• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6477-6483
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• 2014

Background: Shammah is a traditional form of chewing tobacco [smokeless tobacco, (ST)] that is commonly used in the Middle East especially in Saudi Arabia (KSA), Yemen and Sudan. The Substance Abuse Research Centre (SARC) at Jazan University noted that no adequate research and information on the prevalence of shammah use in the province of Jazan, and KSA as well, has been provided in the scientific literature. Materials and Methods: An intensive systematic review of online databases was performed, including AMED (The Allied and Complementary Medicine Database), Biological Abstracts, Cochrane Collection Plus, Dentistry and Oral Sciences Source, E-Journals Database, EBSCO Discovery Service, MEDLINE, PEMSoft, PEP Archive, PsycARTICLES, scopus, Sciencedirect and Google Scholar. Results: Shammah is a mixture of powdered tobacco, lime, ash, black pepper, oils and flavorings. ST in KSA is placed in the buccal or lower labial vestibule of the mouth. The user (or dipper) spits out insoluble debris. The importation of ST products is prohibited in KSA. Accessible information on legislative action to control the use of ST in KSA appeared in 1990. The actual percentage use may be higher, than reported since shammah is illegal in KSA and there may be some reluctance to admit to its use. Conclusions: This review paper is an initial step in a funded research project by SARC to understand the pattern of use of shammah and provide adequate epidemiological data. One goal of this review is to generate further data for public health education.

• Journal of Korean Library and Information Science Society
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• v.46 no.4
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• pp.325-354
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• 2015

Corporate information has great value, but also poses great risk. Information governance is an organization's coordinated, inter-disciplinary approach to satisfying information compliance requirements and managing information risks while optimizing information value. This study aims to suggest the directions of implementing information governance in business firms based on analyses of Sedona Conference Principles of Information Governance. After analysing and reformulating the principles into control standards, and they are investigated and interpreted in terms of practicing information governance.

• Bulletin of the Korean Chemical Society
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• v.32 no.9
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• pp.3219-3222
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• 2011

Three types of ${\beta}$-ketoacyl acyl carrier protein synthase (KAS) are important for overcoming the bacterial resistance problem. Recently, we reported the discovery of a antimicrobial flavonoid, YKAF01 (3,6-dihydroxyflavone), which exhibits antibacterial activity against Gram-positive bacteria through inhibition of ${\beta}$-ketoacyl acyl carrier protein synthase III (KAS III). In this report, we suggested that YKAF01 can be an inhibitor ${\beta}$-ketoacyl acyl carrier protein synthase I (KAS I) with dual inhibitory activity for KAS I as well as KAS III. KAS I is related to the elongation of unsaturated fatty acids in bacterial fatty acid synthesis and can be a good therapeutic target of designing novel antibiotics. We performed docking study of Escherichia coli KAS I (ecKAS I) and YKAF01, and determined their binding model. YKAF01 binds to KAS I with high binding affinity ($2.12{\times}10^6$) and exhibited an antimicrobial activity against the multidrug-resistant E. coli with minimal inhibitory concentration (MIC) value of 512 ${\mu}g$/mL. Further optimization of this compound will be carried out to improve its antimicrobial activity and membrane permeability against bacterial cell membrane.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.05a
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• pp.126-129
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• 2015

Device-to-device (D2D) communications, a subset of Proximity-based Services that enables direct communication between LTE network subscribers, is gaining popularity. It is well underway to be adopted in cellular communication systems for pedestrian and connected-vehicles alike. In this paper, we briefly present our model of an Evolved Packet Core Network-assisted device discovery simulator and show the applicability of Proximity-based Services for Vehicular Ad-hoc Networks. Through the performance evaluation based on the developed simulation environment, it is shown that in case when users gather in the same vicinity, as in public transportation, LTE network data can be efficiently offloaded and multicasted through Wi-Fi for e.g. delivering traffic-related information and for the benefit of infotainment service consumers.

• BMB Reports
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• v.51 no.10
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• pp.484-485
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• 2018

Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is a serine-threonine kinase largely essential for necroptotic cell death; it also plays a role in some inflammatory diseases. High levels of RIP3 are likely sufficient to activate necroptotic and inflammatory pathways downstream of RIP3 in the absence of an upstream stimulus. For example, we have previously detected high levels or RIP3 in the skin of Toxic Epidermal Necrolysis patients; this correlates with increased phosphorylation of MLKL found in these patients. We have long surmised that there are molecular mechanisms to prevent anomalous activity of the RIP3 protein, and so prevent undesirable cell death and inflammatory effects when inappropriately activated. Recent discovery that Carboxyl terminus of Hsp 70-Interacting Protein (CHIP) could mediate ubiquitylation- and lysosome-dependent RIP3 degradation provides a potential protein that has this capacity. However, while screening for RIP3-binding proteins, we discovered that pellino E3 ubiquitin protein ligase 1 (PELI1) also interacts directly with RIP3 protein; further investigation in this study revealed that PELI1 also targets RIP3 for proteasome-dependent degradation. Interestingly, unlike CHIP, which targets RIP3 more generally, PELI1 preferentially targets kinase active RIP3 that has been phosphorylated on T182, subsequently leading to RIP3 degradation.

• Science of Emotion and Sensibility
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• v.23 no.1
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• pp.57-68
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• 2020

This research investigates how digital design agencies and client companies incorporate design thinking-a human-centered approach to solving difficult problems-into their website development processes. Based on a literature review on the design-thinking-driven web development process, multiple case studies of award-winning website projects were performed by in-depth interviews with key practitioners. Through analyses of these cases, their user-centered approaches for website innovation were identified according to the following four phases: web planning (discovery and defining phases) and web design and development (development and delivery phases). Moreover, distinct approaches of design thinking practices were identified according to two website types: a brand promotion website with a killer brand storytelling approach; and a service channel website with a strategic UI/UX-driven approach. Next, the key success drivers of these website projects were suggested in light of the typical themes of design thinking (i.e., human centeredness, research based, context awareness, and collaboration). Some practical limitations were also found in adopting the design-thinking-driven web development process, such as limited research methods and tools, and insufficient prototyping and experimentation. Along with these limitations, it was also discovered that current digital design agencies still face the following challenges in adopting the design-thinking-driven web development process: building a long-term, playful partnership with clients; leveraging decision-makers' design thinking awareness; and coping with limited resources (design thinking practitioners, budgets, and schedules).

• Korean Journal of Social Welfare
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• v.46
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• pp.236-262
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• 2001

This discovery-oriented study explored 31 social workers' perceptions of discrepancies between explicit and implicit rules in their work places that are supposed to affect the quality of social work services, and identified eight categories of dilemmas: (a) confused accountability or purpose, (b) ambiguous principle, (c) improper authority, (d) confused role of social workers, (e) conflict between ideal and reality, (f) confused work ethics, (g) confused boundary of workers' rights, and (h) binds. These eight categories revealed the real philosophy and purposes of social work agencies, work ethics and values prevalent among social work agencies, agencies' orientation toward clients, and the conditions of social support from the society in large. Instead of searching for discrete variables as separately responsible for inefficient social work services, this approach probed malfunctioning implicit rules in a holistic context to see if inefficient or ineffective provision of social work services is a logical response to a much larger and deeper nexus. Insight into discrepant rules does not solely ensure the improvement of social work practice in the field, particularly if their identification is simply used as another opportunity to blame and avoid self-responsibility. However, such discrepancies between implicit and explicit rules are real enough to the staff workers and agency administrators that they may want to begin the dialogue of contradictory rules as a way of sanctioning discussion of previously forbidden topics. This study provided the ground-work for the dialogue.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.20 no.4
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• pp.381-388
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• 2013

Purpose: This study was done to investigate nurses' awareness of death and the meaning of life and identify factors influencing the meaning of life. Methods: Participants were 198 women nurses who had experienced the death of patients. They answered a self-administered questionnaire including demographics, awareness of death scale and meaning in life II scale. Data were analyzed using descriptive statistics, t-test, ANOVA, Scheff$\acute{e}$ test, and multiple regression (enter method). Results: The average score for awareness of death was $127.3{\pm}10.14$. This score is moderate not biased toward positive or negative. The average score for meaning of life was $130.3{\pm}9.42$ with 51% for loss steps, 45.5% for pursuit steps and 3.5% for discovery steps to the meaning of life. Factors affecting the meaning of life were religion, Buddhism (${\beta}=6.25$, p=.015) or Atheist (${\beta}=5.91$, p=.017), educational level, Master's or higher (${\beta}=16.22$, p=.003), work department, special department (${\beta}=3.49$, p=.017). Conclusions: Results of the study indicate a need to provide nursing programs that will promote nurses' spiritual and inner maturity.

• Journal of Korean Institute of Fire Investigation
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• v.11 no.1
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• pp.41-58
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• 2008

The history of illumination has been much long since the discovery of lamplight caused huge changes in human lives. However, the swift development of the illumination actually started with the invention of a carbon filament lamp by Thomas Edison in 1878. Generally, the illumination tools plays important roles in human lives such as reduction of fatigue, improvement of safety and working efficiency, and the creation of enjoyable atmosphere. But, the illumination tools can be an origin of the fire due to carelessness and lack of management. In this study, the principle and structure of the illumination lamp were dealt with. The possibility of the fire outbreak caused by the incandescent lamp and fluorescent lamp most used in home was investigated. The examples of the fire outbreaks by the incandescent and fluorescent lamps and by the contact between the inflammable materials and the distributing wires were mentioned and demonstrated by the experimental.

• Journal of Life Science
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• v.9 no.1
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• pp.99-105
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• 1999

The aims of this studies were carried out to investigate the antioxidant activity on low density lipoprotein(LDL) using substances extracted from Bacillus sp. RH-5. The antioxidative substances produced extracellular in the culture broth by Bacillius sp. RH-S was obtained by elution of chloroform : methanol from silicagel column (80cm x100cm) chromatography. Band 4 eluted from fraction 3 by TLC was appeared at highest level of antioxidative activity using thiocyanate methed. Band 4 at a concentration of 100 or 200$\mu$g/$m\ell$ inhibited oxidation of LDL induced by the mouse transformed macrophage. According to IR. NMR or GC/MASS, the antioxidant substance was identified as 5-hydroxyindole.