• Journal of Veterinary Clinics
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• v.34 no.5
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• pp.392-395
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• 2017

A 2-year-old miniature poodle dog was referred to Seoul Animal Clinic for assessment of traumatic ocular lesion by cat claw. Corneal perforation accompanied by hyphema following iridal laceration was observed in the left eye. Topical antibiotics, mydriatics and systemic antibiotics/steroids were applied to treat severe uveitis with miosis and fibrinous exudate. Although lenticular lesion was explored after mydriasis, it was obscured by severe corneal edema around corneal perforation. Despite aggressive treatments, the uveitis became more serious in the next day. To prevent septic implantation syndrome from anterior lens capsule disruption, phacoemulsification surgery was performed. The anterior lens capsule disruption was detected during continuous curvilinear capsulorhexis. The left eye remained the vision with mild posterior capsule opacification and intermittent conjunctival hyperemia during seven-month follow-up.

• The Plant Pathology Journal
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• v.32 no.3
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• pp.173-181
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• 2016

Gene disruption by homologous recombination is widely used to investigate and analyze the function of genes in Fusarium fujikuroi, a fungus that causes bakanae disease and root rot symptoms in rice. To generate gene deletion constructs, the use of conventional cloning methods, which rely on restriction enzymes and ligases, has had limited success due to a lack of unique restriction enzyme sites. Although strategies that avoid the use of restriction enzymes have been employed to overcome this issue, these methods require complicated PCR steps or are frequently inefficient. Here, we introduce a cloning system that utilizes multi-fragment assembly by In-Fusion to generate a gene disruption construct. This method utilizes DNA fragment fusion and requires only one PCR step and one reaction for construction. Using this strategy, a gene disruption construct for Fusarium cyclin C1 (FCC1), which is associated with fumonisin B1 bio-synthesis, was successfully created and used for fungal transformation. In vivo and in vitro experiments using confirmed fcc1 mutants suggest that fumonisin production is closely related to disease symptoms exhibited by F. fujikuroi strain B14. Taken together, this multi-fragment assembly method represents a simpler and a more convenient process for targeted gene disruption in fungi.

• Journal of Korean Neurosurgical Society
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• v.50 no.1
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• pp.45-47
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• 2011

Abnormal contrast enhancement on brain computed tomography (CT) scan after diagnostic or interventional angiography is not rare, and has known to be induced by temporary blood-brain barrier (BBB) disruption from contrast media. Furthermore, it has been regarded as clinically subtle, but reported to have no symptom or mild transient symptoms. However, we recently experienced two cases of serious BBB disruption during the acute period after coiling of an unruptured intracranial aneurysm. One patient presented with an unruptured paraclinoid internal carotid artery (ICA) aneurysm on the right and the other with an unruptured right supraclinoid ICA aneurysm. Both patients showed similar findings on immediate postembolization CT scan and clinical courses after coiling. Typical radiological, clinical characteristics of BBB disruption were described. In addition, the role of immediate postembolization CT scan are also discussed.

• Journal of Korean Neurosurgical Society
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• v.48 no.6
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• pp.524-527
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• 2010

Temporary disruption of the blood-brain barrier (BBB) after cerebral angiography is presumably caused by nonionic radiographic contrast medium (CM). We hereby report a case of 58-year-old woman who developed decreased mentality, global aphasia and aggravated right hemiparesis after cerebral angiography. Brain CT examination demonstrated gyriform enhancement throughout the left cerebral cortex and thalamus. MR diffusion did not reveal acute infarction. MR angiography did not show any stenosis, spasm or occlusion at the major cerebral vessels. Follow-up CT scan after 1 day did not show any gyriform enhancement. Worsened neurologic signs and symptoms were improved completely after 7 days. In the present study, disruption of the BBB with contrast medium after angiography seems to be the causative factor of transient neurologic deterioration.

• Industrial Engineering and Management Systems
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• v.12 no.2
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• pp.74-84
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• 2013

Modern companies have been facing devastating impacts from unexpected events such as demand uncertainties, natural disasters, and terrorist attacks due to the increasing global supply chain complexity. This paper proposes a multi stage logistic network model under disruption risk. To formulate the problem practically, we consider the effect of continuity rate, which is defined as a percentage of ability of the facility to provide backup allocation to customers in the abnormal situation and affect the investments and operational costs. Then we vary the fixed charge for opening facilities and the operational cost according to the continuity rate. The operational level of the company decreases below the normal condition when disruption occurs. The backup source after the disrup-tion is recovered not only as soon as possible, but also as much as possible. This is a concept of the business continuity plan to reduce the recovery time objective such a continuity rate will affect the investments and op-erational costs. Through numerical experiments, we have shown the proposed idea is capable of designing a resilient logistic network available for business continuity management/plan.

• Journal of Distribution Science
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• v.19 no.11
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• pp.59-68
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• 2021

Purpose: The Covid-19 pandemic has had excessively severe impacts on all the nodes and edges of any supply chain due to changes in consumer behaviours and lockdown restrictions from governments among countries. This article aims to provide a simulating experiment on how a supply chain deals with supply disruption risks by flexibility in the inventory level of each sector as a buffer considering the overall cost to fulfil demand in the market. Research design, data and methodology: Agent-based simulation techniques are used to determine the cost-efficiency and customer waiting time related to varying inventory levels of each member in the supply chain when using inventory buffers. Findings: This study has shown that any sudden changes in the inventory level of each sector are likely to impact the rest of the supply chain. Among all sectors, the wholesaler will be impacted more severely than others. Also, the manufacturing sector is the most suitable node to adjust inventory depending on its manufacturing ability. Conclusion: The findings of the study provide insightful implications for decision-makers to adjust inventory levels and policymakers to maintain manufacturing activities in the context of the pandemic restrictions to deal with the excessive demand and potential supply disruption risks.

• Journal of Distribution Science
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• v.20 no.12
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• pp.89-98
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• 2022

Purpose: Due to the rapid growth of e-commerce in Thailand, the operational excellence of distribution service providers has been elevated. Thus, this research investigated the key drivers of operational performance of e-commerce distributors in Thailand. The research contains key variables: the analytics capabilities of an organization, supply chain disruption orientation, innovation capability, and operational performance. Research design, data, and methodology: An online survey is administered to top managers and key personnel (N=425) employed for at least one year in Thailand's top five e-commerce distributors. The sampling methods were conducted using purposive sampling, quota sampling, and convenience sampling. Confirmatory Factor Analysis and Structural Equation Model were applied to analyze and confirm the model's goodness-of-fit and hypothesis testing. Results: The findings reveal that an organization's analytics capabilities significantly affect supply chain disruption orientation and supply chain resilience. Furthermore, operational performance is affected by supply chain disruption, supplier quality management, and innovation capability. Nevertheless, supply chain resilience and digital supply chain have no significant effect on operational performance. Conclusions: The results imply that supply chain digitalization could drive higher operational performance. Distribution businesses are encountering transformation and disruption, which should address the high level of a digital supply chain, innovation, and quality management to maximize their profit margin and delivery service quality.

• Korean Journal of Childcare and Education
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• v.17 no.4
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• pp.73-91
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• 2021

Objective: This study focused on the relationships between emotionality, social competence and play behavior in a sample of 218 4- to 5-year olds attending daycare centers. Methods: All variables were measured by the daycare teachers of the surveyed children. The data were analyzed using Simple Regression and Multiple Regression through SPSS Win 25.0. Results: First, preschoolers' positive emotionality had a negative effect on their play disruption and play disconnection and a positive effect on play interaction. On the other hand, their negative emotionality had a positive effect on play disruption and play disconnection and a negative effect on play interaction. Second, their positive emotionality had a positive influence on social competence and their negative emotionality had a negative influence. Finally, the effect of their positive emotionality on play disruption was partially mediated, and their play disconnection and play interaction was totally mediated by social competence. On the other hand, the effect of preschoolers' negative emotionality on play disruption and play disconnection was totally mediated, and their play interaction was partially mediated by social competence. Conclusion/Implications: The results of this study imply that we need to help preschoolers promote emotionality and social competence together to change their play behavior positively.

• Journal of Korean Dental Hygiene Science
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• v.4 no.2
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• pp.67-75
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• 2021

Background: Workers' oral health problems result in work disruption, including absenteeism or early leave, which reduces work efficiency. This study was conducted to investigate the subjective oral health status and oral problems of workers,and to identify the factors disrupting workflow due to oral problems. Methods: A self-report questionnaire was administered to 300 industrial workers in a metropolitan area. A total of 284 individuals were finally analyzed, after excluding the data of 16 workers who had missing responses among the recovered questionnaires. Results: Subjective oral health status was average in 44.4%, healthy in 32.0%, and unhealthy in 16.9% of the study population. Subjective oral health problems were the highest in the order of food impaction(28.9%), cavity(26.8%), tooth sensitivity (22.9%), and calculus(21.1%). However, sudden and unexplained tooth pain (12.0%), gum swelling and tooth mobility (10.2%), and wisdom tooth pain (4.9%) were relatively low. The average monthly income (p<.05) and subjective oral health status (p<.01) were statistically significant factors interrupting workflow. Conclusion: To minimize workers' oral health problems and work disruption due to oral diseases, it is necessary to promote workers' oral health and oral disease prevention programs within the workplace.

• International conference on construction engineering and project management
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• 2011.02a
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• pp.340-349
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• 2011

During the negotiation and resolution of delay and disruption disputes on construction projects, the use and misappropriation of float, and the question of float ownership, are considered to be a major concern to those involved. Most practitioners and authors are of the opinion that it is an issue that should be clearly defined and addressed within the provisions of the contract. However, the terms "float" or "ownership of float" are rarely mentioned (if at all) in most of the standard forms of Australian construction contracts, giving little guidance to those involved as to how this issue should be addressed. In October 2002 the United Kingdoms Society of Construction Law (SCL) published a Delay and Disruption Protocol (the Protocol) that contains a suggested approach to the issue. The aim of this research was to obtain an Australian opinion of the suitability of the SCL's Delay and Disruption Protocols suggested approach to the issue of float and ownership of float for use by the Australian construction industry. Qualitative interviews were carried out with Australian construction industry experts experienced in the administration, negotiation, and resolution of delay and disruption disputes to obtain their opinions of the suitability of the SCL's proposed approach. Results indicate general confusion and uncertainty as to how the issue of float and float ownership should be addressed in general, with the SCL's approach adding further to that confusion.