• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2005년도 춘계 학술발표회 논문집
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• pp.335-342
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• 2005

Using higher order Mindlin plates and piezoelectric materials, eigenvalue problems are considered. Since piezoelectric crystal resonators produce a proper amount of electric signal for a thickness-shear frequency, the objective is to decouple the thickness-shear mode from the others. Design variables are the bulk material densities corresponding to the mass of masking plates for electrodes. The design sensitivity expressions for the thickness-shear frequency and mode shape vector are derived using direct differentiation method(DDM). Using the developed design sensitivity analysis (DSA) method, we formulate a topology optimization problem whose objective function is to maximize the thickness-shear component of strain energy density at the thickness-shear mode. Constraints are the allowable volume and area of masking plate. Numerical examples show that the optimal design yields an improved mode shape and thickness-shear energy.

• BMB Reports
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• 제48권4호
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• pp.193-199
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• 2015

Degenerative retinal diseases affect millions of people worldwide, which can lead to the loss of vision. However, therapeutic approaches that can reverse this process are limited. Recent efforts have allowed the possibility of the stem cell-based regeneration of retinal cells and repair of injured retinal tissues. Although the direct differentiation of pluripotent stem cells into terminally differentiated photoreceptor cells comprises one approach, a series of studies revealed the intrinsic regenerative potential of the retina using endogenous retinal stem cells. Muller glial cells, ciliary pigment epithelial cells, and retinal pigment epithelial cells are candidates for such retinal stem cells that can differentiate into multiple types of retinal cells and be integrated into injured or developing retina. In this review, we explore our current understanding of the cellular identity of these candidate retinal stem cells and their therapeutic potential for cell therapy against degenerative retinal diseases. [BMB Reports 2015; 48(4): 193-199]

• 한국항공운항학회지
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• 제15권2호
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• pp.18-24
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• 2007

The high ionospheric spatial gradient during ionospheric storm is the most concern when applying GNSS(Global Navigation Satellite System) augmentation systems for aircraft precision approach. Since the ionospheric gradient level depends on geographical location as well as the storm, understanding the ionospheric gradient statistics over a specific regional area is necessary for operating the augmentation systems. This paper compares three ionosphere gradient computation methods, direct differentiation between two receivers' ionospheric delay signal for a common satellite, derivation from a grid ionosphere map, and derivation from a plate ionosphere map. The plate map method provides a good indication on the gradient variation behavior over a regional area with limited number of GNSS receivers. The residual analysis for the ionosphere storm detection is discussed as well.

• 한국전산구조공학회논문집
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• 제14권2호
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• pp.135-141
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• 2001

차량 충돌시 자동차의 시트는 승객 및 운전자를 보호해야 한다. 따라서 자동차시트는 충분한 강도를 가져야 하며 이것은 여러 가지 법규에 의해서 제재되고 있다. 물리적 실험 결과가 법규에 정한 규정치를 만족시키기 위해 과대설계 될 수 있다. 그러나 이것은 연비를 줄이기 위한 경량화의 만족이라는 설계요구에 상충한다. 본 논문에서는 헤드레스트 강도시험을 시뮬레이션하고 과대 설계되어 있다고 판단되는 어퍼암을 최적화 모델로 최적설계를 수행하였다. 순차 이차 계획법인 PLBA 알고리즘과 민감도 해석을 위하여 직접근사해석법을 사용하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1991년도 하계학술대회 논문집
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• pp.93-96
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• 1991

This paper describes a new algorithm based on design sensitivity analysis for optimal shape design of electrostatic devices. The design sensitivity, the variation of the object function with respect to the design variables, is derived by using implicit differentiation and direct boundary element methods. The proposed algorithm is applied to the optimal shape design of a concentric cable and the rod electrode enclosed by earthed case, It is shown, from the numerical results, that the algorithm is very usefull for the optimal shape design of the electrostatic devices.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1995년도 추계학술대회 논문집
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• pp.628-634
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• 1995

In the area of assembly process of micro-chips and electronic parts on the printed circuit board, surface mounting device(SMD) is used as a fundamental tool. Generally speaking, the motion of the SMD is based on the ball screw system operated by any type of actuators. The ball screw system is a mechanical transformer which converts the mechanical rotational motion to the translational one. Also, this system could be considered as an efficient motion device against mechanical backash and friction. Therefore a dynamic modeling and stste sensitivity analysis of the ball screw system in SMD have to be done in the initial design stage. In this paper, a simple mathematical dynamic model for this system and the sensitivity snalysis are mentioned. Especially, the bond graph approach is used for graphical modeling of the dynamic system before analysis stage. And the direct differentiation method is used for the state sensitivity analysis of the system. Finally, some trends for the state variables with respect to the design variables could be suggested for the better design based on the results on the results of dynamic and state sensitivity.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 1998년도 춘계학술대회논문집; 용평리조트 타워콘도, 21-22 May 1998
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• pp.492-497
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• 1998

Thermoacoustic oscillation is a significant problem in cylindrical-type combustors such as common internal combustion engines, industrial furnaces, gas turbine, etc. This kind of low frequency oscillation can give rise to serious troubles such as the destruction of system or producing of a strong noise. Accurate numerical simulation of thermoacoustic phenomena is a complex and challenging problem. Especially, considering the reaction of mixture intensifies the difficulty of analysis. Like as other simulations of the aerodynamics and aeroacoustics, direct computation of thermoacoustic phenomena requires that the Navier-Stokes equations be solved using accurate numerical differentiation and time-marching schemes, with non-reflecting boundary conditions. In this study,, numerical approach aims at qualitative analysis and efficient prediction of problem, not at the development of an accurate scheme. Overally speaking, numerical prediction is reasonably matched with experimental result.

• 한국가축번식학회지
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• 제27권4호
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• pp.349-357
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• 2003

Although nuclear transfer (NT) techniques are used to clone animals, its efficiency is very low. Moreover, nuclear transfer has resulted in offspring with severe developmental problems, probably due to incomplete nuclear reprogramming. Nuclear reprogramming is characterized by functional modification of the transferred nucleus to allow it to direct normal embryo development with the potential to grow to term. Although the nature of the reprogramming factor(s) in mammals is not clear, various nuclear as well as cytoplasmic components are involved in the processes. In this article we review recent data on factors involved in the nuclear reprogramming of cloned embryos.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 2000년도 특별강연 및 추계학술발표대회 개요집
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• pp.260-263
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• 2000

A methodology is developed and many used to evaluate the response sensitivity of the thermal systems to variations in their design parameters. Technique for computing the sensitivity of temperature distributions to changes in processing parameters needed for deciding the more effective laser input parameters for laser surface hardening treatment are considered. In this study, a state equation governing the heat flow in laser surface treatment is analyzed using a three-dimensional finite element method and sensitivity data of the processing parameter obtained using a direct differentiation method applied for sensitivity analysis. The interesting processing parameter is taken as the laser scan velocity and characteristic beam radius( $r_{b}$) of the sensitivity of the temperature T versus v and $r_{b}$ is analyzed. And these sensitivity results obtained in another parameters are fixed condition. To verifying the numerical analysis results, hardened layer dimensions (width and depth) of the numerical analysis compared with the results of an experimental data.ata.

• Structural Engineering and Mechanics
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• 제4권4호
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• pp.425-436
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• 1996

An application of the perturbation method to optimum structural design with random parameters is presented. It is formulated on the basis of the first-order stochastic finite element perturbation method. It also takes into full account the stress, displacement and eigenvalue constraints, together with the rates of change of the random variables. A method for calculating the sensitivity coefficients in regard to the governing equation and the first-order perturbed equation has been derived, by using a direct differentiation approach. A gradient-based nonlinear programming technique is used to solve the problem. The numerical results are specifically noted, where the stiffness parameter and external load are treated as random variables.