• The Transactions of the Korea Information Processing Society
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• v.3 no.5
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• pp.1082-1092
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• 1996

The design of distrbuted systems is difficult to achieve as the execution patterns of distrbuted systems are typically more complex than those of non- distributed systems. Thus, research toward the development of design methods for distributed systems is quitely needed. As object-oriented systems and distrbuted systems share similar properties, the combination of these two is somehow natural. In this work, a design of distributed systems is introduced. The goal of the method in this paper is to provide assistance to the process of specifying a formal object- oriented specification from graphical representation specification inputs such as data flow diagrams, state transition diagrams and Petri nets. It addresses the extraction of objects, operations and reationshipsfrom the problem domain with emphasis on the specification of the characteristics of distributed systems. This object identification method is supported by a knowledge base that provides for the automated analysis and reasoning about objects and their relationsships. The final object model is represented in a format which provides a formal mechanism for reprsenting the object information.

• The Transactions of the Korea Information Processing Society
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• v.3 no.5
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• pp.1103-1111
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• 1996

The design of distrbuted systems is difficult to achieve as the execution patterns of distrbuted systems are typically more complex than those of non- distributed systems. Thus, research toward the development of design methods for distributed systems is quitely needed. As object-oriented systems and distrbuted systems share similar properties, the combination of these two is somehow natural. In this work, a design of distributed systems is introduced. The goal of the method in this paper is to provide assistance to the process of specifying a formal object- oriented specification from graphical representation specification inputs such as data flow diagrams, state transition diagrams and Petri nets. It addresses the extraction of objects, operations and reationshipsfrom the problem domain with emphasis on the specification of the characteristics of distributed systems. This object identification method is supported by a knowledge base that provides for the automated analysis and reasoning about objects and their relationsships. The final object model is represented in a format which provides a formal mechanism for reprsenting the object information.

• BMB Reports
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• v.53 no.10
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• pp.539-544
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• 2020

Skin aging appears to be the result of overlapping intrinsic (including genetic and hormonal factors) and extrinsic (external environment including chronic light exposure, chemicals, and toxins) processes. These factors cause decreases in the synthesis of collagen type I and elastin in fibroblasts and increases in the melanin in melanocytes. Collagen Type I is the most abundant type of collagen and is a major structural protein in human body tissues. In previous studies, many products containing collagen derived from land and marine animals as well as other sources have been used for a wide range of purposes in cosmetics and food. However, to our knowledge, the effects of human collagen-derived peptides on improvements in skin condition have not been investigated. Here we isolate and identify the domain of a human COL1A2-derived protein which promotes fibroblast cell proliferation and collagen type I synthesis. This human COL 1A2-derived peptide enhances wound healing and elastin production. Finally, the human collagen alpha-2 type I-derived peptide (SMM) ameliorates collagen type I synthesis, cell proliferation, cell migration, and elastin synthesis, supporting a significant anti-wrinkle effect. Collectively, these results demonstrate that human collagen alpha-2 type I-derived peptides is practically accessible in both cosmetics and food, with the goal of improving skin condition.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4279-4282
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• 2013

Background: The activation and inactivation of receptor tyrosine kinases are tightly regulated to ensure faithful replication of cells. After having transduced extracellular growth activating signals, activated EGFR is subjected to downregulation either by clathrin mediated endocytosis or c-Cbl mediated proteasome degradation depending on the ligand concentration. c-Cbl is an ubiquitin ligase which requires a phosphorylated tyrosine residue at position 1045 in the cytoplasmic domain of EGFR to interact and add ubiquitin molecules. While activating mutations in exons 19 and 21 have been associated with the development of several cancers, the status of mutations at tyrosine 1045 coding exon 27 of EGFR remain to be investigated. Consistently, defective phosphorylation at 1045 has been associated with sustained phosphorylation of EGFR in non-small lung carcinomas. Hence in the present study we investigated the genetic status of the tyrosine 1045 coding site within exon 27 of EGFR gene to explore for possible occurrence of mutations in this region, especially since no studies have addressed this issue so far. Materials and Methods: Tumor chromosomal DNA isolated from thirty five surgically excised oral squamous cell carcinoma tissues was subjected to PCR amplification with intronic primers flanking the tyrosine 1045 coding exon 27 of EGFR gene. The PCR amplicons were subsequently subjected to direct sequencing to elucidate the mutation status. Results: Sequence analysis identified no mutations in the tyrosine 1045 codon of EGFR in any of the thirty five samples that were analyzed. Conclusions: The lack of identification of mutation in the tyrosine 1045 codon of EGFR suggests that mutations in this region may be relatively rare in oral squamous cell carcinomas. To the best of our knowledge, this study is the first to have explored the genetic status of exon 27 of EGFR in oral squamous cell carcinoma tissue samples.

• The Journal of the Acoustical Society of Korea
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• v.20 no.3
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• pp.76-82
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• 2001

Most fluid machines can be considered as periodic noise sources when operated under constant conditions, which allows for a frequency domain representation of the source and the associated acoustic field In the duct. In such a representation, the source is characterized by frequency-dependent values of both strength and impedance. Although knowledge of these values can be gained by either experimentation or by modeling, one-port acoustic characteristics of an in-duct source with high flow velocity, high temperature, and high sound level can be measured only by the multiload method using an overdetermined set of open pipes with different lengths as applied loads. However, the problem is that negative source resistances have been often measured. This paper reviews the possible causes of the problem, with reference to experimental and theoretical results, in an attempt to clarify the issue. A new interpretation is given for the violation of basic assumptions and the defect in the algorithm of multiload method. The major cause and mechanism of the problem is due to the violation of time invariance assumption of the source and the load impedance can seriously affect the final measured result of source impedance.

• Research in Community and Public Health Nursing
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• v.15 no.1
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• pp.36-43
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• 2004

Purpose: The main objective of this study was to develop a continuing education program for school health nurses using the Internet, and evaluate the satisfaction of users. Method: A survey using a self reported questionnaire was done to identify areas where education is needed. A stratified random sampling method was employed to select 1.746 school health nurses and to receive the respondings from 584 school health nurses. The contents of the module for the education program were determined to be counseling and teaching techniques to meet health care needs related to sex, and cessation of smoking. The researchers wrote the educational content for the program, and the storyboards and illustrations appropriate to the module were constructed and the domain was registered. The web site was named 'www.healthyyouth.org'. Results: Three topics were identified where education is needed: youth and sex, youth and smoking, and counseling techniques for children, and programs were developed under the web site named. 'www.healthyyouth.org'. Over 90 percent of the respondents reported that the web site was useful and 100 percent reported that they would recommend the web site to other school health nurses. Conclusion: The web based program allowed school health nurses to study and improve their health care knowledge and skills. Since almost all schools in Korea have personal computers in the infirmary, accessibility to the program is excellent. Based on the results of this study, this type of education program will be a useful method for the continuing education of school health nurses.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.44 no.1
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• pp.76-84
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• 2007

The goal of this paper is to improve the watermarking performance using the following two methods; watermark estimation and low density parity check (LDPC) codes. For a blind watermark decoding, the power of a host image, which is hundreds times greater than the watermark power, is the main noise source. Therefore, a technique that can reduce the effect of the power of the host image to the detector is required. To this end, we need to estimate watermark from the watermarked image. In this paper, the watermark estimation is done by an adaptive estimation method with the generalized Gaussian distribution modeling of sub-band coefficients in the wavelet domain. Since the watermark capacity as well as the error rate can be improved by adopting optimum decoding principles and error correcting codes (ECC), we employ the LDPC codes for the decoding of the estimated watermark. Also, in LDPC codes, the knowledge about the noise power can improve the error correction capability. Simulation results demonstrate the superior performance of the proposed algorithm comparing to LDPC decoding with other estimation-based watermarking algorithms.

• Journal of the Korean earth science society
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• v.30 no.1
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• pp.81-95
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• 2009

The purpose of this study wasto analyze the factors that enhance their learning achievement in a fieldtrip environment. For this academic goal, we analyzed a pattern of fieldtrip-related perception and attitudes of 19 science-talented students who participated in the 2007 KESO winter school. As for the perception type, the result of analysis showed that the science-talented students understood a fieldtrip as an experimental inquiry from an inquiry perspective, and that their understanding about a fieldtrip was based on anthropocentrism, positivism and instrumentalism from a science philosophy perspective. Regarding theattitudes type, the result revealed that the purpose of the winter school was mainly to learn knowledge in earth science, and that there was a significant tendency for the participating students to become a future scientist more eagerly than their parents expected. Students' fieldtrip-related academic self-concept was mostly positive while the participants experienced both positive and negative emotions.

• The Journal of the Acoustical Society of Korea
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• v.13 no.1
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• pp.71-83
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• 1994

This paper deals with the improvement of the synthesized speech quality and naturality in the Korean TTS(Text-to-Speech) system. We had extracted the parameters(table2) such as its amplitude, duration and pitch period in a syllable through the analysis of speech waveforms(table1) in the time domain and synthesized syllables using them. To the frequencies of the Korean pronunciation large vocabulary dictionary we had synthesized speeches selected 229 syllables such as V types are 19, CV types are 80. VC types are 30 and CVC types are 100. According to the 4 Korean syllable types from the data format dictionary(table3) we had tested each 15 syllables with the objective MOS(Mean Opinion Score) evaluation method about the 4 items i.e., intelligibility, clearness, loudness, and naturality after selecting random group without the knowledge of them. As the results of experiments the qualities of them are very clear and we can control the prosodic elements such as durations, accents and pitch periods (fig9, 10, 11, 12).

• Mycobiology
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• v.47 no.4
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• pp.473-482
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• 2019

Rice blast disease, caused by the ascomycete fungus Magnaporthe oryzae, is one of the most important diseases in rice production. PAS (period circadian protein, aryl hydrocarbon receptor nuclear translocator protein, single-minded protein) domains are known to be involved in signal transduction pathways, but their functional roles have not been well studied in fungi. In this study, targeted gene deletion was carried out to investigate the functional roles of the PAS-containing gene MoPAS1 (MGG_02665) in M. oryzae. The deletion mutant ΔMopas1 exhibited easily wettable mycelia, reduced conidiation, and defects in appressorium formation and disease development compared to the wild type and complemented transformant. Exogenous cAMP restored appressorium formation in ΔMopas1, but the shape of the restored appressorium was irregular, indicating that MoPAS1 is involved in sensing the hydrophobic surface. To examine the expression and localization of MoPAS1 in M. oryzae during appressorium development and plant infection, we constructed a MoPAS1:GFP fusion construct. MoPAS1:GFP was observed in conidia and germ tubes at 0 and 2 h post-infection (hpi) on hydrophobic cover slips. By 8 hpi, most of the GFP signal was observed in the appressoria. During invasive growth in host cells, MoPAS1:GFP was found to be fully expressed in not only the appressoria but also invasive hyphae, suggesting that MoPAS may contribute to disease development in host cells. These results expand our knowledge of the roles of PAS-containing regulatory genes in the plant-pathogenic fungus M. oryzae.