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Role of Adjunctive Tranexamic Acid in Facilitating Resolution of Chronic Subdural Hematoma after Surgery

  • Kiyoon Yang;Kyung Hwan Kim;Han-Joo Lee;Eun-Oh Jeong;Hyon-Jo Kwon;Seon-Hwan Kim
    • Journal of Korean Neurosurgical Society
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    • v.66 no.4
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    • pp.446-455
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    • 2023
  • Objective : Chronic subdural hematoma (CSDH) is a common neurosurgical disease and generally treated with burr-hole surgery alone. Tranexamic acid (TXA) is an antifibrinolytic agent that potentially reduces recurrence rates and the residual hematoma volume. However, the role of postoperative TXA medication remains unclear to date. This study aimed to verify the effectiveness of adjunctive TXA in the view of early hematoma resolution. Methods : Between January 2018 and September 2021, patients with CSDH who underwent burr-hole trephination in a single tertiary institute were reviewed. The study population was divided into three groups, TXA, non-TXA, and antithrombotics (AT) groups, according to the medical history of cardio-cerebrovascular disease and TXA administration. The primary endpoint was CSDH recurrence, defined as re-appearance or re-accumulation of CSDH requiring neurosurgical interventions. The secondary outcome was CSDH resolution, defined as complete or near-complete resorption of the CSDH. The CSDH resolution time and serial changes of hematoma thickness were also investigated. Results : A total of 240 patients was included in the analysis consisting of 185 male and 55 female, with a median age of 74 years. During the median imaging follow-up period of 75 days, 222 patients were reached to the primary or secondary endpoint. TXA was administered as an adjunctive therapy in 41 patients (TXA group, 16.9%) while 114 patients were included in the non-TXA group (47.9%) and 85 were in the AT group. The recurrence rate was the lowest in the TXA group (2.4%), followed by non-TXA (7.0%) and AT (8.2%) groups. However, there was no statistical significance due to the small number of patients with recurrence. CSDH resolution was achieved in 206 patients, and the median estimated time to resolution was significantly faster in the TXA group (p<0.001). Adjunctive TXA administration was a significant positive factor for achieving CSDH resolution (p<0.001). The hematoma thickness was comparable among the three groups at the initial time and after surgery. However, CSDH thickness in the TXA group decreased abruptly in a month and showed a significant difference from that in the other groups (p<0.001). There was no TXA-related adverse event. Conclusion : The adjunctive use of TXA after CSDH surgery significantly facilitated the resorption of residual CSDH and resulted in the early CSDH resolution. Adjunctive TXA may be an effective treatment option to reduce recurrence by enhancing CSDH resolution in the selective patients.

Economic Effects of Policy Loans: Focusing on Alleviation Effect of Investment Liquidity Constraint (정책융자의 경제적 성과분석: 투자의 유동성 제약완화 중심으로)

  • Nam, Joo-ha
    • International Area Studies Review
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    • v.15 no.1
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    • pp.173-193
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    • 2011
  • Most of the research regarding economic effects of policy loans has thus far been focused on whether policy loans can improve the financial status or the management performance of small and medium enterprises (SMEs). Unlike previous researches, this study implemented an empirical analysis focused on the contribution of policy loans to easing the liquidity restriction of investment. To analyze whether investment liquidity restriction can be alleviated or not, this study attempted an empirical analysis utilizing the nonlinear Euler equation induced through optimization of investment and GMM (generalized method of moments) as its analysis methodology. With the SMEs that received policy financing from the Small and medium Business Corporation (SBC) in 2004, this study analyzed three years of panel data before(2001~2003) and after(2004~2006) receipt of policy loans. According to the empirical results, it appears that policy loans had effects on resolving liquidity restriction of investment, implying that policy financing eases the liquidity restriction of SME investment and would contribute to the growth and development of SMEs. Further, I checked robustness of empirical results using Tobin's q model. The empirical results also support that policy loans help to resolve liquidity constraint. With these results, it is understood that the critical view to date, which has emphasized the ineffectiveness of policy financing due to it having no or insignificant economic effects, may be wrong.

Agricultural Characteristics of an Early-maturing, Multiple Resistant and High Quality Rice variety Cheolweon109

  • Yong-Jae Won;Eok-Keun Ahn;Woong-Jo Hyun;Kuk-Hyun Jeong;Yoon-Sung Lee;Jeong-Joo Kim;Ji-Eun Kwak;Bon-Il Ku;Won-Young Choi;Hyang-Mi Park
    • Proceedings of the Korean Society of Crop Science Conference
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    • 2022.10a
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    • pp.266-266
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    • 2022
  • The outbreaks of blast, bacterial blight and viral diseases have been increasing in early maturing rice cultivating areas in the central northern regions, recently. As the occurrence of sudden insects pests and disasters increases due to global climate warming, it is urgent to develop a variety of disaster-tolerant, high-quality varieties in response. This study was carried out to elucidate the characteristics of early-maturing, high-quality and multiple disease resistant rice variety, Cheolweon109 that was adapted to cultivation in the mid-mountainous regions of the central northern regions. Cheolweon109 was derived from a cross between Suweon546, medium maturing variety, and Sangju44 which is early maturing and resistant to blast, bacterial blight and rice stripe virus. The heading date of Cheolweon109 was July 30, 3 days later than Odae. The culm length of Cheolweon109 was 79 cm, which was about 5 cm taller than Odae, and the ripening ratio was 85.1%, which was 10% higher than that of Odae. This variety had 5.54 MT/ha of milled rice productivity, which was 99% of the Odae. Although Cheolweon109 was tall, it was strong against lodging. It was strong against bacterial blight (K1, K2, K3 race), rice stripe virus, and the pre-harvest sprouting which rate was 2.4%. The appearance of the grains of rice was clean, the glossiness was 70.6, and the head rice ratio was 95.3% high. Because Cheolweon109 had superior disease resistance, disaster resistance, and high quality than Odae, it was expected that can be used to expand the diversity of early maturing and high-quality rice varieties in central northern regions.

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A Study of the 'Sinchungmyeong Jochong(辛丑銘鳥銃)' at the National Museum of Korea - Attribute analysis and point of use estimation - (국립중앙박물관 소장 '신축명 조총(辛丑銘鳥銃)'연구 - 속성 분석과 운용 시기 추정을 중심으로 -)

  • KIM Myunghoon
    • Korean Journal of Heritage: History & Science
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    • v.56 no.4
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    • pp.6-22
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    • 2023
  • The National Museum of Korea's 'Shinchungmyeong Jochong' is the sole firearm in the country bearing inscriptions written in ink('辛丑改備江華庫藏'). Thanks to this written record, it is possible to determine where this firearm was stored and to make an estimate of the time when it was stored. Additionally, it is a valuable artifact that has been exceptionally well preserved and has an artistic design. However, research into the operational period, form, and structural characteristics of this firearm has been limited to date. This study aimed to shed light on the operational period, form, and structural features of the 'Shinchukmyeong Jochong.' To achieve this, the specifications and structural characteristics of the firearm were examined, and comparisons were made with 17 other extant firearms and their attributes. The results confirmed that the 'Shinchungmyeong Jochong' is a representative example of the typical firearms of the Joseon Dynasty. Next, the timing, background, and production subject of the Ganghwado containment of the Jochong were tracked based on letters found with the Jochong. The investigation revealed an entry in the 'Records of King Jeongjo'(『正祖實錄』) indicating that a significant amount of military supplies, including firearms, were stored on Ganghwado in December of the 5th year of Shinchung(1781). The decision to store these materials in Ganghwado Island may have been due to the perception of the Joseon decision-makers, who strategically valued Ganghwado Island, and the relocation of 'Tongaoyeong'(統禦營) and the integration with 'Jinmuyeong'(鎭撫營). After acquisition, it is presumed that the firearm was operated at locations like 'Jinmuyeong'(鎭撫營). The firearm's production is presumed to have been associated associated with institutions such as 'Gungisi'(軍器寺). In conclusion, the 'Shinchungmyeong Jochong' exemplifies a typical firearm of the Joseon Dynasty, and it is likely that it was stored on Ganghwado in December of 1781. Its production is believed to have been related to institutions such as 'Gungisi'. Following its acquisition, it is presumed that the firearm was operated at locations including 'Jinmuyeong'.

A Study on the Predictions of Wave Breaker Index in a Gravel Beach Using Linear Machine Learning Model (선형기계학습모델을 이용한 자갈해빈상에서의 쇄파지표 예측)

  • Eul-Hyuk Ahn;Young-Chan Lee;Do-Sam Kim;Kwang-Ho Lee
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.36 no.2
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    • pp.37-49
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    • 2024
  • To date, numerous empirical formulas have been proposed through hydraulic model experiments to predict the wave breaker index, including wave height and depth of wave breaking, due to the inherent complexity of generation mechanisms. Unfortunately, research on the characteristics of wave breaking and the prediction of the wave breaker index for gravel beaches has been limited. This study aims to forecast the wave breaker index for gravel beaches using representative linear-based machine learning techniques known for their high predictive performance in regression or classification problems across various research fields. Initially, the applicability of existing empirical formulas for wave breaker indices to gravel seabeds was assessed. Various linear-based machine learning algorithms were then employed to build prediction models, aiming to overcome the limitations of existing empirical formulas in predicting wave breaker indices for gravel seabeds. Among the developed machine learning models, a new calculation formula for easily computable wave breaker indices based on the model was proposed, demonstrating high predictive performance for wave height and depth of wave breaking on gravel beaches. The study validated the predictive capabilities of the proposed wave breaker indices through hydraulic model experiments and compared them with existing empirical formulas. Despite its simplicity as a polynomial, the newly proposed empirical formula for wave breaking indices in this study exhibited exceptional predictive performance for gravel beaches.

Predicting Regional Soybean Yield using Crop Growth Simulation Model (작물 생육 모델을 이용한 지역단위 콩 수량 예측)

  • Ban, Ho-Young;Choi, Doug-Hwan;Ahn, Joong-Bae;Lee, Byun-Woo
    • Korean Journal of Remote Sensing
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    • v.33 no.5_2
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    • pp.699-708
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    • 2017
  • The present study was to develop an approach for predicting soybean yield using a crop growth simulation model at the regional level where the detailed and site-specific information on cultivation management practices is not easily accessible for model input. CROPGRO-Soybean model included in Decision Support System for Agrotechnology Transfer (DSSAT) was employed for this study, and Illinois which is a major soybean production region of USA was selected as a study region. As a first step to predict soybean yield of Illinois using CROPGRO-Soybean model, genetic coefficients representative for each soybean maturity group (MG I~VI) were estimated through sowing date experiments using domestic and foreign cultivars with diverse maturity in Seoul National University Farm ($37.27^{\circ}N$, $126.99^{\circ}E$) for two years. The model using the representative genetic coefficients simulated the developmental stages of cultivars within each maturity group fairly well. Soybean yields for the grids of $10km{\times}10km$ in Illinois state were simulated from 2,000 to 2,011 with weather data under 18 simulation conditions including the combinations of three maturity groups, three seeding dates and two irrigation regimes. Planting dates and maturity groups were assigned differently to the three sub-regions divided longitudinally. The yearly state yields that were estimated by averaging all the grid yields simulated under non-irrigated and fully-Irrigated conditions showed a big difference from the statistical yields and did not explain the annual trend of yield increase due to the improved cultivation technologies. Using the grain yield data of 9 agricultural districts in Illinois observed and estimated from the simulated grid yield under 18 simulation conditions, a multiple regression model was constructed to estimate soybean yield at agricultural district level. In this model a year variable was also added to reflect the yearly yield trend. This model explained the yearly and district yield variation fairly well with a determination coefficients of $R^2=0.61$ (n = 108). Yearly state yields which were calculated by weighting the model-estimated yearly average agricultural district yield by the cultivation area of each agricultural district showed very close correspondence ($R^2=0.80$) to the yearly statistical state yields. Furthermore, the model predicted state yield fairly well in 2012 in which data were not used for the model construction and severe yield reduction was recorded due to drought.

Characteristics of Nutrient Uptake and Stubble Regrowth of Grain Sorghum in Plastic Film House (비닐하우스 재배 수수의 그루터기 재생 및 양분흡수 특성)

  • Yun, Eul-Soo;Jung, Ki-Yeul;Park, Chang-Yeong;Hwang, Jae-Bog;Choi, Young-Dae;Jeon, Seung-Ho
    • Korean Journal of Soil Science and Fertilizer
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    • v.45 no.6
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    • pp.992-997
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    • 2012
  • This study was conducted to get the basic information for absorb enhancement of accumulated soil nutrients in plastic film house. The grain sorghum (Sorghum bicolor L.) was sowing in plastic film house which soil nutrient accumulated moderately and was cutting at major growth period of sorghum. We were analyzed the regrowth pattern, biomass due to cutting time and amount of plant nutrient of grain sorghum. The obtained results were as follows. The heading date after cutting of sorghum in plastic film house was came to about 35 days. The accumulated of plant height were the longest as 379.4 cm in cutting at milk stage. The total biomass of sorghum in cutting at heading stage was 1.73 ton $10a^{-1}$ in cutting at heading stage. The high grain yields were produced with non-cutting and cutting at 10 leaves stage as 75~113 kg $10a^{-1}$ but the lowest grain yields were the cutting plots at booting stage as below 24 kg $10a^{-1}$. The content of nutrient in sorghum plant was low as progress of growth. The concentrations in aboveground sorghum due to plant parts was in order to leaves > panicle > stalk. The nitrogen content of sorghum was 0.6~0.7% in stalk, 1.5~1.6% in panicle and 1.8~2.3% in leaves. The amount of nutrient absorbed in sorghum was 4.2 kg $10a^{-1}$ in nitrogen, 1.7 kg $10a^{-1}$ phosphorus and 7.7 kg $10a^{-1}$ in potassium and the absorbing different by cutting time in order to booting > non-cutting > panicle formation ${\geq}$ milk ripe > 10 leaves stage.

Risk Assessment Model for the Delay Protocol in the Conditions of Contract of International Construction Projects (해외 건설공사 공기지연사건의 합리적 대응을 위한 계약조건 리스크 평가 방법)

  • Lee, Hwangku;Shin, Dongwoo;Kim, Kyungrai;Cha, Heesung;Kim, Youngjae
    • Korean Journal of Construction Engineering and Management
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    • v.18 no.6
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    • pp.65-77
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    • 2017
  • Recently, many Korean major construction companies are suffering from profit loss mainly due to a direct impact from delays in their overseas projects. In general, changes are inevitable in a large-scale project, and most of changes are directly linked to construction delay. Therefore, in the event that an extension of time is necessary due to a change, the contractor must manage the delay based on the condition of the contract to effectively manage risks from delay to the completion date. Thus it is important to understand delay protocol defined in the condition of the contract early in the project, but there have been few or no study to propose methodology or tool to support this effort. This paper presents a review on the project planning and controling practices of major Korean construction companies along with the issues on delay claims and disputes in mega-international projects and suggests a tool to assess delay risk in the condition of the contract. To propose a delay risk assessment model for international construction projects, major standard conditions of contract have been reviewed including FIDIC Red Book(1999), PSSCOC(2014) and SIA 9th Edition(2010). To reflect recent trend of major international owners, standard conditions which they are utilizing for their projects also have been reviewed including those of ARAMCO and QP. The model provides a categories of risks to be reviewed on the condition of the contract along with standard level of the risk which is common in the international standard form of the contracts. This study also performed a case study on an actual international project to confirm the effectiveness of proposed model to identify and respond to a delay risk of a project.

Selection and Quality Evaluation of Sprout Soybean [Glycine max (L.) Merrill] Variety for Environment-Friendly Cultivation in Southern Paddy Field (남부지역 친환경 논 재배를 위한 나물콩 품종 선발 및 품질 평가)

  • Kim, Young-Jin;Lee, Kwang-Won;Cho, Sang-Kyun;Oh, Young-Jin;Shin, Sang-Ouk;Paik, Chae-Hoon;Kim, Kyong-Ho;Kim, Tae-Soo;Kim, Ki-Jong
    • Korean Journal of Organic Agriculture
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    • v.19 no.3
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    • pp.357-372
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    • 2011
  • We carried out the experiment to select the suitable sprout soybean varieties for environment-friendly cultivation in paddy field of southern part area, compares of excess moisture injury degree and yield ability among 29 sprout soybean varieties. Plant growth of sprout soybean was generally low in beginning and recovered after flowering due to rainfall. In paddy field cultivation, number of pod per individual and number of seed per individual were less in difference than upland cultivation, and maturing date was delayed 5-14 days than upland cultivation in most species. When environment-friendly cultivation, pest injury was not caused major problem for the growth during the vegetative period of soybean due to ground spider as natural enemy to insect pest. However, damage of stink bugs showed severe during grain filling period, and Dawonkong, Anpyeongkong, Dachaekong and Wonhwangkong showed susceptible to sting bug. SMV infection was weak and showed some necrosis symptoms in Sokangkong, but black root rot was not infected at all. Bacterial pustule began to be infected slowly from pod enlargement stage in most species, displayed severe symptoms in Dawonkong, Pungsannamulkong, Seonamkong and Sobaeknamulkong. The symptoms of pod anthracnose, pod blight and purple spot were greatly appeared after flowering. Disease resistance varieties was Paldokong, Kwangankong, Doremikong, Somyeongkong, Pungsannamulkong, Iksa-namulkong, Seonamkong, Sojinkong, Pureunkong, Bosugkong, Namhaekong and Sorokkong. Lodging index showed 3 in Saebyeolkong, and other species displayed slight lodging in 0-3 degree. 100-seed weight is 9.8-17.2g extent and increased 0.1-3.7g than upland cultivation in most species, but decreased in some species. Government purchase standard, species correspond to small-seed-size namulkong (Sizing screen diameter 4.0-5.6 mm) was Dawonkong, Dachaekong, Bosugkong, Seonamkong, Sokangkong, Hannamkong, Somyeongkong and Wonhwangkong. Species which seed yield was higher than Pungsannamulkong (266kg/10a) were Sorokkong, Hannamkong, Bosugkong and Sowonkong. Considering sprout soybean species, disease endurance, insect resistance, lodging resistance, 100-seed weight, yield ability and excess moisture tolerances synthetically, Seonamkong, Hannamkong, Doremikong, Bosugkong, Pungwonkong, Kwangankong, Sowonkong, Dagikong, Paldokong, Eunhakong and Pungsannamulkong were promising for environment-friendly cultivation in paddy field.

Application of Potassium Feldspar pIR-IRSL Method to Dating Quaternary Marine and Fluvial Terrace Sediments in Korea: A Case Study on a Fluvial Terrace and Gusan Fault in Uljin, Korea (한반도 해안-하안단구 퇴적층에 대한 K 장석 pIR-IRSL연대측정법 적용가능성 고찰: 울진 하안단구와 구산단층 연대측정)

  • Hong, Seongchan;Choi, Jeong-Heon
    • The Journal of the Petrological Society of Korea
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    • v.25 no.3
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    • pp.241-252
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    • 2016
  • In this paper, in order to test the possibility of applying K feldspar $pIR-IRSL_{290}$ signal(read out at $290^{\circ}C$) to date old terrace sediments(up to ~ 200 ka, MIS 7) in Korea, we investigated luminescence properties of $pIR-IRSL_{290}$ signals in K feldspar extracts from 27 marine and fluvial terrace sediment samples, and these were compared with those of quartz OSL and conventional K feldspar $IRSL_{50}$ (readout at $50^{\circ}C$) signals. The averaged $2D_0$ value of K feldspar $pIR-IRSL_{290}$ growth curves was ~ 700 Gy, which is consistent with that of $IRSL_{50}$ signal, and this is 3 times higher than that for quartz OSL (~ 250 Gy) on average. Where possible, K feldspar $pIR-IRSL_{290}$ ages were compared with quartz OSL and conventional $IRSL_{50}$ ages. Our preliminary K feldspar $pIR-IRSL_{290}$ ages were older than quartz OSL ages by about 200%, while fading rate-corrected conventional $IRSL_{50}$ ages are in good agreement with those based on quartz OSL. This seems to indicate the possibility of K-feldspar $pIR-IRSL_{290}$ age overestimation due to the presence of unbleachable $pIR-IRSL_{290}$ signals, even with a prolonged exposure to sunlight. Both quartz OSL and K-feldspar $pIR-IRSL_{290}$ signals for the samples from Noeum fluvial terrace and Gusan fault site were all in dose saturation level, thus unable to estimate the formation ages of the sediments. However, $2D_0$ values derived from the dose response growth curves strongly indicate that the Noeum fluvial terrace sediments have formed before 109-140 ka, while the fluvial sediments from Gusan fault were desposited before 100-105 ka. Further, this seems to suggest that the previous quartz OSL ages of ~40-50 ka for Gusan fault sediments should be the underestimated ones due to dose saturation problem.