• Title/Summary/Keyword: disease pattern

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Spatial and Temporal Features of Motor Modules in an individual with Hemiparesis During the Curvilinear Gait: A Pilot Single-Case Study

  • LEE, Jae-Hyuk
    • Journal of Wellbeing Management and Applied Psychology
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    • v.5 no.1
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    • pp.1-7
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    • 2022
  • Purpose: This study aimed to investigate spatial and temporal features of motor control in an individual with hemiparesis during the curvilinear gait (CG) and proposed an exercise guideline. Research design, data and methodology: An individual aged 63 with hemiparesis by stroke disease was participated in the study. Autoencoder (AE) was used to extract four motor modules from eight muscle activities of the paretic leg during CG. After extraction, each module of four modules was operationally defined by numbering from M1 to M4 according to spatial and temporal features and compared with results reported in a previous study. Results: As a result, an individual with hemiparesis had motor module problems related to difficulty of weight acceptance (module 1), compensation for the weakness of ankle plantar flexor (module 2), a spastic synergistic pattern (module 3) and difficulty with transition from the swing to stance phase (module 4) in terms of spatial features. Also, a delayed activation timing of temporal motor module (module 2) related to the forward propulsion during CG was observed. Conclusions: Gait rehabilitation for the stroke will need to consider clinical significances in respect of the deterioration of motor module and provide the tailored approaches for each gait phase.

Study of age specific lung cancer mortality trends in the US using functional data analysis

  • Tharu, Bhikhari;Pokhrel, Keshav;Aryal, Gokarna;Kafle, Ram C.;Khanal, Netra
    • Communications for Statistical Applications and Methods
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    • v.28 no.2
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    • pp.119-134
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    • 2021
  • Lung cancer is one of the leading causes of cancer deaths in the world. Investigation of mortality rates is pivotal to adequately understand the determinants causing this disease, allocate public health resources, and apply different control measures. Our study aims to analyze and forecast age-specific US lung cancer mortality trends. We report functions of mortality rates for different age groups by incorporating functional principal component analysis to understand the underlying mortality trend with respect to time. The mortality rates of lung cancer have been higher in men than in women. These rates have been decreasing for all age groups since 1990 in men. The same pattern is observed for women since 2000 except for the age group 85 and above. No significant changes in mortality rates in lower age groups have been reported for both gender. Lung cancer mortality rates for males are relatively higher than females. Ten-year predictions of mortality rates depict a continuous decline for both gender with no apparent change for lower age groups (below 40).

Discrimination of Lonicera japonica and Lonicera confusa using chemical analysis and genetic marker

  • Ryuk, Jin Ah;Lee, Hye Won;Ko, Byoung Seob
    • The Korea Journal of Herbology
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    • v.27 no.6
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    • pp.15-21
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    • 2012
  • Objective : Lonicera japonica THUNB. a traditional herbal medicine, has been commonly used anti-inflammatory disease. It has been very complicated with respect to its sources on the market. The significant selection of medicine depends on its origin. However, it is difficult to discrimination criteria for confirming L. japonica authenticity using the senses. This study was performed to determine the discriminant analysis of L. japonica and L. confusa. Methods : The identification of L. japonica and L. confusa were performed by the classification and identification committee of the national center for standardization of herbal medicines. And we examined its differences using HPLC and genetic marker analysis. Results : The analytical pattern of High Performance Liquid Chromatography was determined from the corresponding peak curves ((E)-aldosecologanin, chlorogenic acid, luteolin 7-O-glucoside, sweroside). For L. japonica, additional unknown peaks were detected at 13.8 min, 20.6 min, and 36.9 min. And, we developed genetic marker using the the tRNA-Leu gene, trnL-trnF intergenic spacer and tRNA-Phe region of chloroplast DNA. By the method, 164 bp PCR product amplified from L. confusa was distinguished into L. japonica and L. confusa efficiently. Conclusion : Base on these results, two techniques provide effective approaches to distinguish L. japonica from L. confusa.

A Case-Study of Taeeumin Patient with Atypical Parkinsonian Disorders Having Dizziness and Gait Disturbance (비정형파킨슨증후군 태음인의 어지럼증과 보행장애 치험례)

  • Park, Jieun;Kim, Kukhwa;Lee, Seul;Lee, Yong-jae;Lee, Jeongyun
    • Journal of Sasang Constitutional Medicine
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    • v.34 no.3
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    • pp.69-80
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    • 2022
  • A 52-year-old female diagnosed with Atypical Parkinsonian Disorders (APD) about one year ago suffered from dizziness and gait disturbance. The patient was identified as Taeeumin esophagus-cold lung-dry symptomatology pattern and was treated with Jowisengcheong-tang. The patient's symptoms of dizziness and night sweats were assessed using Global Assessment Scale (GAS). And, the Unified Multiple System Atrophy Rating Scale (UMSARS) and the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) were used to assess the overall function of the patient. The patient's symptoms of dizziness and night sweats were significantly improved, and UMSARS and MDS-UPDRS scores were decreased. This case showed that Sasang constitutional medicine treatment can improve APD symptoms and improve the quality of life of the patient.

Abnormal Electrocardiogram Signal Detection Based on the BiLSTM Network

  • Asif, Husnain;Choe, Tae-Young
    • International Journal of Contents
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    • v.18 no.2
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    • pp.68-80
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    • 2022
  • The health of the human heart is commonly measured using ECG (Electrocardiography) signals. To identify any anomaly in the human heart, the time-sequence of ECG signals is examined manually by a cardiologist or cardiac electrophysiologist. Lightweight anomaly detection on ECG signals in an embedded system is expected to be popular in the near future, because of the increasing number of heart disease symptoms. Some previous research uses deep learning networks such as LSTM and BiLSTM to detect anomaly signals without any handcrafted feature. Unfortunately, lightweight LSTMs show low precision and heavy LSTMs require heavy computing powers and volumes of labeled dataset for symptom classification. This paper proposes an ECG anomaly detection system based on two level BiLSTM for acceptable precision with lightweight networks, which is lightweight and usable at home. Also, this paper presents a new threshold technique which considers statistics of the current ECG pattern. This paper's proposed model with BiLSTM detects ECG signal anomaly in 0.467 ~ 1.0 F1 score, compared to 0.426 ~ 0.978 F1 score of the similar model with LSTM except one highly noisy dataset.

Molecular Detection of Phytoplasmas of the 16SrI and 16SrXXXII Groups in Elaeocarpus sylvestris Trees with Decline Disease in Jeju Island, South Korea

  • Geon-Woo, Lee;Sang-Sub, Han
    • The Plant Pathology Journal
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    • v.39 no.1
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    • pp.149-157
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    • 2023
  • Phytoplasmas were discovered in diseased Elaeocarpus sylvestris trees growing on Jeju Island that showed symptoms of yellowing and darkening in the leaves. Leaf samples from 14 symptomatic plants in Jeju-si and Seogwipo-si were collected and phytoplasma 16S rRNA was successfully amplified by nested polymerase chain reaction using universal primers. The sequence analysis detected two phytoplasmas, which showed 99.5% identity to 'Candidatus Phytoplasma asteris' and 'Ca. P. malaysianum' affiliated to 16SrI and 16SrXXXII groups, respectively. Through polymerase chain reaction-restriction fragment length polymorphism (RFLP) analyses using the AfaI (RsaI) restriction enzyme, the presence of two phytoplasmas strains as well as cases of mixed infection of these strains was detected. In a virtual RFLP analysis with 17 restriction enzymes, the 16S rRNA sequence of the 'Ca. P. asteris' strain was found to match the pattern of the 16SrI-B subgroup. In addition, the phytoplasmas in the mixed-infection cases could be distinguished using specific primer sets. In conclusion, this study confirmed mixed infection of two phytoplasmas in one E. sylvestris plant, and also the presence of two phytoplasmas (of the 16SrI and 16SrXXXII groups) in Jeju Island (Republic of Korea).

A Case of Treament of a Taeumin Patient with Sweaty Scrotum and Dysuria (낭습(囊濕)과 소변불리(小便不利)를 주소로 하는 태음인(太陰人) 환자의 치험 1례)

  • Lim, Jin-ny;Lee, Eui-ju;Koh, Byung-hee;Song, Il-byung
    • Journal of Sasang Constitutional Medicine
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    • v.13 no.3
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    • pp.114-117
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    • 2001
  • 1. Object: The primary purpose of this case study is to report that a Tae-Yin-In patients with sweaty scrotum and dysuria was treated with 'Chung sim youn ja tang' and then his symptom decreased 2. Subject: A male obese patient with sweaty scrotum and dysuria that visit Kirin oriental hospital to be treated for obesity 3. Method: The patient was to have a very low calory diet and to exercise for an hour daily and to take a Herb-medicine, 'Chung sim youn ja tang'. Change of his subjective symptom, sweaty scrotum and dysuria, was measured by VAS(Visual Analog Scale) 4. Result: A Tae-Yin-In patients with sweaty scrotum and dysuria was treated with 'Chung sim youn ja tang' and Change of his subjective symptom, sweaty scrotum and dysuria, was measured by VAS(Visual Analog Scale) then his symptom decreased. 5. Conclusion: 'Chung sim youn ja tang' may have an effect on Treatment of sweaty scrotum and dysuria. Further study is needed how to conclud 'disease pattern of constitution' accroding with co-symptom.

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Treatment of immune-mediated keratitis (IMMK) in dogs with immunosuppressants observed with spectral domain optical coherence tomography (SD-OCT)

  • Hyelin Kim ;Youngseok Jeong ;Eunji Lee;Kangmoon Seo ;Seonmi Kang
    • Journal of Veterinary Science
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    • v.24 no.5
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    • pp.66.1-66.7
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    • 2023
  • Two dogs presented with bilateral pattern-forming corneal opacity. Treatment with topical immunosuppressants was initiated after a complete ophthalmic examination. The response to treatment was assessed by analyzing serial images using slit-lamp biomicroscopy and spectral domain optical coherence tomography (SD-OCT). Both dogs responded to topical immunosuppressants; however, the lesions recurred once the treatment was abated or withdrawn. The most effective immunosuppressant in both dogs was 0.03% tacrolimus ointment. Early and continuous treatment with topical immunosuppressants may be necessary to improve corneal clarity and prevent scarring. SD-OCT could provide useful structural information regarding presumed immune-mediated keratitis and aid in monitoring treatment response.

A Case Study of Taeeumin Patient with Diabetes Treated with Jowiseungchungtang-Gamibang (태음인 당뇨 환자의 조위승청탕가미방 치험 1례)

  • Suzy Han;Chae-Eun Kim;Jun-Sang Yu
    • Journal of Sasang Constitutional Medicine
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    • v.35 no.4
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    • pp.96-104
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    • 2023
  • Objectives The purpose of this study was to report the clinical effect on a 54-year-old diabetes patient, categorized into taeeumin exterior disease, after taking herbal medicine. Methods The patient was diagnosed as taeeumin's esophagus-cold pattern and type 2 diabetes symptoms in taeeumin patient were indigestion, fatigue, and headache. We assessed the changes of fasting blood sugar(FBS), hemoglobin A1c(HbA1c), and total cholesterol. Results and Conclusions FBS, HbA1c, and total cholesterol reduced after treated by Jowiseungchungtang-gamibang three times per day for 5 months. These results show that treating a diabetic patient, accompanied by esophagus-cold symptoms, with Jowiseungchungtang-gamibang particularly improves high blood glucose after orthopedic surgery in practicing healthy eating habits.

Cytomegalovirus Pneumonia: High-Resolution CT Findings in Ten Non-AIDS Immunocompromised Patients

  • Jeung Hee Moon;Eun A Kim;Kyung Soo Lee;Tae Sung Kim;Kyung-Jae Jung;Jae-Hoon Song
    • Korean Journal of Radiology
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    • v.1 no.2
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    • pp.73-78
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    • 2000
  • Objective: To describe the HRCT findings of cytomegalovirus (CMV) pneumonia in non-AIDS immunocompromised patients Materials and Methods: This retrospective study involved the ten all non-AIDS immunocompromised patients with biopsy-proven CMV pneumonia and without other pulmonary infection encountered at our Medical Center between January 1997 and May 1999. HRCT scans were retrospectively analysed by two chest radiologists and decisions regarding the findings were reached by consensus. Results: The most frequent CT pattern was ground-glass opacity, seen in all patients, with bilateral patchy (n = 8) and diffuse (n = 2) distribution. Other findings included poorly-defined small nodules (n = 9) and consolidation (n = 7). There was no zonal predominance. The small nodules, bilateral in eight cases and unilateral in one, were all located in the centrilobular region. Consolidation (n = 7), with patchy distribution, was bilateral in five of seven patients (71%). Pleural effusion and bilateral areas of thickened interlobular septa were seen in six patients (60%). Conclusion: CMV pneumonia in non-AIDS immunocompromised patients appears on HRCT scans as bilateral mixed areas of ground-glass opacity, poorly-defined centrilobular small nodules, and consolidation. Interlobular septal thickening and pleural effusion are frequently associated.

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