• Bulletin of the Korean Chemical Society
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• v.29 no.2
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• pp.323-327
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• 2008

A focused library of pyrazole-based compounds was constructed towards novel transcription factor inhibitors. Complementary hydrogen bonding interaction with b-sheet peptide structures was the basis for the design of 5-amino-3-pyrazole carboxamide scaffold. From the preliminary inhibition assay against several transcription factors, compounds 7e and 8g were identified as novel lead compounds against HIF-1a and NF-AT transcription factors, respectively.

• Proceedings of the Korean Information Science Society Conference
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• 2005.07a
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• pp.295-297
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• 2005

This paper uses our proposed model for connecting ubiquitous physical objects over the web using URI, while utilizing the already developed frameworks, for ubiquitous service discovery like JINI, UPnP, and RDF/OWL for semantic web. By using this proposed scheme, we have presented architecture of a service oriented modular distributed ubiquitous middleware i.e. MDMA

• Archives of Pharmacal Research
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• v.6 no.1
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• pp.93-102
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• 1983

Waksman's group discovered SM in 1944, and opened a new field of antibiotcs: i. e. AGs. A large group of antibiotics containing aminosugar and/or aminocyclitol is called the AGs. A majority of AGs are produced by actinomycetes. In the first period, AGs effective against tuberculosis were chiefly examined. Following the studies on NM and KM, AGs active against staphyllococci and gram-negative robs were investigated. The discovery of GM and synthesis of DKB and AMK led to the studies on the third generation AGs, which show a broad antimicrobial spectrum including Pseudomonas aeruginosa and drug-resistant bacteria. Since opportunistic infection caused by drug-resistant bacteria are increasing, the third generation AGs are extensively investigated at present.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.60.1-60.1
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• 2019

In this talk, I will briefly review the discovery and early-time interferometric observations of the Galactic Center radio source and then go through recent major updates including the improvement in the array capabilities, developments of the scattering and intrinsic structure modeling, and high-frequency astrometric observations of this source. Introduction of the 1.3 mm VLBI observations in 2017 and 2018 (e.g. array configuration and signal-to-noise ratios), as well as the related multi-wavelength campaign (including GMVA and EAVN observations), will be also presented.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.448-449
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• 2016

Enlargement and complexification of current structures increase the expected casualty in case of accident in those e.g., fire. In that case, there only have been basic instructions such as announcement of that situation, alarm bell, exit signs, etc. but any guidance to lead to proper escape route was not been provided so far. To tackle the problem, several schemes have been proposed. However, various risk factors were not considered and route discovery performance must be improved to be applied to structures. Therefore, this paper proposes an optimal route discovery system for emergency escape from disaster situations which takes into account various possible risk factors and enhances the searching efficiency by using the $A^{\ast}$ algorithm. Performance evaluation by computer simulation shows that the proposed scheme effectively leads to safe escape route.

• Journal of Korea Multimedia Society
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• v.10 no.12
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• pp.1679-1686
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• 2007

In this paper, we introduce the sharable and reusable learning objects which are suitable for XML Web services in e-learning systems. These objects are extracted from the principles of pedagogical paradigms for reusable learning units. We call them LIO (Learning Item Object) objects. Existing models, such as Web-hosted and ASP-oriented service model, are difficult to cooperate and integrate among the different kinds of e-learning systems. So we developed the LIO objects that are suitable for XML Web services. The reusable units that are extracted from pedagogical paradigms are tutorial item, resource, case example, simulation, problems, test, discovery and discussion. And these units correspond to the LIO objects in our learning object model. As a result, the proposed model is that learner and instruction designer should increase the power of understanding about learning contents that are based on pedagogical paradigms. By using XML Web services, this guarantees the integration and interoperation of the different kinds of e-learning systems in distributed environments and so educational organizations can expect the cost reduction in constructing e-learning systems.

• Journal of Crop Science and Biotechnology
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• v.10 no.4
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• pp.237-242
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• 2007

Genome duplication(i.e. polyploidy) is a common phenomenon in the evolution of plants. The objective of this study was to achieve a comprehensive understanding of genome duplication for SNP discovery by Thymine/Adenine(TA) cloning for confirmation. Primer pairs were designed from 793 EST contigs expressed in the roots of a supernodulating soybean mutant and screened between 'Pureunkong' and 'Jinpumkong 2' by direct sequencing. Almost 27% of the primer sets were failed to obtain sequence data due to multiple bands on agarose gel or poor quality sequence data from a single band. TA cloning was able to identify duplicate genes and the paralogous sequences were coincident with the nonspecific peaks in direct sequencing. Our study confirmed that heterogeneous products by the co-amplification of a gene family member were the main cause of obtaining multiple bands or poor quality sequence data in direct sequencing. Counts of amplified bands on agarose gel and peaks of sequencing trace suggested that almost 27% of nonrepetitive soybean sequences were present in as many as four copies with an average of 2.33 duplications per segment. Copy numbers would be underestimated because of the presence of long intron between primer binding sites or mutation on priming site. Also, the copy numbers were not accurately estimated due to deletion or tandem duplication in the entire soybean genome.

• Communications of Mathematical Education
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• v.26 no.1
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• pp.1-13
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• 2012

Ki-Won Chang(1903-1966) is considered as the first mathematician who made a contribution to the study of the history of Korean mathematics. In this paper, we introduce contributions of Ki-Won Chang, his discovery of old Korean literatures on mathematics, and his academic contribution on the history of Korean mathematics. Then we analyze and compare his conclusions on old Korean mathematics with recent works of others. This work shows some interesting discovery.

• Journal of Information Processing Systems
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• v.14 no.4
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• pp.851-876
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• 2018

Dynamic time warping (DTW) is the main algorithms for time series alignment. However, it is unsuitable for quasi-periodic time series. In the current situation, except the recently published the shape exchange algorithm (SEA) method and its derivatives, no other technique is able to handle alignment of this type of very complex time series. In this work, we propose a novel algorithm that combines the advantages of the SEA and the DTW methods. Our main contribution consists in the elevation of the DTW power of alignment from the lowest level (Class A, non-periodic time series) to the highest level (Class C, multiple-periods time series containing different number of periods each), according to the recent classification of time series alignment methods proposed by Boucheham (Int J Mach Learn Cybern, vol. 4, no. 5, pp. 537-550, 2013). The new method (quasi-periodic dynamic time warping [QP-DTW]) was compared to both SEA and DTW methods on electrocardiogram (ECG) time series, selected from the Massachusetts Institute of Technology - Beth Israel Hospital (MIT-BIH) public database and from the PTB Diagnostic ECG Database. Results show that the proposed algorithm is more effective than DTW and SEA in terms of alignment accuracy on both qualitative and quantitative levels. Therefore, QP-DTW would potentially be more suitable for many applications related to time series (e.g., data mining, pattern recognition, search/retrieval, motif discovery, classification, etc.).

• Genomics & Informatics
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• v.19 no.1
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• pp.7.1-7.13
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• 2021

Levodopa (L-DOPA) therapy is normally practised to treat motor pattern associated with Parkinson disease (PD). Additionally, several inhibitory drugs such as Entacapone and Opicapone are also cosupplemented to protect peripheral inactivation of exogenous L-DOPA (~80%) that occurs due to metabolic activity of the enzyme catechol-O-methyltransferase (COMT). Although, both Entacapone and Opicapone have U.S. Food and Drug Administration approval but regular use of these drugs is associated with high risk of side effects. Thus, authors have focused on in silico discovery of phytochemicals and evaluation of their effectiveness against human soluble COMT using virtual screening, molecular docking, drug-like property prediction, generation of pharmacophoric property, and molecular dynamics simulation. Overall, study proposed, nine phytochemicals (withaphysalin D, withaphysalin N, withaferin A, withacnistin, withaphysalin C, withaphysalin O, withanolide B, withasomnine, and withaphysalin F) of plant Withania somnifera have strong binding efficiency against human COMT in comparison to both of the drugs i.e., Opicapone and Entacapone, thus may be used as putative bioenhancer in L-DOPA therapy. The present study needs further experimental validation to be used as an adjuvant in PD treatment.