• Journal of Life Science
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• v.9 no.5
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• pp.504-509
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• 1999

The trend of organogenesis in Xenopus presumptive ectoderm was studied by combined dose of activin A and IGF-1(insulin-like growth factor-1). In reference study of Asashima and his colleagues, the inductive patterns of various organs were reported with activin, the potent mesoderm inducing factor. In present study, the inducing pattern was cleared with combined-dose of concentration 1-100 ng/ml activin A and IGF-1. In addition, the result from single treatment of activin A was compared with former study. As a result, eye was differentiated in 5-20% of explants at 10 and 50 ng/ml concentrative combination of activin A. Otic vesicle was appeared in the entire concentrative combination of IGF-1. Pronephric duct was induced 19-38% of explants at the concentration of activin A 100 ng/ml by adding IGF-1. The comparison of single treatment of activin A was showed some difference in dose-dependent inducing pattern.

• Journal of Astronomy and Space Sciences
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• v.31 no.1
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• pp.33-39
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• 2014

This paper describes an experimental approach to evaluate the effective doses of space radiations at high-altitude by combining the measured data from the Liulin-6K spectrometer loaded onto the air-borne RC-800 cockpit and the calculated data from CARI-6M code developed by FAA. In this paper, 15 exposed dose experiments for the flight missions at a high-altitude above 10 km and 3 experiments at a normal altitude below 4 km were executed over the Korean Peninsula in 2012. The results from the high-altitude flight measurements show a dramatic change in the exposed doses as the altitude increases. The effective dose levels (an average of $15.27{\mu}Sv$) of aircrew at the high-altitude are an order of magnitude larger than those (an average of $0.30{\mu}Sv$) of the normal altitude flight. The comparison was made between the measure dose levels and the calculated dose levels and those were similar each other. It indicates that the annual dose levels of the aircrew boarding RC-800 could be above 1 mSv. These results suggest that a proper procedure to manage the exposed dose of aircrew is required for ROK Air Force.

• The Journal of Korean Society for Radiation Therapy
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• v.22 no.2
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• pp.85-95
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• 2010

Purpose: The degradation of an image quality and error of the beam dose calculation can be caused because the metal artifact is generated during the CT simulation of head and neck patient. The usability of the gantry tilt scan for reducing the metal artifact tries to be appraised. Materials and Methods: The inferior $20^{\circ}$ gantry tilt scan was made in order to reduce the metal artifact and $0^{\circ}$ reconstruction image was acquired. The AAPM CT performance Phantom was used in order to compare the CT number of the reconstructed image and Original image. the difference of volume was compared by using the acrylic phantom. The homogeneity of the CT number was evaluated the Intensity volume Histogram (IVH) as in order to evaluate an influence by the metal artifact. A dose was evaluated as the Dose Volume Histogram (DVH). Results: in the comparison of the CT number and volume, the difference showed up less than 0.5%. As to the comparison of IVH, in the gantry tilt scan, influence by an artifact was reduced and the homogeneity of the CT number was improved. The comparison of DVH result reduced the mean dose error of the both sides parotid 0.2~6%. Conclusion: In the Head & Neck radiation therapy, It is difficult and to distinguish tumor and normal tissue and the error of dose is generated by the metal artifact. The delineation of the exact organization was possible if the Gantry tilt scan was used. The CT number homogeneity was improved and the error of dose could be reduced. The Gantry tilt scan confirmed in the Head & Neck radiation therapy to be very useful in the exact radiation therapy.

• Journal of Radiation Protection and Research
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• v.29 no.2
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• pp.105-115
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• 2004

The Monte Carlo simulation requires very much time to obtain a result of acceptable accuracy. Therefore we should know the optimum number of history not to sacrifice time as well as the accuracy. In this study, we have investigated the effects of statistical uncertainties of the photon dose calculation. BEAMnrc and DOSXYZnrc systems were used for the Monte Carlo dose calculation and the case of mediastinum was simulated. The several dose calculation result from various number of histories had been obtained and analyzed using the criteria of isodose curve comparison, dose volume histogram comparison(DVH) and root mean-square differences(RMSD). Statistical uncertainties were observed most evidently in isodose curve comparison and RMSD while DVHs were less sensitive. The acceptable uncertainties $(\bar{{\Delta}D})$ of the Monte Carlo photon dose calculation for the radiation therapy were estimated within total 9% error or 1% error for over than $D_{max}/2$ voxels or voxels at maximum dose.

• Journal of The Korean Radiological Technologist Association
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• v.25 no.1
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• pp.355-359
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• 1999

• Journal of radiological science and technology
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• v.42 no.1
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• pp.47-51
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• 2019

This study was conducted from July 1 to September 30, 2018 using Optically Stimulated Luminescence Dosimeter(OSLD) and photoluminescent glass dosimeter(PLD) to measure the 3-month exposure dose and the cumulative dose in the active working area of the nuclear medicine worker Respectively. As a result, the cumulative dose for three months in the worker and work area was measured as 1.97 mSv and 2.02 mSv in the PLD. The mean surface dose and the mean depth dose of the OSLD were measured to be 2.04 mSv. The difference in the total surface dose measured by the PLD and the OSLD was 0.66mSv and the total mean surface dose was 0.07mSv. The difference between the total depth dose and the total depth dose was 0.1mSv and 0.02mSv, respectively. It was found that the dose value of the OSLD was higher than that of the PLD. In addition, it was found that the maximum difference of 0.01mSv was observed between the PLD and the OSLD of the worker. For the dose measurement of the two dosimetry systems, there was no significant difference between the PLD and the OSLD in the surface dose of 0.239 (p>0.05). Also, the significance of PLD and OSLD in the deep dose was 0.109, which was not statistically significant (p>0.05).

• Journal of radiological science and technology
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• v.42 no.4
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• pp.271-277
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• 2019

CareDose 4D which is the Siemens's Automatic Exposure Control (AEC) can adjust the level of radiation dose distribution which is based on organ characteristic unlike other manufacturer's AEC. Currently, a wide scan range containing different organs is sometimes examined at once (defined as one scan). The purpose of this study was to figure out which organ characteristic option is suitable when one scan method is utilized. Two types of anthropomorphic phantoms were scanned in the same range which were from frontal bone to carina level according to three different organ characteristics such as Thorax, Abdomen, and Neck. All scans and image reconstruction parameters were equally applied and radiation dose were compared. Radiation dose with Thorax organ characteristic was lower than that with Neck. Also, that with Abdomen oran characteristic was lower than Thorax. There were significant differences in radiation dose according to different organ characteristics at the same parameters (P<0.05). Usage of Neck organ characteristic had a result of the highest radiation dose to all phantom. On the other hand, utilization of Abdomen organ characteristic showed the lowest radiation dose. As a result, it is desirable to set appropriate organ characteristic according to examined body part when you checkup patients. Also, when you implement one scan method, selection of Abdomen-based organ characteristic has reduced more radiation dose compared with two different organ characteristic.

• Journal of Radiation Protection and Research
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• v.47 no.2
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• pp.77-85
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• 2022

Background: After the Fukushima Daiichi Nuclear Power Station (FDNPS) accident, a model was developed to estimate the external exposure doses for residents who were expected to return to their homes after evacuation orders were lifted. However, the model's accuracy and uncertainties in parameters used to estimate external doses have not been evaluated. Materials and Methods: The model estimates effective doses based on the integrated ambient dose equivalent (H^*(10)) and life patterns, considering a dose reduction factor to estimate the indoor H^*(10) and a conversion factor from H^*(10) to the effective dose. Because personal dose equivalent (H_p(10)) has been reported to agree well with the effective dose after the FDNPS accident, this study validates the model's accuracy by comparing the estimated effective doses with H_p(10). The H_p(10) and life pattern data were collected for 36 adult participants who lived or worked near the FDNPS in 2019. Results and Discussion: The estimated effective doses correlated significantly with H_p(10); however, the estimated effective doses were lower than H_p(10) for indoor sites. A comparison with the measured indoor H^*(10) showed that the estimated indoor H^*(10) was not underestimated. However, the H_p(10) to H^*(10) ratio indoors, which corresponds to the practical conversion factor from H^*(10) to the effective dose, was significantly larger than the same ratio outdoors, meaning that the conversion factor of 0.6 is not appropriate for indoors due to the changes in irradiation geometry and gamma spectra. This could have led to a lower effective dose than H_p(10). Conclusion: The estimated effective doses correlated significantly with H_p(10), demonstrating the model's applicability for effective dose estimation. However, the lower value of the effective dose indoors could be because the conversion factor did not reflect the actual environment.

• Korean Journal of Clinical Pharmacy
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• v.27 no.2
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• pp.83-91
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• 2017

Background: Piperacillin/tazobactam (TZP) is an antibiotic against a broad spectrum of gram-positive, gram-negative, and aerobic and anaerobic strains of bacteria. Due to changes in its pharmacokinetic and pharmacodynamic parameters by TZP-treated patients' renal functions and obesity, it is important to administrate and monitor TZP based on their renal functions and Body Mass Index (BMI) levels. The purpose of this study was to determine the appropriateness of administration doses of TZP based on renal functions of obese cancer patients in a tertiary hospital. Methods: This study was retrospectively conducted with obese cancer patients with $BMI{\geq}30kg/m^2$ in a tertiary hospital, Korea from September 2004 to August 2014. Data were collected through Electronic Medical Record (EMR) which contained laboratory data and TZP dosing of each patient. Results: Among 7,058 patients during the study period, 102 prescriptions were selected based on inclusion and exclusion criteria and classified by their renal functions. Although TZP should be used based on patients' renal functions to adjust its dose, its initial dose and dosing interval were consistently used without considering patients' renal functions on a regular basis. Especially, in the comparison with FDA dosing standard of TZP, approximately twice patients with $20mL/min{\leq}CrCl{\leq}40mL/min$ received domestically 4.5 g instead of 2.25 g as the TZP starting dose. Conclusion: The appropriate doses of TZP were administered to almost all of obese cancer patients; however, the recommended TZP dose was different between Korea and other countries by twice the amount. Further related studies are necessary to clearly determine the results, to optimize TZP treatment for obese patients with cancer in clinical practice, and to design and develop new TZP formulations for them in pharmaceutical industry.

• Journal of Korean Biological Nursing Science
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• v.14 no.1
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• pp.49-56
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• 2012

Purpose: The purpose of this study was to compare the effects of anorexia induced by consecutive low-dose and high-dose of cisplatin (CDDP) on the hindlimb muscles of rats. Methods: Male Sprague-Dawley rats were assigned to three groups: Control group (C) received a saline (the same dose and duration as the low CDDP group), the high-dose cisplatin (High CDDP) group received a single 5 mg/kg dose of cisplatin, the consecutive low-dose cisplatin (Low CDDP) group had 1 mg/kg of cisplatin administered for five consecutive days. On the 8th day the soleus and gastrocnemius muscles were dissected. Body weight, food intake, activity, muscle weight, Type I, II fiber cross-sectional area (CSA) of the dissected muscles were measured. Results: Body weight, food intake, muscle weight and Type I, II fiber CSA of the High CDDP and Low CDDP groups were significantly less than the C group. The High CDDP group showed significant decreases, compared to the Low CDDP group, in body weight, food intake, activity score, muscle weight and Type I, II fiber CSA. Conclusion: Hindlimb muscle atrophy occurs due to anorexia induced by both consecutive low-dose and high-dose cisplatin. The muscle atrophy induced by consecutive low-dose cisplatin is less apparent than high-dose cisplatin.