• Korean Journal of Pharmacognosy
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• v.33 no.3 s.130
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• pp.187-190
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• 2002

Three diterpene alkaloids, songorine (1), neoline (2), N-deethylneoline (3), were isolated from Kyong-Po Buja (Processed Aconitium carmichaeli, Ranunculaceae) which was used as Chinese traditional medicine with analgesic, anti-inflammatory and cardiotonic activity. Their structures were established by chemical and spectroscopic methods.

• Korean Journal of Pharmacognosy
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• v.25 no.4 s.99
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• pp.319-327
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• 1994

A new diterpene, agastanol[1] with dehydroagastol[2] was isolated from th root of Agastache rugosa, and their structures were elucidated by chemical and instrumental analysis. Agastanol[1], its derivatives, agastanone[3] and methylagastanol[5], and dehydroagastol[2] showed cytotoxic activites against in vitro human cancer cell lines. Agastanol[1] showed weak antifungal activity against Trichophyton rubrum.

• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.3
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• pp.459-465
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• 1995

The ether extract of Salviae miltiorrhizae Radix(SMR) was fractioned to give five subfractions, so that two subfractions of them were recrystallized to yield each pure diterpene quinone pigment. On the basis of spectral evidence, these two compounds were identified as tanshinone II and crytotanshinone. Cryptotanshinone exhibited both of a potent platelet anti-aggregating activity in vitro and a potent antimicrobial activity. GC-MS analysis of the other extract showed that tanshinone II was contained in the largest proportion of all the diterpene quinones. In addition, GC-MS analysis gave other valuable analytical informations.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.2
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• pp.520-523
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• 2005

(R)-(-)-PGME amide of diterpene acid (2) was assigned the absolute configuration from NMR correlation experiments. The compound (2) was tested for its growth inhibitory effects against tumor cell lines by the MTT method.

• Archives of Pharmacal Research
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• v.22 no.2
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• pp.225-227
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• 1999

A new acylcic deterpene (1) and a known acyclic diterpene 12(S)-hydroxygeranyleraniol (2) were isolated form the aerial parts of Carpesium divaricatum. The structure of 1 was determined to be (2E, 10E)-1, 12-dihydroxy-18-acetoxy-3,7,15-trimethylhexadeca-2,10,14-triene (1) on the basis of spectroscopic studies. Compounds 1 and 2 exhibited cytotoxicity against cultured human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and $HCT_{15}$, with $ED_{50}$ values ranging from 4.3-10.2 ${\mu}g/ml$ and 4.1-8.3 ${\mu}g/ml$, respectively.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.140.1-140.1
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• 2003

The diterpene acid 1 was isolated from the roots of Anisotome lyallii(Apiaceae/Umbelliferae). The structure of the compound was elucidated as anisotomenoic acid 1 on the basis of spectroscopic method. This compound was evaluated against p388 murine leukaemia and B16/F10 melanoma cells.

• Korean Journal of Pharmacognosy
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• v.15 no.2
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• pp.108-113
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• 1984

The structure of tuguaconitine, MP $196{\sim}198^{\circ}C$, a new diterpene alkaloid isolated from the roots of Aconitum sibiricum P., was studied. Its empirical formula is $C_{23}H_{35}NO_7$ and spectroscopic evidence shows that the base contains three methoxyl, three hydroxyl and one N-ethyl groups. The acute toxicities of most of Aconitum species were strong and the acute toxicity of the alkaloid fraction of A. sibiricum was decreased by Glycyrrhizae, black bean or Zingiberis extract.

• Korean Journal of Pharmacognosy
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• v.11 no.2
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• pp.61-65
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• 1980

As a folkloric medicine, Siegesbeckia pubescens has been used for treatment of brain stroke and hypertension. Diterpene compound, 16,17-dihydroxy 16-${\beta}-(-)$ kaurane-19-oic acid, was isolated from the plant. Its potential antihypertensive activity was evaluated againstan animal model of hypertension, Okamoto-SHR. When diterpene compound with dose of 50mg/kg/day was orally administered, it exhibited mild antihypertensive activity comparable with propranolol administration dose of 75mg/kg/day.

• KSBB Journal
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• v.8 no.2
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• pp.122-125
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• 1993

Taxol is the promising diterpene alkaloid with antineoplastic activities. The taxol content in various parts of yew trees in Korea, Mt. Deokyu, Mt. Sobaek, Mt. Taebaek and Suwon area, have been determined. The highest taxol content was observed in yew trees of Mt. Soback. In various parts of trees the taxol content in bark was highest and the taxol content in twig was higher than that in leaves.

• Korean Journal of Pharmacognosy
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• v.4 no.4
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• pp.205-207
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• 1973

A component $F,\;C_{20}H_{30}O_4,\;M^+\;(m/e)\;334,\;mp\;258{\sim}260^{\circ},\;[{\alpha}]D=-133.25^{\circ}\;(C=0.2,\;EtOH)$, was isolated from Siegesbeckia pubescens $M_{AKINO}$. This compound was identified as $16{\beta}-(-)-kauran-17$, 19-dioic acid, using spectroscopies and synthesizing various derivatives of the compound F.