• Journal of Gastric Cancer
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• v.14 no.1
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• pp.63-66
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• 2014

We present a rare case of a gastric mixed adenoneuroendocrine tumor and review the related English literature. A 77-year-old Caucasian woman was admitted to our department with nausea, anorexia, weight loss, and anemia. Esophagogastroduodenoscopy showed a large (>7 cm) ulcerative mass in the greater curvature of the stomach. Biopsy showed the presence of an adenocarcinoma with moderate differentiation. The patient underwent D2 subtotal gastrectomy. Histopathological analysis revealed a diagnosis of mixed gastric adenoneuroendocrine carcinoma. The post-operative course was uneventful, and at the 6-month follow-up, the patient was alive without evidence of recurrence. Our review of the English literature suggested that such cases are most often reported from eastern countries. Multimodal treatment should be the aim for these patients because of the neuroendocrine component of the tumor.

• Food Science and Biotechnology
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• v.18 no.3
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• pp.706-711
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• 2009

Lysozyme was treated with digestive enzymes and the production of interleukin 8 (IL-8) was measured in Caco-2 cell with the peptides from lysozyme upon stimulating with lipopolysaccharide (LPS) to investigate the overall anti-inflammatory activity of lysozyme when it is in digestive tracts. Lysozyme reduced IL-8 production, and the peptides from pepsin hydrolysis of lysozyme had the similar effect. The products of trypsin digestion of lysozyme had no effect on the reduction of IL-8 production while those of pepsin-trypsin hydrolysis did. The effectiveness of lowering IL-8 production was not different by time of the peptide addition. When Caco-2 cells were pre-incubated with peptides for 24 hr, the reduction effects were observed from the peptides from pepsin hydrolysis, indicating that some of the peptides are still remaining in the cells. Therefore, it can be concluded that the IL-8 reduction effect of lysozyme against LPS still remained even after the pepsin and trypsin hydrolysis.

• Clinical Endoscopy
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• v.57 no.1
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• pp.1-10
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• 2024

Barrett's esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC), and is caused by chronic gastroesophageal reflux. BE can progress over time from metaplasia to dysplasia, and eventually to EAC. EAC is associated with a poor prognosis, often due to advanced disease at the time of diagnosis. However, if BE is diagnosed early, pharmacologic and endoscopic treatments can prevent progression to EAC. The current standard of care for BE surveillance utilizes the Seattle protocol. Unfortunately, a sizable proportion of early EAC and BE-related high-grade dysplasia (HGD) are missed due to poor adherence to the Seattle protocol and sampling errors. New modalities using artificial intelligence (AI) have been proposed to improve the detection of early EAC and BE-related HGD. This review will focus on AI technology and its application to various endoscopic modalities such as high-definition white light endoscopy, narrow-band imaging, and volumetric laser endomicroscopy.

• Korean Journal of Ichthyology
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• v.17 no.1
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• pp.57-63
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• 2005

The digestive apparatus and food of the Korean bitterling, Acheilognathus signifer, from the upper reaches of the Hongcheon River were investigated by examining their gill rakers, pharyngeal teeth, and digestive-tube contents. Gill rakers of the first arch were relatively few (17 to 21, mean = 19) and short (mean = 0.36 mm, SD = 0.035). The 2nd to 5th pharyngeal teeth were well developed, while the first tooth was poorly developed. Gill rakers and pharyngeal teeth were completely formed early in life. The digestive tube was long and arranged in many coils. The digestive-tube contents of Korean bitterling mainly consisted of phytoplankton and detrital microorganisms.

• Environmental Analysis Health and Toxicology
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• v.24 no.4
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• pp.341-350
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• 2009

This study involves a relationship between butyltins concentrations and histopathological changes of the digestive gland in the equilateral venus, Gomphina veneriformis exposed to TBTCl of 0.4, 0.6 and 0.8 ${\mu}g/L$ for 36 weeks. In the sediment, total butyltin (${\sum}BT$) concentration was detected ND~7.54 (0.4 ${\mu}g/L$), ND~9.76 (0.6 ${\mu}g/L$), 1.22~13.13 ${\mu}g/L$ (0.8 ${\mu}g/L$), respectively. Especially, TBT level in 0.8 ${\mu}g/L$ group was the highest for 36 weeks. In the soft tissue, total butyltin (${\sum}BT$) concentration of the exposure group was 10.14~12.75 (control), 479.29~1,286.56 (0.4 ${\mu}g/L$), 563.32~2,154.82 (0.6 ${\mu}g/L$) and 1,317.70~2,132.60 ${\mu}g/L$ (0.8 ${\mu}g/L$), respectively. Ratio of TBT to ${\sum}BT$ of the tissue of 0.8 ${\mu}g/L$ kept the lowest level for 36 weeks. The ${\sum}BT$ concentrations of sediment were correlated with ${\sum}BT$ concentrations in the tissue. In the exposure groups, necrosis and atrophy of columnar epithelial cell and collapse of epithelial layer in the digestive tubule. And there was a reduction in stain affinity of basophilic cell. Such histological degenerations was more severe in digestive tubule of 0.8 ${\mu}g/L$ group.

• Journal of Sasang Constitutional Medicine
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• v.22 no.2
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• pp.60-69
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• 2010

1. Objectives: The purpose of this study was to analyze the serum lipid, digestive enzymes, thyroid hormone of each Sasang type groups which were classified by Sasang medicine specialist. 2. Methode: The subjects were 1084 (male:female=399:685) person with 371 of Taeeum type, 324 of Soeum type, 389 of Soyang type after the Sasang type classification. The blood samples of the 1084 subjects were to analyze the serum lipid(triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol), digestive enzymes(lipase, amylase), thyroid hormone(T3, TSH). The general linear model (SPSS 12.0) were used for the analysis. 3. Results: Taeeum type group ($133.50\pm89.84$, $189.41\pm33.11$, $107.29\pm28.66$) showed significantly higher triglyceride, total cholesterol, LDL-cholesterol than other two group. In digestive enzymes(lipase, amylase), we found significant differences in the order of Soeum>Soyang>Taeeum. Soeum type group($116.23\pm21.38$) has lower T3 than Soyang type group ($119.90\pm21.60$) with marginal significance (p=0.066). 4. Conclusions: The Results of present study showed that Taeeum type showed significantly highest in triglyceride, total cholesterol, LDL-cholesterol. Soeum type showed significantly highest in digestive enzymes. Blood sample of each Sasang type group will serve as an important evidence for further study showing that the Sasang typology has biological basis.

• The Korean Journal of Malacology
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• v.14 no.2
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• pp.149-159
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• 1998

In order to observe the anticellulolytic localization in the epithelia of the digestive tract such as esophagus, crop, and intestine of a Korean land snail N. samarangae, a cytochemical method and a immunogold labelling method were applied. For the cytochemical study on the cellulase activity, Benedict reaction method applied. And for the immunocytochemical study, the rabbit serum immunoglobuins (IgG) was obtained from the rabbits injected with cellulase which was extracted from body fluid of the snail. The digestive tract tissues of N. samarangae were fixed with 4% paraformaldehyde and 2% OsO4 and embedded in Lowicryl K4M at -40$^{\circ}C$ under UV light (360 nm). The thin sections were loaded on the nickel grids and stained with the serum IgG and protein A-gold complex (particle size: 10 nm). Observations were undertaken with transmission electron microscope (Jeol, JEM-1010). The epithelium of the digestive tract was consisted of five types of cells. In the cytochemical study, the reaction products were found along the periphery of the vacuoles derived from the Bebedict reaction. In the immunocytochemical study, the protein-A gold particles were selectively labelled in Type 1, Type 3 and Type 4 cells in intestinal tissue. membranes of rER, in the surrounding cytoplasm of the rER and secretory granules, and in the apical cytoplasm of the cells. On the material being secreted from the apical cytoplasm was also labelled with the immunogold particles. The all results obtained throughtout present study suggest that the intestinal epithelium of the snail N. samarangae seretes cellulase as one of digestive enzymes.

• Korean Journal of Occupational Health Nursing
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• v.11 no.1
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• pp.5-12
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• 2002

The purpose of this study, as a project for health management at small workplace by Korean association of occupational health nurse, was to evaluate the program for correction of eating habits to prevent digestive disorders of workers. The study cases were twenty nine workers who voluntarily participated in the above program and they were from small(under fifty employees) workplace at Youngdeungpo-gu, Seoul. The study was done between January, 2000 and May, 2000. This program was concerned with daily menu for correction of eating habits and was composed of individual health education and distributing guide books and video. Nurses visited the workplace for the program once a week or two weeks. The result of this program was evaluated by paired t-test of digestive symptoms, eating habits, and self-efficacy before and after the fulfillment of the program. The result could be summarized as below. 1) There were decrease in digestive symptoms and improvement in eating habits and self-efficacy from study cases after fulfillment of the program. 2) The most common digestive symptoms were heartburn, upper abdominal pain, indigestion. The symptom which had been improved through the program were indigestion, heartburn and anorexia in the order. 3) The most improved eating habit was to eat flat foods instead of salty and spicy foods. The most improved self-efficacy was 'I can follow any helpful guides for my health'. The result indicated the program was successful for workers at small workplace. The continual management by nurses' regular visit once a week or two weeks was the most important thing for the successful program.

• The Journal of Internal Korean Medicine
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• v.41 no.1
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• pp.14-28
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• 2020

Objectives: The aim of this study was to analyze consumer experience with Digestive Enzymes, a digestive enzyme product that includes medicinal herbs (Multi-Zyme^®). The goal was to provide basic data on improvements and marketability of future digestive enzyme products containing medicinal herbs. Methods: Qualitative research was conducted to explore the current participants' experience. In-depth interviews with a semi-structured interview guide were conducted to investigate the experience and perception of the participants. The participants were recruited using snowball sampling and purposive sampling, and a qualitative content analysis method was adopted. Credibility was ensured by adopting a member check, triangulation, and peer debriefing method. Results: In-depth interviews were completed with a total of 8 participants. The collected data were classified into 16 codes and then further divided into the following seven categories: direct buying, indirect buying, effects, questions, recommendations, positive perception, and negative perception. The categories were grouped into three themes: 'Experience of purchasing existing health foods', 'Experience of taking Multi-Zyme', and 'Opinions on selling Multi-Zyme at Korean medicine clinics'. Conclusion: The participants experienced effect of the Multi-Zyme^® and were willing to recommend it around. However, the Korean medicine doctors need to inform consumers about the dose and duration when taking Multi-Zyme^® to prevent abuse. Some consumers may trust Multi-Zyme^® sales from Korean medicine clinics, but some held opinions that those sales were not trustworthy, so promotion and improvement are needed.

• Journal of Korean Public Health Nursing
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• v.10 no.1
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• pp.80-94
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• 1996

This study was to investigated the complaints of physical and mental health problem of professors and officials in H University of Seoul and collected during the period from April 25 to May 31. 1995. The complaints of physical and mental health problem were measured by Cornell Medical Index. The results of this study are as follows: 1. Among the items of physical health problem. respondents showed the highest rate of complaints related to fatigability. and among the items of mental health problem. respondents showed the highest rate of complaints related to inadequacy. 2. Females showed significantly higher rates of complaints related to the musculoskeletal system(p<0.001), fatigability(p<.001). habits(p<.01), inadequacy(p<.05). and tension(p<.001) compared with those of males. Twenties showed significantly higher rates of complaints related to the digestive system(p<.01) compared with those of other age groups. Singles showed significantly higher rates of complaints related to the digestive system(p<.05). inadequacy(p<.01) and depression(p<.001) compared with those of marries. Officals showed significantly higher rates of complaints related to the cardiovascular system(p<.01). digestive system(p<.05), musculoskeletal system(p<.05), and tension(p<. 05) compared with those of professors. Resondents who have irregular eating habits showed significantly higher rates of complaints related to the digestive system(p<.01), musculoskeletal system(p<.05). habits(p<.05). and depression(p<.001) compared with those of respondents who have regular eating habits. Respondents who usually sleep below 6 hours a day showed significantly higher rates of complaints related to the cardiovascular system(p<.01). digestive system(p<.05). musculoskeletal system(p<.01). fatigability(p<.05). habits(p<.01). and tension(p<.05) compared with those of respondents who sleep above 6 hours.