• Bulletin of the Korean Chemical Society
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• v.34 no.8
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• pp.2305-2310
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• 2013

A novel series of 2-heteroaryl substituted benzimidazole derivatives, containing the piperidinylphenyl acetamide group at the 1-position, were synthesized and evaluated as MCH-R1 antagonists. Extensive SAR investigation probing the effects of C-2 heteroaryl group led to the identification of 2-[2-(pyridin-3-yl)ethyl] analog 3o, which exhibits highly potent MCH-R1 binding activity with an $IC_{50}$ value of 1 nM. This substance 3o also has low hERG binding activity, good metabolic stability, and favorable pharmacokinetic properties.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.16 no.4
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• pp.233-239
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• 2013

Drug intoxication in children and adolescents is not uncommon in Korea. But the tendency of intoxication is changing with some factors, such as national surveillance system, Naderism and increasing concern among physicians. But the death rate of intoxication among adolescents is increasing in spite of decreasing total death rate of intoxication among children and adolescents. Therefore the physician must be concerned about the basic management of intoxication and figure out the common toxic substance among children and adolescents.

• Journal of Oriental Neuropsychiatry
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• v.16 no.2
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• pp.135-148
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• 2005

Objective : The purpose of this study is to take around the oriental medical treatment about substance related disorder in china. Method : We review the studies which are published by six different journal in China since 1992 to 2002 involved in substance related disorders. Result 1. The kinds of substance which is the subject of each study. It suggest that the narcotics-withdrawal patients in china take kinds of opium many more than phillopon or barbiturate, cocain etc. especially the heroine takes the most portion in the kinds of opium. 2. The type of chinese medicine demonstration which is about the addiction and withdrawal. There are many symptoms in the each period of withdrawal, According to the each period demonstration, the herbal formula must be different. 3. The formula used in treatment and the substance which is used in common Codonopsis radix is widely used, and pinellia ternata, aractylodes japonica, citrus nobilis, vegetable worms, angelica gigas, zizyphus jujuba, panax ginseng, astragalus membranaceus etc are also used in treatment. 4. The methods of acupunture treatment Hapkok(LI-4), Naegwan(PC6), and Sanyinjiao(SP6) are the widely used acu-points. in addition to these acupoints, there are waegwan(TE5) choksamli(ST36) hanggan(LR2)etc. Conclusion : We expect that this review about substance related disorders in TCM help the clinical study of substance related disorders in Korean medicine.

• Korean Journal of Biological Psychiatry
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• v.18 no.2
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• pp.61-71
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• 2011

Substance addiction is a chronically relapsing disorder that has been characterized by a vicious cycle composed of intoxication, craving/anticipation, withdrawal, and response inhibition/bingeing. Here we summarize the findings from neuroimaging studies in addiction according to these behavioral components and suggest the integrated neurobiological model of drug addiction and related brain correlates. The roles of various prefrontal regions, thalamus, memory circuit, anterior cingulated, and insula were also suggested in addition to those of classical mesolimbic dopaminergic system and its responsivity. Limited studies of behavioral addiction demonstrated a similarity with substance addiction on the neurobiological basis. Based on the current understanding of neurobiology of addiction, further researches on interactions of behavioral components and their brain correlates, behavioral addiction, and therapeutic applications will be desired.

• International Journal of Advanced Culture Technology
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• v.6 no.4
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• pp.172-178
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• 2018

In this paper, I tried to pursue health and social welfare together through medical convergence based on the main subject of a culture of convergence. Artists' drug accidents are never ending. Now Korea is also out of the drug cleansing country. it is impossible to get rid of them with the national public power. It is time for a treatment plan for these. They need a certain period of time and regular periods of rest and control over sports. Our humanities are researching to understand the changing human images of today. In parallel, medical convergence will also have to be transformed in various ways for human healing. Recently, we can see the case of healing with the combination of oriental medicine, natural healing and western medicine. Furthermore, the structure of medical convergence for the fight against disease can be analyzed as an example. South Korea is also preparing for various convergence programs focusing on natural sciences such as engineering, medical care, and the environment. In order to prevent drug addiction it is important to determine the department responsible for handling the problem of substance abuse. we need to improve the environment that they can be combined with Ondol therapy and natural healing therapies. Furthermore, I expect that fusion medicine will contribute to improving the quality of life of drug addicts and become a successful model to revitalize local economies in particular.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.11a
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• pp.448-451
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• 2002

The possibility of using polypyrrole as a drug delivery system(DDS) has been studied using indicate (Phenol red) and substance with therapeutic activity(Sodium salicylate). In aqueous solution, negative potential is applied to polypyrrole then anion(with therapeutic activity) of sodium salicylate is released by redox processes of polypyrrole. The release amount of anionic drugs from polypyrrole is measured by UV-visible spectrometer which can measure UV-absorbance of materials. Electrode area that use for release amount measurement is$50mm^{2}(5{\times}10mm)$,and thickness of polypyrrole membrane is $15{\mu}m$. DC 1V applied in saline solution, the release amount according to time increased gradually. In various electrode area, release amount of anionic drug is directly to electrode area.

• Journal of Society of Preventive Korean Medicine
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• v.18 no.1
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• pp.23-41
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• 2014

Objective : The purpose of this study was to lay the groundwork for understanding the details and scope of the legal definition of medicinal products, following the changes in the relevant laws and regulations. This will let readers properly understand the origins of the ongoing conflicts on herbal drugs and new drugs from natural products that are present in the medical field and the medical industry. Possible solutions are proposed in the end. Method : I analyzed the changes in definition of medicinal products since 1945 that have been used in relevant laws and regulations(i.e. Pharmaceutical Affairs Act) and drug approval process(i.e. New Drug Application and Investigational New Drug Application). Results : Legal definition of medicinal products has changed in accordance with the changes in the pharmaceutical industry, such as the establishment of dualistic medical and pharmaceutical System and the introduction of the substance patent. Due to those changes, boundaries of Western medicinal products and health food expanded, while those of herbal medicine products relatively downscaled. Conclusion : Legal definition of medicinal products-i.e. Herbal Drugs, Crude Drugs, and New Drugs from Natural Products-should be reestablished according to academic legitimacy and dualistic medical and pharmaceutical System.

• Journal of Sensor Science and Technology
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• v.13 no.1
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• pp.47-55
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• 2004

This paper presents drug release properties of active drug delivery system (DDS) using volume change of polypyrrole (PPy). The incorporation of various chemical substances into the PPy and controlling its release with the externally applied voltage to the PPy are possible. In order to confirm possibility for drug delivery system qualitatively, indicator(phenol red) was examined as a dopant of PPy. The applied voltage to the PPy electrode was set to -2 V and this negative voltage makes the anionic indicator released in saline solution. After qualitative analysis, in order to confirm quantitative drug release characteristic of PPy, salicylate which is one of the aspirin substance was used as a dopant of PPy. As a result, the salicylate release characteristics with time was thoroughly investigated while varying the electrode area, polymerization time, the applied voltage for drug release. Based on these quantitative results, a preliminary experiment was carried out to check the feasibility of the PPy applicable to the neuronal system.

• Child Health Nursing Research
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• v.9 no.4
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• pp.432-440
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• 2003

Purpose: To provide basic data for strategy of substance abuse through the investigation of the status of substance abuse and knowledge and attitude about drugs in the elementary students. Method: Subjects were 565 6th grade of elementary students. Data were collected from June to July 2001 by using structured questionnaire. Result: 1) Among the students of respondents, 10.2% of them had the experience in smoking, 26.7% and 08% of them in drinking and inhalants, respectively. 2) The degree of students' knowledge about substance was 20.9 points on average with the highest score being 30. Students' knowledge about substances, smoking came on top, next came drinking and inhalants followed them. There were no significant differences in the knowledge of substances by general and drug related characteristics of the students. 3) The students' attitude about substances was negative with 30 points on average with the highest score being 108. As for the attitude about substances, they revealed the most generous in drinking next in smoking and inhalants. Those of boys, bored in school life and experienced in substance abuse were significantly generous in the attitude about substances. 4) There was a significant weak inverse relationship between the student's knowledge and attitude about substances (r=-0.13). As for the relationship between the student's knowledge and attitude about substances, the strongest relationship was shown in inhalants (r=-0.18) next in drinking (r=-0.16) and smoking (r=-0.06). Conclusion: The results of the finding suggest that the developing of programs in substance abuse for the elementary students are needed not only for the prevention but also for the cessation.

• Journal of Industrial Convergence
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• v.21 no.2
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• pp.79-84
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• 2023

This study was analyzed based on 1051 analyzes of questionnaires in order to examine the status and perception of abused drugs according to the gender of the young people entering the adult group from the adolescents. The gender of the young people who participated in the survey was 686 males and 365 females, and the types of abused drugs and their perceptions of harmful effects of narcotics and abused drugs were analyzed according to gender. As a result of the study, the experience of using alcohol, tobacco, appetite suppressants, sedatives, and opioid analgesics was statistically significant according to gender. Among the harmful effects of narcotic drugs and drugs of abuse, significant results were shown on the recognition of risks, induced problems, and sympathy for risks. As for the desirable way to improve the problem of narcotics and substance abuse, 257 women (68.2%) of women wanted publicity (enlightenment) activities, and about effective education for preventing narcotics and substance abuse, 379 men (54.2%) of men %) appeared as online online education. It is considered that proper education and publicity about drug use is necessary in the reality that drug addiction among young people due to drug abuse is increasing.