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Aerobic Exercise Ameliorates Muscle Atrophy Induced by Methylglyoxal via Increasing Gastrocnemius and Extensor Digitorum Longus Muscle Sensitivity

  • Seong-Min Hong;Eun Yoo Lee;Jinho Park;Jiyoun Kim;Sun Yeou Kim
    • Biomolecules & Therapeutics
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    • v.31 no.5
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    • pp.573-582
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    • 2023
  • Muscle atrophy is characterized by the loss of muscle function. Many efforts are being made to prevent muscle atrophy, and exercise is an important alternative. Methylglyoxal is a well-known causative agent of metabolic diseases and diabetic complications. This study aimed to evaluate whether methylglyoxal induces muscle atrophy and to evaluate the ameliorative effect of moderate-intensity aerobic exercise in a methylglyoxal-induced muscle atrophy animal model. Each mouse was randomly divided into three groups: control, methylglyoxal-treated, and methylglyoxal-treated within aerobic exercise. In the exercise group, each mouse was trained on a treadmill for 2 weeks. On the last day, all groups were evaluated for several atrophic behaviors and skeletal muscles, including the soleus, plantaris, gastrocnemius, and extensor digitorum longus were analyzed. In the exercise group, muscle mass was restored, causing in attenuation of muscle atrophy. The gastrocnemius and extensor digitorum longus muscles showed improved fiber cross-sectional area and reduced myofibrils. Further, they produced regulated atrophy-related proteins (i.e., muscle atrophy F-box, muscle RING-finger protein-1, and myosin heavy chain), indicating that aerobic exercise stimulated their muscle sensitivity to reverse skeletal muscle atrophy. In conclusion, shortness of the gastrocnemius caused by methylglyoxal may induce the dynamic imbalance of skeletal muscle atrophy, thus methylglyoxal may be a key target for treating skeletal muscle atrophy. To this end, aerobic exercise may be a powerful tool for regulating methylglyoxal-induced skeletal muscle atrophy.

Fabric Weavability and Machine Efficiency in the Various Weaving Machines such as Projectile, Rapiers, and Air-jet (프로젝타일, 래피어 그리고 에어젯트 직기의 제직성과 직기효율)

  • Kim, S.J.;Yeo, G.D.
    • Textile Coloration and Finishing
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    • v.12 no.1
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    • pp.1-11
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    • 2000
  • This paper surveys the fabric weavability and machine efficiency in the various weaving looms such as Projectile, Rapiers, and Air-jet. Used projectile loom was Sulzer-PU, and FAST-R, THEMA-11E, and Picanol-GTX were used for Rapier looms, as the Air-Jet looms, Picanol PAT and OMNI types were used. Using these looms, 5 harness worsted satin fabrics were woven for surveying the fabric weavability and machine efficiency. Warp yam count of fabric is 1/40Nm, Sirofil, and filling is 1/30 Nm, worsted. End breaks of warp and filling directions for the various types of looms are measured and discussed with the mechanism of each loom. Warp and filling yam tensions are also measured and analysed with open width of shedding motion of each weaving machine. And various warp yam tensions with open width of shedding are measured and analysed according to the warp yam in various heald frame. These results fire also discussed with temples such as bar and ring. Warp yam tensions at the various positions on the fabric with various looms are measured and discussed with fabric mechanical properties such as tensile, bending, shear and surface.

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Giant Molecular Cloud Properties of WISDOM galaxies - NGC 5806 and NGC 6753

  • Choi, Woorak;Liu, Lijie;Bureau, Martin;Davis, Timothy;Chung, Aeree
    • The Bulletin of The Korean Astronomical Society
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    • v.46 no.1
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    • pp.56.2-56.2
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    • 2021
  • Constraining the structure and thus the fate of giant molecular clouds (GMCs), the primary sites of star formation in galaxies, is crucial to understand the evolution of galaxies themselves. Exploiting the unprecedented sensitivity and angular resolution of the Atacama Large Millimeter/sub-millimeter Array (ALMA), we have measured the spatially-resolved (~ 20 pc resolution) properties of the GMCs in two nearby late-type galaxies, NGC 5806 (SAB(s)b) and NGC 6753 ((R)SA(r)b), as part of the WISDOM project. Although these results are preliminary, we identified ~ 200 resolved GMCs in NGC 5806 within a radius of 500 pc, most within a nuclear ring structure, and ~ 400 resolved GMCs in NGC 6753 within a radius of 2 kpc, most within a flocculent spiral structure. The GMCs of NGC 5806 have similar sizes but slightly higher linewidths than clouds in the Milky Way disc. Because the GMCs also have higher surface densities, the calculated cloud Virial parameters are nevertheless about unity, suggesting that the GMCs of NGC 5806 are in gravitational equilibrium and thus long lived. This is contrary to other WISDOM results on earlier-type galaxies, where large cloud linewidths are likely due to shear associated with the local (circular) orbital motions (rather than the clouds' self-gravity), and the clouds are either marginally or not gravitationally bound. These results support the notion that spheroids alter the dynamical states of clouds (morphological quenching), that are otherwise (i.e. in galaxy discs) fairly homogenous and similar to those of the Milky Way.

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The Molecular Gas Kinematics of HI Monsters

  • Kim, Dawoon E.;Chung, Aeree;Yun, Min S.;Iono, Daisuke
    • The Bulletin of The Korean Astronomical Society
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    • v.45 no.1
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    • pp.33.2-33.2
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    • 2020
  • Our HI monster sample is a set of local HI-rich galaxies identified by the ALFALFA survey (Arecibo Legacy Fast Survey ALFA) at z<0.08. Intriguingly, they are also found with a relatively large molecular gas reservoir compared to the galaxies with similar stellar mass and color, yet their star formation rate is quite comparable to normal spirals. This makes our HI monsters good candidates of galaxies in the process of gas accretion which may lead to the stellar mass growth. One feasible explanation for their relatively low star formation activity for a given high cool gas fraction is the gas in monsters being too turbulent to form stars as normal spirals. In order to verify this hypothesis, we probe the molecular gas kinematics of 10 HI monsters which we observed using the Atacama Large Millimeter/sub-millimeter Array (ALMA). We utilize the tilted ring model to investigate what fraction of the molecular gas in the sample is regularly and smoothly rotating. In addition, we model the molecular gas disk using the GALMOD package of the Groningen Image Processing System (GIPSY) and compare with the observations to identify the gas which is offset from the 'co-planar differential rotation'. Based on the results, we discuss the possibility of gas accretion in the sample, and the potential origin of non-regularly rotating gas and the inefficient star formation.

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Evaluation of exposure to ionizing radiation of medical staff performing procedures with glucose labeled with radioactive fluorine - 18F-FDG

  • Michal Biegala;Marcin Brodecki;Teresa Jakubowska;Joanna Domienik-Andrzejewska
    • Nuclear Engineering and Technology
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    • v.56 no.1
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    • pp.335-339
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    • 2024
  • Employees of nuclear medicine facilities performing medical procedures with the use of open radioactive sources require continuous detailed control of exposure to ionizing radiation. Thermoluminescent (TL) detectors placed in dosimeters: for the whole body, for lenses, ring and wrist dosimeters were used to assess exposure. The highest whole-body exposure of (1.70 ± 1.09) µSv/GBq was recorded in nurses administering radiopharmaceutical to patients. The highest exposure to lenses and fingers was recorded for employees of the quality control zone and it was (8.08 ± 2.84) µSv/GBq and a maximum of (1261.46 ± 338.93) µSv/GBq, respectively. Workers in the production zone received the highest doses on their hands, i.e. (175.67 ± 13.25) µSv/GBq. The measurements performed showed that the analyzed workers may be classified as exposure category A. Wrist dosimeters are not recommended for use in isotope laboratories due to underestimation of ionizing radiation doses. Appropriately selected shields, which significantly reduce the dose received by employees, must be used in isotope laboratories. Periodic measurements confirmed that the appropriate optimization of exposure reduces the radiation doses received by employees.

Exploring the Impact of Consumer Benefits and Altruistic Attitudes on Consumer Attributions and Donation Intentions (소비자 혜택 유형 및 타인지향 성향이 패션기업의 기부 활동에 대한 소비자 귀인과 기부 의도에 미치는 영향)

  • Xi Chen;Sojin Jung
    • Journal of the Korean Society of Clothing and Textiles
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    • v.48 no.4
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    • pp.657-672
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    • 2024
  • This experimental study aimed to investigate the determinants of fashion products donation intentions built on two consumer attributions: strategic and value-driven motives. While consumers may perceive that the underlying motivations of a firm's CSR initiatives are to sincerely help society, they may also believe that such initiatives are strategically motivated and that the firm only engages in CSR to improve its corporate image. Therefore, this study tested how extrinsic factors (consumer monetary and non-monetary- benefits for participating in a donation campaign) and intrinsic factors (i.e., altruistic attitudes) influenced perceived value- and strategic-driven motives, which in turn promote donation intentions. An analysis of 268 responses revealed that monetary benefits, such as offering discount coupons, increased consumers'perception of strategic motives, while non-monetary benefits, such as offering a ring and acertificate, enhanced their perception of value-driven motives. In addition, consumers who tended to have a positive altruistic attitude were more likely to perceive value-driven motives, and this orientation also directly increased donation intentions. These findings also confirmed that only value-driven motives promoted donation intentions. However, consumer benefits did not directly affect donation intentions. The findings of this study suggest valuable managerial implications as well as academic contributions.

Development of Collaborative Dual Manipulator System for Packaging Industrial Coils (산업용 코일 포장을 위한 협동 양팔 로봇 시스템의 개발)

  • Haeseong Lee;Yonghee Lee;Jaeheung Park
    • The Journal of Korea Robotics Society
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    • v.19 no.3
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    • pp.236-243
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    • 2024
  • This paper introduces a dual manipulator system designed to automate the packaging process of industrial coils, which exhibit higher variability than other structured industrial fields due to diverse commercial requirements. The conventional solution involves the direct-teaching method, where an operator instructs the robot on a target configuration. However, this method has distinct limitations, such as low flexibility in dealing with varied sizes and safety concerns for the operators handling large products. In this sense, this paper proposes a two-step approach for coil packaging: motion planning and assembly execution. The motion planning includes a Rapidly-exploring Random Tree algorithm and a smoothing method, allowing the robot to reach the target configuration. In the assembly execution, the packaging is considered a peg-in-hole assembly. Unlike typical peg-in-hole assembly handling two workpieces, the packaging includes three workpieces (e.g., coil, inner ring, side plate). To address this assembly, the paper suggests a suitable strategy for dual manipulation. Finally, the validity of the proposed system is demonstrated through experiments with three different sizes of coils, replicating real-world packaging situations.

Study for the Size Reduction of Microstrip Patch Antenna using Corrugation (주름 구조를 이용한 마이크로스트립 패치 안테나의 소형화에 대한 연구)

  • 송무하;우종명
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.14 no.2
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    • pp.192-201
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    • 2003
  • In this paper, to reduce the size of patch, three types of 3-dimensional patch antennas which are one-directionally-corrugaged type, rectangular ring-likely corrugated type, and lattice-likely corrugated type rectangular microstrip patch antennas(MPA) are designed and fabricated at the 1.575 GHz. As the result, one-directionally corrugated rectangular MPA is reduced in the resonant length of patch by 21.4% than that of general plane MPA. -10 dB bandwidth(B.W) is 62 MHz(3.9 %) and this is broader than that(39 MHz, 2.5 %) of plane MPA by 23 MHz(1.5 %). The gain is 5.8 dBd and this is reduced by 0.9 dB than that(6.7 dBd) of plane MPA. Half power beamwidth(HPBW) is broadened by 18$^{\circ}$ than that of plane MPA in the E-plane and this is due to the reduced length of patch. For rectangular ring-likely corrugated retangular MPA, the patch size is miniaturized by 21.6 % than that of plane MPA. For lattice-likely corrugated rectangular MPA, in the linear polarization, the size of patch is miniaturized by 43.3 % than that of plane MPA. -10 dB B.W is 70 MHz(4.4 %) and this is broadened than that of plane MPA by 31 MHz(2 %). Gain is 2.2 dBd and this is smaller than that of plane MPA by 4.5 dB. HPBW is increased in both E-plane and H-plane by 22$^{\circ}$ and 13$^{\circ}$, respectively. For circular polarization, the size of patch is reduced by 41 % than that by 41 %. The axial ratio(AR) is 0.8 dB at the 1.575 GHz and the axial ratio bandwidth(ARBW) within 2 dB is 20 MHz(1.27 %) and this is increased by 10 MHz(0.63 %) than that 10 MHz(0.63 %) of plane MPA. From all the results above, it is conformed that the proposed antenna has merit in size reduction of patch and in the input impedance B.W, and is more profitable in many application than the general plane type MPA.

Synthesis of a Perfluoropolyether Intermediate via Electrophilic Fluorine-Substituting Direct Fluorination (친전자성 불소치환 직접플루오르화 반응에 의한 Perfluoropolyether 중간체의 합성)

  • Yun, Seok-Min;Lim, Jae-Won;Jeong, Eui-Gyung;Park, In-Jun;Lee, Young-Seak
    • Polymer(Korea)
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    • v.35 no.2
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    • pp.166-170
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    • 2011
  • This study reported the synthesis of perfluoropolyether intermediate (TP-$COOCF_3$) having a $CF_3$ functional group via electrophilic fluorine substituting direct fluorination from PFPE intermediate (TP-$COOCH_3$) having a $CH_3$ functional group, which was synthesized by the ring opening polymerization and methyl esterification of HFPO. The effects of reaction conditions such as the amount of solvent, fluorine partial pressure, reaction time, were investigated. The results showed that the yield of fluorination reaction became the highest when the reaction was carried out in a mild condition for a long reaction time, which also minimized side reactions. The sample was characterized by FTIR and NMR, which confirmed the synthesis of the final product, TP-$COOCF_3$, via direct fluorination converting $CH_3$ of TP-$COOCH_3$ to $CF_3$ of TP-$COOCF_3$ with 95.4% yield.

Polyether Ester by Rubber Content and Rubber According to the Type of Dynamic Vulcanized Properties (TPEE) (폴리에스터계 동적가교물의 고무함량 및 고무종류에 따른 물성)

  • Yun, Ju-Ho;Yun, Jung-Hwan;Ha, Seong-Mun;Kim, Il;Sim, Sang-Eun
    • Elastomers and Composites
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    • v.48 no.1
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    • pp.67-75
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    • 2013
  • E-TPE (Engineering Thermoplastic Polyether Ester) was Ester Elastomer with functional groups as recycling and fast processability. In addition, if the car's lightweight enough to highlight eco-friendly materials that help to improve fuel economy has become. Have all the attributes of the rubber and engineering plastics E-TPE the available temperature area is spacious, heat resistance and oil resistance is excellent but getting attention as a new material in the field of auto parts in the field of electrical and electronic domestic depends entirely on imports by the lack of core technology and has been research and development is urgently needed. In this study, the hard segments, polyester (TPEE) as the base soft elastomers of the segments Ethylen-prophylene-Copolymer and CSM (Choloro sulphonated polyethylene Rubber), VAMAC (Ethylene Acrylic Rubber), NBR (Acrylonitrin Butadiene Rubber), 1, 3-Phenylene-bisoxazoline is dealing with Dynamic Vulcanized by content and added rubber properties, thermal variation observed. As a result, the properties of the dynamic vulcanization with NBR compared to other rubber heat resistance and oil resistance is on the increase.