• Wind and Structures
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• v.31 no.6
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• pp.575-591
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• 2020

Wind load is typically considered as one of the governing design loads acting on a structure. Understanding its nature is essential in evaluation of its action on the structure. Many codes and standards are founded on state of the art knowledge and include step by step procedures to calculate wind loads for various types of structures. One of the most accepted means for calculating wind load is using Gust Load Factor or base bending Moment Gust Load Factor (MGLF), where codes are adjusted based on local data available. Although local data may differ, the general procedure is the same. In this paper, ASCE 7-16 (2017), which is used as the main reference in the U.S., and Korean Building Code (KBC 2016) are compared in evaluation of wind loads. The primary purpose of this paper is to provide insight on each code from a structural engineering perspective. Herein, discussion focuses on where the two codes are compatible and differ. In evaluating the action of wind loads on a building, knowledge of the dynamic properties of the structure is critical. For this study, the design of four figurative high-rise buildings with dual systems was analyzed.

• Proceedings of the KIPE Conference
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• 2004.07a
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• pp.355-358
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• 2004

Currently, to overcome the limit of a 14V power supply system and to enhance the stability of this system high and to make the fuel efficiency better, a research development of a 42V power supply system is actively the progress. As an intermediate step to change into an unity power supply system, a 42V/14V dual power supply system uses a DC/DC Converter as one of structure elements. Considering the main electric power sources in the next generation of the car is a 42V system a 14V power supply system has advantages as follows : In be managed efficiently and to increase the redundancy at start, to jump start with any vehicles, etc. We need the introduction of a hi-directional converter that can flow the energy each other in a dual 42V-l2V system. This paper proposed the ZVS hi-directional CUK DC/DC converter which decrease the weight with the size of the DC/DC Converter and minimize the loss when the switching happen. In this paper, a circuit design method and an action principle of the circuit was proposed. To verify the proposed circuit, a comprehensive evaluation with theoretical analysis, simulation results is presented.

• International Journal of Naval Architecture and Ocean Engineering
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• v.5 no.4
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• pp.569-579
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• 2013

A steel-type breakwater that uses a submerged dual horizontal porous plate was originally proposed by Kweon et al. (2005), and its hydrodynamic characteristics and design methodology were investigated in a series of subsequent researches. In particular, Kweon et al. (2011) proposed a method of estimating the vertical uplift force that acts on the horizontal plate, applicable to the design of the pile uplift drag force. However, the difference between the method proposed by Kweon et al. (2011), and the wave force measured at a different time without a phase difference, have not yet been clearly analyzed. In this study, such difference according to the method of estimating the wave force was analyzed, by measuring the wave pressure acting on a breakwater model. The hydraulic model test was conducted in a two-dimensional wave flume of 60.0 m length, 1.5 m height and 1.0 m width. The steepness range of the selected waves is 0.01~0.03, with regular and random signals. 20 pressure gauges were used for the measurement. The analysis results showed that the wave force estimate in the method of Kweon et al. (2011) was smaller than the wave force calculated from the maximum pressure at individual points, under a random wave action. Meanwhile, the method of Goda (1974) that was applied to the horizontal plate produced a smaller wave force, than the method of Kweon et al. (2011). The method of Kweon (2011) was already verified in the real sea test of Kweon et al. (2012), where the safety factor of the pile uplift force was found to be greater than 2.0. Based on these results, it was concluded that the method of estimating the wave force by Kweon et al. (2011) can be satisfactorily used for estimating the uplift force of a pile.

• Membrane Journal
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• v.3 no.2
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• pp.79-82
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• 1993

The sorption equilibria and permeabilities for $CO_2$ in a homogeneous membrane of polystyrene with the glass transition temperature of $95^{\circ}C$ were measured at a temperature of $60^{\circ}C$ and gas pressures up to 1.6 MPa and 2.5 MPa, respectively. The sorption isotherm had the form af dual-mode sorption model at low gas pressures, but became linear at pressures above 1.3 MPa. The linear portion of the isotherm extrapolated to the origin. The pressure dependence of the rnean permeability coefficient deviated upward from the dualsrhode mobility model prediction. It was found that the glass transition was brought out by the plasticization action of sotbed $CO_2$ at a gas pressure of 1.3 MPa from the sorption isotherm. And this result was consistent with an increase in the mean permeability coefficient with applied gas pressure.

• The Korean Journal of Pain
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• v.29 no.3
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• pp.153-157
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• 2016

Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the ${\mu}$-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pain relief. Absorption is rapid, with a mean maximal serum concentration at 1.25-1.5 h after oral intake. It is present primarily in the form of conjugated metabolites after glucuronidation, and excretes rapidly and completely via the kidneys. The most common adverse reactions are nausea, dizziness, vomiting, and somnolence. Constipation is more common in use of the ER formulation. Precautions against concomitant use of central nervous system depressants, including sedatives, hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, and alcohol, or use of tapentadol within 14 days of the cessation of monoamine oxidase inhibitors, are advised. The safety and efficacy have not been established for use during pregnancy, labor, and delivery, or for nursing mothers, pediatric patients less than 18 years of age, and cases of severe renal impairment and severe hepatic impairment. The major concerns for tapentadol are abuse, addiction, seeking behavior, withdrawal, and physical dependence. The presumed problem for use of tapentadol is to control the ratio of MOR agonist and NRI. In conclusion, tapentadol produces both nociceptive and neuropathic pain relief, but with worries about abuse and dependence.

• Archives of Pharmacal Research
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• v.12 no.3
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• pp.166-175
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• 1989

In the previous observations, it was reported that both total ginseng saponin and panaxadiol revealed the marked secretory effect of catecholamines (CA) from the rabbit adrenal gland and that CA secretion induced by them is due to dual mechanisms, cholinergic action and the direct action. In the present study, an attempt to investigate the effect of panaxatriol-type saponin (PT), which is known as an active component of Korean ginseng, on the secretion of CA from the rabbit adrenal gland was made. PT(200 $\mu$g) administered into adrenal vein evoked significantly secretion of CA from the isolated perfused rabbit adrenal gland. Secretory effect of CA produced by PT was attenuated clearly by treatment with chlorisondamine or adenosine, but was markedly increased by physostigmine. Perfusion of Krebs solution containing PT (200 $\mu$g) for 30 min potentiated greatly secretion of CA induced by acetylcholine. PT-induced CA secretion was weakened considerably by ouabain treatement or perfusion of calcium-free Krebs solution. These experimental data demonstrate that PT releases CA from the isolated perfused rabbit adrenal gland by a calcium-dependentd exocytotic mechanism. It seems that the secretory effect of PT is caused through the release of acetylcholine form cholinergic terminals present in the adrenal gland and a direct action on the chromaffin cell itself.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.2
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• pp.81-90
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• 2000

The types of $K^+$ channel which determine the pattern of spontaneous action potential (SAP) were investigated using whole-cell variation of patch clamp techniques under current- and voltage-clamp recording conditions in rat clonal pituitary $GH_3$ cells. Heterogeneous pattern of SAP activities was changed into more regular mode with elongation of activity duration and afterhyperpolarization by treatment of TEA (10 mM). Under this condition, exposure of the class III antiarrhythmic agent E-4031 $(5\;{\mu}M)$ to $GH_3$ cells hardly affected SAP activities. On the other hand, the main $GH_3$ stimulator thyrotropin-releasing hormone (TRH) still produced its dual effects (transient hyperpolarization and later increase in SAP frequency) in the presence of TEA. However, addition of $BaCl_2$ (2 mM) in the presence of TEA completely blocked SAP repolarization process and produced membrane depolarization in all tested cells. This effect was observed even in TEA-untreated cells and was not mimicked by higher concentration of TEA (30 mM). Also this barium-induced membrane depolarization effect was still observed after L-type $Ca^{2+}$ channel was blocked by nicardipine $(10\;{\mu}M).$ These results suggest that barium-sensitive current is important in SAP repolarization process and barium itself may have some depolarizing effect in $GH_3$ cells.

• BMB Reports
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• v.31 no.3
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• pp.264-268
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• 1998

Dopamine (DA) acts on swimming motor neurons (SMNs) of Polyorchis penicillatus as an inhibitory neurotransmitter by hyperpolarizing their membrane potentials, which results from the activation of voltagesensitive potassium channels mediated through a $D_2-type$ receptor. In addition, DA, and not the hyperpolarized membrane potential, directly decreased the input resistance of SMNs by ca. 50% from 1.42 to 0.68 $G{\Omega}$. It strongly indicates that DA can shunt other excitatory synaptic signals onto SMNs where DA usually elicited much greater responses in their neurites than soma. All these evidences suggest that DA may operate in this primitive nervous system in dual modes as an inhibitory neurotransmitter and neuromodulator as well.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.304-304
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• 1994

The possible mechanisms of ginseng saponins on the inhibition of development of morphine tolerance and physical dependence were investigated in the aspects of morphine metabolism by morphine 6-dehydrogenase. Administration of morphine causes a reduction of non-protein sulfhydryl contents in liver, because morphinone is metabolized from morphine by morphine 6-dehydrogenase conjugates with sulfhydryl compounds. However, ginseng saponins inhibited the activity of morphine 6-dehydrogenase which catalized the production of morphinone from morphine. In addition, ginseng' saponins inhibited the reduction of non-protein sulfhydryl levels by Increasing the level of hepatic glutathione. These results suggest that the dual action of the above plays an important role in the inhibition of development of morphine tolerance and physical dependence. On the other hand, it was observed that less polar components of ginseng saponins with parent structures were more active components in vitro.

• Structural Engineering and Mechanics
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• v.27 no.5
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• pp.609-623
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• 2007

The problem of a semi-infinite magneto-electro-elastically impermeable mode-III crack in a magneto-electro-elastic material is considered under the action of impact loads. For the case when a pair of concentrated anti-plane shear impacts, electric displacement and magnetic induction impacts are exerted symmetrically on the upper and lower surfaces of the crack, the magneto-electro-elastic field ahead of the crack tip is determined in explicit form. The dynamic intensity factors and dynamic energy density factor are obtained. The method adopted is to reduce the mixed initial-boundary value problem, by using the Laplace and Fourier transforms, into three simultaneous dual integral equations, one of which is converted into an Abel's integral equation and the others into a singular integral equation with Cauchy kernel. Based on the obtained fundamental solutions of point impact loads, the solutions of two kinds of different loading cases are evaluated by integration. For some particular cases, the present results reduce to the previous results.