• Interaction and multiscale mechanics
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• v.4 no.2
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• pp.165-171
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• 2011

In this study, we proposed a three-dimensional dynamic model under the diffuse interface description for the single crawling cell. From the developed model, we described the clear evolution processes for crawling neutrophil and assessed the reliable quantitative chemotactic property, which confirmed the high possibility of adequate predictions. To establish the system considering of multiple mechanisms such as, diffusion, chemotaxis, and interaction with surface, a diffuse interface model is employed.

• 한국전산유체공학회:학술대회논문집
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• 2010.05a
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• pp.556-561
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• 2010

This paper proposes a three-dimensional haptotaxis model to simulate the migration of the population of cancer cells. The invasion of the cancer cells relates with the hapto- and the effect of the energy between cells and (ECM). The diffuse interface model is employed, which incorporates haptotaxis mechanism and interface energies. The semi-implicit Fourier spectral scheme is adopted for efficient complications. The simulation results reveal rich dynamics of cancer cells migration.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.11
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• pp.1355-1360
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• 2011

The interaction between the cell and the substrate is the most prominent feature affecting the migration of a crawling cell. This paper proposes a three-dimensional dynamic model using the diffuse interface description that reveals the effects of the interaction between a single crawling cell and the substrate during chemotactic migration. To illustrate the effects of interaction between the cell and the substrate, we consider the interfacial energy between the coexistent materials. Multiple mechanisms including the interface energy, chemotaxis effect, and diffusion, are addressed by employing a diffuse interface model.

• Journal of computational fluids engineering
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• v.17 no.3
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• pp.99-107
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• 2012

In this paper, the shock waves in compressible solids and liquids are simulated using a six-equation diffuse interface multiphase flow model that is extended to the Cochran and Chan equation of state. A pressure relaxation method based on a volume fraction function and a pressure-correction equation are newly implemented to the six-equation model. The developed code has been validated by a shock tube problem with liquid nitromethane and an impact problem of a copper plate on a solid explosive. In addition, a new problem, an impact of a copper plate on liquid nitromethane, has been solved. The present code well shows the wave structures in compressible solids and liquids without any numerical oscillations and overshoots. After the impact of a solid copper plate on liquid, two shock waves (one propagates into liquid and the other into solid) are generated and a material interface moves to the impacting direction. The computational results show that the shock velocity inside the liquid linearly increases with the impact velocity.

• International Journal of Naval Architecture and Ocean Engineering
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• v.5 no.3
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• pp.325-332
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• 2013

Diffuse interface model for numerical analysis was used to compute supercavitating flows around various cavitators. The ambient pressures of 2 atm permitted cavitation studies in a range of cavitation number, ${\sigma}=0.1$ to 1.0 on selected conical and disk-headed cavitors. The computed results were compared with relation by Reichardt. Drag coefficient obtained from pressure forces acting on the cavitator also compared well with those obtained from analytical relations.

• International Journal of Naval Architecture and Ocean Engineering
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• v.3 no.4
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• pp.263-273
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• 2011

The diffuse interface model of Saurel et al. (2008) is used for the computation of compressible cavitating flows around underwater missiles. Such systems use gas injection and natural cavitation to reduce drag effects. Consequently material interfaces appear separating liquid and gas. These interfaces may have a really complex dynamics such that only a few formulations are able to predict their evolution. Contrarily to front tracking or interface reconstruction method the interfaces are computed as diffused numerical zones, that are captured in a routinely manner, as is done usually with gas dynamics solvers for shocks and contact discontinuity. With the present approach, a single set of partial differential equations is solved everywhere, with a single numerical scheme. This leads to very efficient solvers. The algorithm derived in Saurel et al. (2009) is used to compute cavitation pockets around solid bodies. It is first validated against experiments done in cavitation tunnel at CNU. Then it is used to compute flows around high speed underwater systems (Shkval-like missile). Performance data are then computed showing method ability to predict forces acting on the system.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.1
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• pp.56-63
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• 2009

Cell migration is one of the essential mechanisms responsible for complex biological processes. Intensive researches have begun to elucidate the mechanisms and search intriguing conditions for efficient control of cell migration. One general mechanism that is widely applicable for cells including Escherichia coli, amoebae and endothelial cell is chemotaxis. The single cell study for bacterial chemotaxis has an advantage over studies with the population of cells in providing a clearer observation of cell migration, which leads to more accurate assessments of chemotaxis. In this paper, we propose a three-dimensional model considering a single bacterium to study its chemotaxis. The semi-implicit Fourier spectral method is applied for high efficiency and numerical stability. The simulation results reveal rich dynamics of cell migration and provide quantitative assessments of bacterial chemotaxis with various chemoattractant gradient fields.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1638-1642
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• 2008

Cell migration is one of the essential mechanisms responsible for complex biological processes. Intensive researches have begun to elucidate the mechanisms and search intriguing conditions for efficient control of cell migration. One general mechanism which is widely applicable for cells including neutrophil, Escherichia coli and endothelial cell is chemotaxis. Especially, understanding the chemotactic mechanics of cell crawling has important implications for various medical and biological applications. The single cell study for chemotaxis has an advantage over studies with the population of cells in providing a clearer observation of cell migration, which leads to more accurate assessments of chemotaxis. In this paper, we propose a three-dimensional model considering a single crawling cell to study its chemotaxis. The semi-implicit Fourier spectral method is applied for high efficiency and numerical stability. The simulation results reveal rich dynamics of cell.

• Journal of the Korean Association of Geographic Information Studies
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• v.9 no.4
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• pp.34-44
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• 2006

Simulation models allow researchers to model large hydrological catchment for comprehensive management of the water resources and explication of the diffuse pollution processes, such as land-use changes by development plan of the region. Recently, there have been reported many researches that examine water body quality using Geographic Information System (GIS) and dynamic watershed models such as AGNPS, HSPF, SWAT that necessitate handling large amounts of data. The aim of this study is to develop a watershed based water quality estimation system for the impact assessment on stream water quality. KBASIN-HSPF, proposed in this study, provides easy data compiling for HSPF by facilitating the setup and simulation process. It also assists the spatial interpretation of point and non-point pollutant information and thiessen rainfall creation and pre and post processing for large environmental data An integration methodology of GIS and water quality model for the preprocessing geo-morphologic data was designed by coupling the data model KBASIN-HSPF interface comprises four modules: registration and modification of basic environmental information, watershed delineation generator, watershed geo-morphologic index calculator and model input file processor. KBASIN-HSPF was applied to simulate the water quality impact by variation of subbasin pollution discharge structure.