• Journal of Life Science
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• v.26 no.2
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• pp.253-258
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• 2016

In this study, nano-micelled curcumin was produced with natural sea salt with a view to comparing the in silico molecular binding affinity of pure curcumin compound to the active site of transthyretin. Using an optical light microscope and an electron microscope, it was found that the structure of the surface and the cross-section of nano-micelled curcumin was significantly different from natural sea salt. In particular, the crystal structure and nano-components in the nano-micelled curcumin were united, and the layer was more strongly stabilized than untreated salts. In the virtual 3D structure, in silico molecular docking study, the ligand binding affinity of nano-micelled curcumin to the transthyretin active site was found to be higher than that of pure curcumin. In addition, a nano-micelled curcumin formula interacted with more amino acid residues of transthyretin domains. The pharmacophore feature of the nano-micelled curcumin also showed more condensed and constrained features than normal curcumin. These results suggest that nano-micelled curcumin may effectively bind to and stabilize transthyretin, thereby regulating transthyretin-related physiological diseases. Collectively, the nano-micelled curcumin process suggests that normal curcumin can be modified more efficiently into the novel bio-functional chemical formula to stabilize the transthyretin structure. Therefore, the nano-micelled curcumin process can be applied to the field of the regulation of Alzheimer's disease.

• Journal of Life Science
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• v.23 no.11
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• pp.1409-1414
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• 2013

Lymph node (LN) is the sites where mature lymphocytes become stimulated to respond to invading pathogens in the body. Lymphocytes screen the surfaces of pathogen-carrying antigen-presenting cells for cognate antigens, while moving along stromal structural back bone. Fibroblastic reticular cells (FRC) is stromal cell forming the 3 dimensional structure networks of the T cell rich zones in LN, and provide a guidance path for immigrating T lymphocytes. In these cooperative environments, the cell to cell bidirectional interactions between FRC and T cells in LN are therefore essential to the normal functioning of these tissues. Not only do FRCs physically construct LN architecture but they are essential for regulating T cell biology within these domains. FRC interact closely with T lymphocytes, is providing scaffolds, secreting soluble factors including cytokine in which FRCs influence T cell immune response. More recently, FRC have been found to induce peripheral T cell tolerance and regulate the extent to which newly activated T cells proliferate within LN. Thus, FRC-T cell crosstalk has important consequences for regulating immune cell function within LN. In addition, FRC have profound effects on innate immune response by secreting anti-microbial peptides and complement, etc in the inflammatory milieu. In summary, we propose a model in which FRC engage in a bidirectional touch to increase the T cell biological efficiency between FRC and T cells. This collaborative feedback loop may help to maintain tissue function during inflammation response.

• Asia pacific journal of information systems
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• v.20 no.1
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• pp.57-79
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• 2010

In a virtual community, one can possess multiple identities and pretend to be different by creating self-identity in contrast with his or her actual self. Does false identity undermine the qualitative growth of a virtual community by reducing members' accountability? Or does it stimulate their contributive behaviors by ensuring freedom of speech? It is imperative to understand the effects of multi-identity considering the distinct properties of a virtual community in which people easily change their identities at little or no cost. To answer these questions, we adopted the concept of self-discrepancy from the social psychology theory rooted in the concept of the self and developed a theoretical model to predict quality of contribution of the individual member in virtual communities. Based on the self-discrepancy theory, we first identified two different domains of the self: (1) an "actual self" that consists of attributes that the person believes he or she currently possesses in real life and (2) a "cyber self" that consists of attributes the person believes he or she possesses in a virtual community. Next, we derived an index for two different types of self-discrepancy by using the differences between the actual and the cyber identities: Personal Self-discrepancy and Social Self-discrepancy. Personal Self-discrepancy reflects the degree of discrepancy between actual and cyber identity regarding a person's intelligence, education, and expertise. Social Self-discrepancy reflects the degree of discrepancy between actual and cyber identity regarding a person's morality, sociability, and accordance with social norms. Finally, we linked them with sense of virtual community, perceived privacy rights, and quality of contribution to examine how having a multi-identity influences an individual's psychological state and contributive behaviors in a virtual community. The results of the analysis based on 266 respondents showed that Social Self-discrepancy negatively influenced both the Sense of Virtual Community and Perceived Privacy Rights, while Personal Self-discrepancy negatively influenced only Perceived Privacy Rights, thereby resulting in reduced quality of contribution in virtual communities. Based on the results of this analysis, we can explain the dysfunctions of multi-identity in virtual communities. First, people who pretend to be different by engaging in socially undesirable behaviors under their alternative identities are more likely to suffer lower levels of psychological wellbeing and thus experience lower levels of sense of virtual community than others. Second, people do not perceive a high level of privacy rights reflecting catharsis, recovery, or autonomy, even though they create different selves and engage in socially undesirable behaviors in a virtual community. Third, people who pretend to be different persons in terms of their intelligence, education, or expertise also indirectly debase the quality of contribution by decreasing perceived privacy rights. The results suggest that virtual community managers should pay more attention to the negative influences exercised by multi-identity on the quality of contribution, thereby controlling the need to create alternative identities in virtual communities. We hope that more research will be conducted on this underexplored area of multi-identity and that our theoretical framework will serve as a useful conceptual tool for all endeavors.

• Journal of Gifted/Talented Education
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• v.26 no.3
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• pp.449-471
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• 2016

This study was conducted in order to investigate how a Problem-Based Learning (PBL) program titled(called) 'Designing Safe and Strong Bridge' effects scientifically gifted students' scientific attitude, scientific career orientation and leadership. The participants were 19 scientifically gifted students in the second grade in C high school in Gyeonggi province; they were selected by participation in the tri-level gifted students identification step. Before and after 14 units of the program, the participants were asked to take tests about scientific attitude, scientific career orientation and leadership and to write a review about the PBL program at the end. The major results of this study are as follows. First, participants' scientific attitude was statistically significantly improved after the PBL program (p<.05). In the sub-domain of this area, six parts excluding the part of openness were significantly developed. Second, the degree of scientific career orientation was statistically significantly improved after the PBL program (p<.05). All 4 sub-domains in the degree of scientific career were significantly developed. Third, all of leadership scores were statistically significantly increased after the PBL program (p<.05). In the first factor, the parts of inner and inter personal characteristics were significantly developed. According to their post-program opinions, participants developed in terms of all the secondary factors, such as ability of interpersonal relation, consideration for others and groups, responsibility for the task, confidence and vision, during the process of PBL problem-solving in the small group work.

• Journal of Information Management
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• v.41 no.4
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• pp.227-249
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• 2010

Scholarly information has increased tremendously according to the development of IT, especially the Internet. However, simultaneously, people have to spend more time and exert more effort because of information overload. There have been many research efforts in the field of expert systems, data mining, and information retrieval, concerning a system that recommends user-expected information items through presumption. Recently, the hybrid system combining a content-based recommendation system and collaborative filtering or combining recommendation systems in other domains has been developed. In this paper we resolved the problem of the current recommendation system and suggested a new system combining collaborative filtering and Naive Bayes Classification. In this way, we resolved the over-specialization problem through collaborative filtering and lack of assessment information or recommendation of new contents through Naive Bayes Classification. For verification, we applied the new model in NDSL's paper service of KISTI, especially papers from journals about Sitology and Electronics, and witnessed high satisfaction from 4 experimental participants.

• Journal of KIISE:Software and Applications
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• v.26 no.11
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• pp.1359-1371
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• 1999

대규모 네트워크 상에서 동작하는 분산 시스템의 구현을 위해 제시된 방법 중의 하나인 이동 코드 개념은 네트워크 공유 자원에 접근할 수 있는 효과적인 방법을 제시하였고 이 개념을 지원하는 많은 언어들의 개발을 가져왔다. 개발된 언어들이 가지고 있는 이동 코드를 지원하기 위한 언어 구문과 적용하려는 문제 영역의 특성을 반영한 언어 구문은 네트워크 프로그래밍을 하는데 있어서 효율과 문제 중심의 프로그램의 두 가지를 모두 가능하게 하고 있다. 본 논문에서는 현재 분산 컴퓨팅 환경에서 가장 많이 사용되고 있는 클라이언트-서버 모델을 확장하여 서버의 자원에 접근할 수 있는 또 다른 방법을 가진 모델을 제시하고, 이 모델을 표현할 수 있는 언어를 설계하였다. 설계된 언어는 이동 코드의 개념을 지원함으로써 대규모 네트워크에서 수행되는 프로그램의 작성을 가능하게 하고, 분산 범위 규칙을 채택함으로써 이동 코드의 기술을 일반 함수를 기술하듯 명확한 관점에서 할 수 있도록 하였다. 또한 네트워크 관련 자원들을 언어 구문으로 채택하여 네트워크 프로그래밍을 언어 수준에서 할 수 있도록 하였다. 언어의 이론적인 설계에 그치지 않고 설계된 언어를 수행할 수 있는 실행 시간 지원 시스템을 구현하였다. 실행 시간 지원 시스템은 언어를 해석하고 실행하는 코드 해석기와 이동 코드를 지원하는 네트워크 감독으로 구성되며 설계된 언어를 사용하여 실제로 네트워크 응용 프로그램을 작성하고 테스트 해 볼 수 있다.Abstract Some studies bring up a concept of code mobility as an innovative way to access network resources in order to develop distributed systems working on a large scale network. After that, many languages are suggested to support this concept. In these languages, language constructors for their particular application domains and mobile codes provide both problem-oriented views to the programmer and reasonable performance to the system. In this thesis, we extend the client-server model that is the most popular model in developing distributed systems these days. We propose a model to have another method to access server's resources and extend the C language to implement the proposed model for the large scale network. The new language has capability to build a software working on a large scale network by supporting mobile code and gives a consistent network programming view to the programmer by adapting distributed semantics. The language also makes network programming easy by providing network primitives at the language level. We implement a prototype of run-time system to support this language. The run-time system is composed of two major parts: code-interpreter that interprets and executes the language and network-daemon that supports mobile codes.

• Journal of the Korea Computer Industry Society
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• v.2 no.7
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• pp.885-894
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• 2001

The production and application of multimedia by domain in accordance with an infant level on the educational spot are some what insufficient to satisfy and difficult to be connected with class activities. Therefore, This essay proposes a way that it products educational program in accordance with a child level using ToolBook II and applies to class activities directly so that the infants can promote learning achievement. The embodied program is to be classified into six domains, a letter world, a figure world, a colorful world, a nursery rhyme world, a nursery tale world and internet site, on the basis of the play domain of infant education course. It is different from the existing CD ROM Title for young children by subject. The program is appropriately applied close multimedia factor for infants, such as images and sounds in order to stimulate their hearing and vision because it is programmed just for young children. And also, it is made up to be able to be applied without suing letters because they are unaccustomed to letter. After it have been applied to infants, A Rating-measure method is chosen in the course of an evaluation. Consequently, It shows that, a letter world, a figure world and a colorful world of each domain have an efficient learning effect and also at the ages of 5~7, 7 year-old infants have the best efficient learning effect.

• KIPS Transactions on Software and Data Engineering
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• v.2 no.3
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• pp.161-172
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• 2013

Metadata registry (MDR) is the international standard, developed by ISO/IEC for exchange and sharing data between databases. Many MDR systems are used in diverse domains such as medical service, bibliography, environment for sharing and integrating data. However, those systems have different physical structures individually because the MDR standard defines only the metamodel for registering and storing metadata. It causes heterogeneity between the system structures and requires additional cost to maintain interoperability. ISO/IEC 13249-8 Metadata Registry Access (MRA) is developing as an international standard to provide a consistent access facility to data stored in different metadata registries. However, MRA does not consider the relationships between the concepts (classes) defined in the MDR specification. It causes that incorrect query results returned from MDR systems. It also requires additional cost of modeling and rewriting queries to reflect each physical model. Therefore, this paper suggests eMRA which considers the relationships between the concepts in MDR. The comparative evaluations are described to show the advantages of eMRA. eMRA has superior performance in query modeling and referential integrity than MRA defined by the relationship between the concept of MDR.

• (The)Study of the Eastern Classic
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• no.62
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• pp.209-229
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• 2016

This thesis is to discover the meanings of boundary through East Asian thought so as to make rooms for discoursing on it. First of all people have their own boundaries of 'Me', and they make others as persons or objects in their thoughts. Originally boundary has represented nation's frontier, and it indicated the worlds of space in Buddhism of East Asian culture. It is represented by loka or visaya in Sanskrit and region, dominion, boundary, border in English, which means the worlds that people would fancy in their minds over domains of politics, societies, culture, arts ect, not to be simple. Accordingly we must not approach to its meaning simply like 'beyond border'. There are many boundaries, which are similar to the sublime, for us to arrive in our lives. Spiritually there are also many boundaries(regions) that are made by our desires, wills and concepts. In a while there are limit or problem in our recognizing things, for example, of human's five senses that would be, to an extent connected with Buddhistic understanding of boundaries. Boundaries resulted from partiality in understanding of objects must be got rid of eventually. In regard of these matters, this thesis discusses the meanings of boundary, those that are inevitably made by human's consciousness, and negative ones to be got over from recognition systems of person or any groups.

• Korean Journal of Family Social Work
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• no.61
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• pp.59-91
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• 2018

Using a Consensus Qualitative Research approach, this study aimed to identify the ageism and explore age-integration as a solution of age discrimination that occurs during the delivery of medical services by nine healthcare professionals who have experience in treating elderly patients. There were two-sided confession has shown by health care professionals about the Ageism. They reported that they don't discriminate by age. However, They also appealed an inconvenience due to the elderly. There were real Ageism in the Healthcare Professional site as a way of Unsuitable care, elderly alienation and dependence on caregivers, polarization of medical service and double discrimination against poor elderly. They found it difficult to offer age integrated health care as a means to mitigate or solve. However they have sought to break barriers to communication, provided a comfortable environment not only for senior citizens but also for all others, and have diversified institutional and service standards. To ensure the healthy life and proper medical service of the rapidly increasing elderly patients, we proposed to do critical review of the factors in the Korean medical system that accelerate the Ageism, reorganization of the health care system for the poor elderly, including the curriculum associated with age-integrating within the health care professional education system, raising the Geriatric Medical Service and the relating professionals and improvements in perception of the health care domains for the elderly and older adults.