• Journal of Ginseng Research
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• 제45권6호
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• pp.676-682
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• 2021

Background: Red ginseng has been found to improve ocular perfusion and dry eye syndrome in glaucomatous eyes; however, its effects on visual function and vision-related quality of life have not been investigated. This study sought to evaluate the effects of red ginseng on visual function and vision-related quality of life in glaucoma patients using contrast sensitivity and a questionnaire. Methods: Participants were randomly assigned to two groups in this prospective, randomized, double-blind study: in one group, red ginseng was taken first, followed by a placebo, and in the other, placebo was taken first, followed by red ginseng. We measured and compared changes in contrast sensitivity and vision-related quality of life between the two groups. Contrast sensitivity was measured using OPTEC® 6500P, and vision-related quality of life was evaluated using the 25-item National Eye Institute Visual Function Questionnaire. One-way and two-way repeated measure analyses of variance were used for the comparison. Relationships between respective changes in dry eye syndrome and contrast sensitivity were also analyzed. Results: Daytime contrast sensitivity and ocular pain improved after the administration of red ginseng. Nighttime contrast sensitivity was improved in early or moderate glaucoma. Improved contrast sensitivity was not associated with improvement in dry eye syndrome. Conclusion: Red ginseng could improve contrast sensitivity and ocular pain in patients with glaucoma. The mechanism underlying improvement in contrast sensitivity appears to be associated with enhanced retinal perfusion or retinal ganglion cell function, but not dry eye syndrome.

• Archives of Plastic Surgery
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• 제49권4호
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• pp.473-478
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• 2022

Background We investigate the effect of involutional blepharoptosis (IB) surgery based on dry eye symptoms by analysis using objective and subjective measures. Methods We recorded various parameters from patients that underwent levator advancement surgery for IB, totaling 125 eyes (total 65 patients, 5 unilateral, 60 bilateral). Subjective assessment comprised a questionnaire on dry eye-related quality of life score (DEQS), a summary score calculated from DEQS, and six-grade evaluation, the patient's own measure of eye comfort. Objective assessment comprised marginal-reflex distance-1 (MRD-1), measurement of tear film breakup time, and superficial keratopathy (SPK) existence by slit lamp microscope. Results Subjective assessments showed that IB patients had improvement of dry eye symptoms and eye comfort when surgery increased MRD-1. On the other hand, objective assessments showed that the presence of SPK is suspected when the postoperative MRD-1 level is 3 mm or higher. Conclusion IB surgery must not only increase MRD-1 value, but also to perform maintenance of the appropriate ocular surface condition. From our parameters, we suggest postoperative MRD-1 value should be maintained at < 3 mm to safe and effective of IB surgery.

• 한국안광학회지
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• 제20권2호
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• pp.247-253
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• 2015

목적: 열화상카메라를 이용하여 정상안 군과 건성안 군의 검결막과 안구표면의 서모그래피를 객관적으로 알아보고자 하였다. 방법: 각막질환, 안외상, 누도이상자, 안과수술 병력 등 안구표면의 눈물막에 영향을 주는 질환이 없고 콘택트렌즈를 사용하지 않는 대학생 72명(144안)을 대상으로 하였다. TBUT, Schirmer I test, McMonnies test를 시행하여 정상안 군과 건성안 군으로 분류하고 열화상카메라(Cox CX series, Answer co., Korea)를 이용하여 안구표면과 검결막의 온도변화를 분석하였다. 결과: 정상안 군에서 안구표면 눈물막의 중심부, 코방향, 귀방향, 위, 아래방향에서 온도변화량은 $-0.13{\pm}0.08$, $-0.14{\pm}0.08$, $-0.12{\pm}0.08$, $-0.14{\pm}0.08$, $-0.10{\pm}0.09(^{\circ}C/sec)$이었고 건성안군에서는 $-0.17{\pm}0.08$, $-0.16{\pm}0.07$, $-0.16{\pm}0.08$, $-0.17{\pm}0.09$, $-0.15{\pm}0.08(^{\circ}C/sec)$로 중심부, 귀방향, 아래방향에서 유의성을 띠었다(p<0.05). 정상안 군으로 분류된 대상자의 중심부, 코방향, 귀방향의 검결막 온도는 $34.36{\pm}1.12$, $34.17{\pm}1.10$, $34.07{\pm}1.12^{\circ}C$였고, 건성안 군은 $34.17{\pm}1.10$, $33.43{\pm}0.97$, $33.51{\pm}1.06^{\circ}C$로 중심부에서 유의한 차이를 보였다(p=0.05). 결론: 건성안 군에서 정상안 군보다 안구표면의 온도 감소가 빠르게 나타났고 검결막의 온도도 낮은 것으로 관찰되었다. 열화상카메라를 활용한 안구표면의 온도변화는 눈물막의 안정성을 평가하는데 객관적이었으며 건성안 연구에 유용할 것으로 기대된다.

• 한국융합학회논문지
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• 제8권1호
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• pp.61-69
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• 2017

본 연구는 스마트 폰 중독사용과 안구건조증, 상지통증 및 우울 간의 관계를 조사하기 위하여 일 지역 대학교에 재학 중인 학부 학생 286명을 대상으로 자가보고 설문지를 사용하여 자료를 수집하였다. 수집한 자료는 SPSS Statistics 22.0을 이용하여 서술통계, $x^2-test$, t-test, ANOVA, Scheffe test 및 Pearson correlation coefficient 로 분석하였다. 대학생의 15%가 스마트 폰 중독사용으로 나타났고 스마트 폰 중독 사용군은 정상 사용군에 비해 안구건조증(t=-4.38, p<.001), 목 통증(t=-2.60, p<.05) 및 우울(t=-4.15, p<.001)이 유의하게 높았다. 스마트 폰 중독사용은 안구건조증(r=.332, p<.001), 목 통증(r=.143, p<.05), 손 통증(r=.138, p<.05) 및 우울(r=.402, p<.001)간에 유의한 상관관계가 있었다. 따라서 대학생의 올바른 스마트 폰 사용을 위한 정기적인 보건교육의 실시와 스마트 폰 중독사용과 이로 인한 건강문제를 예방하기 위한 중재 전략을 개발하는데 있어 우울을 감소시키고 목 통증과 안구건조증을 예방할 수 있는 방안을 고려할 필요가 있다.

• 동의생리병리학회지
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• 제31권2호
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• pp.94-104
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• 2017

By analyzing the research of Dry Eye Syndrome that have been published in the Journals of Korean Medicine, we wished to provide fundamental data for clinical application's development We found 13 research papers related to Dry Eye Syndrome in Electronic databases(OASIS, RISS, NDSL, KISS) from 1995 to 2016. We subdivided the research into published year, published journal, the type of study, methods, etc. 13 research are composed of 4 systematic reviews, 2 clinical studies, and 7 clinical trials. According to the studies, patients with Dry Eye Syndrome tend to be chronic and have Yin-deficieny, and in their clinical trials, various Korean medical treatments were introduced. In the research, Korean medical treatments can be expected positive impact on Dry Eye Syndrome. But we think a variety of clinical treatment methods and additional studies are needed to increase.

• 지역사회간호학회지
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• 제25권1호
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• pp.12-23
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• 2014

Purpose: The purpose of this study is to investigate influence of cellular phone videos and games on dry eye syndrome in university students. Methods: A randomized comparison group pre-post design is used. Sixty university students were randomly assigned to either a video or a game group. Frequencies of blinking, dry eye symptoms scores and amounts of tears were measured. Thirty subjects watched cellular phone video programmes and the other 30 subjects played cellular phone games for 61 minutes. In addition, frequencies of blinking were measured three times during treatment, once immediately after a treatment and twice at an interval of 20 minutes after subsequent treatments. Results: Post-test scores of frequencies of blinking significantly decreased, dry eye symptoms scores including amounts of tears significantly increased greater than pre-test scores in both groups. But there were no significant differences between the groups. Frequencies of blinking were significantly different with respect to the time spent using cellular phone. In both groups, the lowest frequencies of blinking were shown after 40 minutes of cellular phone use. Conclusion: This study shows that using cellular phone has negative influence on dry eye syndrome and eyes require a resting period after cellular phone use over 40 minutes.

• 한국안광학회지
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• 제18권2호
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• pp.93-99
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• 2013

목적: 본 연구는 현장현시 건성안 진단 테스트 중에 현재 사용되고 있으나 부정확한 결과로 신뢰도가 떨어지는 쉬르머 용지를 대체 할 수 있는 차세대 건성안 진단 테스트 용지를 미세유체공학을 이용하여 개발하고자 하였다. 방법: 왁스로 패턴을 제조한 친수성 크로마토그래피 용지를 pH에 따른 색 변화가 나타나도록 안토시안으로 염색을 하였다. 인공 누액의 젖음 속도를 인공 누액과 32명의 참가자의 눈물을 이용하여 임상 측정하였다. 결과: 인공 누액을 이용하였을 경우 쉬르머 용지에서는 소량의 용액은(0.5 ml이하) 흡수거리가 도출되지 않았으나 새로 개발된 용지는 시간에 따른 인공 누액의 흡수거리가 확연히 나타났다. 임상실험에서도 새로 개발된 검사 용지는 TBUT (tear break-up time)결과와 부합하는 건성안 진단 결과를 보였다. 결론: 개발된 건성안 진단 용지는 간편하게 사용될 수 있을 뿐만 아니라 기존 쉬르머 용지와 같은 현장현시 건성안 진단 매체와 비교 했을 경우 건성안 판별의 정확성이 높았다.

• 한국산학기술학회논문지
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• 제17권10호
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• pp.93-103
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• 2016

본 연구는 병원 근로자를 대상으로 안구표면질환지수 설문지를 이용하여 안구건조증 유병률을 알아보고, 안구건조증 유무에 따른 일반적 및 건강관련 특성의 차이를 파악한 후 안구건조증 유병률과 관련요인을 알아보기 위한 서술적 조사 연구이다. 연구 대상자는 G시의 종합병원 근로자 502명(남성 51명, 여성 451명)을 대상으로 하였으며, 자료수집 기간은 2015년 10월 1일부터 2015년 10월 31일까지 설문조사 하였다. 수집된 자료는 로지스틱 회귀분석을 이용하여 분석하였다. 연구결과, 안구건조증 유병률은 76.1%이었으며, 안구건조증 유병율과 관련된 요인으로는 현재 앓고 있거나 약으로 조절하고 있는 질병이 있는 경우에 없는 경우보다 4.73배, 안구건조감을 느낀 대상자 중 안과에 내원하여 약물치료(인공눈물)을 받아 본 적이 있는 대상자에서 없는 대상자보다 2.37배, 안구 건조감을 느낀 적이 있는 대상자가 느낀 적 없는 경우보다 2.23배, 규칙적인 식사를 하지 않은 경우 규칙적인 식사를 하는 경우보다 0.55배의 높은 안구건조증 유병률을 보였다. 특히 안구건조증 대상자 중 54.0%가 중증도 이상임을 감안할 때 안구건조증의 예방과 관리를 위해서 안구건조증 위험인자의 관리 및 생활습관 개선 등 교육의 필요성이 요구된다.

• 한국학교보건학회지
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• 제31권3호
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• pp.178-185
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• 2018

Purpose: This study aims to examine the effects of auriculotherapy on reducing signs of dry eye syndrome. Methods: This study is based on a pretest-posttest nonequivalent control group design. The participants who scored higher than 13 on the Ocular Surface Disease Index (OSDI) were divided randomly into two groups, the experimental group (n=45) and the control group (n=44). Auriculotherapy was performed by researchers for 2 weeks. For the experimental group, seed stickers were applied to the eye, liver, shenmen, and tubercle point of their ears. The pretest and the posttest included the same questionnaires of the OSDI as well as the Visual Function Questionnaire (NEI-VFQ25) and the eye fatigue. Data were analyzed by descriptive statistics, $x^2$ test, t-test and paired t-test, using SAS 20.0 program. Results: The difference in the OSDI's scores showed a significant decrease between the pretest and the posttest (t=-4.12, p<.001) in the experimental group. No significant difference was found in the NEI-VFQ25 (t=-0.10, p=.921, t=-0.91 p=.374). However, the experimental group showed a significant decrease in eye fatigue (t=5.78, p<.001), whereas the control group showed no difference (t=1.38, p=.18). Conclusion: Auriculotherapy can be used effectively on relieving the symptoms of dry eye syndrome and eye fatigue. However, the quality of life related to eyes was not improved by auriculotherapy.

• Medical Lasers
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• 제8권2호
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• pp.50-58
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• 2019

Background and Objectives Low-level light therapy (LLLT) is an application of low-power light for various purposes such as promoting tissue repair, reducing inflammation, causing analgesia, etc. A previous study suggested the effect of light emitting diode (LED) light with the wavelength of 740 nm for promoting wound healing of corneal epithelial cells. This current study aimed to confirm the effect of LLLT for managing inflammation of a dry eye disease (DED) mouse model. Materials and Methods A total of 50C57BL/6 female mice were randomly grouped into 5 groups to compare the effect of LLLT:1) Control group, 2) Only LLLT group, 3) Dry eye group, 4) LLLT in dry eye group, and 5) Early treatment group. DED was induced with 4 daily injections of scopolamine hydrobromide and desiccation stress for 17 days, and LLLT at 740 nm was conducted once every 3 days. To analyze the effect of LLLT on the DED mouse model, tear volume, corneal surface irregularities, and fluorescence in stained cores were measured, and the level of inflammation was assessed with immunohistochemistry. Results The DED mouse model showed significant deterioration in the overall eye condition. After LLLT, the amount of tear volume was increased, and corneal surface irregularities were restored. Also, the number of neutrophils and the level of inflammatory cytokines significantly decreased as well. Conclusion This study showed that LLLT at 740 nm was effective in controlling the corneal conditions and the degree of inflammation in DED. Such findings may suggest therapeutic effects of LLLT at 740 nm on DED.