• Clinical and Experimental Reproductive Medicine
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• 제21권3호
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• pp.261-266
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• 1994

Semen preparation for Assisted Reproductive Technology(ART) involves the separation of the motile sperm from non-motile, dead sperm, cellular debris and seminal fluid. The aim of this study is to compare the motile sperm recovery rate and motility index of different sperm preparation method(swim-up method, 80% isotonic continuous percoll method, two-layer discontinuous percoll method, mini-percoll method). In Mini-Percoll method, pellets from patients were suspended in 0.3ml of medium and layerd on a discontinuous percoll gradient consisting of 0.3ml each of 50, 70, 95% isotonic percoll. All semen samples are divided into normal and subnormal sperm group(oligo-, astheno-, oligoasthenozoospermia). Especially, we evaluated the effect of mini-percoll method in subnormal sperm group. In normal sperm group, mini-percoll method and two layer discontinuous percoll method (40%/80%) allowed increasing of motile sperm recovery rate. But motility index was higher in swimup method than the other methods. In subnormal sperm group, mini-percoll method has advantages as compare with the other methods in motile sperm recovery rate and motility index. These results suggest that modified mini-percoll method could be certainly a valuable tool in some cases of severe male factor sperm.

• 한국전자통신학회논문지
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• 제8권11호
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• pp.1675-1680
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• 2013

최근 저소음, 고속, 고추력의 반송장치가 요구됨에 따라 영구자석 선형동기전동기가 대두되고 있으나 반송경로 전장에 전기자를 설치하는 선형 동기전동기의 특성으로 인해 장거리 반송장치에 적용시 설치비용의 증가를 가져온다. 따라서 우리는 전기자를 분산시켜 배치하는 방법을 제안하여 비용증가의 문제점을 해결하고자 하였다. 하지만 가동자의 진행시 분산배치된 전기자 사이를 통과하게 되면 전기자의 불연속 구간인 단부에 의해 디텐트력이 발생하여 추력 맥동이 발생하고 기기 성능저하와 소음, 진동의 원인이 된다. 따라서 본 논문에서는 단부에 의한 영향을 저감하기 위해 전기자 끝단의 치 높이와 보조치 형상에 따른 디텐트력의 특성을 파악하고 다구찌의 실험계획법을 이용하여 단부 효과를 가장 저감할 수 있는 형상을 제안하였다.

• Journal of Power Electronics
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• 제17권6호
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• pp.1535-1544
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• 2017

Advances in FPGA technology have enabled fast real-time simulation of power converters, filters and loads. FPGA based HIL (Hardware-In-the-Loop) simulators have revolutionized control hardware and software development for power electronics. Common time step sizes in the order of 100ns are sufficient for simulating switching frequency current and voltage ripples. In order to keep the time step as small as possible, ideal switching function models are often used to simulate the phase legs. This often produces inferior results when simulating the discontinuous conduction mode (DCM) and disabled operational states. Therefore, the corresponding measurement and protection units cannot be tested properly. This paper describes a new solution for this problem utilizing a discrete-time PI controller. The PI controller simulates the proper DC and low frequency AC components of the phase leg voltage during disabled operation. It also retains the advantage of fast real-time execution of switch-based models when an accurate simulation of high frequency junction capacitor oscillations is not necessary.

• Coupled systems mechanics
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• 제8권1호
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• pp.71-93
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• 2019

Finite element simulations of solid mechanics problems often involve the use of Non-Confirming Meshes (NCM) to increase accuracy in capturing nonlinear behavior, including damage and plasticity, in part of a solid domain without an undue increase in computational costs. In the presence of material nonlinearity and plasticity, higher-order variables are often needed to capture nonlinear behavior and material history on non-conforming interfaces. The most popular formulations for coupling non-conforming meshes are dual methods that involve the interpolation of a traction field on the interface. These methods are subject to the Ladyzhenskaya-Babuska-Brezzi (LBB) stability condition, and are therefore limited in their implementation with the higher-order elements needed to capture nonlinear material behavior. Alternatively, the enriched discontinuous Galerkin approach (EDGA) (Haikal and Hjelmstad 2010) is a primal method that provides higher order kinematic fields on the interface, and in which interface tractions are computed from local finite element estimates, therefore facilitating its implementation with nonlinear material models. The inclusion of higher-order interface variables, however, presents the issue of preserving material history at integration points when a increase in integration order is needed. In this study, the enriched discontinuous Galerkin approach (EDGA) is extended to the case of small-deformation plasticity. An interface-driven Gauss-Kronrod integration rule is proposed to enable adaptive enrichment on the interface while preserving history-dependent material data at existing integration points. The method is implemented using classical J2 plasticity theory as well as the pressure-dependent Drucker-Prager material model. We show that an efficient treatment of interface variables can improve algorithmic performance and provide a consistent approach for coupling non-conforming meshes in inelasticity.

• Wind and Structures
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• 제34권1호
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• pp.59-72
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• 2022

In this work the numerical results of the flow around a 5:1 rectangular cylinder at Reynolds numbers 3 000 and 40 000, zero angle of attack and smooth incoming flow condition are presented. Implicit Large Eddy Simulations (ILES) have been performed with a high-order accurate spatial scheme and an implicit high-order accurate time integration method. The spatial approximation is based on a discontinuous Galerkin (dG) method, while the time integration exploits a linearly-implicit Rosenbrock-type Runge-Kutta scheme. The aim of this work is to show the feasibility of high-fidelity flow simulations with a moderate number of DOFs and large time step sizes. Moreover, the effect of different parameters, i.e., dimension of the computational domain, mesh type, grid resolution, boundary conditions, time step size and polynomial approximation, on the results accuracy is investigated. Our best dG result at Re=3 000 perfectly agrees with a reference DNS obtained using Nek5000 and about 40 times more degrees of freedom. The Re=40 000 computations, which are strongly under-resolved, show a reasonable correspondence with the experimental data of Mannini et al. (2017) and the LES of Zhang and Xu (2020).

• 대한토목학회논문집
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• 제29권3B호
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• pp.231-237
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• 2009

본 연구에서는 2-방정식 난류모형인 ${\kappa}-{\varepsilon}$ 모형을 이용하여 2차원적으로 발달하는 하층 밀도류를 모의하기 위한 수치모형을 제시하였다. 타원형 편미분 방정식으로 흐름에 대한 지배방정식을 구성하였으며, 수치기법으로는 유한체적법을 사용하였다. 연구를 통해 개발된 수치모형을 기존의 실험결과와 비교하여 적용성을 검토하였다. 불연속 유입조건 밀도류의 시간별 진행에서 흐름의 불안정에 의한 와(渦)의 발생을 확인하였으며, 진행중인 불연속 유입 밀도류의 진행단계 변화와 선단부 속도의 관계를 살펴보았다. 또한, 무거운 유체 위로 이동하던 주변수체가 벽면을 접하면서 발생된 단파가 밀도류의 진행에 미치는 영향을 수직구조를 통해 살펴보았다. 한편, 개발된 모형을 이용한 수치모의에서 선단부의 진행 속도가 실험보다 느리게 모의되었다. 이는 3차원 현상인 난류의 불안정성을 모의하는 2차원 모형의 한계인 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5973-5981
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• 2013

At present, the most common cause of cancer-related death in women is breast cancer. In a large proportion of breast cancers, there is the overexpression of human epidermal growth factor receptor 2 (HER2). This receptor is a 185 KDa growth factor glycoprotein, also known as the first tumor-associated antigen for different types of breast cancers. Moreover, HER2 is an appropriate cell-surface specific antigen for passive immunotherapy, which relies on the repeated application of monoclonal antibodies that are transferred to the patient. However, vaccination is preferable because it would stimulate a patient's own immune system to actively respond to a disease. In the current study, several bioinformatics tools were used for designing synthetic peptide vaccines. PEPOP was used to predict peptides from HER2 ECD subdomain III in the form of discontinuous-continuous B-cell epitopes. Then, T-cell epitope prediction web servers MHCPred, SYFPEITHI, HLA peptide motif search, Propred, and SVMHC were used to identify class-I and II MHC peptides. In this way, PEPOP selected 12 discontinuous peptides from the 3D structure of the HER2 ECD subdomain III. Furthermore, T-cell epitope prediction analyses identified four peptides containing the segments 77 (384-391) and 99 (495-503) for both B and T-cell epitopes. This work is the only study to our knowledge focusing on design of in silico potential novel cancer peptide vaccines of the HER2 ECD subdomain III that contain epitopes for both B and T-cells. These findings based on bioinformatics analyses may be used in vaccine design and cancer therapy; saving time and minimizing the number of tests needed to select the best possible epitopes.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2003년도 somma/kms meeting
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• pp.363-363
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• 2003

• 한국암반공학회:학술대회논문집
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• 한국암반공학회 2007년도 춘계학술발표회 논문집
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• pp.311-324
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• 2007

• 충청수학회지
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• 제4권1호
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• pp.91-97
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• 1991

This paper studies the structure and continuity of derivations of the Banach algebra $C^n(I)$ of n times continuously differentiable functions on an interval I into Banach $C^n(I)$-modules.