• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2006.10a
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• pp.110-110
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• 2006

• Toxicological Research
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• v.30 no.1
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• pp.1-5
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• 2014

Xenograft models of human cancer play an important role in the screening and evaluation of candidates for new anticancer agents. The models, which are derived from human tumor cell lines and are classified according to the transplant site, such as ectopic xenograft and orthotopic xenograft, are still utilized to evaluate therapeutic efficacy and toxicity. The metastasis model is modified for the evaluation and prediction of cancer progression. Recently, animal models are made from patient-derived tumor tissue. The patient-derived tumor xenograft models with physiological characters similar to those of patients have been established for personalized medicine. In the discovery of anticancer drugs, standard animal models save time and money and provide evidence to support clinical trials. The current strategy for using xenograft models as an informative tool is introduced.

• Korean Journal of Veterinary Research
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• v.33 no.3
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• pp.555-565
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• 1993

The studies on the liver fluke of Korea have been reviewed. The fluke is Fasciola hepatica. Its intermediate host is Lymnaea biridis, whose principal habitats are rice paddies. The first fascioliasis of Korean native(beef) cattle was reported in 1915. Bovine fascioliasis is present throughout the conuntry, including north Korea, with the average prevalence of 30%. The prevalence of the disease is about the same in dairy cattle, which have been imported from other countries since 1960s. The disease was also found in Korea in other species of animals such as sheep, goats, deer of zoo and farms, and guinea pigs of a laboratory. Human fascioliasis was reported ; 35 cases by fecal examination and 11 by both parasitology and pathology. Of the latter 11 cases, 5 were ectopic parasitism. Economic loss due to the reduced carcass weight and milk production, and liver condemnation was great. Almost all flukicides developed in other countries are commercially available in Korea.

• Journal of Chest Surgery
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• v.53 no.2
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• pp.89-91
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• 2020

Bronchopulmonary sequestration (BPS) is a rare congenital abnormality of the lower airway, generally characterized by blood supply received from the systemic circulation. We present a rare case of a 19-year-old man with incidentally detected BPS supplied by a branch of a pulmonary artery, rather than a systemic artery. Computed tomography showed a sequestered segment supplied by a branch of the left pulmonary artery and containing an ectopic bronchus. As chest computed tomography revealed necrosis in the sequestered tissue, infection was presumed, and the tissue was surgically removed. This may represent a very unusual occurrence, as such cases have yet to be reported in the literature.

• Korean Journal of Head & Neck Oncology
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• v.30 no.2
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• pp.79-82
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• 2014

Salivary gland tumors take possession of almost 5% in head and neck malignancies. Among these, mucoepidermoid carcinoma(MEC) is most common malignany in major salivary glands(12-29%) and the parotid gland is most predilection site. Intra-oral MEC has a tendency to various locations, and the predilection sites are palate, cheek, mandible, lip and tongue in order of frequency. A few cases of MEC are occurred in with retromolar trigone, oropharynx, and ectopic salivary gland. Recently, we experienced a-65-year old woman with retromolar trigonal mass, and she was finally diagnosed as MEC. We report it with review of literature.

• Proceedings of the Botanical Society of Korea Conference
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• 1996.07a
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• pp.4-9
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• 1996

The majority of plants sense environmental signals, such as day length or temperature, to select their transition timing from vegetative growth t flowering. Here, we report the identification of a regulatory gene, OsMADS1, that controls the photoperiod sensitivity of flowering time. Constitutive expression of OsMADS1 in a long-day flowering plant, Nicotiana sylvestris, resulted in flowering in both short-day long-day conditions. Similarly, ectopic expression of the gene in a short-day flowering plant, N. tabacum cv. Maryland Mammoth, also induced flowering regardless of the day length. The transition time was dependent on the level of the OsMADS1 transcript in transgenic plants. These suggest that OsMADS1 is a key regulatory factor that determines the transition from shoot apex to floral meristem and that it can be used for controlling flowering time in a variety of plant species.

• Molecules and Cells
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• v.20 no.3
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• pp.409-415
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• 2005

Infection of Drosophila melanogaster adults with 6 Vibrio species revealed that V. cholerae was lethal (100% mortality) within 20 h as a result of systemic infection. Avirulent infection by V. vulnificus restricted the subsequent virulent infection by V. cholerae. The immediate transcription of antimicrobial peptides (AMPs), most notably Attacin A, was delayed in V. cholerae infection compared to V. vulnificus infection. Ectopic expression of Attacin A and Metchnikowin enhanced the survival of D. melanogaster upon V. cholerae infection. These results suggest that AMPs are important in the response to infections by Vibrio species and that the signaling pathways governing their expression may be targeted by V. cholerae virulence factors to elude the innate immunity of Drosophila.

• Journal of the korean academy of Pediatric Dentistry
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• v.24 no.4
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• pp.788-794
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• 1997

As one of the developmental disturbance in shape of teeth, a twinning has very rare frequency in permanent teeth. Because it is possible to diagnose the twinning by use of the radiograph, it is very important to detect this anomaly early by careful examining the radiographs. The twinning produces several orthodontic problem such as crowding, protrusion, ectopic eruption of adjacent teeth. Therefore it is necessary, in proper time, the extraction and orthodontic treatment should perform.

• Korean Journal of Bronchoesophagology
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• v.3 no.2
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• pp.318-322
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• 1997

Lingual thyroid is the term applied to a mass of ectopic thyroid tissue located on the base of the tongue in the midline. It may be found anywhere between the circumvallate papillae and the epiglottis. It is believed to be caused by developmental anomalies involving the descent of the embryologic gland anlage from its position posterior to the tuberculum impar to its normal pretracheal location between week 3 and week 7 of embryologic development. Differential diagnosis of the lingual thyroid would include lingual tonsillar hypertrophy, vallecular cyst, thyroglossal duct cyst, epidermal cyst, lymphoma. Lingual thyroid is found in approximately 1 in 100,000 people, and affected individuals have no other thyroid tissue in 70% to 100% of cases. Recently, we have experienced a case of lingual thyroid with mild dysphagia in a 48-year-old male. Now we report the case with literature review.

• Journal of Korean Foot and Ankle Society
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• v.6 no.2
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• pp.224-228
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• 2002

Ossification of the Achilles tendon is a rare condition to be distinguished from the more frequently occuring tendon calcification. It is characterized by the presence of an ossific mass contained within the fibrocartilaginous substance of the tendon and is usually associated with prior surgery or trauma to the tendon. We treated a 13 year old girl with ossification of the Achilles tendon after sprain-like injury. We excised it one year later and the microscopic finding of the extirpated bony mass revealed fully maturated lamellar bone.