• 농약과학회지
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• 제17권3호
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• pp.155-161
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• 2013

본 연구는 인삼 재배 중 사용되는 clothianidin과 thiacloprid의 생산단계 잔류허용기준 설정을 통하여 안전한 인삼 생산에 기여하고자 수행되었다. 먼저, clothianidin과 thiacloprid을 살포하고, 살포 후 0, 2, 5, 8, 12, 16, 20, 24, 28, 33, 42일의 총 11회에 걸쳐 인삼 시료를 채취하여 각각의 농약을 분석하고 생물학적 반감기를 산출한 다음 생산단계 잔류허용기준(PHRL)을 설정하였다. 인삼 중 clothianidin과 thiacloprid은 acetonitrile을 이용하여 추출하여 UPLC/TQD로 분석하였다. 두 농약에서 검출한계는 모두 0.01 mg/kg이었다. Clothianidin의 회수율은 0.2 mg/kg 과 1.0 mg/kg 두 수준에서 각각 $108.6{\pm}5.4%$, $100.4{\pm}1.1%$이었으며, thiacloprid의 회수율은 0.5 mg/kg과 2.5 mg/kg 수준에서 각각 $93.4{\pm}4.9%$, $91.1{\pm}6.2%$이었다. 인삼에서 clothianidin의 생물학적 반감기는 기준량 살포 시 14.6일, 배량 살포시 10.2일 이었고, thiacloprid의 생물학적 반감기는 기준량 살포 시 9.7일, 배량 살포시 11.2일이었다. 잔류회귀 감소식을 이용한 생산단계 잔류허용기준은 clothianidin과 thiacloprid은 각각 수확 10일 전 0.30 mg/kg과 0.18 mg/kg으로 제안하였다.

• 대한방사선기술학회지:방사선기술과학
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• 제33권4호
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• pp.341-348
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• 2010

상 하지 촬영 시 서울 경기지역 병원의 FPD(Flat Pannel Detector) System 사용 실태와 격자 사용에 따른 환자 선량 및 C-D Phantom에 의한 화질평가, 임상 평가자들에 의한 영상평가를 한 결과 다음과 같은 결론을 얻었다. 1. FPD system(12대)의 사용 실태 조사결과 격자비는 8 : 1에서 13 : 1까지이며, 12 : 1이 6대로 가장 많았다. 이 중 격자의 탈 부착이 가능한 장비는 8대이지만, 사용하지 않는 것이 5대(62.5%)로 격자를 그대로 사용하는 곳이 9곳(75.5%)이었다. 2. 실험에 사용된 장비에서 격자사용으로 환자가 받은 선량이 4.13배에서 4.79배까지 많이 받는 것으로 나타났다. 3. 노출조건(mAs)의 변화(0.5배나 2.0배)에 따라 환자가 받는 선량의 차이는 환자 두께에 따라 크게 차이 나지는 않았다. 4. C-D Phantom에 따른 영상의 화질평가는 격자 사용 시와 노출량이 많아질 때 영상의 식별은 잘 되었다. 5. 임상 평가는 두께가 얇은 Hand PA 영상에서는 격자사용을 하지 않는 것이 더 좋았다. 두께가 두꺼운 Knee AP 영상에서는 격자를 사용하는 것이 좋다는 평가를 받았다. 그러나 환자선량이 적어진다면 격자를 사용하지 않겠다는 의견이 5명 중 3명으로 더 많았다.

• 한국방사선학회논문지
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• 제13권7호
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• pp.925-932
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• 2019

플라스틱 섬광체와 상용 50 mm, f1.8 렌즈 및 고감도 CMOS 카메라를 사용하여 방사선치료 시 흡수선량을 측정할 수 있는 광 도시메트리 시스템을 구축하였다. 아울러 촬영된 방사선 분포 영상에 대한 비네팅 보정, 기하학적 왜곡 보정, 스케일 보정을 통하여 화소값으로 선량을 교정하는 절차를 확립하였다. 개발된 광 도시메트리 시스템을 6 MV 의료용 선형가속기에 대하여 선량 특성 평가를 수행한 결과, 심부선량백분율은 이온챔버로 측정한 결과에 비하여 빌드 업 깊이 이상에서는 오차 범위 2% 이내로 일치하였으며, 90% 조사야에 대하여 2.8%의 평탄도가 측정됨에 따라 방사선치료선량 측정 시스템으로서의 충분한 활용가능성을 확인하였다.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.208-210
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• 2002

In a treatment planning for actual patients with a complex internal structure, we often expect that proton beams, which pass through both a bolus and the heterogeneity in body, will form complex dose distributions. Therefore, the accuracy of the calculated dose distributions has to be verified for such a complex object. Then dose distributions formed by proton beams passing through both the bolus and phantoms simulating a clinical heterogeneity in patients were measured using a silicon semiconductor detector. The calculated results by the range-modulated pencil beam algorithm (RMPBA) produced large errors compared with the measured dose distributions since dose calculation using the RMPBA could not predict accurately the edge-scattering effect both in the bolus and in clinical heterogeneous phantoms. On the other hand, in spite of this troublesome heterogeneity, calculated results by the simplified Monte Carlo (SMC) method reproduced the experimental ones well. It is obvious that the dose-calculations by the SMC method will be more useful for application to the treatment planning for proton therapy.

• International Journal of Contents
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• 제13권4호
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• pp.12-15
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• 2017

Among the possible stereotactic body radiation therapy (SBRT) modalities used to treat patients with metastatic spinal tumors, this study compared Cyberknife, tomotherapy, and volumetric modulated arc radiotherapy (VMAT). We established treatment plans for each of them modality and quantitatively analyzed the dose evaluation factors of the dose-volume histogram (DVH) for all spinal bones, focusing on the tumor and spinal cord, in order to examine the usefulness of VMAT. For the treatment planning dose, the mean dose ($D_{max}$) and $D_{5%}$ showed statistical differences in the target dose, but no difference was shown in the spinal cord dose. For the DVH indices, tomotherapy showed the best performance was the best in terms of uniformity index, while VMAT showed better performance was better than the other two modalities in terms of the conformity index and the dose gradient index. VMAT had a much shorter treatment time than Cyberknife and tomotherapy. These findings suggest that VMAT FFF is the most effective therapy for SBRT of patients with metastatic spinal tumors for whom a high dose of radiation is prescribed.

• Nuclear Engineering and Technology
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• 제49권7호
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• pp.1505-1512
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• 2017

Because accelerator-based boron neutron capture therapy (BNCT) systems are planned for use in hospitals, entry into the medical room should be controlled as hospitals are generally assumed to be public and safe places. In this paper, computational investigation of the medical staff effective dose during BNCT has been performed in different situations using Monte Carlo N-Particle (MCNP4C) code and two voxel based male phantoms. The results show that the medical staff effective dose is highly dependent on the position of the medical staff. The results also show that the maximum medical staff effective dose in an emergency situation in the presence of a patient is ${\sim}25.5{\mu}Sv/s$.

• 대한디지털의료영상학회논문지
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• 제12권1호
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• pp.19-25
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• 2010

This study is mainly for the reduction of exposure dose by using a heavy elements filter(Gd) in the digital radiology. They contained heavy elements filter of Gd and X-ray beam hardening filters such as Al and Cu. According to the results of experimental evaluation, X-ray property was not changed with variety of kVp in the case of the Gd filter. The surface dose and absorption dose were increased in order of Cu and Al. The contrast of image showed the higher value in order of Cu, Al and Gd. While the use of Gd has increased the numerical value of the CR image, and grayscale has decreased noise value of the DR image.

• 대한약침학회지
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• 제22권3호
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• pp.171-175
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• 2019

Objectives: TA is a polyherbal extract comprising seven herbs, typically used for the pharmacopuncture treatment of patients with traffic accident- related injuries and musculoskeletal diseases. This animal study was conducted to evaluate the safety of the TA extract, using a single-dose toxicity test. Methods: The dose range and sampling time were first established. Six- week-old Sprague-Dawley rats were administered 1.0 mL of TA or normal saline (control), intramuscularly, for the single-dose toxicity test. The general condition, mortality, and histology of all rats were observed for 2 weeks. Results: No abnormal symptoms or deaths were observed in any group. The body weights of the rats in the TA and control groups were similar. No significant differences in histopathology were observed between the groups. Conclusion : Our study indicates that 1.0 mL of TA extract may be safely administered for pharmacopuncture for treatment of patients in traditional medicine clinics.

• Natural Product Sciences
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• 제28권3호
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• pp.105-114
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• 2022

Tinospora crispa (L.) is a medicinal plant traditionally used to treat various ailments including diabetes. The stem has been widely studied for its antidiabetic properties, however the antidiabetic potential of its leaves has not been explored. This study investigates the antidiabetic properties of methanolic T. crispa stem and leaves extracts on alloxan-induced diabetic rats. The stems and leaves were extracted using Soxhlet extraction with methanol as solvent. Crude extracts were administered at 500 mg/kg body weight (BW) (high dose) and 250 mg/kg BW (low dose) via oral route to alloxan induced diabetic rats. T. crispa stem and leaves extracts was found to significantly reduce blood glucose following a twelve-week treatment period. The highest mean difference in blood glucose level was exhibited by animals in the high dose treated stem and low dose leaf extracts. Both extracts showed approximately 75% percentage recovery from hyperglycaemia. The highest regenerative capacity was observed in animals treated with the low dose leaf extract.

• Nuclear Engineering and Technology
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• 제56권7호
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• pp.2781-2789
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• 2024

We developed lead gloves that minimize radiation dose to the operator's hands during interventional radiological procedures and that do not impede the operator's surgical capabilities. Existing lead gloves can protect the operator's hands by shielding radiation, but use of such gloves may impair preception sensitivity, resulting in a reduction in the operator's surgical ability. Accordingly, in this study, we developed modified lead gloves that can reduce radiation dose while maintaining operator sensitivity during procedures by modifying the operator's main surgical finger area in existing lead gloves. To evaluate the performance of developed modified lead gloves, radiation was applied in surgical conditions without gloves and with surgical gloves, lead gloves, and modified lead gloves. The radiation dose was evaluated for each condition. When the modified lead gloves were worn, the degree of shielding was similar to when conventional lead gloves were worn. Based on these results, if the operator wears modified lead gloves during interventional radiological procedures, they will protect the hands from radiation while maintaining physical sensitivity in the hands.