• 대한약리학회지
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• 제19권1호
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• pp.93-99
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• 1983

Hydrocortisone 5 mg/kg which exerts minimal effect on the renal function and furosemide 1 mg/kg which induces moderate amount of diuresis were injected intraperitoneally to study their effects on the renal cyclic nucleotides content in rats. 1) The renal tissue levels of cAMP were significantly increased by administration of hydrocortisone, but there was no significant change in the furosemide group compared with that of saline treated control group. Moderate elevation in renal cAMP level was noted by the combined administration of hydrocortisone and furosemide, but this elevation was less than that of hvdrocortisone treated group. 2) The renal cGMP level did not show nay remarkable change after the administration of hydrocortisone, however, there were a significant increase by the administration of furosemide alone or combination of both drugs. The level of renal cGMP was higher and maintained longer in the combined treated group than furosemide treated group. The result of this experiment indicates that the potentiating effect of hydrocortisone on the diuretic action of furosemide nay be related to the renal levels of cGMP rather than that of cAMP.

• 대한수의학회지
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• 제36권1호
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• pp.65-74
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• 1996

Atrial Natriuretic Peptide(ANP) is a hormone with potent natriuretic, diuretic and relaxing properties of vascular smooth muscle. Specific chemical modulator responsible for the ANP secretion has not yet been found. Although atrial stretch of stretch-release is to be a major stimulus for the secretion of ANP, the precise mechano-molecular transduction mechanism responsible for its evoked secretion remains to be elucidated. It is interested to clarify the effect of superoxide anion in the stretch-induced ANP secretion. In order to investigate the effectg of $H_2O_2$ in the regulation of ANP secretion, a perfused model of left atrium of rats was used. The results obtained were as follows; 1. The ANP secretion and the extracellular fluid(ECF) translocation were accentuated by the effect of repetitive atrial distension-reduction volume at atrial pressure($4cmH_2O$). 2. The dilution curve showed to be in parallel between pure atriopeptin III (AP III) and perfusated buffer. 3. $H_2O_2(5{\times}10^{-4}M)$ accenturated a strectch-release induced increase of the ANP secretion. The amount of released ANP was significantly(p<0.01) increased. These results suggest that the superoxide anion may be involved in the regulatory mechanism of mechanically activated ANP release.

• 약학회지
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• 제26권4호
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• pp.197-208
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• 1982

In this study attemps were made to obtain evidence as to the action of Mori Radicis Cortex on the renal' function of anesthetized mongrel dogs. 1. A light brown powder isolated from Mori Radicis Cortex (MRC) by a slight modification of Tanemura's method, when given intravenously in doses ranging 0.5 to 5.0mg/kg, elicited diuresis with the increase of positive water clearance and amounts of $Na^{+}$ and $K^{+}$ excreted in the urine. At this time the glomerular filtration rate, renal plasma flow and osmolar clearance were not observed to have any significant changes. This diuresis was augmented in process of time and its maximum effect was exhibited about 30 minutes after administration of MRC. 2. The MRC, when administered into a intra carotid artery, responded promptly with diuresis and natriuresis at a level too small to effect renal functions when administered intravenously. In this experiment the patterns of changes of renal function were the patterns of changes of renal function were the same as those of the above intravenously administered experiment. 3. When infused directly into a renal artery, the MRC exhibited little effect on either kidney. 4. During water diuresis, the MRC did not elicit diuretic action or significant changes in renal functions. The above observations suggest that the diuresis of MRC is brought about by the inhibition of the release of antidiuretic hormone with the mechanism facilitating the excretion of $Na^{+/}$ and $K^{+}$ in urine.

• Biomolecules & Therapeutics
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• 제4권2호
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• pp.174-183
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• 1996

The general pharmacological properties of Artemisia extract powder (DA-9601) produced from Artemisia asiatica leaves were investigated in mice, rats, guinea pigs and rabbits. DA-9601 at the dose of 800 mg/kg po had no influences on general behaviour, barbital sleeping time and motor coordination of mice. The material at the oral dose of 800 mg/kg did exhibit neither analgesic action nor hypothermic effect. Anticonvulsant action, muscle relaxant action and the effect on intestinal propulsion were not identified at 800 mg/kg po. In the isolated ileum and trachea of guinea pig, the material did not show direct erect and inhibitory action of chemically or electrically stimulated contraction at the concentration of $2\times10^{-5}$g/ml. The sinus rates of atria and contractility of papillary muscle of guinea pig were not influenced by DA-9601 at a dose of $2\times10^{-5}$g/ml. No influences on blood pressure and respiration were observed at 40 mg/kg iv, in rabbits. However, transient decreases in blood pressure of rabbits were observed as given 120 mg/kg in iv route with slight respiratory depression, and slight diuretic effect could be found without any changes in $Na^+$ and $K^+$ excretion.

• 한국작물학회지
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• 제41권spc1호
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• pp.46-68
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• 1996

The objective of this report is to review the up to present papers including 79 references about functional ingredients in maize and their variations. Maize is a good source of such antioxidants as ${\alpha}-,\;{\gamma}-tocopherols,\;{\alpha}-,\;{\beta}-carotene,\;{\beta}-cryptoxanthin$, zeaxanthin, quercetin and chlorogenic acid. Unsaponifiable standard extracts of Zea mays L. (ZML) have a beneficial effect on various dental diseases. Flavonoids, flavonoid biosynthetic pathway and their controling genes were also reviewed in this report. Flavonoids are required for successful fertilization in maize pollen, and maysin has a potent antibiotic activities to earworm and fall armyworm in maize silks. Maize silks have been used in traditional medicine for diuretic, vascular diseases and diabetes, etc. and boiling water extracts of maize silk have hemodynamic effects, but their ingredients still remain obscure.

• 생약학회지
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• 제19권2호
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• pp.102-110
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• 1988

The pharmacological activities on water extracts of Cortex, Ramulus and Folium from the Eucommia ulmoides Oliver were studied, and the following results were observed. The vasodilative action on the rabbit ear blood vessel was recognized in the Cortex, Ramulus and Folium. The spontaneous motility and the contraction induced by Ach., $BaCl_2$ and histamine in the isolated ileum of mice were suppressed and inhibited in the Ramulus only. On the contrary, the analgesic and anti-inflammatory activities were noted in the Cortex and Folium. Furthermore, the hypotensive effect was recognized in the Folium. The diuretic, bile secretory and anti-fatigue effects were shown in the Cortex and Folium.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.68-68
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• 2003

Herbchoke solution produced by Choa pharmaceutical company contained pyroligneous liquid and extracts from artichoke leaves. Pyroligneous liquid is produced by process carbonizing Oak in 350∼400$^{\circ}C$. It contain water 96%, acetic acid 3% and organic compound 1%. There are 200 kinds of constituents including minerals, vitamin B-complex and organic acids in it. The organic acids of them were presumed as active materials. It is traditionally used for treatment of stress related disorder, hepatic disease, immune disorder, G-I disorder and inflammatory disease. Extracts from artichoke leaves are traditionally used for treatment of stress related disorder, that is, hepatic disease, dyspeptic disorder, hyperlipidemic disorder and diuretic disorder. The aim of this study was to investigate anti-stress effects of Hervchoke juice produced from Choa pharmaceutical company.

• 사상체질의학회지
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• 제2권1호
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• pp.213-221
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• 1990

Effect of Jeo Ryong-Tang water Extract on Renal Function in Rabbit and Dog. In order to investigate the Pharmacological action of Jeo Ryoung-Tang on renal function, this study was performed in rabbit and dog, making use of it's water extract. Jeo Ryoung-Tang water extract (JRWE), when given into ear vein of rabbits, produced diuresis in a small dose, but antidiuresis in a large dose. Diuretic action of JRWE accompanied the increase of glomerular filtration rate (GFR), renal plasma flow (RPF) and amounts of $Na^+$ in exdreated in urin, but fractional excretion of filtered $Na^+$ was not changed. JRWE, when injected into proleg's vein of dog, produced diuresis, At this time, changes of renal function were similar to that of diuresis in rabbit. JRWE, when infused into a renal artery of dog, exhibited the diuresis in both kidney. It is thought that JRWE, when given into vein of rabbit or dog, induces the diuresis, and the mechanism of it's diuresis is the increase of renal plasma flow through secondary action by some endogenous humoural substance.

• 대한약리학회지
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• 제2권1호
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• pp.5-12
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• 1966

In this study the influence of Bradykinin, a biogenic polypeptide, on the excretory function of the dog kidney was investigated, utilizing the clearance and stop-flow method. The results are summarized as follows; 1) Bradykinin administered intravenously elicited a marked antidiuresis. 2) When given into the renal artery, however, prompt increase of the urine flow, sodium excretion and free water clearance without significant change in the glomerular filtration rate ensued. 3) It was also effective during an osmotic diuresis with 10% Mannitol infusion, though the response was not so marked. 4) The stop-flow experiment showed that sodium reabsorption in the proximal tubules is inhibited by the infusion of bradykinin into the renal artery. It was thus concluded that the diuretic effect of bradykinin given intra-arterially results from the inhibition of sodium transport in the proximal tubules.

• 약학회지
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• 제28권3호
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• pp.149-160
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• 1984

In order to certify the diuretic mechanism of dopamine, this study was performed in dog. The following results were obtained. Dopamine, when given intravenously, produced diuresis, and increased glomerular filtration rate (GFR), renal plasma flow (RPF), and amount of sodium excreted in urine. When infused directly into a renal artery, dopamine elicited a marked diuresis confined only to the infused side, with concomitant rises in osmolar clearance and sodium excretion as well as a slight increase in free water clearance. Simultaneously total renal plasma flow and medullary plasma flow increased markedly with a increase of glomerular filtration rate and renal plasma flow. Medullary concentration gradient of sodium also markedly lowered in the infused kidney. These changes were not observed during mannitol diuresis and renal action of dopamine were not apparent in dog pretreated with haloperidol. From the above experimental results, it is thought that dopamine, when given into a vien or infused directly into a renal artery, induces diuresis, and the mechanism of its action is due to dual actions which are hemodynamic effect along with glomerular filtraction rate, and the increased response in the medullary blood flow.