• Title/Summary/Keyword: disease

Search Result 35,688, Processing Time 0.144 seconds

Cytosolic prion protein induces apoptosis in human neuronal cell SH-SY5Y via mitochondrial disruption pathway

  • Wang, Xin;Dong, Chen-Fang;Shi, Qi;Shi, Song;Wang, Gui-Rong;Lei, Yan-Jun;Xu, Kun;An, Run;Chen, Jian-Ming;Jiang, Hui-Ying;Tian, Chan;Gao, Chen;Zhao, Yu-Jun;Han, Jun;Dong, Xiao-Ping
    • BMB Reports
    • /
    • v.42 no.7
    • /
    • pp.444-449
    • /
    • 2009
  • Different neurodegenerative disorders like prion disease, is caused by protein misfolding conformers. Reverse-transfected cytosolic prion protein (PrP) and PrP expressed in the cytosol have been shown to be neurotoxic. To investigate the possible mechanism of neurotoxicity due to accumulation of PrP in cytosol, a PrP mutant lacking the signal and GPI (CytoPrP) was introduced into the SH-SY5Y cell. MTT and trypan blue assays indicated that the viability of cells expressing CytoPrP was remarkably reduced after treatment of MG-132. Obvious apoptosis phenomena were detected in the cells accumulated with CytoPrP, including loss of mitochondrial transmembrane potential, increase of caspase-3 activity, more annexin V/PI-double positive-stained cells and reduced Bcl-2 level. Moreover, DNA fragmentation and TUNEL assays also revealed clear evidences of late apoptosis in the cells accumulated CytoPrP. These data suggest that the accumulation of CytoPrP in cytoplasm may trigger cell apoptosis, in which mitochondrial relative apoptosis pathway seems to play critical role.

Two adolescent patients with coexistent Graves' disease and Moyamoya disease in Korea

  • Cheon, Chong Kun;Kim, Su Yung;Yoo, Jae-Ho
    • Clinical and Experimental Pediatrics
    • /
    • v.57 no.6
    • /
    • pp.287-291
    • /
    • 2014
  • Moyamoya disease is a cerebrovascular condition that results in the narrowing of the vessels of the circle of Willis and collateral vessel formation at the base of the brain. Although relationships between Graves' disease and cerebrovascular accidents in Moyamoya disease are obscure, the coexistence of the two diseases is noteworthy. Moyamoya disease has been rarely reported in adolescent patients with thyrotoxicosis. Recently, we encountered two adolescent Korean patients with Moyamoya disease associated with Graves' disease who presented with episodic right-sided hemiparesis and syncope. These two girls who had Graves' disease had no history of other diseases or head trauma. A thyroid function test revealed a euthyroid state and a high thyroid-stimulating hormone (TSH) receptor antibody titer at that time. The patients were diagnosed with Moyamoya disease based on brain magnetic resonance angiography and cerebral four-vessel angiography. The patients underwent cranial revascularization by encephalo-duroarterio-synangiosis as soon as a diagnosis was made, which resulted in successful symptom resolution. They fared well and had no additional neurological symptoms as of their last follow-up visits. Here, we report these two cases of confirmed Moyamoya disease complicated by Graves' disease with a review of the literature, and discuss the possible association between the two diseases. To our knowledge, this is the first report in South Korea on Moyamoya disease associated with Graves' disease in adolescents with a euthyroid.

Lame Disease (라임병에 관하여)

  • Shin, Sang-Won;Park, Seung-Chull
    • Journal of agricultural medicine and community health
    • /
    • v.16 no.2
    • /
    • pp.172-176
    • /
    • 1991
  • Lyme disease, or Lyme borreliosis. is an infection caused by spirohete Borrellia burgdorferi. This disease was recognized in Lyme, Conneticut U.S.A. in 1975. The onset of the disease is usually heralded by the appearance of a pathognomic skin lesion, known as erythema chronicum migrans, and accompanied by flue like or meningitis like symptoms. Unless treatment is initiated early, the disease usually disseminated, often resulting carduac, neurologic, or joint manifestations. All stages of the disease are usually curable by appropriate antibiotic therapy, and can prevent severe late cardiac, neurologic, and joint complications. Lyme disease is typically defined by clinical evidence supported by serologic test. The diagnosis require serologic confirmantion of erythema chronicum migrans, occurring in patient in nonendemic countries. Determination of antibody titer against B. burgdorferi by enzyme linked immunosorbent assay(ELISA) currently the most practical diagnostic test. Currently Lyme disease occurs in U.S.A. Europe, and Australia. It has recently recognized in China, Japan, and Soviet Union also. In United States, Lyme disease is most common vector borne infection. There is no reported case of patients with this disease in Korea. But the vector of this disease, -Ixodes ticks- had been identified in Korea. And Korea is geographically closely related to China and Japan where Lyme disease is already reported. We expect first case of Lyme disease could he reported in near future. We review the clinical manifestations and diagnostic method of Lyme disease.

  • PDF

A Study on the Sasang Constitutional application of Clinical Acupuncture (임상 침법의 사상의학적 활용)

  • Yoo, Jong-Hyang;Kim, Yun-Young;Park, Ki-Hyeun;Jang, Eun-Su;Lee, Si-Woo
    • Korean Journal of Oriental Medicine
    • /
    • v.16 no.3
    • /
    • pp.15-22
    • /
    • 2010
  • Objective : This study aims to search Four-constitution Medicine based acupuncture by investigators and its effect on constitution-specific symptoms. Method : Among 463 oriental medical doctors who are the members of society of Four-constitution Medicine, 191 results are collected. The items of the questionnaire are sex, age, work experiences, working type, constitution diagnosis & prescription, the use of constitution acupuncture and so on. Result : The proportion of acupuncture treatment applied constitution-based acupuncture to patients are "Must Use" 12.6%, "Almost Use" 14.1%, "Sometimes Use" 42.9% and "Never Use" is 1.0%. The average ratio of patients treated by constitution-based acupuncture to all patients is 47%. 1. Digestive tract disease is found to be the most effective disease with constitution based acupuncture. Musculoskelectal problems, cardiovascular disease, respiratory disease, neuropsychiatric disease and urogenital disease are followed. On the oriental medicine, spleen system disease is the most frequently applied and heart system disease, neuropsychiatric disease, liver system disease, locomotorium disease and pulmonary system disease are followed. 2. Acupuncture therapeutic measures are different according to disease. For example, Sa-am acupuncture is the most widely used for spleen system disease, locomotorium disease, heart system disease, neuropsychiatric disease, pulmonary system disease. Eight constitution medicine acupuncture is effective for ophthalmic & otolaryngologic disease. Conclusion : This study is to investigate constitution-based acupuncture technique. In conclusion, the most widely used technique is Sa-am acupuncture and it is the most successful in treating digestive tract disease.

The Study of Throat Disease's Concept, Pathology and Medical treatment in Sasang Constitutional Medicine (사상의학(四象醫學)에서 인후질환(咽喉疾患)의 의미(意味)와 병리(病理) 및 치료(治療)에 대한 고찰(考察))

  • Ban, Duk-Jin;Park, Seong-Sik
    • Journal of Sasang Constitutional Medicine
    • /
    • v.20 no.3
    • /
    • pp.40-50
    • /
    • 2008
  • 1. Objectives We analyze throat disease focused on Sasang constitutional medicine and find out throat disease's concept, pathology and medical treatment. 2. Methods We consider term, conceuption, symptoms, mechanism and medical treatment of throat disease in "Dongyisusebowon", "Dongyisusebowon Gabogubon", "Dongyisusebowon sasangchobongwon", "Dongyisasangshinpyun" and "Dongmuyoogo" 3. Results and conclusions 1) We find out throat disease's some concept that are refered variety in sasang constitutional medicine. 2) Throat disease's pathology are different according to sasang constitution. In Soeumin throat disease belong to taeeum syndrome and soeum syndrome, in Soyangin throat disease belong to chest heat syndrome, in Taeumin throat disease belong to dry heat syndrome, in Taeyangin throat disease belong to Yul gyuk syndrome 3) In sasang constitutional medicine, medical treatment of throat disease focus on not throat disease but human being and medical treatment of throat disease are almost internal treatment but in Soyangin and Taeumin, medical treatment of throat disease are external treatment.

  • PDF

Clinical Study of Menstruation Pattern according to Sasang Constitutional Diseases (사상체질 병증별 월경 양상의 임상 연구)

  • Lim, Sung-Rak;Kim, Koo;Oh, Seung-Yun;Kwon, Young-Mi;Joo, Jong-Cheon
    • Journal of Sasang Constitutional Medicine
    • /
    • v.21 no.1
    • /
    • pp.217-226
    • /
    • 2009
  • 1. Objective To investigate characteristics of menstrual patterns according to Sasang Constitutional disease, and to utilize for diagnosis and treatment of Sasang Constitutional disease. 2. Method The recruited subjects were 430 women who convinced their Sasang Constitution by taking herbal medicine and improving of chief complaint. The items of data contain age at menarche, age at menopause, menstrual cycle, menstrual duration, cyclic regularity of menstruation, severity of menstrual pain, the worst day of menstrual pain, type of menstrual pain, amount of menstruation. 3. Results 1) Severity of menstrual pain, the worst day of menstrual pain, menstrual pain accompanied with nausea were significant among Sasang Constitutional diseases. 2) In Bae-chu-pyo-byeong disease (背椎表病證), Wi-wan-han disease (胃院寒證), So-eum disease (少陰證) and Tae-eum disease (太陰證), menstrual pain was severer than other diseases. 3) In Hae-yeok disease and So-yang-sang-pung disease (少陽傷風證), the worst day of menstrual pain was a day before menstruation. In Hyung-gyeok-yeol disease (胸膈熱證), Tae-eum disease (太陰證), So-eum disease (少陰證), the frequency of a day after menstruation in the worst day of menstrual pain was higher than other diseases. In Wi-wan-han disease (胃院寒證), Mang-yang disease (亡陽證), the frequency of two day after menstruation in the worst day of menstrual pain was higher than other diseases. 4) In So-yang-sang-pung disease (少陽傷風證), Mang-eum disease (亡陰證), Eum-heo-o-yeol diasese (陰虛午熱證), Ul-gwang disease (鬱狂證), Tae-eum disease (太陰證), So-eum disease (少陰證), the frequency of menstrual pain accompanied with nausea were higher than other diseases. 4. Conclusion Menstrual patterns, especially menstrual pain is different among Sasang Constitutional diseases. Assessing menstrual pain can be used for diagnosing Sasang Constitutional diseases, deciding treatment course, determinating prognosis.

  • PDF

The Relationship between Oral Disease and Respiratory Disease in the Elderly (임상가를 위한 특집 1 - 노년의 구강 질환과 호흡기 질환의 관계)

  • Jeong, Jin-Seok;Heo, Seok-Mo
    • The Journal of the Korean dental association
    • /
    • v.51 no.9
    • /
    • pp.494-500
    • /
    • 2013
  • Recently, several researches indicated the relationship between oral condition and respiratory disease such as pneumonia and chronic obstructive pulmonary disease (COPD). Respiratory disease is known as common chronic disease in the elderly increasing mortality and morbidity. In this study, we have reviewed the association between oral disease and respiratory disease in the elderly. The related data were searched and collected from abroad and domestic studies. The studies included the randomized controlled clinical trials (RCTs), longitudinal, cohort, case-control, and systematic review studies. With the data from the studies, we concluded that poor oral hygiene or periodontal disease can influence the pneumonia in the elderly. Further studies will be needed to investigate the association between oral disease and COPD.

Comparison with 'Gu-Bon' and 'In-Bon' on Symptom of Soeumin's Disease and Soyangin's Disease (갑오본(甲午本)(구본(舊本))과 신축본(辛丑本)(인본(印本))을 중심으로 한 소음인(少陰人) 병증(病證)과 소양인(少陽人) 병증(病證)에 관한 고찰(考察))

  • Lee, Eui-Ju;Koh, Byung-Hee;Song, Il-Byung;Lim, Jin-Ny
    • Journal of Sasang Constitutional Medicine
    • /
    • v.13 no.2
    • /
    • pp.62-73
    • /
    • 2001
  • 1. Purpose 'Gu-Bon' of ${\ulcorner}$Soose Bowon${\lrcorner}$ found lately was written in 1940, through comparing with 'Gu-Bon' and 'In-Bon'. In 'Gu-Bon' and 'In-Bon', there are many different contents. The aim of the present study was to find changes of Dong-Mu's recognition on Symptom of Soeumin's Disease and Soyangin's Disease from 1894 to 1900 2. Methods Comparing with 'Gu-Bon' and 'In-Bon' on Symptom of Soeumin's Disease and Soyangin's Disease, Mechanism . region . main symptom and treatment of Soeumin's Disease and Soyangin's Disease are arranged. and changes of Dong-Mu's recognition on Symptom of Soeumin's Disease and Soyangin's Disease from 1894 to 1900 was found 3. Results 1) In 'Gu-Bon' of ${\ulcorner}$Soose Bowon${\lrcorner}$, Dong-mu recognized Symptom of Soeumin's Disease and Soyangin's Disease, mainly through the conception of 'ventral-dorsal--interior-exterior' and 'Main Qi of life protection' 2) In 'In-Bon' of ${\ulcorner}$Soose Bowon${\lrcorner}$, Dong-mu recognized Symptom of Soeumin's Disease and Soyangin's Disease, mainly through the conception of 'ventral-dorsal-interior-exterior' and 'Ascending of Yang-Qi and Descending of Yin-Qi' 3) In 'Gu-Bon' of ${\ulcorner}$Soose Bowon${\lrcorner}$, Symptom of Soeumin's Disease was classified into 'Taeyang Disease' and 'Yang-myoung Disease'. But In 'In-Bon' of ${\ulcorner}$Soose Bowon${\lrcorner}$, Symptom of Soeumin's Disease was classified into 'Mang-yang' and 'Ul-guang'

  • PDF