• International Journal of Computer Science & Network Security
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• 제22권6호
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• pp.339-345
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• 2022

Outcome-based education (OBE) is a tried-and-true teaching technique based on a set of predetermined goals. Program Educational Objectives (PEOs), Program Outcomes (POs), and Course Outcomes (COs) are the components of OBE. At the end of each year, the Program Outcomes are evaluated, and faculty members can submit many recommended measures which dependent on the relationship between the program outcomes and its courses outcomes to improve the quality of program and hence the overall educational program. When a vast number of courses are considered, bad actions may be proposed, resulting in unwanted and incorrect decisions. In this paper, a recommender system, using collaborative filtering and association rules algorithms, is proposed for predicting the best relationship between the program outcomes and its courses in order to improve the attributes of the graduates. First, a parallel algorithm is used for Collaborative Filtering on Data Model, which is designed to increase the efficiency of processing big data. Then, a parallel similar learning outcomes discovery method based on matrix correlation is proposed by mining association rules. As a case study, the proposed recommender system is applied to the Computer Information Systems program, College of Computer Sciences and Information Technology, Al-Baha University, Saudi Arabia for helping Program Quality Administration improving the quality of program outcomes. The obtained results revealed that the suggested recommender system provides more actions for boosting Graduate Attributes quality.

• 한국응용곤충학회지
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• 제61권2호
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• pp.289-291
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• 2022

본 연구를 통해 국내미기록속인 까마귀나비속의 푸른줄까마귀왕나비를 최초로 보고한다. 푸른줄까마귀왕나비의 암컷 형태와 생식기, 채집지 등의 정보를 제공하였다. 또한 신속한 종 동정을 위한 DNA 바코드 염기서열을 정보를 제공하였다.

• Journal of Gastric Cancer
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• 제22권4호
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• pp.273-305
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• 2022

Gastric cancer (GC) is one of the most common lethal malignant neoplasms worldwide, with limited treatment options for both locally advanced and/or metastatic conditions, resulting in a dismal prognosis. Although the widely used morphological classifications may be helpful for endoscopic or surgical treatment choices, they are still insufficient to guide precise and/or personalized therapy for individual patients. Recent advances in genomic technology and high-throughput analysis may improve the understanding of molecular pathways associated with GC pathogenesis and aid in the classification of GC at the molecular level. Advances in next-generation sequencing have enabled the identification of several genetic alterations through single experiments. Thus, understanding the driver alterations involved in gastric carcinogenesis has become increasingly important because it can aid in the discovery of potential biomarkers and therapeutic targets. In this article, we review the molecular classifications of GC, focusing on The Cancer Genome Atlas (TCGA) classification. We further describe the currently available biomarker-targeted therapies and potential biomarker-guided therapies. This review will help clinicians by providing an inclusive understanding of the molecular pathology of GC and may assist in selecting the best treatment approaches for patients with GC.

• Parasites, Hosts and Diseases
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• 제61권1호
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• pp.78-83
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• 2023

The use of an effective antimalarial drug is the cornerstone of malaria control. However, the development and spread of resistant Plasmodium falciparum strains have placed the global eradication of malaria in serious jeopardy. Molecular marker analysis constitutes the hallmark of the monitoring of Plasmodium drug-resistance. This study included 96 P. falciparum PCR-positive samples from southern Somalia. The P. falciparum chloroquine resistance transporter gene had high frequencies of K76T, A220S, Q271E, N326S, and R371I point mutations. The N86Y and Y184F mutant alleles of the P. falciparum multidrug resistance 1 gene were present in 84.7 and 62.4% of the isolates, respectively. No mutation was found in the P. falciparum Kelch-13 gene. This study revealed that chloroquine resistance markers are present at high frequencies, while the parasite remains sensitive to artemisinin (ART). The continuous monitoring of ART-resistant markers and in vitro susceptibility testing are strongly recommended to track resistant strains in real time.

• Journal of Microbiology and Biotechnology
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• 제33권3호
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• pp.277-287
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• 2023

Since the first discovery of antibiotics, introduction of new antibiotics has been coupled with the occurrence of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs). Rapid dissemination of ARB and ARGs in the aquatic environments has become a global concern. ARB and ARGs have been already disseminated in the aquatic environments via various routes. Main hosts of most of ARGs were found to belong to Gammaproteobacteria class, including clinically important potential pathogens. Transmission of ARGs also occurs by horizontal gene transfer (HGT) mechanisms between bacterial strains in the aquatic environments, resulting in ubiquity of ARGs. Thus, a few of ARGs and MGEs (e.g., strA, sul1, int1) have been suggested as indicators for global comparability of contamination level in the aquatic environments. With ARB and ARGs contamination, the occurrence of critical pathogens has been globally issued due to their widespread in the aquatic environments. Thus, active surveillance systems have been launched worldwide. In this review, we described advancement of methodologies for ARGs detection, and occurrence of ARB and ARGs and their dissemination in the aquatic environments. Even though numerous studies have been conducted for ARB and ARGs, there is still no clear strategy to tackle antibiotic resistance (AR) in the aquatic environments. At least, for consistent surveillance, a strict framework should be established for further research in the aquatic environments.

• ALGAE
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• 제39권2호
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• pp.59-74
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• 2024

Terrestrial cyanobacteria are extremely diverse. In urban areas, they can be found as black stains on the surface of building walls, stone monuments, or man-made structures. Many of the terrestrial cyanobacteria are still understudied. To expand knowledge of terrestrial cyanobacterial diversity, a polyphasic characterization was performed to identify 12 strains isolated from campus of University of the Ryukyus, Okinawa, Japan. Multigene phylogenetic analyses based on 16S rRNA gene and 16S-23S rRNA internal transcribed spacer (ITS) region showed that the isolated strains formed two independent subclades within Nodosilinea, and were distantly related to all described Nodosilinea species. The 16S-23S rRNA ITS secondary structures showed variations for D1-D1' and Box B domain, while V3 domain was almost identical among entire species of Nodosilinea, including the studied strains. In addition, a unique morphological character, i.e. forming nodule or spiral shape, was also observed in certain studied strains. According to polyphasic characterization, Nodosilinea coculeatus sp. nov. and Nodosilinea terrestrialis sp. nov., were proposed as two new species of terrestrial cyanobacteria from Okinawa.

• IMMUNE NETWORK
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• 제23권2호
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• pp.13.1-13.24
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• 2023

The coronavirus disease 2019 (COVID-19) pandemic is one of the most consequential global health crises in over a century. Since its discovery in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to mutate into different variants and sublineages, rendering previously potent treatments and vaccines ineffective. With significant strides in clinical and pharmaceutical research, different therapeutic strategies continue to be developed. The currently available treatments can be broadly classified based on their potential targets and molecular mechanisms. Antiviral agents function by disrupting different stages of SARS-CoV-2 infection, while immune-based treatments mainly act on the human inflammatory response responsible for disease severity. In this review, we discuss some of the current treatments for COVID-19, their mode of actions, and their efficacy against variants of concern. This review highlights the need to constantly evaluate COVID-19 treatment strategies to protect high risk populations and fill in the gaps left by vaccination.

• IMMUNE NETWORK
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• 제22권1호
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• pp.2.1-2.22
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• 2022

Targeting immune evasion via immune checkpoint pathways has changed the treatment paradigm in cancer. Since CTLA-4 antibody was first approved in 2011 for treatment of metastatic melanoma, eight immune checkpoint inhibitors (ICIs) centered on PD-1 pathway blockade are approved and currently administered to treat 18 different types of cancers. The first part of the review focuses on the history of CTLA-4 and PD-1 discovery and the preclinical experiments that demonstrated the possibility of anti-CTLA-4 and anti-PD-1 as anti-cancer therapeutics. The approval process of clinical trials and clinical utility of ICIs are described, specifically focusing on non-small cell lung cancer (NSCLC), in which immunotherapies are most actively applied. Additionally, this review covers the combination therapy and novel ICIs currently under investigation in NSCLC. Although ICIs are now key pivotal cancer therapy option in clinical settings, they show inconsistent therapeutic efficacy and limited responsiveness. Thus, newly proposed action mechanism to overcome the limitations of ICIs in a near future are also discussed.

• 한국전자거래학회지
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• 제15권2호
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• pp.167-189
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• 2010

유비쿼터스 기술이 도시 인프라와 접목되면서 유비쿼터스 도시라는 시민의 생활 편의와 질적 향상을 추구하는 새로운 도시 패러다임이 제시되고 있다. 도시통합운영센터는 유비쿼터스 도시의 필수 요소로써 시민을 위한 다양한 서비스를 위해 정보를 수집, 가공 및 제공하는 역할을 한다. 따라서 본 논문에서는 도시가 제공하는 서비스의 효율적 제공 및 관리를 위한 도시통합운영센터의 프레임워크를 제안하고자 한다. 본 연구에서 제시하는 도시통합운영센터는 유비쿼터스 도시가 제공하는 서비스의 효율적인 개발 환경과 운영 환경을 제공하는 것을 그 목적으로 한다. 이러한 목적을 달성하기 위해 시맨틱 웹 서비스 기술을 도시통합운영센터에 적용하며, OWL-S를 이용하여 서비스에 대한 의미정보를 기술함으로써 자동화된 서비스의 선택 및 발견, 그리고 조합을 지원하는 지능화된 서비스를 제공하는 것이 가능하다. 또한 도시통합운영센터의 서비스 간 재사용성과 상호운영성, 그리고 가용성을 보장하기위해 본 논문에서는 서비스 기능 단위의 단위 서비스 모델링 방법론을 제안하고자 한다. 이를 통해 도시통합운영센터에 필요한 공통의 서비스를 도출하고 이들을 의미적 정보로 연결함으로써 보다 발전된 형태의 도시통합운영센터의 서비스 프레임워크를 개발하였다.

• 대한한방내과학회지
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• 제36권3호
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• pp.361-379
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• 2015

Objectives This study aims to review and summarize existing evidence on moxibustion treatment for cancer patients. Methods Literature published until May 2015 in international journals were searched on PubMed, CAJ (CNKI-Medicine), NDSL (National discovery for science leaders), Sage Journal, ScienceDirect, Taylor&Francis Online (HSS), and Wiley Interscience (including Blackwell); and articles in Korean journals were searched on Korean Studies Information Service System (KISS), DBPIA, E-Article, KSI e-book, New article, Korea Institute of Science and Technology Information (KISTI), and Kyobo scholar. Results We analyzed 65 relevant studies. The number of studies conducted annually has increased and most are conducted in Korea and China. Moxibustion decreases the side effects of palliative treatment, thereby synergizing with anticancer treatment; it also improves the immune system, reduces tumor factors, and relieves symptoms. The mechanism of moxibustion is multi-fold: thermo, chemo, aero and kinetic. Only the kinetic effect is not significant. It also needs a complement to moxibustion because of harmful smoke. Conclusions Thus, the effect and mechanism of moxibustion in cancer patients was reviewed. There is an unmet need to develop a model of moxibustion and test it based on Korean medicine.