• 자원ㆍ환경경제연구
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• 제27권4호
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• pp.725-743
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• 2018

어느 한 집단이 정치적, 혹은 경제적으로 영향력이 클 경우 정책수단이 비록 효과적 혹은 효율적이라도 선택될 가능성은 현실적으로 낮다. 왜냐하면 그 과정에서 높은 정치적 비용이 수반되기 때문이다. 본 논문에서는 에너지를 소비하는 공해발생자와 공해피해자 간 타협을 도출하는 데 있어서 에너지보조금의 정치적 역할을 분석한다. Dolbear(1967)의 삼각 에즈워즈 상자 모형을 이용하여 정책선택이 두 집단의 소득분배와 후생수준에 미치는 영향을 중심으로 직접규제와 조세의 단일 정책수단 도입 효과와 에너지보조금을 포함한 정책조합의 효과를 비교한다. 분석결과, 에너지보조금이 사용됨으로써 공해발생자와 피해자 간의 타협 가능성은 증가하는 것으로 나타났다.

• International Journal of Computer Science & Network Security
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• 제21권7호
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• pp.63-69
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• 2021

Flipped learning is necessary for modern education but quite difficult to implement. In pedagogical science, the question remains to what extent the practical work of the teacher in combination with the technologies of flipped learning will improve the quality of higher education. The aim of this article is to study the effectiveness and feasibility of using flipped learning technologies, assessing their perception by students (advantages and problems), identified an algorithm for introducing flipped learning technology in higher education institutions. Research methods. The main method is an experiment. An evaluation of the effectiveness of the study was conducted using a questionnaire and observation method. Statistical methods were used to evaluate the results of the experiment. The research hypothesis is that flipped learning allows the teacher to spend more time on an individual approach, to understand the real needs of students, and provide effective feedback, thereby improving the quality of learning and motivation of students, especially while studying complex material. The results of the study are to prove the effectiveness of the technology of flipped education in the study of complex disciplines, courses, topics. The use of flipped learning strategies improves the self-regulation of the educational process, group work skills, improves students' ability to learn, overcome difficulties. The technology of flipped learning in the presence of modern technical means and constant work on improving the level of digital literacy is an effective means for students to master complex topics and problematic issues that require additional consideration and discussion. The perspective of further research is the consideration of integrated approaches to the application of flipped learning technologies to the principles of STEAM-education, multilingual and multicultural programs, etc. It is also worth continuing to develop a set of methods aimed at enhancing the student's learning activities, the formation of group work skills, direct participation in creating the foundations of higher education.

• Nuclear Engineering and Technology
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• 제53권1호
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• pp.234-243
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• 2021

In the research or project planning for the decommissioning of a nuclear power plant, one of several preparations will be the establishment of a list of potential radionuclides to be considered at the time of characterization or final status surveys. Reliable data for selection of potential radionuclides during the transition period to prepare for decommissioning will depend heavily on historical data at the site or, where possible, sampling analysis. However, during the transition period, direct sampling can be challenging, depending on the circumstances of the site or national regulation. A methodology of selecting potential radionuclides for nuclear facility sites which largely consists of three major processes: production of initial list of radionuclides, selection of the insignificant radionuclide that will be eliminated, and consideration of site characterization or sampling. For developing a preliminary list of potential radionuclides for Kori Unit 1 decommissioning, the list of initial radionuclides was made referring to the technical documents applied at decommissioned NPPs in the U.S and additional reference materials applied until the operation of NPPs in Korea. For the screening of insignificant radionuclides, we applied criterion of less than 0.1% of the amount of radioactivity inventory and confirmed the dose fraction using the RESRAD code. The final suit of radionuclides was established, which should be supplemented by reflecting site characterization and sampling process in the future. Thus, the methodology and results for the selection of potential radionuclides suggested in this paper can give an insight as a future reference to deriving DCGLs in relation to site remediation of decommissioning nuclear plants.

• Journal of Ginseng Research
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• 제43권4호
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• pp.692-698
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• 2019

Background: Breast cancer is a severe disease and the second leading cause of cancer death in women worldwide. To surmount this, various diagnosis and treatment options for breast cancer have been developed. One of the most effective strategies for cancer treatment is to induce apoptosis using naturally occurring compounds. Compound K (CK) is a ginseng saponin metabolite generated by human intestinal bacteria. CK has been studied for its cardioprotective, antiinflammatory, and liver-protective effects; however, the role of CK in breast cancer is not fully understood. Methods: To investigate the anticancer effects of CK in SKBR3 and MDA-MB-231 cells, cell viability assays and flow cytometry analysis were used. In addition, the direct targets of CK anticancer activity were identified using immunoblotting analysis and overexpression experiments. Invasion, migration, and clonogenic assays were carried out to determine the effects of CK on cancer metastasis. Results: CK-induced cell apoptosis in SKBR3 cells as determined through 3-(4-5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide assays, propidium iodide (PI) and annexin V staining, and morphological changes. CK increased the cleaved forms of caspase-7, caspase-8, and caspase-9, whereas the expression of Bcl-2 was reduced by CK. In assays probing the cell survival pathway, CK activated only AKT1 and not AKT2. Moreover, CK inhibited breast cancer cell invasion, migration, and colony formation. Through regulation of AKT1 activity, CK exerts anticancer effects by inducing apoptosis. Conclusion: Our results suggest that CK could be used as a therapeutic compound for breast cancer.

• Animal Bioscience
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• 제35권1호
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• pp.22-28
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• 2022

Objective: Endoplasmic reticulum (ER) stress engages the unfolded protein response (UPR) that serves as an important mechanism for modulating hepatic fatty acid oxidation and lipogenesis. Chronic fasting in mice induced the UPR activation to regulate lipid metabolism. However, there is no direct evidence of whether negative energy balance (NEB) induces ER stress in the liver of cows. This study aimed to elucidate the relationship between the NEB attributed to feed deprivation and ER stress in bovine hepatocytes. Methods: Blood samples and liver biopsy tissues were collected from 6 non-lactating cows before and after their starvation for 48 h. The blood non-esterified fatty acids (NEFA), β-hydroxybutyric acid (BHBA) and glucose level were analyzed. Real-time quantitative polymerase chain reaction and Western blotting were used to explore the regulation of genes associated with UPR and lipid metabolism. Results: The starvation increased the plasma BHBA and NEFA levels and decreased the glucose level. Additionally, the starvation caused significant increases in the mRNA expression level of spliced X-box binding protein 1 (XBP1s) and the protein level of phosphorylated inositol-requiring kinase 1 alpha (p-IRE1α; an upstream protein of XBP1) in the liver. The mRNA expression levels of peroxisome proliferator-activated receptor alpha and its target fatty acid oxidation- and ketogenesis-related genes were significantly upregulated by the starvation-mediated NEB. Furthermore, we found that the mRNA expression levels of lipogenic genes were not significantly changed after starvation. Conclusion: These findings suggest that in the initial stage of NEB in dairy cows, the liver coordinates an adaptive response by activating the IRE1 arm of the UPR to enhance ketogenesis, thereby avoiding a fatty liver status.

• 한국융합학회논문지
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• 제13권5호
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• pp.209-217
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• 2022

가상현실은 오큘러스로 대표되는 웨어러블 장치의 도입과 함께 새로운 국면을 맞이하였다. 이에 본 연구에서는 영어학습을 위해 1인칭 시점으로 가상현실에 직접 몰입을 가능하게 하는 오큘러스 리프트(Oculus Rift) 기반의 몰입형 가상현실을 제안한다. 학습자 시점 기반의 몰입형 가상현실에 대한 전반적이고 통합적인 고찰을 통해, 언어학습을 위한 교수설계 시 고려할 사항을 제공하는 것은 의미 있는 일이다. 따라서 본 연구는 몰입형 가상현실의 언어교육 적용의 극대화 방안을 모색하는 것을 목적으로 한다. 이러한 연구 목적을 위하여 그간의 몰입형 가상현실의 교육적 활용 사례들을 살펴보았다. 그리고 몰입형 가상현실 기반 영어학습을 위한 설계 요소의 적용을 목적으로 학습이론의 설정, 학습의 차이 고려, 학습과제 선정, 교사의 영향력 규정, 적용 감각의 종류 결정, 설계의 융통성, 사용환경을 제안하였다. 그 결과들을 통합하여 교수설계에 대한 다양한 논의와 방향성을 제시하였다.

• Journal of Ginseng Research
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• 제47권1호
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• pp.9-22
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• 2023

As a famous herbal medicine in China and Asia, ginseng (Panax ginseng C. A. Meyer) is also known as the "King of All Herbs" and has long been used in medicine and healthcare. In addition to the obvious biological activities of ginsenosides, ginseng polysaccharides (GPs) exhibit excellent antitumor, antioxidant stress, and immunomodulatory effects. In particular, GPs can exert an antitumor effect and is a potential immunomodulator. However, due to the complexity and diversity in the structures and components of GPs, their specific physicochemical properties, and underlying mechanisms remain unclear. In this article, we have summarized the factors influencing the antitumor activity of GPs and their mechanism of action, including the stimulation of the immune system, regulation of the gut microbiota, and direct action on tumor cells

• 한국IT서비스학회지
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• 제22권6호
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• pp.1-15
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• 2023

This study compares and analyzes the legal systems of Korea, the European Union, China, and the United States based on the disclosure principles and processing policies for personal data processing and provides references for seeking improvements in our legal system. Furthermore, this research aims to suggest institutional implications to overcome data transfer limitations in the upcoming digital economy. Findings on a comparative analysis of the relevant legal systems for disclosing privacy policies in four countries showed that Korea's privacy policy is under the eight principles of privacy proposed by the OECD. However, there are limitations in the current situation where personal information is increasingly transferred overseas due to direct international trade e-commerce. On the other hand, the European Union enacted the General Data Protection Regulation (GDPR) in 2016 and emphasized the transfer of personal information under the Privacy Policy. China also showed differences in the inclusion of required items in its privacy policy based on its values and principles regarding transferring personal information and handling sensitive information. The U.S. CPRA amended §1798.135 of the CCPA to add a section on the processing of sensitive information, requiring companies to disclose how they limit the use of sensitive information and limit the use of such data, thereby strengthening the protection of data providers' rights to sensitive information. Thus, we should review our privacy policies to specify detailed standards for the privacy policy items required by data providers in the era of digital economy and digital commerce. In addition, privacy-related organizations and stakeholders should analyze the legal systems and items related to the principles of personal data disclosure and privacy policies in major countries so that personal data providers can be more conveniently and accurately informed about processing their personal information.

• IMMUNE NETWORK
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• 제23권4호
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• pp.28.1-28.20
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• 2023

Lipid accumulation in macrophages is a prominent phenomenon observed in atherosclerosis. Previously, intimal foamy macrophages (FM) showed decreased inflammatory gene expression compared to intimal non-foamy macrophages (NFM). Since reprogramming of lipid metabolism in macrophages affects immunological functions, lipid profiling of intimal macrophages appears to be important for understanding the phenotypic changes of macrophages in atherosclerotic lesions. While lipidomic analysis has been performed in atherosclerotic aortic tissues and cultured macrophages, direct lipid profiling has not been performed in primary aortic macrophages from atherosclerotic aortas. We utilized nanoflow ultrahigh-performance liquid chromatography-tandem mass spectrometry to provide comprehensive lipid profiles of intimal non-foamy and foamy macrophages and adventitial macrophages from Ldlr^-/- mouse aortas. We also analyzed the gene expression of each macrophage type related to lipid metabolism. FM showed increased levels of fatty acids, cholesterol esters, phosphatidylcholine, lysophosphatidylcholine, phosphatidylinositol, and sphingomyelin. However, phosphatidylethanolamine, phosphatidic acid, and ceramide levels were decreased in FM compared to those in NFM. Interestingly, FM showed decreased triacylglycerol (TG) levels. Expressions of lipolysis-related genes including Pnpla2 and Lpl were markedly increased but expressions of Lpin2 and Dgat1 related to TG synthesis were decreased in FM. Analysis of transcriptome and lipidome data revealed differences in the regulation of each lipid metabolic pathway in aortic macrophages. These comprehensive lipidomic data could clarify the phenotypes of macrophages in the atherosclerotic aorta.

• 한국산업융합학회 논문집
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• 제27권1호
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• pp.63-70
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• 2024

Lithium-ion batteries (LIB) are widely used in various sectors, such as transportation (e.g., electric vehicles (EV)) and energy (e.g., energy storage facilities) due to their high energy density, broad operating temperature (-20 ℃ ~ 60 ℃), and high capacities. LIBs are powerful but fragile on external factors, including pressure, physical damage, overheating, and overcharging, that cause thermal runaway causing fires and explosions. During a LIB fire, a large amount of oxygen is generated from the decomposition of ionogenic materials. A water fire extinguisher that helps with cooling and suffocating must be essentially required at the same time. In fact, however, it is difficult to suppress LIB fires in the case of EVs because a LIB is installed with a battery pack housing that interrupts direct extinguishing by water. Thus, this study aims to investigate effective fire extinguishing measurements for LIB fires by using an EV. Relevant documents, including research articles and reports, were reviewed to identify effective ways of LIBs fire extinguishing. A real-scale fire experiment generating thermal runaway was carried out to figure out the combustion characteristics of EVs. This study revealed that the most effective fire extinguishing measurements for LIB fires are applying fire blankets and water tanks. However, there is still a lack of adequate regulation and guidelines for LIB fire extinguishment. Taking this into account, developing functional fire extinguishment measurements and available regulatory instruments is an urgent issue to secure the safety of firefighters and citizens.