• MALSORI
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• no.38
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• pp.1-24
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• 1999

There is an indisputable connection between prosody and focus. The focal prominence in Korean, a prosodic realization of pitch prominence in an utterance, defines a focused constituent, the domain of which is identified by the Focus Identification Principle. To this is added the Basic Focus Rule which makes it possible to capture and interpret the focal domain, which can then be tested against the available context. The focal domain can be contextually made available by setting it off with information structure boundaries(I/S) identified by the Information Structure Identification Principle. The fragment of the utterance enclosed within the IS boundaries can be recognized as 'new' information with the help of the Focus Domain Identification Rule. Since information structures are pragmatically tied to semantic levels of grammatical systems, the Basic Focus Rule is now replaced by the Focal Prominence Principle ensuring the focal prominence within the focal domain. Close relationships exist between patterns of intonation and their expressiveness in terms of giving a pragmatically-oriented description of focus. This is particularly manifested in Korean sentences containing contrastiveness.

• 한국지구물리탐사학회:학술대회논문집
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• 2003.11a
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• pp.464-469
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• 2003

The traditional and still most widely used, test methods for concrete structures are destructive method, such as coring, drilling or otherwise removing part of the structure to permit visual inspection of the interior. While these methods are highly reliable, they are also time consuming and expensive, and the defects they leave behind often become focal point for deterioration. In this study, tomography by theoretical inversion method in case of elastic wave using impact-echo method among concrete non-destruction test method was made. Taken model experiments are theoretical inversion method and time domain and frequency domain test on pier test model at laboratory level. Also experiment concerning frequency domain on 3 kinds of tunnel model with I-dimension form was carried out.

• Food Science of Animal Resources
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• v.18 no.4
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• pp.292-300
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• 1998

This study was undertaken to determine the influence in the Z-disk domain of titin on the tenderization of meat by the structure change of myofibrillar Z-disks during post-mortem aging. After weakening the structure of Z-disks, the Z-disk region was splitted. As the results, myofibrils were fragmented by mechanical strength. Using indirect immunofluorescence microscopy, we show that the Z-disk domain of titin was disappeared from myofibrils in this period. There phenomenon were also shown by treating myofibrils with a solution containing 0.1mM $Ca^{2+}$. We conclude that change in Z-disk domain of titin is directly effected on the tenderization of meat during post-mortem aging and these change is due to manily calcium ions.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.56-64
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• 2008

To maintain effectively the functionality of major railroad facilities such as bridges, identifying and evaluating damage in a structure and taking appropriate action via continuous structural health monitoring are very important. However, most damage identification methods for structural health monitoring developed to date utilize modal domain responses which inevitably contain errors in transforming the domain of responses. In this paper, a damage identification method using time-domain operational deflection shapes is proposed. Since the proposed method utilizes time-domain responses, the error in the process of transformation to response domain can be avoided, and the accuracy of structural health evaluation can be improved. The feasibility of the proposed method is verified via a numerical example of a simple bridge structure.

• Journal of the Korean Chemical Society
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• v.67 no.5
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• pp.348-352
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• 2023

p97, a universally conserved AAA+ ATPase, holds a central position in the ubiquitin-proteasome system, orchestrating myriad cellular activities with significant therapeutic implications. This protein primarily interacts with a diverse set of adaptor proteins through its N-terminal domain (NTD), which is structurally located at the periphery of the D1 hexamer ring. While there have been numerous structural elucidations of p97 complexed with adaptor proteins, the stoichiometry has remained elusive. In this work, we present the crystal structure of the p97-N/D1 hexamer bound to the FAF1-UBX domain at a resolution of 3.1 Å. Our findings reveal a 6:6 stoichiometry between the p97 hexamer and FAF1-UBX domain, deepening our understanding from preceding structural studies related to p97-NTD and UBX domain-containing proteins. These insights lay the groundwork for potential therapeutic interventions addressing cancer and neurodegenerative diseases.

• Smart Structures and Systems
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• v.8 no.4
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• pp.343-365
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• 2011

Structural system identification (SSI) is an inverse problem of difficult solution. Currently, difficulties lie in the development of algorithms which can cater to large size problems. In this paper, a parameter estimation technique based on evolutionary strategy is presented to overcome some of the difficulties encountered in using the traditional system identification methods in terms of convergence. In this paper, a non-traditional form of system identification technique employing evolutionary algorithms is proposed. In order to improve the convergence characteristics, it is proposed to employ immune algorithms which are proved to be built with superior diversification mechanism than the conventional evolutionary algorithms and are being used for several practical complex optimisation problems. In order to reduce the number of design variables, domain decomposition methods are used, where the identification process of the entire structure is carried out in multiple stages rather than in single step. The domain decomposition based methods also help in limiting the number of sensors to be employed during dynamic testing of the structure to be identified, as the process of system identification is carried out in multiple stages. A fifteen storey framed structure, truss bridge and 40 m tall microwave tower are considered as a numerical examples to demonstrate the effectiveness of the domain decomposition based structural system identification technique using immune algorithm.

• Bulletin of the Korean Chemical Society
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• v.29 no.5
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• pp.1013-1017
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• 2008

Syndecan-3 is a cell-surface heparan sulfate proteoglycan, which performs a variety of functions during cell adhension process. It is also a coreceptor for growth factor, mediating cell-cell and cell-matrix interaction. Syndecan-3 contains a cytoplasmic domain potentially associated with the cytoskeleton. Syndecan-3 is specifically expressed in neuron cell and has related to neuron cell differentiation and development of actin filament in cell migration. Syndecans each have a unique, central, and variable (V) region in their cytoplasmic domains. And that region of syndecan-3 may modulate the interactions of the conserved C1 regions of the cytoplasmic domains by tyrosine phosphorylation. Cytoplasmic domain of syndecan-3 has been synthesized for NMR structural studies. The solution structure of syndecan-3 cytoplasmic domain has been determined by two-dimensional NMR spectroscopy and simulated-annealing calculation. The cytoplasmic domain of the syndecan proteins has a tendency to form a dimmer conformation with a central cavity, however, that of syndecan-3 demonstrated a monomer conformation with a flexible region near C-terminus. The structural information might add knowledge about the structure-function relationships among syndecan proteins.

• Journal of Microbiology and Biotechnology
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• v.26 no.2
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• pp.226-232
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• 2016

Dihydrodipicolinate reductase is an enzyme that converts dihydrodipicolinate to tetrahydrodipicolinate using an NAD(P)H cofactor in L-lysine biosynthesis. To increase the understanding of the molecular mechanisms of lysine biosynthesis, we determined the crystal structure of dihydrodipicolinate reductase from Corynebacterium glutamicum (CgDapB). CgDapB functions as a tetramer, and each protomer is composed of two domains, an Nterminal domain and a C-terminal domain. The N-terminal domain mainly contributes to nucleotide binding, whereas the C-terminal domain is involved in substrate binding. We elucidated the mode of cofactor binding to CgDapB by determining the crystal structure of the enzyme in complex with NADP⁺ and found that CgDapB utilizes both NADH and NADPH as cofactors. Moreover, we determined the substrate binding mode of the enzyme based on the coordination mode of two sulfate ions in our structure. Compared with Mycobacterium tuberculosis DapB in complex with its cofactor and inhibitor, we propose that the domain movement for active site constitution occurs when both cofactor and substrate bind to the enzyme.

• Journal of the Korean Magnetic Resonance Society
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• v.11 no.1
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• pp.24-29
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• 2007

[ ${\beta}ig-h3$ ] is an extracellular matrix protein that mediates cell adhesion through interaction with integrins. The 18 residue YH motifs within each fas-1 domain are known to be responsible for the interaction with the ${\alpha}_v{\beta}_5$ integrin, and the synthetic YH motif peptides are known to inhibit endothelial tube formation and reduces the number of blood vessels, and so expected to be an effective inhibitor of angiogenesis. In this study, we solved the 3D structure of the 18 residue YH motif peptide (EALRDLLNNHILKSAMCA; D2 peptide) within the second fas-1 domain of ${\beta}ig-h3$ using NMR. The Peptide has ${\alpha}-helix$ structure at the C terminal region but the N terminal region is flexible. The present structural information may be helpful for developing more effective peptide drug candidate for the treatment of diseases dependent on angiogenesis.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.32 no.9
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• pp.41-48
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• 2004

In this work, a domain-wise hash structure is developed for efficient data handling, and by using the developed domain-wise hash structure, an automatic triangular mesh generation algorithm is proposed. To generate the optimal nodal points and triangles efficiently, the advancing layer method and Delaunay triangulation method are utilized. To investigate the performance of the proposed algorithm, benchmarking tests are carried out for various models including convex, concave and complicated shapes through the developed object oriented C++ mesh generation code.