• Clinical and Experimental Pediatrics
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• 제49권8호
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• pp.839-844
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• 2006

목 적 : 발열을 주소로 소아응급실에 내원한 소아의 임상적 특성에 대하여 조사를 하고자 연구를 시행하였다. 방 법 : 2004년 9월부터 2005년 8월까지 일산백병원 소아응급실에 내원한 8,881명의 환아와 이 중 $38.3^{\circ}C$이상의 발열을 주소로 내원한 1,764명의 환아를 대상으로 발열 환아의 발생 빈도, 월별 분포, 연령별 분포, 진단명을 조사 분석하였다. 결 과 : 조사 기간동안 소아응급실에 내원한 8,881명 중 1,764명이 발열로 내원하여 발열환자의 빈도는 19.9%이었고, 1,764명 중 26.4%가 입원하였다. 내원 발열 환아가 가장 많았던 연령군은 12-23개월 군이었고, 4-11개월 군과 2세 군이 뒤를 이었다. 가장 많은 진단명은 급성 인두염이었고, 급성 장염, 폐렴도 흔한 진단이었다. 연중 발열 환자가 가장 많았던 시기는 4-7월이었고, 이 중 5월에 발열 환자가 가장 많았다. 발열환자의 빈도는 8월이 가장 높았으나 통계적 의미는 없었으며, '봄 여름군', '가을 겨울군'으로 나눠서 비교한 발열환자의 빈도는 통계적으로 의미 있는 차이가 있었다. 결 론 : 소아 응급실에서 발열 환아의 연중 발생빈도는 19.9%이었고, 12-23개월의 환아가 빈도가 높았으며, 5월에 발열 환아가 가장 많았다. 본 연구에서도 급성 인두염, 급성 장염, 급성 비인두염, 급성 기관지염과 같은 비응급 질환의 비율이 높았다. 응급실에 내원하는 비응급 질환을 줄이기 위해 의료체계 개선과 보호자 교육이 필요할 것으로 생각된다.

• Pediatric Infection and Vaccine
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• 제22권1호
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• pp.23-28
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• 2015

목적: 호산구성 수막염은 척수액에서 호산구가 ${\geq}10/mm^3$ 또는 백혈구 중 10% 이상인 것으로 정의하며, 기생충에 의한 신경계 감염으로 주로 보고된다. 기생충에 의한 감염이 흔한 국가 외에서는 호산구성 수막염에 관한 소아에 대한 국내외 보고는 드물다. 이 연구는 국내 단일기관에서 소아 호산구성 수막염 임상특징 분석하고자 한다. 방법: 2007년 1월에서 2012년 7월까지 5년간 세브란스 어린이병원을 방문한(입원, 외래) 18세 미만의 환자들 총 6,335명을 스크리닝했고, 그 중 호산구성 수막염에 맞는 39명을 대상으로 의무기록을 바탕으로 후향적으로 분석하였다. 결과: 뇌척수액 검사상 호산구성 수막염으로 진단된 환자는 39명(0.6%)이었으며, 평균연령은 6세(생후 7일-18세)였고, 남녀의 비는 1.3:1이었다. 혈액검사에서 호산구 증가가 동반되는 경우가 18례(46%) 있었다. 기저질환 및 과거력으로 신경계 질환 36례(92%) 있었다. 항경련제를 복용한 경우는 22례가 있었고, 이외 다른 약물의 복용이 1례 있었다. 뇌수술 이후에 발생한 경우가 35례(90%)였다. 증상은 주로 발열(50%), 두통(20%), 구토(15%), 경련(10%), 어지러움증(5%) 등이 있었다. 뇌척수액의 단백 수치는 평균 180 mg/dL (16-633 mg/dL)로 상승된 값을 보였다. 증상 지속시간은 평균 5일로 치료는 정맥 항생제 및 스테로이드를 투여하였다. 세균배양 된 예가 1례, 애완동물을 기른 예가 1례 있었고 이외에 기생충 관련된 정보는 없었다. 결론: 국내 소아 호산구성 수막염은 기생충 감염보다는 중추신경계의 수술과 관련 있거나 약제에 의한 것으로 생각된다. 따라서 호산구성 수막염의 원인을 잘 고려하여 불필요한 검사나 치료를 줄일 수 있을 것이며, 향후 다기관을 통한 분석이 필요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7485-7489
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• 2015

Background: Breast cancer is the most common type of cancer in women throughout the world. However, in comparison with Western women, it presents relatively early in women of Asian ethnicity. Early menarche, late menopause, use of OCP's, family history of benign or malignant breast disease, exposure to radiation and BMI in the under-weight range are well known risk factors for the development of breast cancer in premenopausal women. Early detection with the use of breast self-examination (BSE) and breast cancer screening programs can lead to a reduction in the mortality rates due to breast cancer. The aim of our study was to assess the risk factors for breast cancer among young women and to emphasize the importance of early screening among them. Materials and Methods: We conducted a cross-sectional study among women aged 18 to 25 using a self-administered questionnaire. Data was collected over a period of 6 months from June to December, 2014. A total of 300 young women selected randomly from Dow Medical College and various departments of Karachi University successfully completed the survey. Results: Respondents were 18-25 years of age (mean age=21.5). Out of the 300 young females, 90 (30%) had at least one risk factor, 90 (30%) had two, 40 (13%) had three, 8 (2.7%) had four, 2 (0.7%) had five while one female was found to have six positive risk factors for breast cancer. Some 66 women (22%) experienced symptoms of breast cancer such as non-cyclical pain and lumps. While 222 women (74%) had never performed breast self-examination, 22 (7.3%) had had a breast examination done by a health professional while 32 (10.7%) had participated in breast screening programs. A total of 223 (74.3%) women considered breast cancer screening important for young women. Conclusions: The percentage of young women with risk factors for breast cancer was found to be alarmingly high. Therefore, screening for breast cancer should start at an early age especially in high risk groups. Awareness about breast self-examination should be emphasized. Moreover, screening programs should be started to ensure early detection and reduction of mortality rates caused by breast cancer also in young Pakistani females.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7021-7027
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• 2014

Background: The problem of cancer, especially lung cancer, is very acute in Bangladesh. The present study was conducted to evaluate the risk of lung cancer among Bangladeshi people based on hereditary, socio-economic and demographic factors. Materials and Methods: This study was carried out in 208 people (patients-104, controls-104) from January 2012 to September 2013 using a structured questionnaire containing details of lung cancer risk factors including smoking, secondhand smoke, tobacco leaf intake, age, gender, family history, chronic lung diseases, radiotherapy in the chest area, diet, obesity, physical activity, alcohol consumption, occupation, education, and income. Descriptive statistics and testing of hypotheses were used for the analysis using SPSS software (version 20). Results: According to this study, lung cancer was more prevalent in males than females. Smoking was the highest risk factor (OR=9.707; RR=3.924; sensitivity=0.8872 and P<0.0001) followed by previous lung disease (asthma, tuberculosis etc.) (OR=7.095; RR=1.508; sensitivity=0.316 and P<0.0001)) for male patients. Highly cooked food (OR=2.485; RR=1.126; sensitivity=0.418 and P=0.004)) and also genetic inheritance (OR=1.93; RR=1.335; sensitivity=0.163 and P=0.138) demonstrated significant correlation with lung cancer as risk factors after these two and alcohol consumption was not prevalent. On the other hand, for female patients, tobacco leaf intake represented the highest risk (OR=2.00; RR=1.429; sensitivity= 0.667 and P=0.5603) while genetic inheritance and highly cooked food also correlate with lung cancer but not so significantly. Socioeconomic status and education level also play important roles in causing lung cancer. Some 78.5% male and 83.3% of female cancer patients were rural residents, while 58.2% lived at the margin or below the poverty line. Most male (39.8%) and female (50.0%) patients had completed only primary level education, and 27.6% male and 33.3% female patients were illiterate. Smoking was found to be more prevalent among the less educated persons. Conclusions: The results obtained in this study indicate the importance of creating awareness about lung cancer risk factors among Bangladeshi people and making appropriate access to health services for the illiterate, poor, rural people.

• Clinics in Shoulder and Elbow
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• 제11권1호
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• pp.57-61
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• 2008

흉쇄 관절의 결핵성 관절염은 매우 드문 질환으로 임상 증상이 뚜렷하지 않기 때문에 진단이 늦어지는 경우가 많다. 흉쇄 관절 부위의 점진적으로 진행하는 동통이나 종창, 미열이 있으면서 결핵의 과거력이 있는 경우에 결핵성 관절염을 의심해야 하고 혈액 검사, 방사선 검사, 조직 검사를 통한 조기 진단이 중요하다. 흉쇄 관절 결핵 관절염의 경우 1년 이상의 항결핵제 투여가 필요하며 증상의 호전이 없거나 증상이 진행되어 흉쇄 관절의 관절 파괴 소견이 보이는 경우 수술적 치료가 필요하게 되는데 수술적 치료 시 흉쇄 관절의 늑쇄골 인대의 손상을 최소화하면서 과도한 변연 절제술로 인해 흉쇄 관절의 주위의 종격동, 늑막 등의 중요 구조물이 손상되는 것을 피해야 한다. 저자들은 경험한 2예의 흉쇄 관절 결핵 관절염에서 변연 절제술로 증상의 호전을 가져온 1예와 변연 절제술 후 종격동 농양, 삼출성 늑막염 등의 합병증이 발생된 1예를 함께 보고하고자 한다.

• Childhood Kidney Diseases
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• 제2권2호
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• pp.169-177
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• 1998

목 적 : 중복요관은 전체 인구의 약 $0.8\%$에 이르는 비교적 발생 빈도가 높은 기형의 하나로 최근에는 산전 초음파를 통해 발견되기도 하지만, 혈뇨나 복통, 요로감염의 증상으로 진단되어지며, 다른 비뇨기 계통의 기형을 동반하는 경우가 있다. 저자들은 중복요관 환아들을 대상으로 진단의 단서가 되었던 임상양상과 동반 질환 여부 및 치료 등에 대하여 알아보고자 하였다. 방 법 : 18세 미만의 61례의 중복요관 환아를 대상으로 후향적 고찰을 시행하였다. 결 과 : 61명의 전체환아의 진단당시의 평균연령은 5.6세였고, 추적관찰의 평균기간은 3년 7개월이었으며, 여아가 42명이었고 남아가 19명으로 남녀 비는 1:2.2였다. 양측 중복요관 환아는 16명($26.2\%$), 완전 중복요관 환아는 24명($39.3\%$)이었다. 산전 초음파상 이상소견으로 발견된 경우가 8례($13\%$)있었고, 요로감염을 단서로 진단되었던 경우가 19례($31.1\%$)로 가장 많았다. 동반질환은 비뇨기 계통이 아닌 기형이나 질환이 11례($18\%$)있었고, 50명($82\%$)은 중복요관 이외의 비뇨기계 다른 질환을 동반하였다. 편측 중복요관환아 45명의 경우 좌측이 23명($51.1\%$)이었고, 이들중 21명($46.7\%$)이 완전 중복요관으로 진단되었다. 전체환아중 비뇨기계의 문제를 동반하여 수술을 받았던 환아는 37명($60.6\%$)이었고, 이 중 방광 요관역류를 동반한 예가 27명($44.3\%$)으로 가장 많았다. 결 론 : 중복요관 환아의 $60.6\%$가 수술을 요하는 비뇨기계의 다른 질환들을 동반하였으며, 특히 요로감염이 선행하는 경우가 많다는 것을 알 수 있었다. 비뇨기계증상 없이 산전진찰이나 우연히 발견되었던 경우가 전체 대상 환아의 $42.6\%$를 차지하므로, 따라서 산전초음파에서 비뇨기계의 비정상적인 소견이 발견되었거나 요로감염, 혈뇨, 복통 등의 증상이 있는 소아들은 반드시 방사선학적 검사를 통하여 중복요관 및 다른 기형이 동반되는지를 확인하여 조기진단 및 적절한 치료를 시행하고, 복부초음파, 배설성 방광요도조영술, 소변 배양검사 등의 주기적인 추적관찰로 향후 발생할수 있는 합병증을 예방할 수 있을 것으로 생각된다.

• 대한한방내과학회지
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• 제19권1호
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• pp.301-317
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• 1998

A clinical analysis was carried out for 32 patients who were treated in Dept. of Dong-shin Oriental Medicine Hospital from 10st January to 16st May in 1998 and ruled out as dememtia. The results were summarized as follows. 1. In the distribution of sex, female was more than male. And the age of seventies(17 cases, 53.125%) was highest in the frequency of age. 2. In the distribution of having history of drinking and smoking were each 4 cases(12.5%) and 7 cases(21.875%). 3. In the distribution of seasons, the ratio of spring and winter were each 16 cases(50.0%), 15 cases(46.875%), that of summer and fall were comparatively low. 4. In the period from onset to admission, the period within a week had 20 cases(62.5%) as top, and the most period of treatment was 2 and 3 weeks(28.125%). 5. The number of cases that had preceding disease was 35 cases(71.875%), a major portion of preceding diseases were hypertension, diabetes mellitus, stroke. 6. The most common symptom was disorientation(78.125%), and the next common symptom was motor desability(71.875%), and memory disturbance, verbal disturbance was each 59.375 and 47.1%. 7. In the distribution of the CT scan films, 15 cases(46.875%) showed cerebral infarction and that of another 5cases (15.625%) showed cerebral hemorrhage, that of another 2 cases(6.25%) showed brain atrophy. 8. In the lipid density of blood, T-Cholesterol, TG, HDL-Cholesterol, LDL- Cholesterol was within normal limit. 9. In the MMSE-K, the most score was from 16 point to 20 point, and second only was from 11 point to 15 point, and the next was from 6 point to 10 point. 10. In the Ischemic score, 20 cases(62.5%) was diagnosed as brain vascular type dementia, and mixed type dementia was 9 cases(28.125%), Alzheimer type dementia was 3 cases(9.375%). 11. The most used recipes were a sort of recipes to activate of flow the vital energy and the blood, to remove the phlegm(41 cases 33.9%), especially DODAMHOALHEL TANG (12 cases, 9.9%), ANSINCHUNGNOITANG (8 case, 6.6%) was the most used recipe. 12. In the judgement of efficacy, 17 cases(53.125%) showed excellent efficacy, 10 cases(31.25%) showed good efficacy, 5 cases(15.625%) showed no change and that according to MMSE-K, 4 case(18.18%) showed excellent efficacy, 15 cases(68.18%) showed good efficacy, 15 cases(68.18%) showed no change.

• 한국임상약학회지
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• 제24권1호
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• pp.15-25
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• 2014

Background: Elderly patients with gastrointestinal (GI) and cardiovascular (CV) risk factors may be more easily exposed to NSAID-related side effects (SEs). Based on the ACG guideline of year 2009, the aim of the study is to evaluate proper use of NSAIDs and gastroprotective drugs according to the degree of GI and CV risk strengths in the patients. Methods: Retrospectively surveyed 410 elderly patients with NSAIDs for more than 30 days at a general hospital in Korea. GI risk factor includes age, ulcer history, high-dose NSIADs, concurrent aspirin use, steroids or anticoagulants. CV risk factor includes angina, myocardial infarction, cerebral infarction, atrial fibrillation or coronary intervention requiring low-dose aspirin. These factors were classified as high/low cardiovascular groups and high/moderate/low GI groups. Results: There were 14 patients in high CV risk group and high GI risk group. The group was recommended not to use NSAIDs as it is not adequate. There were 101 patients in high CV risk group and moderate GI risk group. This group was recommended to use naproxen and PPI/misoprostol. But all patients except one were not adequate. There were 9 patients in low CV risk group and high GI risk group. This group was recommended to use selective COX-2 inhibitor and PPI/misoprostol. 5 cases were proper while 4 cases did not. There were 285 patients in low CV risk and moderate GI risk group who were recommended to use non selective NSAIDs and PPI/misoprostol or selective COX-2 inhibitor only. 103 patients were proper while 182 patients not adequate. Overall, the SEs were higher in those cases for inadequate use of drugs comparing to the adequate. CV SEs were statistically significant. However, SEs for each risk groups were different. For the case of low CV risk group and high/moderate GI risk group, the inadequate use of drugs makes the SE high and the other groups are not. Also, it was not statistically significant. Conclusions: In elderly patients, the inappropriate use of NSAIDs can increase the risk of the disease. Therefore, GI and CV risk must be considered simultaneously, and the proper use of NSAIDs and gastroprotective drugs for each risk groups should be reconsidered.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5715-5719
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• 2015

Background: Breast cancer is the most common malignancy of women in the world. The disease is caused by infectious and non-infectious, environmental and lifestyle factors. Tobacco smoke has been one of the most widely studied environmental factors wiith possible relevance to breast cancer. The purpose of this study was to assess the impact of tobacco smoking in breast cancer patients in a hospital based cohort and to establish prognostic implications if any. Materials and Methods: A retrospective audit of 100 women with pathological diagnosis of invasive breast cancer was included in this study. The verbal questionnaire elicited information on current and previous history of exposure to smoking in addition to active smoking. All analyses were adjusted for potential confounders, including stage at presentation, alcohol intake, hormonal replacement therapy, oral contraceptive intake, obesity and menopausal status. Results: The mean age at presentation of breast cancer was $51.4{\pm}10.86$ years. Mean age of presentation was $53.1{\pm}11.5$ and $45.7{\pm}11.9$ years in never smokers and passive smokers, respectively. Age at presentation varied widely in patients exposed to tobacco smoke for >10 years in childhood from $40.3{\pm}12.0$ years to $47.7{\pm}13.9$ in patients exposed for > 20years as adults. Among passive smokers, 60.9% were premenopausal and 39.1% of patients were postmenopausal. In never smokers, 71.4% were post menopausal. Expression of receptors in non-smokers vs passive smokers was comparable with no significant differences. Metastatic potential in lung parenchyma was slightlyelevated in passive smokers as compared to never smokers although statistically non-significant. Conclusions: An inverse relationship exists between the intensity and duration of smoking and the age at presentation and poor prognostic factors. The results strongly suggest efforts should be taken to prevent smoking, encourage quitting and restrict exposure to second hand smoke in India.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.275-282
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• 2015

Background: Breast cancer (BC) is the most-common malignancy of women worldwide. Though there are differences among developed and developing countries, BC remains the most common cancer type of women in Turkey. Objective: This study aimed to identify the level of knowledge, awareness, and their potential predictors towards BC in Ankara, Turkey. Materials and Methods: The present descriptive study was conducted on 376 females attending a breast health outpatient clinic. A self-administered questionnaire was designed to evaluate knowledge level about BC and predictors effecting its level. Data analysis was performed using the chi-square test. A value of p<0.05 was considered statistically significant. Results: Mean age of the participants was $46.2{\pm}9.93$ (22-75). The majority (92.6 %) were married; 41.5% were educated less than nine years. Most of the women were housewives (82.7%) and, were living in an urban region (86.4%). Predictors of effecting responses to seven knowledge and awareness questions about BC varied from demographic features including older age groups, higher educational levels, being married, living in an urban area, being employee, smoking, having greater BMI to additional attributes associated breast health such as the increased number of births, applying for the purpose of control, positive family history of breast diseases, any diagnoses of breast diseases and performing BSE practice. Conclusions: It was determined that females in Turkey have better knowledge of BC than other developing countries even though it is not at the desired level. These findings revealed that females should be more informed about BC risk factors, prognosis and treatments by primary health-care providers to counteract the ascending burden of this disease.