• 한국전문물리치료학회지
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• 제28권3호
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• pp.177-185
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• 2021

Background: Muscle undergoes change continuously with aging. Sarcopenia, in which muscle mass decrease with aging, is associated with various diseases, the risk of falling, and the deterioration of quality of life. Obesity and sarcopenia also have a synergy effect on the disease of the older adults. Objects: This study examined the risk factors for sarcopenia, sarcopenic obesity, and sarcopenia without obesity and developed prediction models. Methods: This machine-learning study used the 2008-2011 Korea National Health and Nutrition Examination Surveys in the analysis. After data curation, 5,563 older participants were selected, of whom 1,169 had sarcopenia, 538 had sarcopenic obesity, and 631 had sarcopenia without obesity; the remaining 4,394 were normal. Decision tree and random forest models were used to identify risk factors. Results: The risk factors for sarcopenia chosen by both methods were body mass index (BMI) and duration of moderate physical activity; those for sarcopenic obesity were sex, BMI, and duration of moderate physical activity; and those for sarcopenia without obesity were BMI and sex. The areas under the receiver operating characteristic curves of all prediction models exceeded 0.75. BMI could predict sarcopenia-related disease. Conclusion: Risk factors for sarcopenia-related diseases should be identified and programs for sarcopenia-related disease prevention should be developed. Data-mining research using population data should be conducted to enhance the effectiveness of early treatment for people with sarcopenia-related diseases through predictive models.

• 대한상한금궤의학회지
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• 제13권1호
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• pp.179-188
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• 2021

화폐상 습진(Nummular eczema) 병변으로 내원한 환자에게 고문자적 해석을 바탕으로 당귀회역탕(當歸回逆湯)을 진단하여 다음 결론을 얻었다. 1. 화폐상 습진(Nummular eczema) 환자에게 당귀회역탕(當歸回逆湯)을 30일 투약 후 DLQI 18점에서 0점, VAS 10에서 1로 개선되었다. 2. 『상한론(傷寒論)』 351조(條)에서 궐(厥), 세(細)를 피부병변부 발생의 원인과 관계된 병리적인 단어로 추론하고 고문자적으로 해석하여 당귀회역탕(當歸回逆湯)을 투여하고 치료함으로써 한의학적 임상 진단 방법을 구체화할 수 있는 가능성을 제시하였다.

• Tuberculosis and Respiratory Diseases
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• 제53권2호
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• pp.136-147
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• 2002

연구배경 : 간질성 폐질환은 병리소견, 임상경과 및 치료에 대한 반응에 있어서 다양한 양상을 보이지만 궁극적으로는 폐섬유화로 진행한다. 최근 간질성 폐질환의 병태생리에 있어서 폐상피세포의 아포프토시스가 폐섬유화로의 진행에 관여한다는 것이 보고되고 있다. 이에 저자들은 간질성 폐질환 환자에서 아포프토시스가 갖는 임상 및 병리학적 의미를 확인하기 위하여 TUNEL을 이용한 아포프토시스의 지수와 임상양상, 병리소견, HRCT소견, 그리고 치료반응 등과의 상관관계를 분석하였다. 방 법 : 개흉폐생검을 통해서 확진된 간질성 폐질환 환자 20명을 대상으로 하였다. 아포프토시스의 지수는 TUNEL 양성세포의 분율에 따라서 0-2로 구분하였다. 임상양상은 CRP 점수체계를 응용하여 이용하였다. 병리소견은 섬유화, 세포충실도, 탈락화, 육아조직성 정도에 따라 점수화하였다. HRCT소견은 간유리음영과 봉와양음영을 각 엽별로 침범한 정도에 따라서 점수화하였다. 치료의 반응은 치료전과 치료후 3개월째에 시행한 CRP 점수체계의 변화율이 10%이상 증가하였을 때 치료효과가 있는 것으로 판정하였다. 결 과 : 대상 환자는 20명(남 14명, 여 6명)으로 조직학적 아형으로는 AIP 3명, NIP 2 명, BOOP 8명, UIP 7 명이었다. 아포프토시스 지수와 CRP 점수체계의 요소들과는 유의한 상관관계가 없었으며 또한 HRCT소견인 간유리음영점수와 섬유화점수는 역시 유의한 상관관계가 없었다. 조직학적소견에서는 섬유화 점수, 세포충실도 점수, 그리고 탈락화 점수에서 아포프토시스 지수와 유의한 상관관계를 보였다. 부신피질호르몬 치료를 받은 16명의 환자중에서 9명 (56.3%)에서 치료효과가 있었는데 부신 피질호르몬 치료효과 유무와 아포프토시스 지수사이에는 상관관계는 없었다. 급, 아급성 간질성폐렴에서는 세포충실도 점수와 탈락화 점수가 아포프토시스 지수와 유의한 상관관계를 보였으며 만성 간질성 폐렴에서는 섬유화 점수와 세포충실도 유의한 상관관계를 보였다. 결 론 : 간질성 폐질환에서 아포프토시스 지수와 병리학적 지표들과의 유의한 상관관계를 관찰한 본 연구를 통하여 간질성 폐질환의 병태생리에 아포프토시스가 관여한다는 사실을 확인할 수 있었다.

• Journal of Periodontal and Implant Science
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• 제23권1호
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• pp.170-182
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• 1993

The purpose of this study was to evaluate the clinical and microbiological effects of minocycline-loaded polycaprolactone strip on periodontal disease. Ten patients with probing depth (deeper than 5mm) were tested. Of the two periodontal pockets selected from each patient, one randomly selected pocket was treated by the insertion of 30% minocycline-loaded polycaprolactone sttip as the experimental group and the other with a minocycline-free polycaprolactone strip as the control group. All groups were examined by clinical and microbiological methods. 1. Plaque index scores, gingival index scores and sulcular bleeding index scores in both group were significantly reduced from the baseline to 2 weeks. Plaque index scores of experimental group and sulcular bleeding index scores of control group tended to be progressively reduced in all experimental periods. 2. Probing depth amounts in both group were significantly reduced from 4 weeks to 8 weeks. 3. Attachment loss amounts in both group shows no singnificant differences in time. Attachment loss amounts in experimental group tended to be less than those in control group. 4. The number of cocci in both groups were significantly increased in all experimental periods, but that of the non-motile rods were significantly reduced from 2 weeks in experimental group, and from 4 weeks in control group, that of the motile rods were reduced from 4 weeks in experimental group and from 1 week in control group. The number of spirochetes were reduced from I week during all experimental period in experimental group, but there was no changes in control group.

• 보건행정학회지
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• 제29권3호
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• pp.288-302
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• 2019

Background: The one-person households (OPH) are rapidly increasing and vulnerable to socioeconomic and health problems. Because it is predicted to be inequitable to health care utilization, we would like to find out about the equity of health care utilization of the OPH by comparison with the multi-person households (MPH). Methods: This study followed the theoretical framework of Wagstaff and van Doorslaer (2000), O'Donnell and his colleagues (2008), where the horizontal inequity index is the difference between the concentration indices of actual health care utilization and health care needs. This study employed the 9th Korea Health Panel survey, and a total of 10,807 cases were analyzed. Health care needs were measured by age, sex, subjective health status, chronic disease count, Charlson's Comorbidity Index, limitation of activities, and disability. Results: Compared with the MPH, there were pro-poor inequities in hospitalization, emergency utilization, hospitalization out-of-pocket payments, and pro-rich inequities in outpatient out-of-pocket payments for the OPH. The decomposition of the concentration index revealed that chronic disease count made the largest contribution to socioeconomic inequality in outpatient utilization. Age, health insurance, economic activities, and subjective health status also proved more important contributors to inequality. The variables contributing to the hospitalization and emergency utilization inequity were age, education, Charlson's Comorbidity Index, marital status, and income. Conclusion: Because the OPH was more vulnerable to health problems than the MPH and there were pro-poor inequities in medical utilization, hospitalization, and emergency costs, it is necessary to develop a policy that can correct and improve the portion of high contribution to medical utilization of the OPH.

• 한국치위생학회지
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• 제14권6호
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• pp.805-812
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• 2014

Objectives: The purpose of the study was to examine the association between diabetes mellitus and community periodontal index in Korean adults. Methods: The study populations were recruited by the Fifth Korea National Health and Nutrition Examination Survey. Study subjects were 10,411 who were examined oral examination, blood test, and aged over 19 years. Using multiple logistic regression analyses, the variables were adjusted for gender, age, household income, family history of diabetes, body mess index, smoking habit, and frequency of tooth brushing. Periodontal tissue examination of the subjects was performed and scored by Community periodontal index(CPI). Using probe, six teeth were examined for hemorrhage, plaque, and pocket depth and classified into $CPI_0$, $CPI_1$, $CPI_2$, $CPI_3$ and $CPI_4$. Healthy periodontal groups($CPI_{0-2}$) and periodontal disease groups($CPI_{3-4}$) were divided by the periodontal disease status. The definition of diabetes mellitus(DM) was decided by the diagnosis by the doctors and fasting blood sugar level. Those who were diagnosed as DM were included in DM group. The DM variables included normal blood sugar level, increased fasting blood sugar level, and DM blood sugar level. The DM variables were compared to periodontal disease blood sugar level and analyzed. Results: The periodontitis prevalence rate was 23.2%. Those who had diabetes mellitus accounted for 5.5% of the subjects. Those who had impaired fasting glucose accounted for 17.7% and 7.9% of subjects were diabetes mellitus by blood test. In the confirmed diabetes group by doctor, the periodontitis prevalence rate was significantly higher than the non-diabetic group. Diabetic group by blood test had the highest prevalence rate of periodontitis than those who had impaired fasting glucose group or normal group. After adjusting for gender, age, household income, family history of diabetes, body mass index, smoking habit, and frequency of tooth brushing, the risk of periodontitis in diagnosed diabetes mellitus was 1.57 times(95% CI; 1.27-1.94) higher than the normal group. In impaired fasting glucose group and diabetes mellitus group by blood test, the risk of periodontitis was 1.11 times(95% CI; 0.95-1.30) and 1.45 times(95% CI; 1.45-2.12) higher, respectively. Conclusions: There was a significant relationship between diabetes mellitus and periodontitis in Korean adults. These results suggest that diabetes mellitus is a risk factor for periodontitis.

• 대한한의학회지
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• 제17권1호
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• pp.48-83
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• 1996

Our conclusions for function evaluation tools of Stroke patients are as follows. 1. Evaluating tools of Activities of Daily Living, Katz Index, Barthel Index, Modified Barthel Index have high validity and reliability because of ease of measuring, high accuracy, consistency, sensitivity and sufficient stastistics, but they mainly measure motor function except sense, mentation, language, and social conception. Therefore cerebrovascular disease and brain injury in trauma patients with lacked acknowledgement and sensation, we are not able to apply these tools. 2. PULSES Profile is a useful scale for measuring the patient's over-all status, upper and lower limb functions, sensory components, excretary functions, and intellectual and emotional adaptabilities. It is recognized as a good, useful tool to evaluate patient's whole function. 3. Motor Assessment Scale was designed to measure the progress of stroke patients. The scale was supplemented with upper arm function items. We believe that the Motor Assessment Scale could be a useful evaluation tool with inter-rater reliability ,test-retest reliability. 4. The existing evaluation tools, Katz Index, Barthel Index, Modified Barthel Index, PULSES Profile, Motor Assessment Scale, mainly measured the rehabilitational motor function of sequela of cerebrovascular patients. On the other hand CNS & INH stroke scale can measure cerebrovascular disease patient's neurologic deficits and over-all stautus, which are recognition ability, speech status, motor function, sensory function, activities of daily living. Those scales have been recognized as useful tools to measure function of cerebrovascular disease patients and have increased in use. 5. Every function evaluation tool was recognized to have some validity and inter-rater, test-retest reliability in items of each evaluation tool and total scores of each evaluation tools, but it is thought that none of these scales have been fully validated and proved reliable. Therefore afterward, the development of a highly reliable rating system may best be accomplished by a careful comparison of several tools, using the same patients and the same observers in order to choose the most reliable items from each. 6. Ideal evaluation tools must have the following conditions; (1) It should show the objective functional statues at the same time. (2) It should be repeated consecutively to know changed function status. (3) It should be easy to observe the treatment program. (4) It should have the same result with another rater to help rater exchange information with treatment team members. (5) It should be practical and simple. (6) The patient should not suffer from the observer.

• Journal of Nutrition and Health
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• 제38권6호
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• pp.445-454
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• 2005

The purpose of this study was to compare the validity of obese index among body mass index (BMI), waist to hip ratio (WHR), and waist circumference (WC) and to determine which is the best in relation to cardiovascular disease (CVD) risk in Korean elderly more than 65 ages. Data from the 1998 Korean Health and Nutrition Survey were used (n=1017). Anthropometric indices and CVD risk factors were measured, and chi-square test, analysis of variance following duncan's multiple range test, partial correlation analysis, and Receiver Operator Characteristic (ROC) curves were used in the analysis. Anthropometric values were decreased in both male and female when ages were goes up. In female elderly, it specially showed the characteristics of upper body fat and systolic blood pressure risk (p<0.05). Among life style factors the current smokers were prevalent in obese male (p<0.05), but not prevalent in female having obese or upper body fat. Also, person with upper body obesity have more exercise than that of normal group (p<0.01). Mean BMI values of the current smoker was lower than that of normal group in both sexes (p<0.01). Mean BMI value of person with other risk factors were higher than that of normal groups (p<0.05). Among 7 CVD risk factors in partial correlation analysis, WC had the highest correlation coefficient in 5 in male, whereas BMI in 4 in female. In ROC analyses of 12 risk factors and health conditions, the largest area under curve of obese indices for risk factors were WC>WHR>BMI in male and BMI>WHR>WC in female. The optimal cutoff values of each index (BMI : WHR : WC) for one or more risk factors were 19.02 : 0.84 : 71.3 in male and 19.04 : 0.88 : 85.6 in female. In conclusion, Most Korean elderly showed non-obese and abdominal obesity likewise other Asians. Also CVD risk factors were prevalent in Korean elderly within normal limits of obese indices. Therefore the upper body fat indices reflected in the aged whose muscle mass is replaced by fat must be used as an indicator of CVD risk together with BMI. Although WHR was the worst index based on partial correlation analysis and so located between BMI and WC in ROC curve analysis in both sexes, it need to be use with WC to screen the cardiovascular risk group.

• 한국산학기술학회논문지
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• 제17권10호
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• pp.93-103
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• 2016

본 연구는 병원 근로자를 대상으로 안구표면질환지수 설문지를 이용하여 안구건조증 유병률을 알아보고, 안구건조증 유무에 따른 일반적 및 건강관련 특성의 차이를 파악한 후 안구건조증 유병률과 관련요인을 알아보기 위한 서술적 조사 연구이다. 연구 대상자는 G시의 종합병원 근로자 502명(남성 51명, 여성 451명)을 대상으로 하였으며, 자료수집 기간은 2015년 10월 1일부터 2015년 10월 31일까지 설문조사 하였다. 수집된 자료는 로지스틱 회귀분석을 이용하여 분석하였다. 연구결과, 안구건조증 유병률은 76.1%이었으며, 안구건조증 유병율과 관련된 요인으로는 현재 앓고 있거나 약으로 조절하고 있는 질병이 있는 경우에 없는 경우보다 4.73배, 안구건조감을 느낀 대상자 중 안과에 내원하여 약물치료(인공눈물)을 받아 본 적이 있는 대상자에서 없는 대상자보다 2.37배, 안구 건조감을 느낀 적이 있는 대상자가 느낀 적 없는 경우보다 2.23배, 규칙적인 식사를 하지 않은 경우 규칙적인 식사를 하는 경우보다 0.55배의 높은 안구건조증 유병률을 보였다. 특히 안구건조증 대상자 중 54.0%가 중증도 이상임을 감안할 때 안구건조증의 예방과 관리를 위해서 안구건조증 위험인자의 관리 및 생활습관 개선 등 교육의 필요성이 요구된다.

• 한국치위생학회지
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• 제13권6호
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• pp.1041-1046
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• 2013

Objectives : The purpose of the study is to investigate the significant(SiC) index of the 12 year old children's permanent teeth caries experience. A total of 428 children aged 12 years old were recruited from metropolitan city(215 children) and rural area(213 children) in this study. SiC index was obtained from DMFT index. Data were analyzed by gender, region, and DMFT. Methods : DMFT index and Sic index were analyzed and compared by pit and sealant fissure treatment, dental caries, gender, and areas. A total of 428 children aged 12 years old were recruited from metropolitan city(215 children) and rural area(213 children) in this study. Results : Boy students(6.73) tended to have a higher SiC index than girl students(7.84). There were significant differences(p<0.05). DMFT index in urban area was 2.59, and that in rural area was 3.35. In SiC index, rural children showed a higher index(7.77) than urban children(6.72).There existed a significance between DMFT index and SiC index(p<0.05). Conclusions : It is important to educate and to develop the oral disease prevention program for the high risk group children. This study showed the relationship between DMFT index and SiC index in 12 year old children in urban and rural areas.