wood. However, the set-recovery of dimensions was found to be the problem of densified wood due to low fixation during the densification process. Alkali pretreatment before densification is thought to be a modification process to improve the dimensional stability of densified wood. In this research, the wood samples used were boiled in a 1.25 N sodium hydroxide (NaOH) solution at different times, followed by densification for 5 h at 100℃. The alkali pretreatment for 1, 3, and 5 h of boiling increased the dimensional stability of densified woods and anti-swelling efficiency values were 8.52%, 63.24%, and 48.94%, respectively. The boiling of wood in NaOH solution decreased the holocellulose content, as well as lignin to a lesser degree, and a lower crystallinity index was observed. The lower hydroxyl groups and a higher proportion of lignin in treated samples seem to have contributed to the high dimensional stability detected.