• 동의생리병리학회지
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• 제16권1호
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• pp.62-66
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• 2002

Hypertension is not only a well-established cardiovascular risk factor but also increase the risk of atherosclerosis. Most studies conducted to investigate the effectiveness of treatment for cardiovascular disease such as hypertension have focused primarily on conventional drug and physiotherapeutic treatments. BanhabackchulChunma-tang(半夏白朮天麻湯:BCT) is popular herbal medicine used in clinic for the treatment of various symptoms of drulatory disorders and weakness of digestive system, including anorexa and nausea with vertigo, severe headache, vomiting and so on. However, the mechanisms underlying its efficacy are unknown. This study investigated the effects of BCT as an alternative medication on the contraction induced by phenylephrine and KCI in rat thoratic aorta. BCT revealed siginificant relaxation on phenylephrine-induced arterial contraction, but revealed noncompetitive effect on concentration responses of phenylephrine-induced contraction. Treatment of N-L/sup ω/ -argine methyl ester(L-NAME) and methylene blue(MB)(10/sup -5/M) reduced the relaxation of BCT. BCT also increased in vitro NO production. It suggest that the relaxation effect of BBT is related with NO pathway, becausse the effect of L-NAME and MB are due to inhibition of NO synthesis from endothelial cells. These results indicate that BCT would be effective in hypertension treatment and its mechanism of relaxtion on arterial contraction is likely to be related with NO production, blocking of α-receptor and signal transduction after receptor activation.

• 대한수의학회지
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• 제12권1호
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• pp.127-132
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• 1972

Experimental studies on the water content of muscles and the histological changes of muscles, digestive tract and kidney, influenced by forced oral administration of excessive tap water, were performed by using 10 Korean bulls. Experimental animals were divided into two groups, five heads for test group and five for control group. All of the bulls used in this experiment were weighing between 250 kg and 300 kg and 3 and 4 years of age. In each test animal, a total of 140 litters of tap water was passed in the forestomach by means of catheterization within 12 to 18 hours. And each of them was slaughtered immediately after the animals showing symptoms of respiratory distress. In control group, the animals were allowed to drink tap water normally. From test and control animals after slaughter, each 10 gm of M. biceps femoris, M. satorius, M. adductor, M. gluteous supercialis, M. iliocostalis lumborum, and M. transversus costarum were taken from definite parts in order to measure water content. In the histopathological studies tissues of rumen, reticulum, omasum, abomasum, duodenum, colon and kidney were taken as wall as the above mentioned muscles. The results obtained were as follows; 1. Increase of water content in the muscles of test group were 4.6% in M. satorius, 4.24% in M. transversus costarum, 4.14% in M. gluteous supercialis, 4.02% in M. adductor, 3.88% in M. biceps femoris, and 2.46% in M. iliocostalis lumborum respectively. The highest increase was found in M. satorius and the lowest in M. iliocostalis lumborum. 2. In test animal, average increasing value of water content in muscles was 3.9% and shown highly significant (p<0.01). 3. On the microscopical findings of carcass, marked watery edema was observed all of the subcutaneous tissues and intermuscular connective tissues. 4. Microscopically, the epimysium, perimysium and endomysium were widened, and the muscle fibers were lacerated. The cells of stratum lucidum in the epithelium of rumen and reticulum were shown marked vacuolization. In the kidney, dilatation of Bowman's spaces and proximal tubles was observed.

• Journal of Acupuncture Research
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• 제26권1호
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• pp.121-133
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• 2009

Objectives : The purpose of this study is to find out the clinical possibility of Bufonis Venenum used without toxicity and side effect. Methods : We investigated the pharmacological effects, toxicity and processing of Bufonis Venenum through the literatures and studies. Results : Bufonis Venenum is made by parotid gland of dermato gland of Bufo bufo gargarizns or B. melanostictus Schneider, and it is dried for using. The medical ation of Bufonis Venenum are cardiotonic, respiration stimulation, anticancer, topical anesthesia. The toxic symptoms of Bufonis Venenum are relative with digestive, circulatory, nervous system similared with digitalis toxicity. It is important to take 0.015-0.03g by mouth, external use about 1-4% 0.5-3ml and 2-8ml injections by 20ml mix to 5% dextrose fluid. Bufonis Venenum is processed to prevent toxicity and evaluate efficacy by alcohol and milk. There are 68 prescription consisted by Bufonis Venenum in KTKP(Korean Traditional Knowledge Portal). They usually use for antiabcess, anticancer with Moschus moschiferus(麝香), Cinnabar(朱砂). Conclusions : The results from above literary studies show that internal, external medicine and Aqua-acupuncture of Bufonis Venenum could be clinically used to sedative, antiinflammatory, anticancer and topical ataralgesia without toxity through optimum dose and processing.

• Journal of Acupuncture Research
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• 제30권5호
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• pp.77-86
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• 2013

Objectives : The aim of the study was to investigate the characteristics of Ryodoraku score according to dyspepsia in diagnosed as Soeumin by 'portable Ryodoraku device'. Methods : Using Mann-Whitney U test, we divided 34 'Soeumin' patients into two group(normal and with chronic dyspepsia) and analyzed Ryodoraku score, especially in 'the spleen meridian' and 'the stomach meridian' which is belived to be related with dyspepsia. Soeumin subjects are classified by 'Sasang constitutional program' in portable Ryodoraku device. All of them complete the questionnaire regarding their Digestive conditions. 'short from leeds dyspepsia questionnaire(SF-LDQ)' made by rome III diagnostic is chosed as questionnaire. Results: 1. We found the RS measured from a group of people who has chronic dyspepsia was significantly greater than that from control group. 2. Regarding the effect of 'dyspepsia' in Ryodoraku, the mean score of the F6(stomach meridian) in the chronic dyspepsia group was significantly higher than that in the control group. 3. The mean score of the F6(stomach meridian RS) in the chronic dyspepsia group was not significantly higher than that in the control group. 4. In cases where people has chronic dyspepsia, the difference between RS measured in the right-side of a body and that in the left-side of a body was mostly greater than 40, whereas the case of difference that is less than 2 was rare. Conclusions : Portable Ryodoraku device might be used to classify enforce 'Sasang constitution', and also it might be used to analyze 'Ryodoraku data' based on characteristic clinical symptoms of four constitution diagnosis alone.

• Journal of Dental Anesthesia and Pain Medicine
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• 제20권2호
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• pp.83-87
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• 2020

Foreign body (FB) ingestion is commonly seen in the ear nose and throat (ENT) field, with different presentations and sequelae. FBs can arrest in the upper aerodigestive tract or continue further down into either the airway tract to the bronchus or the digestive tract to the intestines. The pathway of an FB depends on the size and shape of the FB and how sharp its edges are. Since the 20th century, the use of disposable stainless-steel needles in the oral cavity has proven to be an effective and safe method for performing various intraoral procedures like dental infiltration or a root canal wash. Complications from their use are rare. Generally, dental needle breakages are caused by patients biting the needle, incorrect injection techniques, or inadequate preventative measures. The sudden movement of a patient during a procedure is one of the most common causes of breakage. Occasionally, needles are swallowed during dental procedures such as a root canal. Here, we report a case of a patient that swallowed a broken needle during a dental procedure. A few days later, the patient presented with neck pain, swelling, and a FB sensation. When the patient presented, she claimed that her symptoms had onset after consuming a meal containing duck meat. Initially, the patient was diagnosed as having ingested a duck bone. However, intraoperatively, the FB was discovered to be an injection needle that had migrated from the throat to the neck.

• 셀메드
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• 제3권3호
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• pp.21.1-21.5
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• 2013

Cholesterol gallstones are a digestive disease of high prevalence that has many risk factors; for this reason, research has focused mainly on how to prevent it rather than how to treat it. Many molecules of the hepatic, bile and intestinal systems are involved in the pathophysiology of this disease, making it very difficult to find a therapeutic target. The pharmacological treatment is limited, so when gallstones generate symptoms, medical treatment indicates gallbladder removal. Ursodeoxycholic acid is used to dissolve cholesterol stones, and ezetimibe and statins are other drugs with possible applications in the treatment of this disease. Given the small number of drugs that have been developed for treating this disease, the research of natural products becomes of paramount importance. Resources such as black radish, glucosinolates, fenugreek, capsaicin, curcumin, garlic, and onion, have all shown significant effects in the prevention and treatment of cholesterol gallstones. In this review, we made a synthesis of the scientific reports that deal with these natural products and that can serve as antecedents for finding a way to treat the most common disease of the gallbladder.

• 동의생리병리학회지
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• 제18권4호
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• pp.965-975
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• 2004

The writer reviewed on Chojop and came to conclusions as follows. Symptoms of Chojop is appeared digestive ailment such as belching, nausea, regurgitation of acid, stomachache etc., if being serious, felt oppressed with palpitating in chest and uneasiness at times. In Dangaesimbub written by Chujinhyung, the causes of Chojop were mainly regarded as phlegmatic fire(痰火) and suggested the way of treatment. The causes of Chojop are movable fire with phlegm, insufficiency of blood caused by thinking to excess, and Shinyanghohan(腎陽虛汗) that is piled cold phlegm by voidance and coldness of Renal Yang, but the main cause is brought to a conclusion as phlegmatic fire. The phlegmatic fire is come from being in discord with the spleen and the stomach, or from in harmony between vigor and blood according to essence and vital energy which are disturbed by combined feelings. That is caused by disharmony between inner and outer conditions according to individuals. The distinctive features in shapes of Chojop are revealed to shapes such as manlike woman, womanlike man, wearing darkish or reddish color between two eyebrows, being almond eyed, strong eyebrows, being sunk the upper part of the nose bridge, lots of facial blots, Dam-body, Ki type, Shin type, Birds group, and Yangmyung type. The doctors can prescribe Whadamchungwhatang to Yangmyung type, Yanghyulsamul-tang for patients with strong eyebrows so flourishing blood and vigor, Hyangsapyungwuisan for patients belong to Birds group, Soshikchungul-tang for Ki type, and Palmiwhan for man belonged to Bangkwang-body with voidance and coldness of Renal Yang chiefly.

• 대한예방한의학회지
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• 제24권2호
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• pp.31-41
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• 2020

Background : The introduction of policies expanding the coverage of uninsured Korean Medicine (KM) services have requires an understanding of the following components of the service : current financial expenses, degree of financial burden on the patient, and financial effect of the coverage expansion. Objectives : This study aims to determine the annual trend of outpatients' characteristics and the category of out-of-pocket spending in KM. Methods : This study uses data from the Korea Health Panel to analyze use of KM in the Korean population. Using the user characteristics and behavior drawn from the Korea Health Panel data, out-of-pocket spending trends of KM were analyzed by year. The diagnosis and prescription of out-of-pocket spending were also analyzed. Results : The proportion of patients receiving uninsured medical treatment and the number of uninsured medical treatment in outpatient clinics have increased. However, the average out-of-pocket spending per person and out-of-pocket spending per visit are consistent or have decreased. Meaningful trends are the increase of R00-R99 (unclassified symptoms) and the decrease of K00-K93 (digestive system disease) and J00-J99 (respiratory system disease). Conclusions : Expansion of KM medical service and insurance is influenced by uninsured medical treatment of KM. Hence, research to increase medical treatment categories for out-of-pocket spending or explore diseases where KM diagnosis has been proven effective should be further developed.

• Journal of Chest Surgery
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• 제35권12호
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• pp.914-916
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• 2002

폐방선균증은 Actinomycosis israelii에 의해 발생되는 만성, 화농성, 육아종성 질환이다. 주로 구강내 또는 상부위장관에 정상적으로 존재하며, 구인도의 상부위장관에서 오염된 분비물의 흡인에 의해 기관지를 통해 흉곽내로 들어간다. 주로 만성적인 기침, 객담, 혈담, 미열, 흉통, 체중감소 등의 증상을 나타내며, 흉부 방사선 검사상에서는 종괴양 병변이나, 폐침윤, 농양, 결핵과 비슷한 소견을 보이며, 악성 종양과의 감별진단은 어려운 것으로 알려져 있다. 따라서 대개 진단 및 치료를 위하여 수술이 필요하며 수술후 조직학적 검사상에서 유황과립을 포함하는 실모양의 개체를 확인하면 확진할 수 있다. 치료는 페니실린이 가장 좋은 약으로 알려져 있으며, 구인도나 치성 농양의 치료나 재발을 방지하기 위하여 수술 후 2개월 내지 3개월 가량 사용하는 것이 좋을 것으로 생각된다. 본 저자들은 방사선학적으로 폐암이 의심되었던 환자에서 종괴 절제후 방선균증을 확진 및 치료하여 문헌고찰과 함께 보고하는 바이다.

• 대한한의학원전학회지
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• 제29권1호
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• pp.139-172
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• 2016

Objectives : The purpose of research thesis is an advanced interpretation of the Name of Constitutional Disease of Dong-uisusebowon(東醫壽世保元) 1901 edition(辛丑本) evaluated to interpretation incompleted, and application of clinical diagnosis by rivised interpretation. Methods : A study on translation of sasangin(四象人)'s constitutional disease is researched the methods of documentary research on Dong-uisusebowon(東醫壽世保元) 1901 edition(辛丑本) and 1894 edition(甲午本). Results : Result of analysis of 4 meaning unit is as follows. Viscera or entrails means root or terminus of organ whom getting disease. Cold or heat based means being chilled or hot of triple energizer. Eexterior or interior means origin of disease of exterior or interior. Cold or heat means being chilled or hot of digestive system. Conclusions : In the clinical diagnosis using revised interpretaion, diagnosis of exterior or interior disease can be decided by symptoms of Taeyang syndrome(太陽病)'s fever and aversion to cold or not. Diagnosis of cold or heat disease can be decided by diarrhea or constipation.