• 한국의학물리학회지:의학물리
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• 제33권4호
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• pp.80-87
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• 2022

Purpose: Proton therapy has different relative biological effectiveness (RBE) compared with X-ray treatment, which is the standard in radiation therapy, and the fixed RBE value of 1.1 is widely used. However, RBE depends on a charged particle's linear energy transfer (LET); therefore, measuring LET is important. We have developed a LET measurement method using the inefficiency characteristic of an EBT3 film on a proton beam's Bragg peak (BP) region. Methods: A Gafchromic EBT3 film was used to measure the proton beam LET. It measured the dose at a 10-cm pristine BP proton beam in water to determine the quenching factor of the EBT3 film as a reference beam condition. Monte Carlo (MC) calculations of dose-averaged LET (LET_d) were used to determine the quenching factor and validation. The dose-averaged LETs at the 12-, 16-, and 20-cm pristine BP proton beam in water were calculated with the quenching factor. Results: Using the passive scattering proton beam nozzle of the National Cancer Center in Korea, the LET_d was measured for each beam range. The quenching factor was determined to be 26.15 with 0.3% uncertainty under the reference beam condition. The dose-averaged LETs were measured for each test beam condition. Conclusions: We developed a method for measuring the proton beam LET using an EBT3 film. This study showed that the magnitude of the quenching effect can be estimated using only one beam range, and the quenching factor determined under the reference condition can be applied to any therapeutic proton beam range.

• Journal of Radiation Protection and Research
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• 제10권2호
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• pp.89-95
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• 1985

연속감속근사법(CSDA)과 감속평균선질계수를 이용하여 선량당량 정의에서의 본래의 LET분포 개념을 하전입자속 스펙트럼의 개념으로 변환함으로써 새로운 선량당량 산정법을 도출하였다. 이 산정법을 몬테칼로법에 적용함으로써 주어진 방사선장에 위치한 피사체 내에서의 선량당량을 직접적으로 간편하게 산출할 수 있다. 산정에 필요한 감속평균 선질계수는 중성자와 연조직과의 상호작용으로부터 발생될 수 있는 모든 하전입자에 대하여 10 MeV 이하의 에너지 범위에서 산출하여 제시하였다.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.216-218
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• 2002

Fluence and LET spectrum for 290,400 MeV/u $\^$12/C and 400 MeV/u $\^$20/Ne beams have been measured by a $\Delta$E-E counter telescope. Total charge-changing cross sections are deduced from measured fluence. The measured cross sections agree with previous measurements, however, they are disagreement with a model calculation. To dose-averaged LETs, the model calculation can reproduce the measured LETs except for peak LETs at Bragg peak region.