• Title/Summary/Keyword: distribution modeling

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Composite model for seawater intrusion in groundwater and soil salinization due to sea level rise (해수면 상승으로 인한 지하수 해수침투 및 토양 염류화 합성 평가모델)

  • Jung, Euntae;Park, Namsik;Cho, Kwangwoo
    • Journal of Korea Water Resources Association
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    • v.50 no.6
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    • pp.387-395
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    • 2017
  • Sea level rise, accompanied by climate change, is expected to exacerbate seawater intrusion in the coastal groundwater system. As the salinity of saturated groundwater increases, salinity can increase even in the unsaturated soil above the groundwater surface, which may cause crop damage in the agricultural land. The other adverse impact of sea level rise is reduced unsaturated soil thicknesses. In this study, a composite model to assess impacts of sea level rise in coastal agricultural land is proposed. The composite model is based on the combined applications of a three dimensional model for simulating saltwater intrusion into the groundwater and a vertical one dimensional model for simulating unsaturated zone flow and transport. The water level and salinity distribution of groundwater are calculated using the three dimensional seawater intrusion model. At some uppermost nodes, where salinity are higher than the reference value, of the 3D mesh one dimensional unsaturated zone modeling is conducted along the soil layer between the ground water surface and the ground surface. A particular location is judged salinized when the concentration at the root-zone depth exceeds the tolerable salinity for ordinary crops. The developed model is applied to a hypothetical agricultural reclamation land. IPCC RCP 4.5 and 8.5 scenarios were used as sea level rise data. Results are presented for 2050 and 2100. As a result of the study, it is predicted that by 2100 in the climate change scenario RCP 8.5, there will be 7.8% increase in groundwater saltwater-intruded area, 6.0% increase of salinized soil area, and 1.6% in increase in water-logging area.

A Novel Suberoylanilide Hydroxamic Acid Histone Deacetylase Inhibitor Derivative, N25, Exhibiting Improved Antitumor Activity in both Human U251 and H460 Cells

  • Zhang, Song;Huang, Wei-Bin;Wu, Li;Wang, Lai-You;Ye, Lian-Bao;Feng, Bing-Hong
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.10
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    • pp.4331-4338
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    • 2014
  • $N^1$-(2, 5-dimethoxyphenyl)-$N^8$-hydroxyoctanediamide (N25) is a novel SAHA cap derivative of HDACi, with a patent (No. CN 103159646). This invention is a hydroxamic acid compound with a structural formula of $RNHCO(CH_2)6CONHOH$ (wherein R=2, 5dimethoxyaniline), a pharmaceutically acceptable salt which is soluble. In the present study, we investigated the effects of N25 with regard to drug distribution and molecular docking, and anti-proliferation, apoptosis, cell cycling, and $LD_{50}$. First, we designed a molecular approach for modeling selected SAHA derivatives based on available structural information regarding human HDAC8 in complex with SAHA (PDB code 1T69). N25 was found to be stabilized by direct interaction with the HDAC8. Anti-proliferative activity was observed in human glioma U251, U87, T98G cells and human lung cancer H460, A549, H1299 cells at moderate concentrations ($0.5-30{\mu}M$). Compared with SAHA, N25 displayed an increased antitumor activity in U251 and H460 cells. We further analyzed cell death mechanisms activated by N25 in U251 and H460 cells. N25 significantly increased acetylation of Histone 3 and inhibited HDAC4. On RT-PCR analysis, N25 increased the mRNA levels of p21, however, decreased the levels of p53. These resulted in promotion of apoptosis, inducing G0/G1 arrest in U251 cells and G2/M arrest in H460 cells in a time-dependent and dose-dependent manner. In addition, N25 was able to distribute to brain tissue through the blood-brain barrier of mice ($LD_{50}$: 240.840mg/kg). In conclusion, our findings demonstrate that N25 will provide an invaluable tool to investigate the molecular mechanism with potential chemotherapeutic value in several malignancies, especially human glioma.

Preliminary Estimation of Earthquake Losses Based on HAZUS in a Coastal Facility Area with Blocks Applying Site Classification (블록별 부지분류 적용 해안시설 영역에서의 HAZUS 기반 지진피해 추정)

  • Sun, Chang-Guk;Chun, Sung-Ho
    • Journal of the Korean Association of Geographic Information Studies
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    • v.17 no.4
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    • pp.10-27
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    • 2014
  • HAZUS-MH is a GIS-based computer program that estimates potential losses from multi-hazard phenomena: earthquakes, floods and hurricanes. With respect to seismic disaster, characteristics of a hypothetical or actual earthquake are entered into HAZUS. Then HAZUS estimates the intensity of ground shaking and calculates the correspondent losses. In this study, HAZUS was used as a part of the preparations of the future seismic events at a coastal plant facility area. To reliably characterize the target facility area, many geotechnical characteristics data were synthesized from the existing site investigation reports. And the buildings and facilities were sorted by analyzing their material and structural characteristics. In particular, the study area was divided into 17 blocks taking into account the situation of both land development and facility distribution. The ground conditions of blocks were categorized according to the site classification scheme for earthquake-resistant design. Moreover, seismic fragility curves of a main facilities were derived based on the numerical modeling and were incorporated into the database in HAZUS. The results estimated in the study area using HAZUS showed various seismic damage and loss potentials depending on site conditions and structural categories. This case study verified the usefulness of the HAZUS for estimating earthquake losses in coastal facility areas.

Assessment of Surface Boundary Conditions for Predicting Ground Temperature Distribution (지중온도 변화 예측을 위한 지표면 경계조건 검토)

  • Jang, Changkyu;Choi, Changho;Lee, Chulho;Lee, Jangguen
    • Journal of the Korean Geotechnical Society
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    • v.29 no.8
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    • pp.75-84
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    • 2013
  • Soil freezing is a phenomenon arising due to temperature difference between atmosphere and ground, and physical properties of soils vary upon the phase change of soil void from liquid to solid (ice). A heat-transfer mechanism for this case can be explained by the conduction in soil layers and the convection on ground surface. Accordingly, the evaluation of proper thermal properties of soils and the convective condition of ground surface is an important task for understanding freezing phenomenon. To describe convection on ground surface, simplified coefficient methods can be applied to deal with various conditions, such as atmospheric temperature, surface vegetation conditions, and soil constituents. In this study, two methods such as n-factor and convection coefficient for the convective ground surface boundary were applied within a commercial numerical program (TEMP/W) for modeling soil freezing phenomenon. Furthermore, the numerical results were compared to laboratory testing results. In the series of the comparison results, the convection coefficient is more appropriate than n-factor method to model the convective boundary condition.

An Exploratory Study for Identifying Key Factors in Online Games Development Strategy Utilizing Web Community (온라인게임 개발전략에 관한 탐색적 연구 : 게임 커뮤니티 활용을 중심으로)

  • Jung, Jai-Jin;Chang, Chung-Moo;Kim, Tae-Ung
    • The KIPS Transactions:PartD
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    • v.11D no.4
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    • pp.991-1002
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    • 2004
  • Online game business has emerged as the most lucrative entertainment industry, with over 20 million platers. The popularity of online games can be attributed to the presence of numerous PC Bangs around the country, which have pushed online games into the mainstream culture while broadband internet services facilitated online game play. The age distribution of online game players is expanding and a variety of new games are under development to target certain age groups. While the online game market continues to expand, with many new online game publishers entering the market, relatively little is known about which factors are strategically important for successful development of online games. A conceptual framework is proposed, and a structural equation modeling, for Identifying the factors affecting the market success of online games, is developed. The concept of online game community, idea generation, systematic development strategy, flexible development process, utilizing demo-version, outsourcing, etc, are ail introduced into the model, as the independent variables affecting the success level of online games directly and indirectly. Based on data collected from questionnaire survey, the validity of the model has been tested and interesting conclusions have been developed concerning the relationships between these variables. Statistical results show that utilizing online game community and system atic development strategy is the key for successful online game development. Other interesting results concerning game development strategy are also provided. It is hoped that this result might provide the useful guidelines for developing the successful online game contents. With a better understanding of key success factors, online game developers should be able to make adjustments in their development and marketing plans, providing them with a sustainable advantage over their competition.

Emerging P2P Traffic Analysis and Modeling (P2P 트래픽의 특성 분석과 트래픽 모델링)

  • 주성돈;이채우
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.29 no.2B
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    • pp.279-288
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    • 2004
  • Rapidly emerging P2P(Peer to Peer) applications generate very bursty traffic, which gives a lot of burden to network, and the amount of such traffic is increasing rapidly. Thus it is becoming more important to understand the characteristics of such traffic and reflect it when we design and analyze the network. To do that we measured the traffic in a campus network and present flow statistics and traffic models of the measured traffic, and compare them with those of the web traffic. The results indicate that P2P traffic is much burstier than web traffic and as a result it negatively affects network performance. We modeled P2P traffic using self-similar traffic model to predict packet delay and loss occurred in network which are very important to evaluate network performance. We also predict queue length distribution and loss probability in SSQ(Single Sewer Queue). To assess accuracy of traffic model, we compare the SSQ statistics of traffic models with that of the traffic trace. The results show that self-similar traffic models we use can predict P2P traffic behavior in network precisely. It is expected that the traffic models we derived can be used when we design network capacity and predict network performance and QoS of the P2P applications.

A Study on Analysis Technique for Chloride Penetration in Cracked Concrete under Combined Deterioration (복합열화에 노출된 균열부 콘크리트 내의 염화물 침투 해석 기법에 대한 연구)

  • Kwon, Seung-Jun;Song, Ha-Won;Byun, Keun-Joo
    • Journal of the Korea Concrete Institute
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    • v.19 no.3
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    • pp.359-366
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    • 2007
  • Recently, analysis researches on durability are focused on chloride attack and carbonation due to increased social and engineering significance. Generally, chloride penetration and carbonation occur simultaneously except for in submerged condition and chloride behavior in carbonated concrete is evaluated to be different from that in normal concrete. Furthermore, if unavoidable crack occurs in concrete, it influences not only single attack but also coupled deterioration more severely. This is a study on analysis technique with system dynamics for chloride penetration in concrete structures exposed to coupled chloride attack and carbonation through chloride diffusion, permeation, and carbonation reaction. For the purpose, a modeling for chloride behavior considering diffusion and permeation is performed through previous models for early-aged concrete such as MCHHM (multi component hydration heat model) and MPSFM (micro pore structure formation). Then model for combined deterioration is developed considering changed characteristics such as pore distribution, saturation and dissociation of bound chloride content under carbonation. The developed model is verified through comparison with previous experimental data. Additionally, simulation for combined deterioration in cracked concrete is carried out through utilizing previously developed models for chloride penetration and carbonation in cracked concrete. From the simulated results, CCTZ (chloride-carbonation transition zone) for evaluating combined deterioration is proposed. It is numerically verified that concrete with slag has better resistance to combined deterioration than concrete with OPC in sound and cracked concrete.

Analysis of Near Field for Base Station Panel Antenna(4 X 2 Dipole Array) (기지국용 판넬 안테나(4 X 2 Dipole Array)의 근역장 분석)

  • Lee, Dugro;Park, Ju-Derk;Choi, Jae-Ic;Kim, Nam
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.15 no.5
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    • pp.473-479
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    • 2004
  • In this paper, power density in near field is calculated about analytic object which has comparatively large volume in considering used wavelength such as cellular base station antenna. Panel sector antenna which is used widespreadly in domestic cellular wireless communication system is modeled and electromagnetic field distribution in reactive near field region is calculated by FDTD (Finite Difference Time Domain) method. After that, antenna gain in far field region is obtain by near to far transformation. Power spectral density in radiated near field is calculated in applying to gain-based model with antenna gain in far field. Finally, compliance distance is obtained in considering the result from radiated near field calculation and basic restrictions on occupational and general public exposure limits in ICNIRP guideline. In the center of main radiating position, the result from gain-based model is -14.55 ㏈m and the result from surface scanning method is -15.75 ㏈m. When the losses from cables and connectors used in measurement are considered, the results from gain-based model and surface scanning method are nearly coincident.

A Comparison of the Atmospheric CO2 Concentrations Obtained by an Inverse Modeling System and Passenger Aircraft Based Measurement (인버스 모델링 방법을 통해 추정된 대기 중 이산화탄소 농도와 항공 관측 자료 비교)

  • Kim, Hyunjung;Kim, Hyun Mee;Kim, Jinwoong;Cho, Chun-Ho
    • Atmosphere
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    • v.26 no.3
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    • pp.387-400
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    • 2016
  • In this study, the atmospheric $CO_2$ concentrations estimated by CT2013B, a recent version of CarbonTracker, are compared with $CO_2$ measurements from the Comprehensive Observation Network for Trace gases by Airliner (CONTRAIL) project during 2010-2011. CarbonTracker is an inversion system that estimates surface $CO_2$ fluxes using atmospheric $CO_2$ concentrations. Overall, the model results represented the atmospheric $CO_2$ concentrations well with a slight overestimation compared to observations. In the case of horizontal distribution, variations in the model and observation difference were large in northern Eurasia because most of the model and data mismatch were located in the stratosphere where the model could not represent $CO_2$ variations well enough due to low model resolution at high altitude and existing phase shift from the troposphere. In addition, the model and observation difference became larger in boreal summer. Despite relatively large differences at high latitudes and in boreal summer, overall, the modeled $CO_2$ concentrations fitted well to observations. Vertical profiles of modeled and observed $CO_2$ concentrations showed that the model overestimates the observations at all altitudes, showing nearly constant differences, which implies that the surface $CO_2$ concentration is transported well vertically in the transport model. At Narita, overall differences were small, although the correlation between modeled and observed $CO_2$ concentrations decreased at higher altitude, showing relatively large differences above 225 hPa. The vertical profiles at Moscow and Delhi located on land and at Hawaii on the ocean showed that the model is less accurate on land than on the ocean due to various effects (e.g., biospheric effect) on land compared to the homogeneous ocean surface.

Estimation of BDI Volatility: Leverage GARCH Models (BDI의 변동성 추정: 레버리지 GARCH 모형을 중심으로)

  • Mo, Soo-Won;Lee, Kwang-Bae
    • Journal of Korea Port Economic Association
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    • v.30 no.3
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    • pp.1-14
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    • 2014
  • This paper aims at measuring how new information is incorporated into volatility estimates. Various GARCH models are compared and estimated with daily BDI(Baltic Dry Index) data. While most researchers agree that volatility is predictable, they differ on how this volatility predictability should be modelled. This study, hence, introduces the asymmetric or leverage volatility models, in which good news and bad news have different predictability for future. We provide the systematic comparison of volatility models focusing on the asymmetric effect of news on volatility. Specifically, three diagnostic tests are provided: the sign bias test, the negative size bias test, and the positive size bias test. From the Ljung-Box test statistic for twelfth-order serial correlation for the level we do not find any significant serial correlation in the unpredictable BDI. The coefficients of skewness and kurtosis both indicate that the unpredictable BDI has a distribution which is skewed to the left and significantly flat tailed. Furthermore, the Ljung-Box test statistic for twelfth-order serial correlations in the squares strongly suggests the presence of time-varying volatility. The sign bias test, the negative size bias test, and the positive size bias test strongly indicate that large positive(negative) BDI shocks cause more volatility than small ones. This paper, also, shows that three leverage models have problems in capturing the correct impact of news on volatility and that negative shocks do not cause higher volatility than positive shocks. Specifically, the GARCH model successfully reveals the shape of the news impact curve and is a useful approach to modeling conditional heteroscedasticity of daily BDI.