• The Journal of the Society of Korean Medicine Diagnostics
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• v.17 no.3
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• pp.203-214
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• 2013

Objectives Yusanghan(類傷寒) means disease which chills and fever manifest like Cold damage(傷寒) but not Cold damage. However, study on Yussanghan is insignificant. The purpose of this study is to examine the origin and development process of Yusanghan. Methods: 1. Terms and disease related with Yusanghan was collected from books covering Cold damage of all time and analyzed. 2. The transition history was researched by analyzing collected terms. 3. Total appearance frequency of all time by collected disease was researched. Results: Yusanghan was appeared in Hwalinseo(活人書), which Ju Geong(朱肱) of the Song Dynasty wrote, for the first time and the definition and type were established. For the types of those, there are four diseases such as Phlegm-Fluid Retention(痰飮), Food Accumulation(食積), Vexation of Deficiency Type(虛煩), Beriberi(脚氣). Since then, the theory about Yusanghan had developed and the number of types had also increased until the Myung Dynasty. Conclusions: In early days, External Contraction Diseases(外感病) was not included in Yusanghan, but since the late Myung Dynasty, there were a lot of doctors who included External Contraction Diseases in Yusanghan, not in Cold damage. There are Summerheat Stroke, Wind-Dampness(風濕), and Warm Disease(溫病) etc. for included External Contraction Diseases. Because of this, the number of types of Yusanhan had significantly increased.

• Smart Structures and Systems
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• v.22 no.5
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• pp.587-609
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• 2018

There is greater significance in identifying the incipient damages in structures at the time of their initiation as timely rectification of these minor incipient cracks can save huge maintenance cost. However, the change in the global dynamic characteristics of a structure due to these subtle damages are insignificant enough to detect using the majority of the current damage diagnostic techniques. Keeping this in view, we propose a hybrid damage diagnostic technique for detection of minor incipient damages in the structures. In the proposed automated hybrid algorithm, the raw dynamic signatures obtained from the structure are decomposed to uni-modal signals and the dynamic signature are reconstructed by identifying and combining only the uni-modal signals altered by the minor incipient damage. We use these reconstructed signals for damage diagnostics using ARMAX model. Numerical simulation studies are carried out to investigate and evaluate the proposed hybrid damage diagnostic algorithm and their capability in identifying minor/incipient damage with noisy measurements. Finally, experimental studies on a beam are also presented to compliment the numerical simulations in order to demonstrate the practical application of the proposed algorithm.

• Composites Research
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• v.28 no.4
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• pp.148-154
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• 2015

In order to detect damage in early stages and properly maintaining structures, the structural health monitoring technology is employed. In most cases, active-sensing SHM needs many piezoelectric (PZT) sensors and actuators. Thus, if there is a defect on PZT used for active-sensing SHM, the structural status could be misclassified. This study, for reliable SHM performance, investigated to detect defects of sensors by using the admittance-based sensor diagnostics. This study also introduced an algorithm that can diagnose sensor defects based only on data measured from the sensors in case that information about the changes in adhesive and environmental investigation, this study confirms that the proposed algorithm could be efficiently applied to real-world structures in which a significant temperature variation could take place.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1658-1663
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• 2006

Panax notoginseng (Buck) F.H chen. root (PNS) is used as a therapeutic agent to stop haemorrhages and a tonic to promote health in Korean and Chinses medicine. The pharmacokinetic profiles of the main PNS are still not accurately investigated. Our preliminary aim is to elucidate the pharmacokinetics features of the PNS in rats. Objective of this study is to determine whether PNS affects hepatic microvascular dysfunction elicited by gut ischemia and reperfusion (I/R), since gut I/R causes hepatic microvascular dysfunction, and to investigate the role of nitric oxide (NO). No has been found to be a modulator of the adhesive interactions between platelet and endothelial cells. Male Wistar rats were exposed to 30 min of gut ischemia followed by 60 min of reperfusion. Intravital microscopy was used to monitor the number of non-perfused sinusoids (NPS). In another set of experiments, PNS (1 g/kg pre day intragastrically) was administered to rats for 7 days. In some experiments, dexamethasone (ST) (2 mg/kg per day intravenously) was administered. In control rats, gut I/R elicited increases in the number of NPS, and plasma TNF-${\alpha}$ and ALT activities, and these changes were mitigated by the pretreatment with PNS. Pretreatment with an No synthase inhibitor diminished the protective effects of PNS on the increase in NPS and plasma TNF-${\alpha}$ levels, but not its effect on the increase in plasma ALT activities. Pretreatment with PNS increased plasma nitrite/nitrate levels. The responses caused by gut I/R were attenuated by the pretreatment with ST. Pretreatment with an NO synthase inhibitor did not affect the effect of ST. These results suggest that PNS attenuates the gut I/R-induced hepatic microvascular dysfunction and inflammatory responses such as TNF-${\alpha}$ production in the early phase via enhancement of NO production, and sequential hepatocellular damage via its anti-inflammatory effect like corticosteroid effect.

• Journal of Acupuncture Research
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• v.33 no.2
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• pp.51-60
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• 2016

Objectives : Although integrative Korean medical treatments have been suggested to be effective for treating Bell's palsy, the effect of Korean medical treatment according to when treatment was started is unknown in the clinical field. Therefore, this study was conducted to determine the results of treating Bell's palsy according to different starting points of integrative Korean medical treatments. Methods : We screened patients who visited the Facial Palsy Center at Kyung Hee University Hospital for Korean and Western combined medical treatment from March 2011 to February 2016. A total of 821 out of 2086 patients were studied, including their basic characteristics and results of an electromyography. Patients who started Korean medical treatment within 3 days of onset were placed in group A, within 9 days of onset in group B, and patients who started treatment after 10 days of onset were placed in group C. We tried to compare the level of facial nerve damage by electromyography between groups. Results : The patients in group C had the highest axonal loss rates in all branches(frontal, oculi, nasal, oris). The post hoc analyses revealed the difference of axonal loss rates between group A and B was not statistically significant. Only group C showed statistically higher axonal loss rates in all branches. Conclusion : The study results showed that the patients who had delayed Korean medical treatments had a higher level of facial nerve damage by electromyography. According to the results of this study, early application of integrative Korean medical treatment is suggested.

• International Journal of Industrial Entomology and Biomaterials
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• v.31 no.2
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• pp.70-74
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• 2015

The current market size of insect industry in Korea is estimated at 300 million dollars and more than 500 local farms are related to many insect industry. One of the strong candidates for insect industry is Korean horn beetle, Allomyrina dichotoma. Early this year, we reported a viral disease extremely fatal to A. dichotoma larvae. While we were proceeding a nationwide investigation of this disease, it was informed that similar disease symptom has been occurred occasionally during past over 10 years. The symptom can be easily confused with early stage of bacterial infection or physiological damage such as low temperature and high humidity. A peroral infection with the purified virus to healthy larvae produced a result that only 21% of larvae survived and became pupae. Although some of the survived adult beetle was deformational, many of them had no abnormal appearance and even succeeded in mating. Later, these beetles were examined if they were carrying the virus, and all except one were confirmed as live virus carrier. This implies that these beetles may fly out and spread the disease to the nature. We found the evidence for this possibility by collecting a few wild A. dichotoma larvae which were virus infected, near two local farms rearing A. dichotoma larvae. So far, transovarial transmission of this virus to the eggs, or horizontal transmission to other commercially reared insects is not known yet.

• Korean Journal of Clinical Laboratory Science
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• v.54 no.4
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• pp.249-255
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• 2022

Alzheimer's disease (AD) represents a major public health concern and has been identified as a research priority. Clinical research evidence supports that the core cerebrospinal fluid (CSF) biomarkers for AD, including amyloid-β (Aβ42), total tau (T-tau), and phosphorylated tau (P-tau), reflect key elements of AD pathophysiology. Nevertheless, advances in the clinical identification of new indicators will be critical not only for the discovery of sensitive, specific, and reliable biomarkers of preclinical AD pathology, but also for the development of tests that facilitate the early detection and differential diagnosis of dementia and disease progression monitoring. The early detection of AD in its presymptomatic stages would represent a great opportunity for earlier therapeutic intervention. The chance of successful treatment would be increased since interventions would be performed before extensive synaptic damage and neuronal loss would have occurred. In this study, the importance of developing an early diagnostic method using cognitive decline biomarkers that can discriminate between normal, mild cognitive impairment (MCI), and AD preclinical stages has been emphasized.