• Education of Primary School Mathematics
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• v.24 no.3
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• pp.157-174
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• 2021

This study analyzed the process of establishing a social structure in a third-grade mathematics classroom for one semester and explored learning processes based on various social interactions and relationships between the teacher and students. In the early phase of the semester, main foci were placed on establishing an overall social norms and basic social structure for effective mathematical learning. In the middle phase of the semester, an emphasis among students' interactions was given to exploration of mathematical concepts. Students tended to ask whatever they did not know exactly and clearly understood what to explain. In the late phase of the semester, students' individual disposition was further considered. Disciplinary personality traits including intellectual courage, honesty, consideration, and cooperation were emphasized along with mathematical exploration. Based on these research results, this study was intended to provide implications for implementing more meaningful mathematics lessons by fully considering not only mathematical connections but also social connections.

• Microbiology and Biotechnology Letters
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• v.45 no.2
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• pp.149-154
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• 2017

To increase the efficiency of esterase production by Bacillus, high cell-density culture of recombinant Escherichia coli through fed batch fermentation was tested. Cells were cultured to $OD_{600}$ of 76 (35.8 g/l DCW) with dissolved oxygen level controlled to least above 30% air saturation by supplying pure oxygen. Cells were cultured to an $OD_{600}$ of 90 (42.4 g/l DCW) with glucose feeding controlled to at least 1 g/l. However, the cells reached stationary phase at the late stage of culture, despite glucose being supplied. Cells were cultured to an $OD_{600}$ of 185 (87.3 g/l DCW) by supplying additional medium with fortified yeast extract. To increase the productivity of the recombinant protein, cell growth and esterase productivity based on induction time were evaluated. Late exponential phase induction for esterase production in fed batch fermentation resulted in maximum optical density $OD_{600}$ of 190 (89 g/l DCW) and maximum esterase activity of 1745 U/l, corresponding to a 5.8-fold enhancement in esterase production, compared to the early exponential phase induction. In this study, we established fermentation methods for achieving maximum production of Bacillus-derived esterase by optimizing IPTG induction time in high-cell density culture by supplying pure oxygen and a nitrogen source.

• Journal of Ecology and Environment
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• v.30 no.1
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• pp.23-38
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• 2007

Based on a time series of ocean climate indices and catch records for seven pelagic fish species in the Tsushima Warm Current (TWC) and Kuroshio-Oyashio Current (KOC) regions from 1910 to 2004, we detected regional synchrony in the long-term fluctuations of the fish populations and identified alternation patterns of dominant species related to climate shifts. The annual catches of Pacific herring, Japanese sardines, Japanese anchovies, jack mackerel, chub mackerel, Pacific saury and common squid in the TWC region fluctuated in phase with those in the KOC region, which suggests that they were controlled by the same basin-wide climate forcing. After the collapse of the herring fishery, the alternation sequence was: sardines (1930s), Pacific saury, jack mackerel, common squid and anchovies ($1950s{\sim}1960s$), herring ($late\;1960s{\sim}early\;1970s$), chub mackerel (1970s) and then sardines (1980s). As sardine biomass decreased in the late stages of the cool regime, catch of the other four species increased immediately during the warm period of the 1990s. Regional differences in the amplitude of long-term catch fluctuations for the seven pelagic fishes could be explained by regional differences in availability, fishing techniques and activity.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6491-6499
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• 2015

Background: Red-fleshed sweet orange juice (ROJ) comes from a new variety of citrus cultivated in Brazil that contains high levels of ${\beta}$-carotene and lycopene, and similar amounts of hesperidin (HSP) and nutrients, equivalently to blond orange juice (BOJ). Such bioactive compounds are associated with chemopreventive actions in several cancer cell lines. The purpose of this study was to examine the cytotoxicity, cell cycle, apoptosis, and cytokine secretion after BOJ, ROJ, and HSP treatment of a novel T acute lymphoblastic leukemia cell line, Loucy. Materials and Methods: Loucy cells were incubated for 24-h with BOJ, ROJ, and HSP, and the viability was measured using trypan blue. Cell cycling and apoptosis were assessed by propidium iodide (PI) and annexin V-FITC/PI flow cytometry, respectively. Secretion of cytokines $IL-1{\alpha}$, $IL1-{\beta}$, IL-2, IL-4, IL-6, IL-10, IL-17A, $IFN{\gamma}$, $TNF{\alpha}$, $TGF{\beta}$, $MIP{\alpha}$, and $MIP{\beta}$ was determined by ELISA array. Results: BOJ and ROJ treatments promoted Loucy cell cytotoxicity. Additionally, BOJ induced cell cycle arrest in the G0/G1 phase, and decreased the cell accumulation in the G2/M. ROJ decreased only the G0/G1 fraction, while HSP did not change the cell cycle. BOJ led to apoptosis in a different fashion of ROJ, while the first treatment induced apoptosis by increase of late apoptosis and primary necrotic fractions, the second increased early and late apoptosis, and primary necrotic fraction compared to positive controls. HSP had no effect on apoptosis. IL-6 and IL-10 were abrogated by all treatments. Conclusions: Taking together, these results suggest potential chemopreventive effects of BOJ and ROJ on Loucy cells.

• Journal of Ecology and Environment
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• v.34 no.4
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• pp.401-410
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• 2011

We assayed the effects of simulated acid rain on the mass loss, $CO_2$ evolution, dehydrogenase activity, and microbial biomass-C of decomposing Sorbus alnifolia leaf litter at the microcosm. The dilute sulfuric acid solution composed the simulated acid rain, and the microcosm decomposition experiment was performed at 23$^{\circ}C$ and 40% humidity. During the early decomposition stage, decomposition rate of S. alnifolia leaf litter, and microbial biomass, $CO_2$ evolution and dehydrogenase activity were inhibited at a lower pH; however, during the late decomposition stage, these characteristics were not affected by pH level. The fungal component of the microbial community was conspicuous at lower pH levels and at the late decomposition stage. Conversely, the bacterial community was most evident during the initial decomposition phase and was especially dominant at higher pH levels. These changes in microbial community structure resulting from changes in microcosm acidity suggest that pH is an important aspect in the maintenance of the decomposition process. Litter decomposition exhibited a positive, linear relationship with both microbial respiration and microbial biomass. Fungal biomass exhibited a significant, positive relationship with $CO_2$ evolution from the decaying litter. Acid rain had a significant effect on microbial biomass and microbial community structure according to acid tolerance of each microbial species. Fungal biomass and decomposition activities were not only more important at a low pH than at a high pH but also fungal activity, such as $CO_2$ evolution, was closely related with litter decomposition rate.

• 한국석유지질학회:학술대회논문집
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• autumn
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• pp.57-72
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• 2000

The Murzuk Basin covers an area in excess of $350,000{\cal}km^2$, and is one of several intra-cratonic sag basins located on the Saharan Platform of North Africa. Compared with some of these basins, the Murzuk Basin has a relatively simple structure and stratigraphy, probably as a result of it's location on a the East Saharan Craton. The basin contains a sedimentary fill which reaches a thickness of about $4,000{\cal}m$ in the basin centre. This fill can be divided into a predominantly marine Paleozoic section, and a continental Mesozoic section. The principal hydrocarbon play consists of a glacial-marine sandstone reservoir of Cambro-Ordovician age, sourced and sealed by overlying Silurian shales. The present day borders of the basin are defined by tectonic uplifts, each of multi-phase generation, and the present day basin geometry bears little relation to the more extensive Early Palaeozoic sedimentary basin within which the reservoir and source rocks were deposited. The key to the understanding of the Cambro-Ordovician play is the relative timing of oil generation compared to the Cretaceous and Tertiary inversion tectonics which influenced source burial depth, reactivated faults and reorganised migration pathways. At the present day only a limited area of the basin centre remains within the oil generating window. Modelling of the timing and distribution of source rock maturity uses input data from AFTA and fluid inclusion studies to define palaeo temperatures, shale velocity work to estimate maximum burial depth and source rock geochemistry to define kinetics and pseudo-Ro. Migration pathways are investigated through structural analysis. The majority of the discovered fields and identified exploration prospects in the Murzuk Basin involve traps associated with high angle reverse faults. Extensional faulting occurred in the Cambro-Ordovician and this was followed by repeated compressional movements during Late Silurian, Late Carboniferous, Mid Cretaceous and Tertiary, each associated with regional uplift and erosion.

• Economic and Environmental Geology
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• v.36 no.6
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• pp.545-556
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• 2003

Detailed interdisciplinary investigations demonstrate that the Yeongsan River estuarine-filled sediments clearly record important paleoenvironmental changes during the Last Glacial and Holocene. The sediments from 18.9 m(20.5∼l.6m in depth) long core MW-1 are differentiated by changes in sedimentary textures and palynomorph assemblages. Chronology was provided by AMS$^{14}$C dating and regional pollen correlation. Three paleoenvironrnental phases are recognized: (1) The Last Glacial deposits consist mainly of fluvial sediments and paleosols, experienced deposition alternating with pedogenesis. The appearance of the paleosols suggests that the paleoclimate might be cold and humid. (2) The early and middle Holocene phase started abruptly in response to the rapid global climatic warming. and is characterized by abundant marine palynomorphs. (3) The late Holocene is marked by more cool conditions. The paleoenvironmental changes recorded in the sediments coincide not only with local but also with broad-scale, probably global climate changes.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.2
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• pp.192-200
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• 2019

Objective: Leukemia inhibitory factor (LIF) binds to a heterodimeric receptor composed of LIF receptor (LIFR) and glycoprotein 130 (GP130) to transmit signals into the cell. LIF plays an important role in reproduction by regulating immune response, decidualization, and implantation in several species. However, the expression of LIF and LIFR in the endometrium throughout the estrous cycle and pregnancy in pigs is not fully understood. Methods: We analyzed the expression of LIF and LIFR in the endometrium on days 0 (estrus), 3, 6, 9, 12, 15, and 18 of the estrous cycle, and days 12, 15, 30, 60, 90, and 114 of pregnancy, in conceptuses on days 12 and 15, and in chorioallantoic tissues on days 30, 60, 90, and 114 of pregnancy in pigs. We also determined the effects of estrogen and progesterone on the expression of LIF and LIFR in endometrial tissues. Results: The expression of LIF increased in the endometrium during the late diestrus phase of the estrous cycle and during mid- to late- pregnancy, while the expression of LIFR increased during early pregnancy. The expression of LIF was induced by increasing doses of estrogen, whereas the expression of LIFR was induced by increasing doses of progesterone. Conclusion: These results indicate that the expression of LIF and its receptor LIFR in the endometrium is regulated in a stage-specific manner during the estrous cycle and pregnancy, suggesting that LIF and its receptor signaling system may play critical roles in regulating endometrial function in pigs.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.33 no.2
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• pp.174-181
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• 1988

A comparison was made the differences of growth and some yield components of two soybean ecotypes (summer and two autumn types) at different planting dates (15 April, 15 May, and 15 June) and also made the different patterns of dry matter accumulation of one summer type and two autumn types of soybeans at Agricultural Experiment Farm, College of Agriculture, Dankook University, Cheonan City, in 1987. [Planting date experiment] Days to emergence of four varieties were observed no difference. and, therefore, it was speculated that field observation of the difference of cold tolerence between varieties was difficult. Shortening rate of flowering clays as planting dates delayed was no different between two ecotypes, summer vs. autumn types of soybean. Summer types, DN82029-3 and ES18085-1, were observed not greater difference of days to maturity between early and late planting dates as compared with that of autumn types, Changyeobkong and Paldalkong. At late planting, summer types were observed more to hasten days to ripening due to high temperature in late growing season than that of autumn types. This caused to decrease somewhat greater rate of some yield componments, and finally yield as planting date delayed. As compared to autumn types, summer types, DN82029-3 and ES18085-1 showed longer stem height and lower airdry weight at late planting. [Dry matter accumulation pattern] Stem elongation after flowering of three varieties, DN82029-3, Changyeobkong and Danyeobkong, ranged 17 to 32 cm and increment of leaf area index 0.83-1.53. DN82029-3 reached 49 days faster in maximum total dry weight than that of autumn types, Changyeobkong and Danyeobkong. However. maximum total dry weight of DN82029-3 showed 50% to autumn types. At 15 May planting, summer type, day-neutrality, transfered faster into reproductive growth phase without enough growth of vegetative growth and also hastened ripening days, and thus lower dry matter accumulation and finally lower yield.

• The Korean Journal of Nuclear Medicine
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• v.8 no.1_2
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• pp.1-11
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• 1974

The author in an attempt to evaluate hemodynamic changes in the clinical stages of Korean hemorrhagic fever measured plasma volume, cardiac output and effective renal plasma flow utilizing radioisoto es during various phases of the disease. Cardiac output was measured by radiocardiography with external monitoring method using RIHSA. Effective renal plasma flow was obtained from blood clearance curve drawn by external monitoring after radiohippuran injection according to the method described by Razzak et al. The study was carried out in thirty-eight cases of Korean hemorrhagic fever and the following conclusions were obtained. 1. Plasma volume was increased in the patients during the oliguric-and hypertensive diuretic phases, while it was normal in the patients during the normotensive-diuretic phase. 2. Cardiac index was increased in the patients during the oliguric phase and was slightly increased in the patients at the hypertensive diuretic phase. It was normal in the other phases. 3. Total peripheral resistance was increased in the hypertensive patients during diuretic phase, while it was normal in the rest of phases. 4. Effective renal plasma flow was significantly reduced in the patients during the oliguric and diuretic phases as well as at one month after the oliguric onset. There was no significant difference between the oliguric and the early diuretic phases. Renal plasma flow in the group of patients at one month after the oliguric onset was about 45% of the normal, however, it returned to normal level at six months after the onset. 5. Clinical syndrome of relative hypervolemia was observed in some patients during the oliguric phase or hypertensive diuretic phase. Characteristic hemodynamic findings were high cardiac output and normal to relatively increased peripheral resistance in these cases. Relatively increased circulating blood volume due to decreased effective vascular space was suggested for the mechanism of relative hypervolemia. 6. Cardiac hemodynamic alteration returned to normal during late stage of the diuretic phase, while renal hemodynamic changes were normalized at six months after the onset.