• Toxicological Research
• /
• v.34 no.4
• /
• pp.303-310
• /
• 2018

The methods of applied genetic toxicology are changing from qualitative hazard identification to quantitative risk assessment. Recently, quantitative analysis with point of departure (PoD) metrics and benchmark dose (BMD) modeling have been applied to in vitro genotoxicity data. Two software packages are commonly used for BMD analysis. In previous studies, we performed quantitative dose-response analysis by using the PROAST software to quantitatively evaluate the mutagenicity of four piperidine nitroxides with various substituent groups on the 4-position of the piperidine ring and six cigarette whole smoke solutions (WSSs) prepared by bubbling machine-generated whole smoke. In the present study, we reanalyzed the obtained genotoxicity data by using the EPA's BMD software (BMDS) to evaluate the inter-platform quantitative agreement of the estimates of genotoxic potency. We calculated the BMDs for 10%, 50%, and 100% (i.e., a two-fold increase), and 200% increases over the concurrent vehicle controls to achieve better discrimination of the dose-responses, along with their BMDLs (the lower 95% confidence interval of the BMD) and BMDUs (the upper 95% confidence interval of the BMD). The BMD values and rankings estimated in this study by using the EPA's BMDS were reasonably similar to those calculated in our previous studies by using PROAST. These results indicated that both software packages were suitable for dose-response analysis using the mouse lymphoma assay and that the BMD modeling results from these software packages produced comparable rank orders of the mutagenic potency.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.17 no.7 s.124
• /
• pp.632-637
• /
• 2007

The dynamic behavior of two steel bridges crossed by the Korean High Speed Train(KHST) has been investigated experimentally and the results are compared with the specification requirement of BRDM and other typical PSC Box bridge's responses. The investigated bridges are a 2-girder steel bridge of 1@40m span length(E-Won Bridge), 2@50m span length (Ji-Tan Bridge), and a PSC Box girder bridge of 2@40m span length (Yeon-Jae Bridge). A set of experimental tests were performed during operation of KHST, and a number of accelerometers, LVDTs and ring-type displacement transducers were utilized for measurement of three kinds of dynamic responses (acceleration, deflection, and end-rotation angle). Measured responses show that the vertical deflections and end-rotation angles of the three bridges are all satisfying the spec. requirement with large margin, but it was also found acceleration responses which are very close or exceed the limit value. Most of the excessive acceleration responses were found when the passing velocity of the KHST is close to the critical velocity ($V_{cr}$) which causes resonance. No noticeable differences of dynamic responses due to the different materials(steel or concrete) could be found within these experimental results.

• Journal of the Korean Vacuum Society
• /
• v.5 no.3
• /
• pp.245-250
• /
• 1996

$Y_2O_3$ thin film on si(100) was successfully grown by ionized cluster beam(ICBD) technique at substrate temperature of around $500^{\circ}C$ and pressure of ~$10^{-5}$Torr.To prevent the oxidation of Si substrae, a very thin yttrium layer was deposited on Si before reactive depositing of oxygen and yttrium source. In asdeposited stage, b.c.c and h.c.p strucutres of $Y_2O_3$ were observed from S-ary analysis. From the observation of spots and ring patterns in selected area diffractin(SAD) patterns. crystallane formation and growth could be proceeded during the deposition. $Y_2O_3$/mixed layer/$SiO_2=170\AA/50\AA/10\AA$ structure were verified by high resolution transmition electron imcroscopy(HRTEM) image, and the formation of amorphous layer of SiO2 was discussed . Electricla charateristics of the film were also investigated . In as-deposited Pt/$Y_2O_3$/Si sturcuture, leakage current was less than $10^{-6}$A/$\textrm{cm}^2$ at 7MV/cm strength.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.5 no.4
• /
• pp.121-129
• /
• 1997

Gear train system test rig of power circulating type was fabricated, and systematic experiment for measuring dynamic characteristics of the planetary gear trains in the low speed region has been carried out using the test rig. The measured parameters are fillet strains of the sun gear and ring gear, carrier displacements, torques of the input and output shafts. The results are as follows : i) Even though the loading torque is constant, torque variation has been observed on the input and output hafts, ii) The variation of the torque has two frequency components, i.e. lower one of the input shaft rotation and higher one of the two teeth meshing, iii) The variation of the fillet strains shows the same tendency as that of the torque, iv) The loci of the carrier depend on the torque and rotational speed.

• Analytical Science and Technology
• /
• v.28 no.5
• /
• pp.347-352
• /
• 2015

Chemical properties such as heat of formation and density of methylnitroimidazole derivatives were predicted and analyzed by using density functional theory (DFT). Successive addition of energetic nitro groups into an imidazole ring increases both the heat of formation and the density. Using the chemical property values computed by DFT, explosive performance was analyzed with the Cheetah program, and compared with those of TNT, RDX, and HMX, which are currently used widely in military systems. When both C-J pressure and detonation velocity were used as explosive performance, methyldinitroimidazole derivatives show better performance than TNT, while methyltrinitroimidzole is almost close to RDX. Since methylnitroimidazole derivatives have a good merit, i.e. low melting point for melt loading, they are forecasted to be used widely in various military and civilian application.

• Communications of the Korean Mathematical Society
• /
• v.22 no.1
• /
• pp.41-51
• /
• 2007

Let R be a ring with left identity e and suitably-restricted additive torsion, and Z(R) its center. Let H : $R{\times}R{\times}R{\rightarrow}R$ be a symmetric 3-additive mapping, and let h be the trace of H. In this paper we show that (i) if for each $x{\in}R$, $$n=<<\cdots,\;x>,\;\cdots,x>{\in}Z(R)$$ with $n\geq1$ fixed, then h is commuting on R. Moreover, h is of the form $$h(x)=\lambda_0x^3+\lambda_1(x)x^2+\lambda_2(x)x+\lambda_3(x)\;for\;all\;x{\in}R$$, where $\lambda_0\;{\in}\;Z(R)$, $\lambda_1\;:\;R{\rightarrow}R$ is an additive commuting mapping, $\lambda_2\;:\;R{\rightarrow}R$ is the commuting trace of a bi-additive mapping and the mapping $\lambda_3\;:\;R{\rightarrow}Z(R)$ is the trace of a symmetric 3-additive mapping; (ii) for each $x{\in}R$, either $n=0\;or\;<n,\;x^m>=0$ with $n\geq0,\;m\geq1$ fixed, then h = 0 on R, where denotes the product yx+xy and Z(R) is the center of R. We also present the conditions which implies commutativity in rings with identity as motivated by the above result.

• Journal of Biomedical Engineering Research
• /
• v.7 no.1
• /
• pp.59-66
• /
• 1986

A prototype ultrasound sector B-scanner has been developed where the front-end hardware refers to all the necessary circuits for transmitting the ultrasound pulses into the human body and receiving the reflected echo signals from it. The front-end hardware can generally be divided into three parts, i.e., a pulse generator for insonification, a receiver which is responsible for processing of low-level analog signals, and a steering controller for driving the mechanical sector probe whose functions and design concepts are described in this paper. The front-end hardware is implemented which incorporates the following features: improvement of the axial resolution using a circuit which reduces the ring-down time, flexibility of generating time-gain compensation curve, and adoption of a one-chip microcomputer for generating the rate pulses based on the sensor output waveforms.

• Carbon letters
• /
• v.5 no.4
• /
• pp.159-163
• /
• 2004

The polymer-ceramic hybrid, known as 'ceramer', was synthesized by a sol-gel process by incorporating different amount of alkoxide as source of silicon in resorcinol-formaldehyde in presence of basic catalyst to get different percentage of silicon in ultimate carbonized composites. FTIR of the ceramer confirms that it is a network of Si-O-Si, Si-O-$CH_2$ and Si-OH type groups linked with benzene ring. Different amount of silicon in the ceramer exhibits varying temperature of thermal stability and lower coefficient of thermal expansion as compared to pure resorcinol-formaldehyde resin. The lower value of CTE in ceramer is due to existence of silica and resorcinol -formaldehyde in co-continuous phase. Unidirectional composites prepared with ceramer matrix and high-strength carbon fibers show lower value of flexural strength at polymer stage as compared to those prepared with resorcinol-formaldehyde resin. However, after heat treatment to $1450^{\circ}C$, the ceramer matrix composites show large improvement in the mechanical properties, i.e. with 7% silicon in the ceramer, the flexural strength is enhanced by 100% and flexural modulus value by 40% as compared to that of pure resorcinol-formaldehyde resin matrix composites.

• Molecules and Cells
• /
• v.27 no.3
• /
• pp.359-363
• /
• 2009

Chfr, a checkpoint with FHA and RING finger domains, plays an important role in cell cycle progression and tumor suppression. Chfr possesses the E3 ubiquitin ligase activity and stimulates the formation of polyubiquitin chains by Ub-conjugating enzymes, and induces the proteasome-dependent degradation of a number of cellular proteins, including Plk1 and Aurora A. While Chfr is a nuclear protein that functions within the cell nucleus, how Chfr is localized in the nucleus has not been clearly demonstrated. Here, we show that nuclear localization of Chfr is mediated by nuclear localization signal (NLS) sequences. To reveal the signal sequences responsible for nuclear localization, a short lysine-rich stretch (KKK) at amino acid residues 257-259 was replaced with alanine, which completely abolished nuclear localization. Moreover, we show that nuclear localization of Chfr is essential for its checkpoint function but not for its stability. Thus, our results suggest that NLS-mediated nuclear localization of Chfr leads to its accumulation within the nucleus, which may be important in the regulation of Chfr activation and Chfr-mediated cellular processes, including cell cycle progression and tumor suppression.

• The Korean Journal of Malacology
• /
• v.24 no.3
• /
• pp.189-197
• /
• 2008

In order to develop the sustainable ecological management, short-necked clams, Ruditapes philippinarum, were collected from Yoengi coast in Tongyoeng, Korea. The growth of the clam was estimated as: $L_f=68.08{\cdot}(1-e^{-0.145(t+0.324)})$ from ring radius composition of shell. Instantaneous co-efficiency of total mortality and natural mortality were calculated as: 0.991/year and 0.494/year, respectively. The age of the clams from the first capture was estimated to be 3.28. The total biomass was estimated to be 212 MT in the fisheries area (6.4 ha). Applied by these parameters, the annual recruit biomass and the current yield per recruit were calculated to be 649.5 individual/$m^2$ and $0.7\;g/m^2$, respectively. The current fishing intensity was much lower for maximum sustainable yield and acceptable biological catch. Although higher yield per recruit could be achieved by increasing fishing intensity, it is favorable to retain the current fishing intensity because of the unique fishing attitude on Yeongi coast in Tongyoeng, Korea.