• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.31 no.3
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• pp.219-227
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• 2005

Purpose: Abnormalities in the p53 gene are regarded as the most consistent genetic abnormalities detected in head and neck squamous cell carcinogenesis. Two new members of the p53 gene family, p73 and p63 have recently been identified. They share considerable sequence homology with p53 in the transactivation, DNA binding, and oligomerization domains, indicating possible involvement in carcinogenesis. Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. The aim of this study was to analyze expression of p63 in squamous cell carcinogenesis and to compare with immunochemical markers representing cell proliferation and apoptosis. Materials and Methods: Using the Syrian hamster oral cancer model, the fraction of apoptotic (apoptotic index-AI), proliferating (mitotic index-MI) and p63 expressing keratinocytes were examined at normal, dysplastic and malignant oral epithelium using the TUNEL assay, PCNA and p63 immunostaining. Results: p63 significantly increased between normal and dysplastic epithelium and between dysplastic and malignant epithelium. PCNA significantly increased between normal and dysplastic epithelium and between normal and malignant epithelium. However, increase between dysplastic and malignant epithelium, though still increasing, was not statistically significant. The percentage of TUNEL positive cells increased from normal to dysplastic epithelium and returned to normal keratinocyte level in the malignant epithelium. However, differences between tissue types were not significant. The ratio of MI:AI increased significantly only in the dysplastic-malignant epithelial transition. The increase of p63 expression closely reflected the change in the MI:AI ratio during oral carcinogenesis. Conclusion: The p63 may be associated with the regulation of epithelial proliferation and apoptosis in DMBA-induced hamster buccal pouch squamous cell carcinogenesis. Further study is required to investigate which p63 isoforms are involved in hamster buccal pouch carcinogenesis.

• Journal of the Korean GEO-environmental Society
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• v.15 no.6
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• pp.67-73
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• 2014

Landslide disasters including debris flows are the one of the most frequent natural disasters in Korea, and losses of lives and property damages due to these catastrophic events have been increased every year. Various mitigation programs and related policies have been conducted in order to respond and prepare landslide disasters. Most landslide reduction programs are, however, focused on recovery actions after the disasters and lead to unrealistic consequences to the affected people and their properties. The main objective of this study, therefore, is to evaluate the landslide hazard based on the identification of geomorphological features, which is for the preparedness of the landslide disasters. Two methodologies, SINMAP and vector dispersion analyses are used to simulate those characteristics where landslides are actually located. Results showed that both methods well discriminate geomorphic features between stable and unstable domains. This proves that geomorphological characteristics well describe a relationship with the existing landslide hazard. SINMAP analysis which is based on the consecutive model considering external factors like infiltration is well identify the landslide hazard especially for debris flow type landslides rather than vector dispersion focusing on a specific area. Combining with other methods focusing specific characteristics of geomorphological feature, accurate landslide hazard assessments are implemented.

• Journal of The Korean Association For Science Education
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• v.18 no.4
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• pp.527-537
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• 1998

This article is a part of a research on the elementary science curriculum development to enhance creative problem-solving abilities. The components of the curriculum have been identified as 'scientific knowledge', 'process skills' & 'divergent/critical thinking'. Among these components, construction of the scientific knowledge that enables creative problem-solving abilities has been selected as an intensive research topic for the purpose of the present research. To avoid or to prevent the knowledge learned from separate facts and concepts, five themes have been selected so as to incorporate with all three areas of the elementary science curriculum, i.e., physical science, earth science and life science. The five themes are, 'structure', 'change', 'interaction', 'energy' and 'stability'. The contents of elementary science, which have been selected from the 3rd, 6th and 7th National Elementary Science curriculum, were reconstructed based on the five themes given above. The results of reconstruction are presented in the form of matrix, such that the vertical axis represents how the concepts are related within each domain of science, while the horizontal axis shows how the concepts are interconnected between domains of science. Therefore, based upon the five themes, individual or separate knowledge can be put into more unified knowledge so that contribution of knowledge transfer to new ones can be expected for leaners who will be creative in problem-solving. The process and products of the curriculum development as well as the background of the present research are described and discussed in detail.

• Journal of The Korean Association For Science Education
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• v.33 no.5
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• pp.1041-1054
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• 2013

Big ideas are overarching principles that help students to build a holistic understanding of domain-specific knowledge and assimilate individual facts and theories. This study aims to design a standard-based integrated science curriculum framework based on Big Ideas. The core contents were extracted by analysing the 2009 National Science Standards curriculum of primary and middle schools. Four Big Ideas, 'diversity,' 'structure,' 'interaction,' and 'change,' were generated after the process of examination and categorization of core contents. The scientific facts, disciplinary concepts, and interdisciplinary concepts of every scientific domains included in each Big Idea are represented as a knowledge pyramid. Essential questions guiding the direction of curriculum design were proposed on each Big idea. Based on the framework, teaching modules for 'structure' were developed for grades 5~6.

• Journal of The Korean Association For Science Education
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• v.33 no.5
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• pp.1021-1040
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• 2013

In order to explore the influences of coteaching through mentoring upon the teaching professionalism of beginning science-gifted education teachers, this case study deeply investigated the change processes in the aspects of pedagogical content knowledge (PCK). Two beginning teachers planned, performed and reflected together their science instructions for science-gifted students in secondary school during four 3-hour classes. Since the second instruction, pre-, during-, and post-mentoring were conducted, we collected various data related to teachers' planning processes, videotaped all coteaching science classes, and wrote field notes. We also recorded in-depth interviews with the teachers and the whole process of mentoring. All the data were analyzed by using the constant comparative method. The results of the analyses indicated that coteaching through mentoring positively changed the teachers' PCK. Above all, we found that coteaching and mentoring strategies generated a significant synergy effect through a mutually complementary relationship. The teachers developed deep practical knowledge about the enrichment curriculum, which placed more emphasis on developing cognitive and/or affective characteristics of science-gifted students. The teachers also improved their knowledge about the characteristics of science-gifted students and the instructional strategies appropriate for developing them. Moreover, practical knowledge about assessment domains and methods used in science-gifted education were improved. Knowledge on science content necessary for effective inquiry instruction was also improved.

• Child Health Nursing Research
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• v.8 no.4
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• pp.449-457
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• 2002

The main purpose of this study is to examine the concepts appeared on researches and provide the future research directions in field of child health nursing. A descriptive study was conducted. 205 studies were included in an analysis the concepts in terms of the domain of client for a total 321 researches. All were originally published between 1990 and 2000 in Korea. An analysis of concepts for this study was used the metaparadigm framework for nursing proposed by H.S. Kim(2000). The concepts for this study were categorized by essentialistic concepts, problematic concepts, health-care experiential concepts with the following results. 1. Based on the four domains suggested Kim (2000), 205 studies(63.9％) belong to the domain of client ; 109 studies(34％) belong to the practice domain of nursing; 3 studies(0.9％) belong to the client-nurse domain; and 4 studies belong to the domain of environment, respectively. 2. In the domain of client, 117(57.1％) studies used concept of parent. Among them, mother was the prevailing research population(103 studies). 64 studies(31.2％) used child population and the developmental stage of children varied from preterm to puberty but school aged children was the most target population(28 studies). Family as a concept of client was used in 20 studies(9.8％) but most primary care provider was the mother. 3. In terms of research design, non-experimental design(83.5％) is the most and among them survey was 159 studies(77.6％). Qualitative research(23 studies) and experimental research(10 studies) methods were used relatively few. 4. In terms of the categories of concepts, 196 (61.4％) studies included the essentialistic concepts like stress and coping(20.4％), mothering role and child care(7.8％), health (5.6％), breast feeding(4.7％). 31 studies included problematic concepts like power-lessness, safety, obesity, pain, anxiety. And 65 studies included health-care experiential concepts like compliance, growth, hope, environment but relatively few. The findings of this study provide the evidence that research related problematic concept and health-care experiential concept should be conducted actively to improve the practice of child health nursing. Also to deeply understand the phenomena of client in field of child health nursing, interpretive research methods should be conducted actively, too.

• Child Health Nursing Research
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• v.9 no.1
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• pp.9-17
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• 2003

Families of children with cancer face many illness-related demands. The perceived social support is a critical resource for the family adaptation process. And the patterns of family adaptation to childhood cancer varies as characteristics of disease, which is prognosis, the influence of cognition function, and treatment process. The conceptual definition of social support is not unidimensional. However, most studies focus on general aspect of mediating effects on adaptation. Diverse dimensions of perceived social support should be considered in its effectiveness for intervention. Therefore, this study was undertaken to determine whether family's perceived social support influences the family adaptation of family with pediatric cancer and what dimension influences mostly in family adaptation as the characteristics of disease in the family of children with cancer. The subject was consisted of 102 families with pediatric cancer who had been diagnosed as leukemia or brain tumor last 2 years. Those families had participated in the education program or meetings for family who have with pediatric cancer children. The measurement for this study were Personal Resource Questionnaire (PRQ) Part-Ⅱ developed by Brandt and Weinert to measure parents' perceived social support, and the McCubbin's Coping Health Inventory for Parents (CHIP) to measure family coping. The results of this study can be summarized as follows; Regression analysis showed that perceived social support has effect on family adaptation with β=.43, p<.01. In the group of family of child with leukemia, social support as general has effect on adaptation (β=.40, p<.01) and specially, social support perceived as intimacy was strongly effect on family adaptation. And In the group of brain tumor, Social support has effect on adaptation(β=.46, p<.01) and among the social support domains, the self esteem dimension was most predictable to family adaptation. In conclusion, the perceived social support is a predictor on family adaptation and useful vehicle to help family who has child with pediatric cancer. An important clinical implication is that specified support program for intervention may be useful and critical for the family who has diverse pediatric conditions of childhood cancer. Further studies should stress the effects of family support for clinical intervention and is needed with diverse stage of development and pediatric conditions.

• 대한공업교육학회지
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• v.37 no.2
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• pp.21-55
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• 2012

The purpose of this study was to develop teacher-training for improvement of teaching efficacy of technology teacher. The study was carried out through Delphi research method. It was executed for investigating the professional and wide-range opinions of expert panel to examine the validity. The validity was confirmed by concurrence ratio, convergence ratio, contents validity ratio (CVR). Major results of this study were as follows: First, necessity, nature, purpose of teacher-training for improvement of teaching efficacy of technology teacher was set up. And this teacher-training have 12 objectives in 3 domains (cognitive, affective, psychomotor). Second, contents of this teacher-training were designed to be applicable for 10 modules (300 hours). For example, module1 (introduction of technology education), module2 (construction technology), module3 (information communication technology), etc. Third, educational method, training educator, evaluation method of this teacher-training were developed. Fourth, each module of this teacher-training is 30 hours in length. And summer or winter vacation is appropriate for this teacher-training time. Appropriate teacher-training time is six hours a day. Fifth, roles of educational institution for this teacher-training were suggested. Sixth, strategies to vitalize this teacher-training were suggested.

• The KIPS Transactions:PartA
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• v.16A no.4
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• pp.227-234
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• 2009

OSGi technology has applied to Home Network, but now it is loaded into even heterogeneous devices in various domains. Therefore, it is necessary to cooperate with each other framework for offering effective services in distributed OSGi frameworks. However until now, OSGi specification doesn't provide any methodthat can share the services registered on remote OSGi frameworks. In order to solve this problem, there have been several researches that used existing distributed middleware technologies such as JXTA and Web Services. However these technologies have some weakness, that is, they consume lots of computing resources and need additional process to transform the services. A middleware called R-OSGi uses only OSGi technology for sharing remote OSGi services, but R-OSGi may have a communication bottleneck and SPOF (Single Point of Failure) problem, because it has a central service registry. In this paper we present RSP (Remote Service Provider), which is a P2P-based effective service sharing scheme on distributed OSGi framework. RSP doesn't need to install additional software nor have the additional transformation process of the service representation, because it uses only OSGi technology. In addition it doesn't have any bottleneck problem and improves scalability by providing the service discovery mechanism using P2P. RSP can also access remote services transparently and it can guarantee reliability by sending an immediate notice about changes of the remote services.

• The KIPS Transactions:PartD
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• v.17D no.2
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• pp.157-166
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• 2010

More recently, RFID (Radio Frequency Identification) systems have begun to find greater use in various industrial fields. The use of RFID system in these application domains has been promoted by efforts to develop the RFID tags which are low in cost, small in size, and high in performance. The RFID applications enable the real-time capture and update of RFID tag information, while simultaneously allowing business process change through real-time alerting and alarms. These be developed to monitor person or objects with RFID tags in a place and to provide visibility and traceability of the seamless flows of RFID tags. In this time, the RFID readers should be placed in diverse locations, the RFID flows between these readers can be tested based on various scenarios. However, due to the high cost of RFID readers, it may be difficult to prepare the similar environment equipped with RFID read/write devices. In this paper, we propose a simulator to allow RFID application testing without installing physical devices. It can model the RFID deployment environment, place various RFID readers and sensors on this model, and move the RFID tags through the business processes. This simulator can improve the software development productivity by accurately testing RFID middleware and applications. In addition, when data security cannot be ensured by any fault, it can decide where the problem is occurred between RFID hardware and middleware.