• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.4
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• pp.788-800
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• 2002

Aging is characterized by an age-dependent reduction in bone density. Pronounced bone loss by postmenopausal estrogen deficiency induces a bad effect on dynamic balance of bone metabolism. When the bone density is reduced to the level below the fracture threshold, the risk for fracture is greatly increased. The purpose of this study is to examine what are the effects of the Yuklinzu(YLZ: 毓麟珠) on the ovariectomized rat model of postmenopausal osteoporosis. The results of the experiment are as follows: Body weight in control group showed significant increase in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum albumin in control group showed significant decrease in comparison with sham. That in YLZ-treated was slightly decreased in comparison with control. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum phosphorous in control group showed significant increase in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum calcium in control group showed no change in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum GOT in control group showed no change in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum GPT did not significant change among the three groups. The level of serum estrogen in control group showed slightly increased in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum T3 in control group showed no change in comparison with sham, and that in YLZ-treated showed no change in comparison with control. The level of serum T4 in control group showed significant increase in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. Mechanical strength of the femur neck in control group showed significant decrease in comparison with sham. That in YLZ-treated showed slightly increased in comparison with control. Trabecular bone area as well as trabecular thickness in control group showed significant decrease in comparison with sham. Those in YLZ-treated showed significant increase in comparison with control. Trabecular number and did not significant change among the three groups. Trabecular separation only in YLZ-treated showed significant decrease in comparison with control. Osteoclast number and oseoblast surface in control group showed significant increase in comparison with sham. Those in YLZ-treated showed slightly decreased in comparison with control. According to the above these results, YLZ has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause.

• Journal of Pharmaceutical Investigation
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• v.27 no.4
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• pp.287-293
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• 1997

To make a stable o/w emulsion, the effects of egg lecithin as an emulsifier and polyvinylpyrrolidone (PVP) as an auxiliary emulsifier on the physical stability of emulsion were investigated. The oil-in-water emulsion system was manufactured by microfluidizer and evaluated the physical stability. Average particle size and size distribution of emulsion was measured by dynamic light scattering analyzer and interfacial tension was measured. From the interfacial tension tested, critical micelle concentration of the egg lecithin was 0.1 %w/v and optimal concentration for the preparation of emulsion was 1.0 %w/v. The mean particle size was about $0.2\;{\mu}m$ which was suitable for injections. The short-term accelerated stability studies were conducted by centrifugation, freeze-thaw method and shaking of the emulsion samples. The addition of PVP was caused the reduction in the particle size and improved the physical stability of emulsion. These results suggested that a mixed interfacial film comprising the egg lecithin and PVP was formed at the o/w interface and it was effective in preventing phase separation under thermic or mechanical stress. We used antineoplaston A10 (A10) as a model drug which is peptide and amino acid derivative having a action to the living organism against the development of neoplastic growth by a nonimmunological progress. It has a poor solubility in water and there may be a difficulty in formulation of A10. Emulsion formulation study about A10 was performed. Solubility of A10 in emulsion was about five times as high as that in water. From the results of solubility and partition coefficient, almost A10 molecules in o/w emulsion exist in the interface between oil and water.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.42 no.3
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• pp.169-178
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• 2006

This research aims at establishing the fundamental characteristics of the kite through the analysis of the flow field around various types of kites. The approach of this study were adopted for the analysis; visualization by CFD(computational fluid dynamics). Also, the lift/drag and PIV(particle image velocimetry) tests of kites had been performed in our previous finding. For this situation, models of canvas kite were designed by solidworks(design program) for the CFD test using the same conditions as in the lift/drag tests. And we utilized FloWorks as a CFD analysis program. The results obtained from the above approach are summarized as follows: According to comparison of the measured and analyzed results from mechanical tests, PIV and CFD test, the results of all test were similar. The numerical results of lift-coefficient and drag-coefficient were 5-20% less than those of the tests when attack angle is $10^{\circ},\;20^{\circ}\;and\;30^{\circ}$. In particular, it showed the 20% discrepancy at $40^{\circ}$. The numerical results of the ratio of drag and lift were 8-13% less than those of the tests at $10^{\circ}$ and 10% less than those of the tests at $20^{\circ},\;30^{\circ}\;and\;40^{\circ}$. Pressure distribution gradually became stable at $10^{\circ}$. In particular, the rectangular and triangular types had the centre of the high pressure field towards the leading edge and the inverted triangular type had it towards the trailing edge. The increase of the attack angle resulted in the eddy in order of the rectangular, triangular and inverted triangular type. The magnitude of the eddy followed the same order. The effect of edge-eddy was biggest in the triangular type followed by the rectangular and then the inverted triangular type. The action point of dynamic pressure as a function of the attack angle was close to the rear area of the model with the small attack angle, and with large attack angle, the action point was close to the front part of the model.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.7
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• pp.265-274
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• 2018

The increasing use of curved beams in buildings, vehicles, ships, and aircraft has prompted studies directed toward the development of an accurate method for analyzing the dynamic behavior of such structures. The stability behavior of elastic curved beams has been the subject of a large number of investigations. Solutions of the relevant differential equations have been obtained traditionally using standard finite difference or finite element methods. These techniques require a great deal of computer time as the number of discrete nodes becomes relatively large under the conditions of complex geometry and loading. One of the efficient procedures for the solution of partial differential equations is the method of differential quadrature. The differential quadrature method (DQM) has been applied to a large number of cases to overcome the difficulties of the complex algorithms of programming for the computer, as well as the excessive use of storage due to the conditions of complex geometry and loading. The in-plane buckling of curved beams considering the extensibility of the arch axis was analyzed under uniformly distributed radial loads using the DQM. The critical loads were calculated for the member with various parameter ratios, boundary conditions, and opening angles. The results were compared with the precise results by other methods for cases, in which they were available. The DQM, using only a limited number of grid points, provided results that agreed very well (less than 0.3%) with the exact ones. New results according to diverse variations were obtained, showing the important roles in the buckling behavior of curved beams, and can be used in comparisons with other numerical solutions or with experimental test data.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.3
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• pp.1255-1262
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• 2012

Look into the nuclear power plant of Wolsong currently, it is controlled in order to required operating pressure with PI controller. PI controller has a simple structure and satisfy design requirements to gain setting. However, It is difficult to control without changing the gain from produce changes in parameters such as loss of the valves and the pipes. To solve these problems, the dynamic change of the PI controller gain, or to compensate for the PI controller output is desirable to configure the controller. The aim of this research and development in the parameter variations can be controlled to a stable controller design which is reduced an error and a vibration. Proposed PI/NN control techniques is the PI controller and the neural network controller that combines a parallel and the neural network controller part is compensated output of the controller for changes in the parameters were designed to be robust. To directly evaluate the controller performance can be difficult to test in real processes to reflect the characteristics of the process. Therefore, we develope the simulator model using the real process data and simulation results when compared with the simulated process characteristics that showed changes in the parameters. As a result the PI/NN controller error and was confirmed to reduce vibrations.

• The Journal of the Acoustical Society of Korea
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• v.24 no.2
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• pp.78-86
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• 2005

This study considers the magnitude of the harmonic components radiated from the ultrasonic contrast agents (UCA) activated by a typical diagnostic ultrasound. The nonlinear dynamic response of UCA to a 2 MHz diagnostic ultrasound pulse was predicted using Gilmore Model. The elastic property of the shell membrane of the UCA was ignored in the numerical model. Simulation was carried out for the UCA varying from 1 - 9 $\mu$m in its initial radius and the driving diagnostic ultrasound whose mechanical index (MI) ranges from 0.125 to 8. The powers of the sub. ultra and second harmonics of the acoustic signal from the UCA activated were compared with that of the fundamental component. The results show that. if the UCA is bigger than its resonant size (2 $\mu$m in radius for the present case) the sub harmonic power was much bigger than the fundamental. In particular, the 2nd harmonic component currently used as an imaging parameter for the harmonic imaging, was predicted to be lower in power than both the sub and the ultra harmonic component. This study indicates that, for obtaining harmonic imaging with UCA, the sub or ultra harmonics could be taken as imaging parameters better than the 2nd harmonic component.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.688-695
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• 2017

This paper deals with characteristics analysis of a permanent magnet (PM) linear generator using analytical methods for wave energy harvesting. The wave energy is carried out from the movement of a yo-yo system. A linear generator using permanent magnets to generate a magnetic force itself does not require a separate power supply and has the advantage of simple maintenance. In addition to the use of a rare earth, a permanent magnet having a high-energy density can be miniaturized and lightweight, and can obtain high energy-conversion efficiency. We derived magnetic field solutions produced by the permanent magnet and armature reaction based on 2D polar coordinates and magnetic vector potential. Induced voltage is obtained via arbitrary sinusoidal input. In addition, electrical parameters are obtained, such as back-EMF constant, resistance, and self- and mutual-winding inductances. The space harmonic method used in this paper is confirmed by comparing it with finite element method (FEM) results. These facilitate the characterization of the PM-type linear generator and provide a basis for comparative studies, design optimization, and machine dynamic modeling.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.8
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• pp.18-25
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• 2020

With the development of water internet technology, data communication between objects is expanding. Research related to data communication technology between vehicles that incorporates related technologies into vehicles has been actively conducted. For data communication between mobile terminals, data stability, reliability, and real-time performance must be guaranteed. The 5 GHz Wi-Fi band, which is advantageous in bandwidth, communications speed, and wireless saturation of the wireless network, was selected as the data communications network between vehicles. This study analyzes how to design and implement a 5 GHz Wi-Fi network in a vehicle network. Considering the characteristics of the mobile communication terminal device, a continuous variable communications structure is proposed to enable high-speed data switching. We simplify the access point access procedure to reduce the latency between wireless terminals. By limiting the Transmission Control Protocol Internet Protocol (TCP/IP)-based Dynamic Host Configuration Protocol (DHCP) server function and implementing it in a broadcast transmission protocol method, communication delay between terminal devices is improved. Compared to the general commercial Wi-Fi communication method, the connection operation and response speed have been improved by five seconds or more. Utilizing this method can be applied to various types of event data communication between vehicles. It can also be extended to wireless data-based intelligent road networks and systems for autonomous driving.

• International Journal of Highway Engineering
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• v.6 no.4 s.22
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• pp.45-53
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• 2004

This study dealt with correlation analysis between deformation strength and rut resistance of asphalt concretes based on binder grade in Superpave specification with changing submerging time. Currently, Mashall mix design is known to have little correlation with rutting related performance. Therefore, some agencies started to use the Superpave method for asphalt mix design. But this method has a weak point in that it can not distinct mechanical property of the asphalt mixtures designed. For solution of these problem, this study used deformation strength, $S_D$, of Kim test which is a new approach under development for finding property which represents rut resistance characteristics of asphalt mixtures under static loading. This study used two aggregates from two regions and five PG asphalt binders. Final rut depth (DR) and dynamic stability (DS) from wheel tracking (WT) test were obtained. and $S_D$ value of the same mixture specimen which was made by gyratory compactor was obtained using loading head [4(1.0)]. Three submerging times 30min, 40min, 50min were used as a test variable at $60^{\circ}C$. Correlation analysis of DR and DS with $S_D$ were performed based on PG grade. It was found out that the $S_D$ has a high correlation with DR and DS of superpave mixtures. The highest $R^2$ was found from the $S_D$ values of 30min. submerged specimen.

• Journal of the Korea Society of Computer and Information
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• v.19 no.4
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• pp.1-8
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• 2014

As cores in multi-core processors are integrated in a single chip, power density increased considerably, resulting in high temperature. For this reason, many research groups have focused on the techniques to solve thermal problems. In general, the approaches using mechanical cooling system or DTM(Dynamic Thermal Management) have been used to reduce the temperature in the microprocessors. However, existing approaches cannot solve thermal problems due to high cost and performance degradation. However, floorplan scheme does not require extra cooling cost and performance degradation. In this paper, we propose the diverse floorplan schemes in order to alleviate the thermal problem caused by the hottest unit in multi-core processors. Simulation results show that the peak temperature can be reduced efficiently when the hottest unit is located near to L2 cache. Compared to baseline floorplan, the peak temperature of core-central and core-edge are decreased by $8.04^{\circ}C$, $8.05^{\circ}C$ on average, respectively.