• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2002년도 제7차 학술대회 초록집
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• pp.86-86
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• 2002

Purpose： To evaluate the white matter fiber configuration in various developmental CNS anomaly 대상 및 방법： Jubert Syndrome, congenital schizencephaly, callosal agenesis and hemiplegic cerebral palsy patients were evaluated by diffusion tensor MRI. All studies were performed using a 1.5T Philips Gyroscan Intern system. Diffusion weighted imaging was performed using single-shot echo planar imaging, with navigator echo phase correction and SENSE. Diffusion weighting was performed along six independent axes, using diffusion weighting of b=600s/$\textrm{mm}^2$. 128 matrix/zero filled to 256, 23cm FOV, 3mm slice thickness were used for imaging parameters. Data were processed on a Window-2000 PC equipped with IDL and PRIDE (Philips Medical System).

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2002년도 제7차 학술대회 초록집
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• pp.85-85
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• 2002

Purpose： To evaluate the white matter fiber connectivity of normal human using diffusion tensor MRI. Method： Normal young healthy volunteers (2 women and 1 man) and 3 brain tumor patients participated in this study. All studies were performed using a 1.5T Philips Gyroscan Intern system. Diffusion weighted imaging was performed using single-shot echo planar imaging, with navigator echo phase correction and SENSE. Diffusion weighting was performed along six independent axes, using diffusion weighting of b=800s/$\textrm{mm}^2$. 128matrix, 23cm FOV, 2.5mm slice thickness were used for Imaging parameters. Data were processed on a Window-2000 PC equipped with IDL and PRIDE (Philips Medical System). Corticospinal tract was traced from mid-pons level via posterior limb of internal capsule. Corpus callosum, cerebellar peduncles and frontal fibers were traced by fiber tractography.

• The Journal of Korean Physical Therapy
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• 제32권6호
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• pp.388-390
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• 2020

Objectives: The nigrostriatal tract (NST) connect from the substantia nigra pars compacta to the striatum. A few previous studies have reported on the NST in the Parkinson's disease using a proboblistic tractography method. However, no study has been conducted for identification of the NST using streamline DTT technique. In the current study, we used streamline DTI technique to investigate the reconstruction method and characteristics of the NST in normal subjects. Methods: Eleven healthy subjects were recruited in this study. The NST from the substantia nigra of the midbrain and the striatum of basal ganglia was reconstructed using DTI data. Fractional anisotropy, apparent diffusion coefficient (ADC) values and fiber numbers of the NST were measured. Results: In all subjects, the NST between the substantia nigra of the midbrain and the striatum. Mean values for FA, ADC, and tract volume were 0.460, 0.818, and 154.3 in the right NST, and 0.485, 0.818, and 176.3 in the left NST respectively. Conclusions: we reconstructed the NRT from the substantia nigra of the midbrain and the striatum of the basal ganglia using streamline tractography method. We believe that the findings and the proposed streamline reconstruction method of this study would be useful in future researches on the NST of the human brain.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2018년도 춘계 종합학술대회 논문집
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• pp.61-62
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• 2018

DTI (Diffusion Tensor Imaging)에서는 임상적으로 매우 중요하나 긴 획득시간으로 인하여 적용에 어려움이 있었다. 그러나 최근에 개발된 다중대역병렬기법 (Multiband SENSE)은 동시에 여러 개의 절편을 획득이 가능한 기법으로 기존에 사용되는 병렬기법(SENSE)과 비교하여도 매우 유용한 것을 알 수 있다.

• The Journal of Korean Physical Therapy
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• 제30권2호
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• pp.73-77
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• 2018

Purpose: The prefrontal lobe, supplementary motor area, cerebellum, and basal ganglia are activated during gait. In addition, gait is controlled by nerves, such as the corticospinal tract (CST) and corticoreticular pathway (CRP). In this study, the presence of an injury to the CST and CRP was identified by diffusion tensor imaging and the characteristics of the gait pattern were investigated according to inferior cerebral artery infarction. Methods: One patient and six control subjects of a similar age participated. A 69-year-old female patient had an injury to the left basal ganglia, insular gyrus, corona radiata, dorsolateral prefrontal cortex, and postcentral gyrus due to an inferior cerebral artery infarction. Diffusion tensor imaging (DTI) data was acquired 4 weeks after the stroke. The kinematic and spatio-temporal parameters of gait were collected using a three-dimensional gait analysis system. Results: On 4 weeks DTI, the CST and CRP in the affected hemisphere did not show injury to the affected and unaffected hemisphere. Gait analysis showed that the cadence of spatio-temporal parameter was decreased significantly in the patient. The angle of the knee joint was decreased significantly in the affected and unaffected sides compared to the control group. Conclusion: The results of diffusion tensor imaging showed that although the patient was evaluated to be capable of an independent gait, the quality and quantity of gait might be reduced. This study could help better understand the gait ability analysis of stroke patients and the abnormal gait pattern of patients with a brain injury.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2006년도 제11차 학술대회
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• pp.48-48
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• 2006

• Investigative Magnetic Resonance Imaging
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• 제9권1호
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• pp.2-8
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• 2005

목적 : 뇌종양 및 확산텐서 영상으로 얻어진 그 주변 신경 다발을 동시에 가시화하는 소프트웨어를 구현하고 그것을 통해 뇌종양이 그 주변 신경다발에 미치는 영향에 대한 조사에의 적용 가능성을 시험해 보고자하였다. 대상 및 방법 : IDL을 기반으로 뇌종양과 그 주변 신경다발의 통합적 가시화를 구현하였다. 뇌종양을 가진 한 환자에 대한 T1 강조영상 및 확산텐서 영상을 포함하는 자기공명영상이 3.0T자기공명장치에서 획득되었다. 우리는 해부학적 정보를 위해 두개골을 제거한 뇌 영상과 구획화된 뇌종양을 위한 대조강화 T1 강조 영상을 이용하여 서피스 및 볼륨렌더링을 사용하였다. 대뇌 백질 신경 다발추적을 위해 사용되는 확산텐서영상을 위해서는 25개 방향의 확산경사 자계를 이용하는 SE-EPI방법을 사용하였다. 신경 다발추적 방법으로는 streamline과 tensorline 방법을 사용하였다. T1 강조 영상 및 확산텐서 영상의 공간적 불일치를 보정하기 위해 SPM을 이용한 정합을 수행하였다. 우리의 소프트웨어는 PC 윈도우 환경에서 작동할 수 있도록 구현되었다. 결과 : 한 명의 뇌종양 환자에 대하여 튜브 모양의 신경다발, 대뇌 백질 서피스 렌더링 , 뇌종양의 볼륨/서피스렌더링의 통합적 가시화를 성공적으로 구현하였다. 결론 : 우리의 결과는 뇌종양 및 그 주변 신경다발의 통합적 가시화의 실현 가능성을 보여주었다. 더불어 우리의 구현된 통합적 가시화는 뇌종양 부위 및 그 주변 부의의 대뇌 백질 확산 비등방성의 정량적인 분석에 사용될 수 있을 것으로 기대된다.

• 대한의용생체공학회:의공학회지
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• 제29권2호
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• pp.114-121
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• 2008

Within 2 to 5 months after stroke, patients recover variable degrees of function, depending on the initial deficit. An impaired hand function is one of the most serious disability in chronic stroke patients. Therefore, to evaluate the extent of motor dysfunction in the hemiplegic hand is important in stroke rehabilitation. In this paper, motor recoveries in 8 chronic stroke patients with Fugl-Meyer (FM) and white matter changes before and after the training program with a designed bilateral symmetrical arm trainer (BSAT) system were examined. The training was performed at 1 hr/day, 5 days/week during 6weeks. In all patients, FM was significantly improved after the 6-week training. Diffusion tensor imaging (DTI) results showed that tractional anisotropy ratio (FAR) and fiber tracking ratio (FTR) in the posterior internal capsule were significantly increased after the training. It seemed that the cortical reorganization was induced by the 6 week training with the BSAT. In all parameters proposed this study, a significant correlation was found between these parameters (FAR and FTR) and motor recoveries. This study demonstrated that DTI technique could be useful in predicting motor recovery in chronic hemiparetic patients.

• PNF and Movement
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• 제14권1호
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• pp.41-47
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• 2016

Purpose: In general, confabulation is defined as confusion of reality with past events without apparent prompting, in association with disruption of the capacity for retrieval and encoding of memory. We report on a patient who showed spontaneous confabulation associated with injury of the Papez circuit following middle cerebral artery (MCA) infarction. Methods: A 67-year-old female patient suffered cerebral infarct resulting from spontaneous MCA territory. After onset of the MCA infarct, she showed severe memory impairment and provoked confabulation. The Papez circuit was reconstructed for evaluation of part of it using diffusion tensor tractography (DTT). Fractional anisotropy (FA), mean diffusivity (MD), and tract volume were measured. Results: The right thalamocingulate tract showed a significant decrement of FA value and tract volume, and an increment of MD value by more than two standard deviations of that of normal control subjects. The tract volume in the left fornix and mammillothalamic tract decreased by more than two standard deviations of that of normal control subjects. Conclusion: Injuries of the Papez circuit were demonstrated in a patient who showed severe memory impairment and provoked confabulation following MCA infarct. We believe that analysis of the Papez circuit tract using DTT is useful in elucidating the cause of provoked confabulation in patients with MCA infarct.

• Journal of Yeungnam Medical Science
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• 제31권2호
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• pp.152-156
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• 2014

We report on a patient who showed visual recovery following bilateral occipital lobe infarct, as evaluated by follow up functional magnetic resonance imaging (fMRI) and diffusion tensor tractography (DTT). A 56-year-old female patient exhibited severe visual impairment since onset of the cerebral infarct in the bilateral occipital lobes. The patient complained that she could not see anything, although the central part of the visual field remained dimly at 1 week after onset. However, her visual function has shown improvement with time. As a result, at 5 weeks after onset, she notified that her visual field and visual acuity had improved. fMRI and DTT were acquired at 1 week and 4 weeks after onset, using a 1.5-T Philips Gyroscan Intera. The fiber number of left optic radiation (OR) increased from 257 (1-week) to 353 (4-week), although the fiber numbers for right OR were similar. No activation in the occipital lobe was observed on 1-week fMRI. By contrast, activation of the visual cortex, including the bilateral primary visual cortex, was observed on 4-week fMRI. We demonstrated visual recovery in this patient in terms of the changes observed on DTT and fMRI. It appears that the recovery of the left OR was attributed more to resolution of local factors, such as peri-infarct edema, than brain plasticity.