• Clinical and Experimental Otorhinolaryngology
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• 제11권4호
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• pp.224-232
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• 2018

Objectives. Spiral ganglion neurons (SGNs) include potential endogenous progenitor populations for the regeneration of the peripheral auditory system. However, whether these populations are present in adult mice is largely unknown. We examined the presence and characteristics of SGN-neural stem cells (NSCs) in mice as a function of age. Methods. The expression of Nestin and Ki67 was examined in sequentially dissected cochlear modiolar tissues from mice of different ages (from postnatal day to 24 weeks) and the sphere-forming populations from the SGNs were isolated and differentiated into different cell types. Results. There were significant decreases in Nestin and Ki67 double-positive mitotic progenitor cells in vivo with increasing mouse age. The SGNs formed spheres exhibiting self-renewing activity and multipotent capacity, which were seen in NSCs and were capable of differentiating into neuron and glial cell types. The SGN spheres derived from mice at an early age (postnatal day or 2 weeks) contained more mitotic stem cells than those from mice at a late age. Conclusion. Our findings showed the presence of self-renewing and proliferative subtypes of SGN-NSCs which might serve as a promising source for the regeneration of auditory neurons even in adult mice.

• 대한치위생과학회지
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• 제3권2호
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• pp.51-58
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• 2020

Oral examination ensures early detection and treatment of oral diseases and improvement of quality of health-related life. This is imperative as it reduces individuals' dental medical expenses and social costs caused by diseases. However, as the low oral examination acceptance rate continues to be a problem, this study was conducted to identify the factors that influence the oral examination of an economically active population. In this study, 4,836 economically active individuals between the ages of 20 and 65 years were studied using data from the 7th National Health and Nutrition Survey in 2018. Logistic regression analysis was performed to determine the factors influencing demographic and sociological characteristics on oral examination after adjusting for complaints of mastication and speech discomfort. As a result of confirming the factors influencing the oral examination, increase in age tended to be inversely proportional to the oral examination. Income level, type of job, and job position were identified as factors that influenced oral examinations. Compared to the group with a high socioeconomic status, which is represented by a group with a high income level or a stable job type or job position, the group with low economic status was found to have a negative effect on oral examination. Oral management of vulnerable groups, who might not be considered while devising oral health management policies, should be promoted through the development and provision of oral health management policies that consider employment status and environment.

• 융합정보논문지
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• 제11권6호
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• pp.181-187
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• 2021

화장품 시장은 2026년의 초고령사회(Super aged society)가 예측되는 만큼 타 산업과 비교하여 지속적 시장 창출이 기대되는 산업이고, 우리나라 역시 고령화 시대의 진입 속에서 항노화에 관한 관심이 증대되고, 이에 관한 결과로 기능성 화장품에 대한 수요가 증가가 나타났다. 특히, 노년층을 위한 기능성 성분 소재에 관한 연구가 증가하고 있다. 소재 개발의 연구는 화장품 산업에 있어서 신제품 개발로 이어지는 아주 중요한 과정이다. 본 연구는 학술정보시스템(Research information Shining Service, RISS)을 이용하여 국내 천연주름 개선 기능성 화장품 소재개발을 주제로 한 연구를 중심으로 주름 개선화장품의 연구 방향에 대한 여러 가지 주름생성 저해 방법을 실험한 결과와 신소재에 대한 안전하면서도 주름 개선기능이 탁월한 천연 소재 주름 개선 기능성 성분에 관한 최신 연구 동향을 살펴보았다.

• 한국발생생물학회지:발생과생식
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• 제24권4호
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• pp.287-296
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• 2020

The absence of functional estrogen receptor α (Esr1) results in an overgrowth of the epididymal fat, as observed in estrogen receptor α knockout (ERαKO) mouse. The present research was aimed to evaluate expression of various molecules associated with adipocyte differentiation and maturation in the epididymal fat of ERαKO mouse at several postnatal ages by using quantitative real-time polymerase chain reaction. The highest transcript levels of all molecules were detected at 12 months of postnatal age, except leptin which the mRNA level was increased at 5 months of age and was unchanged until 12 months of age. The expression levels of CCAAT enhancer binding protein (Cebp) alpha, androgen receptor, and lipoprotein lipase were decreased at 5 months of age but increased at about 8 months of age. The mRNA levels of Cebp gamma and sterol regulatory element binding transcription factor 1 remained steady until 8 months of age. Continuous increases of transcript levels during postnatal period were found in Cebp beta, estrogen receptor (ER) beta, fatty acid binding protein 4, and delta like non-canonical Notch ligand 1. The increases of peroxisome proliferator-activated receptor gamma and adiponectin mRNA levels were detected as early as 8 months of age. The levels of fatty acid synthase and resistin transcript at 5 and 8 months of age were lower than that at 2 months of age. These findings show the aberrant expression patterns of genes related to adipocyte differentiation and maturation in the postnatal epididymal fat pad by the disruption of ER alpha function.

• 한국재료학회지
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• 제32권3호
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• pp.115-124
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• 2022

Porous basalt aggregate is commonly used in roadbed engineering, but its application in concrete has rarely been studied. This paper studies the application of porous basalt in concrete. Porous basalt aggregate is assessed for its effects on mechanical strength and durability of prepared C50 concrete; because it has a hole structure, porous basalt aggregate is known for its porosity, and porous basalt aggregates can be made full of water through changing the content of saturated basalt; after full-water condition is achieved in porous basalt aggregate mixture of C50 concrete, we discuss its mechanical properties and durability. The effects of C50 concrete prepared with basalt aggregate on the compressive strength, water absorption, and electric flux of concrete specimens of different ages were studied through experiments, and the effects of different replacement rates of saturated porous basalt aggregate on the properties of concrete were also studied. The results show that porous basalt aggregate can be prepared as C50 concrete. For early saturated porous basalt aggregate concrete, its compressive strength decreases with the increase of the replacement rate of saturated aggregate; this occurs up to concrete curing at 28 d, when the replacement rate of saturated basalt aggregate is greater than or equal to 40 %. The compressive strength of concrete increases with the increase of the replacement rate of saturated aggregate. The 28 d electric flux decreases with the increase of the replacement rate of saturated aggregate, indicating that saturated porous basalt aggregate can improve the chloride ion permeability resistance of concrete in later stages.

• 감성과학
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• 제25권4호
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• pp.107-118
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• 2022

Human can rapidly detect and deal with dangerous elements in their environment, and they generally manifest as attentional bias toward threat. Past studies have reported that this attentional bias is affected by anxiety level. Other studies, however, have argued that children and adolescents show attentional bias to threatening stimuli, regardless of their anxiety levels. Few studies directly have compared the two age groups in terms of attentional bias to threat, and furthermore, most previous studies have focused on attentional capture and the early stages of attention, without investigating further attentional holding by the stimuli. In this study, we investigated both attentional bias patterns (attentional capture and holding) with respect to negative emotional stimulus in neurotypical adults and adolescents. The effects of anxiety level on attentional bias were also examined. The results obtained for adult participants showed that abrupt onset of a distractor delayed attentional capture to the target, regardless of distractor type (angry or neutral faces), while it had no effect on attention holding. In adolescents, on the other hand, only the angry face distractor resulted in longer reaction time for detecting a target. Regarding anxiety, state anxiety revealed a significant positive correlation with attentional capture to a face distractor in adult participants but not in adolescents. Overall, this is the first study to investigate developmental tendencies of attentional bias to negative facial emotion in both adults and adolescents, providing novel evidence on attentional bias to threats at different ages. Our results can be applied to understanding the attentional mechanisms in people with emotion-related developmental disorders, as well as typical development.

• 대한소아치과학회지
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• 제51권2호
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• pp.185-196
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• 2024

Temporomandibular joint disorders (TMDs) can occur at any age, including childhood and adolescence, and pain-related TMDs can affect growth and quality of life. In the present study, recent trends in the diagnosis and treatment of TMDs in children and adolescents were analyzed over a 10-year period. Using 10 years of data from the Health Insurance Review and Assessment Service (HIRA) and Jeonbuk National University (JBNU) Dental Hospital, patients between 0 and 19 years of age diagnosed with K07.6 (temporomandibular joint disorders) were analyzed by 5-year bins. Both datasets indicated a higher prevalence in females (1.2-fold in HIRA, 1.5-fold in JBNU) and in ages 15 to 19 years (72.1% in HIRA, 74.7% in JBNU). HIRA reported a 42.3% increase in prevalence per 100,000 people, from 651.4 in 2011 to 927.0 in 2020. JBNU reported K07.66 (masticatory muscle disorders) as the most common diagnosis in subjects under 10 years of age and K07.60 (internal derangement of temporomandibular joint) in those over 10 years of age. In addition, both were treated mainly by a combination of physical therapy and medication, and the treatment rate increased in accordance with age. Because TMDs can affect various structures in the orofacial region and cause pain that tends to differ with age, an early and specific diagnosis appropriate for age is important for treatment. Therefore, pediatric dentists need to promptly recognize TMDs in children and adolescents and consult with specialists as the prevalence increases.

• 고전문학과교육
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• 제39호
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• pp.221-246
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• 2018

이 글에서 필자는 대략 10~17세기에 걸쳐서 일본의 상층 귀족이 화가(和歌)와 한시(漢詩)를 '혼효(混淆)'하여 창안해서 향유한 세 가지 양식의 양상과 특징을 살펴보았다. 세 가지 양식이라고 한 것은 '화한낭영(和漢朗詠)', '시가합(詩歌合)', 그리고 '연구연가(聯句連歌)'를 가리킨다. '화한낭영'은 10세기에, '시가합'은 12세기에, '연구연가'는 14세기에 각각 등장했으며, 그 후 일본 문학사에 지속적으로 영향을 끼쳤다. 화한혼효가 진행되면서 화가와 한시의 거리가 점차 가까워지더니 마침내 둘이 결합해서 한 작품을 이루게 되었다. 즉 화가와 한시는, 낭영하기에 적합한 작품이라고 해서 한데 모였고(화한낭영) 경합을 위해 작품 대 작품으로 맞섰으며(시가합) 종국에는 장시(長詩)를 구성하는 행으로 갈마드는 데까지 이르렀다(연구연가). 화한혼효는 자국어 노래를 한시에 손색이 없게 만들고자 하는, 중세 동아시아 문학사의 공통된 움직임의 일본 버전이라고 말할 수 있다. 한편 한시가 화가와 병렬, 경합 교대, 결합되면서 어떤 위상 변화가 나타났는지 확인함으로써 세 가지 양식이 존재한 시기의 한시에 대한 일본인의 태도, 거기에 상응해서 발현된 일본 한시의 특징에 대해서도 논의할 단서를 발견할 수 있다. '나'가 아닌 '좌중'의 기호, 시인의 내면이 아닌 시대가 숭상하는 내용과 표현, 자기표현이라는 서정시의 본령이 아닌 즐거운 오락을 위한 수단이라는 점이 중세 전 후기 일본 한시의 특징이고, 이러한 특징은 일본 한문학사의 저층을 흐르는 흐름이었다고 할 수 있다. 필자는 동아시아 문학사의 관점에서 중세 시기 일본 한문학사를 논할 실마리가 여기에 있다고 생각한다.

• 콘크리트학회논문집
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• 제13권6호
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• pp.629-636
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• 2001

최근 철근콘크리트 골조 구조물에 대한 장기변형 특성을 고려하여 고층건물의 설계 및 시공에 적용하려는 연구가 활발하게 진행되고 있다. 그러나 기존의 연구에서 고려하고 있는 시공단계는 reshoring을 고려하지 못하고 거푸집제거 및 shoring을 한 단계로 고려하기 때문에 동바리를 제거하기전의 초기재령에서 발생하는 변형을 고려하지 못한다. 본 연구에서는 동바리의 설치/제거를 포함한 실제적인 시공과정을 고려하여 거푸집의 강성, 동바리의 강성 그리고 시간에 따른 콘크리트의 강성의 변화에 따른 축력변화를 예측할 수 있는 2차원 골조해석 프로그램을 개발하였다. 예제해석결과 동바리의 축력이 시간에 따라서 감소한다. 또한, 동바리의 개수와 상관없이 기둥과 동바리와의 축력 재분배에 의해서 외측기둥에는 실제 설계 값보다 비탄성 하중이 작게 작용하고 내측 기둥에서는 크게 나타난다. 한편, 프로그램의 타당성을 검증하기 위하여 실제 철근콘크리트 골조 구조물을 타설-거푸집 제거-reshoring-동바리 제거-부가하중작용과 같은 일반적인 시공순서에 따라서 제작하였다. 실험결과 동바리를 제거하기 전에 기둥에 변형이 발생하며 동바리의 축력이 기둥에 분배되었다. 따라서 개발된 해석프로그램은 실험결과를 비교적 잘 예측하였다.

• 자원환경지질
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• 제26권3호
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• pp.311-325
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• 1993

The Ohto and Tohyun copper mine which are located 4 km southeast of Euiseong, Gyeongsangbukdo, Republic of Korea show various common geologic and mineralogic features. Both copper deposits are of hydrothermal-vein types, and associated with fracture system developed during formation of the Geumseong-san caldera in late Cretaceous age. According to structures and mineral assemblages, the mineralization processes have progressed in four stages: three hypogene mineralization stages and one supergene stage. Three hypogene stages are 1) stage I forming $N5{\sim}20^{\circ}E$ veins in the Ohto mine, 2) stage II building $N5^{\circ}W{\sim}N5^{\circ}E$ veins in the Tohyun mine, and 3) stage ill bringing $N80^{\circ}E$ veins which crosscut veins of the stage II. The vein ores consist mainly of pyrite, arsenopyrite, galena and chalcopyrite, minor or trace amounts of magnetite, hematite, pyrrhotite, stannite, bournonite, boulangerite, stibnite, galenobismutite, native bismuth, marcasite, geothite and malachite. The main gangue minerals are quartz and calcite. Wallrock is altered by sericitization, chloritization, pyritization, carbonitization and argillization. Arsenic and copper contents in arsenopyrite increase from stage I to stage III (from 31.28 to 33043 atom.% As) and (from 0.04 to 0040 atom.% Co). Going from stage I to stage III Fe and Mn contents in sphalerite decreases from 12.56 to 0.44 wt.% and from 0.24 to 0.01 wt.%, respectively. The compositional data of arsenopyrite in the early stage I indicate a temperature of $420{\sim}365^{\circ}C$ and sulfur fugacity of $10^{-6.5}{\sim}10^{-8.3}$ atm. Chalcopyrite and pyrrhotite assemblage suggest that Middle stage I was deposited at below $334^{\circ}C$. The compositional data of arsenopyrite in early stage II suggest a temperature range of $425{\sim}390^{\circ}C$ and sulfur fugacity codition of $10^{-6.4}{\sim}10^{-7.3}$ atm. Based on fluid inclusion the Middle stage II was regarded as to be deposited at $420{\sim}337^{\circ}C$ (Chi et al., 1989). Referring composition of sphalerite and stannite middle-late stage II seem to be deposited around $246^{\circ}C$ and $10^{-16.5}$ atm. sulfur fugacity. The ${\delta}^{34}S$ values of sulfide minerals in the Stage I, II, III range from 4.9 to 7.6%0 and indicate igneous ore fluid origin. Based on differences in mineral assemblages, chemical composition and chemical environments of Ohto and Tohyun mine its mineralization are considered to be formed at diffent mineralization ages and by different ore fluids.