• Polymer(Korea)
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• v.35 no.5
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• pp.424-430
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• 2011

Biodegradable poly[(glycine ethyl ester)-(phenylalanine ethyl ester) phosphazene](PGPP) microparticles were fabricated by electrohydrodynamic atomization to apply drug release test. Atomization parameters such as applied voltage, polymer concentration, and molecular weight were investigated to inspect their effects on the size and morphology of microparticles. The average diameter of PGPP microparticles decreased as increasing applied voltage and solution flow rate. Dichloromethane/dioxane mixture shows better results for the preparation of microparticles than single solvent owing to the different PGPP solubility in solvent. Blending PGPP polymers with proper molecular weights not only favored the production of spherical PGPP microparticles via electrohydrodynamic atomization, but also provided a way to adjust drug (rifampicin) release behavior. Drug-loaded biodegradable polyphosphazene microspheres can be fabricated via electrohydrodynamic atomization, which has potential use in biomedical applications.

• The Journal of Korean Society for School & Community Health Education
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• v.14 no.2
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• pp.1-14
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• 2013

Objectives: The purpose of this study was to identify the relationship of internet use time and health risk behaviors among adolescents and provide data to set up a strategy for preventing internet addiction. Methods: The data of the 2011 Youth Health Risk Behavior web-based Survey Collected by Korean Center for Disease Control was analyzed using t-test, ANOVA, Chi-square test for this study. Results: There were significant differences between boys and girls in internet use time. Boy's internet use time was different according to city size(F=13.20, p<.001), grade(F=35.85, p<.001), school record(F=298.95, p<.001), economic state(F=326.75, p<.001), living with parents(t=11.60, p<.001), father's education level(F=147.92, p<.001), and mother's education level(F=110.93, p<.001). Girls' internet use time was also different according to school grade(t=-8.68, p<.001), grade(F=61.03, p<.001), school record(F=233.32, p<.001), economic state(F=185.78, p<.001), living with parents(t=10.81, p<.001), father's education level(F=86.54, p<.001), and mother's education level(F=92.64, p<.001). Regarding the health risk behaviors, present smoking, present alcohol drink, drug use skipping breakfast, eating fast food, drinking soda, sexual behavior, suicidal attempt, engagement time in physical education classes, severe exercise, and sleeping satisfaction made differences in the internet use time. Conclusions: The results suggest that health risk behaviors are influenced by internet use time of adolescents. Thus, these results may be contribute to development of programs to prevent internet addiction.

• Nuclear Engineering and Technology
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• v.56 no.10
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• pp.4423-4436
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• 2024

The development and assessment of pharmaceutical dosage forms make considerable use of gamma-scintigraphy. Gamma scintigraphy is an imaging technique that is integrated with CT to assess and evaluate the targeting of drugs to various delivery sites, the impact of treatment, and the severity of the disease. A small number of radioisotopes were tagged with the delivery system and emitted radiation can be visualized by the gamma camera which forms a 2-D image displaying the tissue-specific distribution of radioactivity. The isotopes that are used widely include Technetium-99 m (99Tc), Iodine (131I), Fluorodeoxyglucose (18F-FDG), Fluoromisonidazole (18F-FMISO) and Gallium (Ga67), Indium (111In). This review mainly covers different applications of gamma scintigraphy for the assessment of drug targeting via different routes to different organs and their visualization by gamma scintigraphy. The review mainly focuses assessment of drug targeting in the tumor tissue, thyroid gland, brain, pulmonary pathway, skin deposition, detection of renal impairment as well as cardiac diseases, drug release from formulations, drug deposition in arthritis, drug retention in the scalp, and behavior of formulation when administered via intra-vaginal route. Various pre-clinical and clinical studies were included in the review that demonstrates the importance and future of gamma scintigraphy in sensing drug delivery.

• Korean Journal of Clinical Pharmacy
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• v.29 no.3
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• pp.202-208
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• 2019

Objective: Suicide has recently become an important social problem. Thus, we analyzed prescription drugs that cause suicidal ideation. Methods: Of 156 drugs on the the Minister of Food and Drug Safty (MFDS) EZ-Drug site that had "suicide" listed as a side effect, 78 had "suicide" listed as a warning or contraindication; those 78 drugs were analyzed using data from the 2016 Health Insurance and Review and Assessment Services National Patient Sample (HIRA-NPS). Results: 51 "suicide risk" drugs was identified. Of all patients, 5.2% had received such drugs. The prescription rate was 0.8% of all prescriptions, accounting for 1.6% of all prescription days. From logistic regression analysis, the prescription rate for the drugs was approximately 1.1 times higher for women than for men. With regard to age, the prescription rate for patients 66 years and older was 15.5 times higher than those for patients 25-years and lower. With regard to medical departments, the prescription rates in psychiatry and dermatology departments were 8.1 times higher and 0.6 times lower than those in internal medicine departments, respectively. With regard to region, the prescription rates in Daegu and Jeju were 1.3 times higher and 0.79 times lower than those in Seoul, respectively. Conclusion: Drug-induced suicidal behavior is possible, and therefore efforts are needed to prevent it.

• Korean Journal of Health Education and Promotion
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• v.25 no.3
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• pp.59-75
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• 2008

Objectives: The purpose of this study was to identify the stages of change distributions for nine major health behaviors among poor children in underserved area, and to provide basic information for developing specific objectives and strategies for health education program. Methods: The health behavior data were obtained with a self-administered questionnaire and analysed for 3,081 poor children in 106 local children's centers nationwide. Stages of change classification were based on self-reported responses to five statements. The health behaviors included were balanced diet, safety behavior (helmet and protective device use while riding), regular exercise, smoking, alcohol use, drug use, sleep pattern, weight management and stress management. Results: Poor children were more likely in precontemplation and less frequently in action and maintenance stages for a safety behavior. 33.1% of respondents were precontemplators, 29.9% contemplators, and 6.5% in preparation stage. Only 4.3% and 9.6% were in action and maintenance stages, respectively. Gender differences were apparent. Boys were more likely to be precontemplators for nine health behaviors. Children from the lowest socioeconomic status and disrupted family were more likely to be in precontemplation for weight management and exercise behaviors. Children living with both parents were more likely to be in the action and maintenance stages for nine health behaviors. Stages of change for balanced diet and smoking were significantly related with those for other eight health behaviors. And the stage of exercise adoption was found to be significantly related with those for other seven health behaviors. Conclusion: Safety education must receive high priority in health education program for low income children. Balanced diet smoking cessation and regular exercise could be a possible gateway behavior toward healthier lifestyle practices.

• Health Policy and Management
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• v.7 no.1
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• pp.125-154
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• 1997

The hospital, clinical department and the physician factor in explaining variations of hospital resource use in surgically admitted patients was compared. This analysis was based on 6, 361 discharges in 28 hospitals for three surgical conditions - lens procedures anal and stomal procedures, uterine and ovarian procedures using medical insurnce claim data. The results were as follows: 1. Regression analysis indicated that the hospital and clinical department characteristics, such as hospital ownership and size, were more significant predictors of the resource use indicators than the physician and patients' social characteristics. 2. Regarding to the physician factors, the hospital where the physician received the residency training and the medical shool where he/she graduated had less effect compared to the hospitals where he/she currently works. Between the residency trained hospital and medical school, the is more important than the latter. 3. When the hospital charges were divided into type of service provided i. e. room, drug, laboratory & radiologic, procedure & operation, and anesthesic charges, variance due to the hospital factor was larger than that due to the physician factor in each item. In summary, the hospital and clinical departmental factor played an important role than physician factor ; indicating to reduce the variation in hospital resource use, the policy that affects hospital behavior would be more effective than that targets individual physician behavior.

• Journal of the Korean Society of School Health
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• v.33 no.2
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• pp.125-138
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• 2020

Purpose: The study investigated the effect of adolescent health behavior on the prevalence of current allergic diseases. Methods: The subjects were 57,303 middle and high school youth. Data were analyzed using Rao-Scott χ² test and complex sample logistic regression analysis. Results: While controlling the affect of the general characteristics of the subjects, health behaviors affecting the current prevalence of allergic diseases were smoking, drinking, physical activity, eating habits, drug abuse, and mental health. Smoking behaviors affecting the current prevalence of allergic diseases were lifetime smoking experience, smoking days, liquid e-cigarette lifetime smoking experience, number of liquid electronic cigarette smoking days, e-cigarette lifetime smoking experience, e-cigarette smoking days, amount of smoking, second-hand smoking and drinking behaviors were lifetime drinking, drinking days, the amount of drinking, and severe drinking. Variables such as physical activity exceeding 60 minutes days, intake of energy and sweet drinks, water intake, habitual drug use and mental health behavior such as stress perception, weekday sleep time, subjective sleep satisfaction, depression, suicidal thoughts/ plan/ attempts affect current allergic diseases (p<.001). Conclusion: The results showed that current allergic disease related health behaviors in Korean adolescents. Therefore, considering these factors, it may be helpful to facilitate a health promotion plan for prevention and management of such diseases and to promote evidence-based health practices at school.

• The Journal of Korean Society for School & Community Health Education
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• v.6
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• pp.1-16
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• 2005

This study was conducted to the middle and high school students in some Seoul and Kyunki areas to identify the smoking behavior characteristics among adolescences. A self-administered survey was conducted to the 2nd grad students in 4 middle schools and 6 high schools and the survey Questionnaire included general characteristics, smoking and drug use history, the close people's smoking and drug use, smoking and drug abuse prevention education, smoking intention, and smoking attitude. A total of 2,452 youths finished the survey (1,182 middle school students and 1,270 high school students). Current smoking students were 14.6%, the ex-smokers were 5.5%, and the never smokers were 85.4%. Majority of students smoked less than 5 bars of cigarettes and their first smoking experiences were related to their family members (siblings, parents, and relatives), friends, advertisement in order. Other GYTS countries reported the similar sources of the smoking start and friend was prior smoking start factor to the other sources. The students who wanted to Quit smoking were 6.7% and the students who ever had tried to Quit smoking were 9.1%. The major reasons of Quitting smoking were for their health and for their financial burden. Approximately 60% learned about smoking and drug abuse in their regular school classes, 8.4% were in the special school activities, and 7.9% were in the class closing time sometimes in order. The students who learned in any regular class were smaller in the high school students than in the middle school students. The learning experiences in school of other GYTS countries were similar to that of Korea. In conclusion, students' smoking was affected not only by the preventive activities in school but also by the close people's behaviors and care in this study; therefore, the active partnership between school and family must be a strong strategy for youth's smoking prevention.

• Toxicological Research
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• v.25 no.1
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• pp.9-15
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• 2009

Historically, research in toxicology has utilized non-human mammalian species, particularly rats and mice, to study in vivo the effects of toxic exposure on physiology and behavior. However, ethical considerations and the overwhelming increase in the number of chemicals to be screened has led to a shift away from in vivo work. The decline in in vivo experimentation has been accompanied by an increase in alternative methods for detecting and predicting detrimental effects: in vitro experimentation and in silico modeling. Yet, these new methodologies can not replace the need for in vivo work on animal physiology and behavior. The development of new, non-mammalian model systems shows great promise in restoring our ability to use behavioral endpoints in toxicological testing. Of these systems, the zebrafish, Danio rerio, is the model organism for which we are accumulating enough knowledge in vivo, in vitro, and in silico to enable us to develop a comprehensive, high-throughput toxicology screening system.

• Journal of The Korean Society of Integrative Medicine
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• v.9 no.1
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• pp.59-67
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• 2021

Purpose : This study examined the factors related to sexual intercourse among adolescents in South Korea. Methods : The study sample was comprised of 65,528 middle and high school students aged 12 to 18 years in 2016. For this study, using the data from the 12th Korea youth risk behavior web-based survey, a chi-squared test, and hierarchical logistic regression analysis we reconducted with the SPSS 22.0 program considering personal, family, school, and regional characteristics. Results : The proportion of adolescents who had sexual intercourse was 6.0 % of boys and 2.7 % of girls, and 6.3 % of high school students and 2.4 % of middle school students. The statistically significant related factors of sexual intercourse were gender, grade, attempted suicide, ever drinking, ever smoking, habitual or purposeful drug use, weekly allowance, and coed school in the final model 4. Adolescents with suicide attempts had 2.49 times more sexual intercourse than adolescents with no experience of suicide attempts. Compared to adolescents without alcohol, smoking, and habitual drug use, those who have experienced alcohol, smoking, habitual or purposeful drug use were 2.22 times, 3.76 times, and 3.39 times more likely to have had sexual intercourse, respectively. Adolescents with a weekly allowance of more than 100,000 won per week and adolescents in coed schools were 2.84 times and 1.40 times more likely to have had sexual intercourse, respectively. Conclusion : Multi-level interventions should be considered in school sexual education programs while considering the substantiality of sex education and the actual adolescents' needs. In addition, sexual health interventions in cyberspace for high-risk groups may be needed to consider the emotional and mental characteristics, given the factors related to sexual intercourse in adolescents.