• Journal of Electrical Engineering and Technology
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• v.12 no.5
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• pp.2031-2042
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• 2017

In this paper, a novel traffic flow control method based-on ramp metering and speed regulation using an adaptive sliding mode control (ASMC) method along with a deadzoned parameter adaptation law is proposed at a stochastic macroscopic level traffic environment, where the influence of the density and speed disturbances is accounted for in the traffic dynamic equations. The goal of this paper is to design a local traffic flow controller using both ramp metering and speed regulation based on ASMC, in order to achieve the desired density and speed for the maintenance of the maximum mainline throughput against disturbances in practice. The proposed method is advantageous in that it can improve the traffic flow performance compared to the traditional methods using only ramp metering, even in the presence of ramp storage limitation and disturbances. Moreover, a prior knowledge of disturbance magnitude is not required in the process of designing the controller unlike the conventional sliding mode controller. A stability analysis is presented to show that the traffic system under the proposed traffic flow control method is guaranteed to be uniformly bounded and its ultimate bound can be adjusted to be sufficiently small in terms of deadzone. The validity of the proposed method is demonstrated under different traffic situations (i.e., different initial traffic status), in the sense that the proposed control method is capable of stabilizing traffic flow better than the previously well-known Asservissement Lineaire d'Entree Autoroutiere (ALINEA) strategy and also feedback linearization control (FLC) method.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.3
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• pp.349-360
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• 2018

Autophagy has been studied as a therapeutic strategy for cardiovascular diseases. However, insufficient studies have been reported concerning the influence of vascular smooth muscle cells (VSMCs) through autophagy regulation. The aim of the present study was to determine the effects of VSMCs on the regulation of autophagy under in vitro conditions similar to vascular status of the equipped micro-tubule target agent-eluting stent and increased release of platelet-derived growth factor-BB (PDGF-BB). Cell viability and proliferation were measured using MTT and cell counting assays. Immunofluorescence using an $anti-{\alpha}-tubulin$ antibody was performed to determine microtubule dynamic formation. Cell apoptosis was measured by cleavage of caspase-3 using western blot analysis, and by nuclear fragmentation using a fluorescence assay. Autophagy activity was assessed by microtubule-associated protein light chain 3-II (LC-II) using western blot analysis. Levels of intracellular reactive oxygen species (ROS) were measured using $H_2DCFDA$. The proliferation and viability of VSMCs were inhibited by microtubule regulation. Additionally, microtubule-regulated and PDGF-BB-stimulated VSMCs increased the cleavage of caspase-3 more than only the microtubule-regulated condition, similar to that of LC3-II, implying autophagy. Inhibitory autophagy of microtubule-regulated and PDGF-BB-stimulated VSMCs resulted in low viability. However, enhancement of autophagy maintained survival through the reduction of ROS. These results suggest that the apoptosis of conditioned VSMCs is decreased by the blocking generation of ROS via the promotion of autophagy, and proliferation is also inhibited. Thus, promoting autophagy as a therapeutic target for vascular restenosis and atherosclerosis may be a good strategy.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.4
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• pp.355-363
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• 2021

Dynamic changes in adipose tissue blood flow (ATBF) with nutritional status play a role in the regulation of metabolic and endocrine functions. Activation of the sympathetic nervous system via β-adrenergic receptors (β-AR) contributes to the control of postprandial enhancement of ATBF. Herein, we sought to identify the role of each β-AR subtype in the regulation of ATBF in mice. We monitored the changes in visceral epididymal ATBF (VAT BF), induced by local infusion of dobutamine, salbutamol, and CL316,243 (a selective β1-, β2-, and β3-AR agonist, respectively) into VAT of lean CD-1 mice and global adipose triglyceride lipase (ATGL) knockout (KO) mice, using laser Doppler flowmetry. Administration of CL316,243, known to promote lipolysis in adipocytes, significantly increased VAT BF of CD-1 mice to a greater extent compared to that of the vehicle, whereas administration of dobutamine or salbutamol did not produce significant differences in VAT BF. The increase in VAT BF induced by β3-AR stimulation disappeared in ATGL KO mice as opposed to their wild-type (WT) littermates, implying a role of ATGL-mediated lipolysis in the regulation of VAT BF. Different vascular reactivities occurred despite no significant differences in vessel density and adiposity between the groups. Additionally, the expression levels of the angiogenesis-related genes were significantly higher in VAT of ATGL KO mice than in that of WT, implicating an association of ATBF responsiveness with angiogenic activity in VAT. Our findings suggest a potential role of β3-AR signaling in the regulation of VAT BF via ATGL-mediated lipolysis in mice.

• Genomics & Informatics
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• v.15 no.4
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• pp.114-122
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• 2017

It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture. Such spatial genomic organization is functionally important for the spatial disposition of chromosomes to control cell fate during development and differentiation. Thus, the dysregulation of proper long-range chromatin interactions may influence the development of tumorigenesis and cancer progression.

• Proceedings of the KIPE Conference
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• 1997.07a
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• pp.299-302
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• 1997

This paper describes a dynamic var compensator to compensate the line reactance for power transmission and distribution system. The compensator consists of a voltage source inverter with dc capacitor, coupling transformers, and control circuit. The operation of compensator was verified by computer simulations with EMPT and experimental works with a scaled hardware model. The advantage of the proposed system is rapid and continuous regulation of the reactive power.

• Fire Science and Engineering
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• v.10 no.4
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• pp.37-42
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• 1996

The "Intelligent Fire detecting and Extinguishing System" is an up-to-date fire protection system for modern high-rise buildings, international airports, enormous industrial facilities, dome stadiums such as specific areas in which the application of our local fire protection regulation could not be satisfied. The state-of-the art initiating devices communicated with sophisticated network control panels enable peoples to get reliable and powerful suppressions using water or gas, providing absolute protection. The Intelligent Water Cannon System, the Low Pressure $CO_2$ System and the MXL Networking Fire Alarm System introduced in this paper accomplish the dynamic protection for the special hazards.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1993.10a
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• pp.194-211
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• 1993

This paper proposes an optimal incentive scheme for environmental pollution and output control in oligopoly markets under asymmetric information situation where the regulator has no information about each firm's technology on output productions and pollution abatements. We compare two interesting optimal incentive schemes (one is static model previously proposed and the other is dynamic model suggested in this paper), analyze features of these schemes, and carefully discuss its relevances to other schemes.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.107-108
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• 2003

The epidermal growth factor (EGF) is an important signaling ligand for the mitogenesis of many cells. The EGF receptors use signaling molecule multicomplexes and dynamic protein networks for the transmission and amplification of the signals as well as for the regulation of the cellular responses. EGF signaling has been reported to be enhanced in various tumors by the overexpressed EGF receptor and/or the mediators such as phospholipase C-$\gamma$1(PLC$\gamma$1). (omitted)

• Journal of Korean Association for Spatial Structures
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• v.5 no.1 s.15
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• pp.65-71
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• 2005

This research analyzed dynamic responses of the preflex railroad bridge. Vertical deflection and acceleration induced by operating train loads and test train loads were measured. Deflection of bridge by train traveling satisfies deflection limitation regulation (L/800) about the concrete bridge, but compare with UIC standard, vibration acceleration happened fairly greatly. Also test result show that acceleration receives greatly effect about the speed than deflection. It must discuss about vibration acceleration problems for speed elevation hereafter.

• BMB Reports
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• v.33 no.6
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• pp.427-439
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• 2000

The activity of the phagocyte respiratory burst oxidase is regulated by complex and dynamic alterations in protein-protein interactions that result in the rapid assembly of an active multicomponent NADPH oxidase enzyme on the plasma membrane. While the enzymatic activity has been studied for the past 20 years, the past decade has seen remarkable progress in our understanding of the enzyme and its activation at the molecular level. This article describes the current state of knowledge, and proposes a model for the mechanism by which protein-protein interactions regulate enzyme activity in this system.