• Journal of Acupuncture Research
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• v.21 no.1
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• pp.202-210
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• 2004

Objective: In order to find oriental medical therapies on Parkinson's disease and to make a fundamental basis for clinical application, this study was performed. Methods: We reviewed 35 kinds of the ancient and modern text, and related articles. Results: Parkinson's disease is an extrapyramidal disease characterized by akinesia, tremor at rest, rigidity, and slowness of movement. In old oriental medical text, Parkinson's disease is described as Jinjeon(振顫), Chi, Gyeong (痙), Gyejong, Ryeon(攣) and Pyeongo(偏枯), Tantan, Jungbu(中腑症) of Jungpung(中風). According to the text, major pathological causes were Wind(風), Fire(火), Phlegm(痰), and Blood stasis(瘀血). And Parkinson's disease can be classified into four clinical types as liver & kidney yin-deficiency, qi & blood deficiency, retention of phlegm-heat, and qi-stagnation & blood stasis. Standardized acupuncture points are GV20, GB20, GV14 on head, CV12, ST25 on abdomen, GV26, ST7, GB1, S14, LI20 on face, LI4, LI11, TE5, SI3, HT3, LI15, SI6 on upper extremity, and ST36, GB34, SP6, LR3, KI1, GB30, BL40 on lower extremity. Other methods, such as scalp acupuncture, electro-acupuncture, and herb-acupuncture, can be applied to treat Parkinson's disease. Conclusions: We find out that there are oriental medical concepts related with Parkinson's disease such as Jinjeon(振顫), Chi, Gyeong (痙), Gyejong, Ryeon(攣) and Pyeongo(偏枯), Tantan, Jungbu(中腑症) of Jungpung(中風), of which major causes are Wind(風), Fire(火), Phlegm(痰), and Blood stasis(瘀血). We can also apply many effective acupuncture points and acupuncture therapies according to differential diagnosis, for example, liver & kidney yin-deficiency. qi & blood deficiency, retention of phlegm-heat, and qi-stagnation & blood stasis.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1715-1720
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• 2013

Background: The discovery that microRNAs (miRNAs) regulate proliferation, invasion and metastasis provides a principal molecular basis of tumor heterogeneity. Microvessel distribution is an important characteristic of solid tumors, with significant hypoxia occurring in the center of tumors with low blood flow. The distribution of miR-374a in breast tumors was examined as a factor likely to be important in breast cancer progression. Methods: Breast tissue samples from 40 patients with breast cancer were classified into two groups: a highly invasive and metastatic group (HIMG) and a low-invasive and metastatic Group (LIMG). Samples were collected from the center and edge of each tumor. In each group, six specimens were examined by microRNA array, and the remaining 14 specimens were used for real-time RT-qPCR, Western blot and immunohistochemical analyses. Correlation analysis was performed for the miRNAs and target proteins. Follow-up was carried out during 28 months to 68 months after surgery, and survival data were analyzed. Results: In the LIMG, the relative content of miR-374a was lower in the center of the tumor than at its edge; in the HIMG, it was lower at the edge of the tumor, and miR-374a levels were lower in breast cancer tissues than in normal tissues. There was no difference between VEGF-A and VCAM-1 mRNA levels at the edge and center of the tumor; however, we observed a significant difference between VEGF-A and VCAM-1 protein expression levels in these two regions. There was a negative correlation between miR-374a and target protein levels. The microvessel density (MVD) was lower in the center of the tumor than at its edge in HIMG, but the LIMG vessels were uniformly distributed. There was a significant positive correlation between MVD and the number of lymph node metastases (Pearson correlation, r=0.912, P<0.01). The median follow-up time was 48.5 months. LIMG had higher rate of disease-free survival (100%, P=0.013) and longer median survival time (66 months) than HIMG, which had a lower rate of 75% and shorter median survival time (54 months). Conclusions: Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution, and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a. These data might explain the differences in the distribution of MVD in breast cancer and variation in breast cancer prognosis.

• Geotechnical Engineering
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• v.14 no.2
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• pp.107-126
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• 1998

Ground settlements induced by tunnel excavation cause the foundations of the neighboring building structures to deform. An expert system called NESASS( Neural network Expert System for Adjacent Structure Safety analysis) was developed to analyze the structural safety of such building structures. NESASS predicts the trend of ground settlements resulting from tunnel excavation and carries out a safety analysis for building structures on the basis of the predicted ground settlements. Using neural network technique. the NESASS learns the database consisting of the measured ground settlements collected from numerous actual fields and infers a settlement trend at the field of interest. The NESASS calculates the magnitudes of angular distortion, deflection ratio, and differential settlement of the structure. and in turn, determines the safety of the structure. In addition, the NESASS predicts the patterns of cracks to be formed in the structure, using Dulacska model for crack evaluation. In this study, the ground settlements measured from Seoul subway construction sites were collected and classified with respect to the major factors influencing ground settlement. Subsequently, a database of ground settlement due to tunnel excavation was built. A parametric study was performed to select the optimal neural network model for the database. A comparison of the ground settlement predicted by the NESASS with the measured ones indicates that the NESASS leads to reasonable predictions. The results of confidence evaluation for safety evaluation system of the NESASS are presented in this paper.

• Environmental Mutagens and Carcinogens
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• v.9 no.1
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• pp.1-12
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• 1989

To study the selective organospecific carcinogenesis by the specific chemical carcinogens, the breast cancer induction model by oral administration of 7, 12-dimethylbenzanthracene (DMBA) or by intravenous injection of N-methylni-trosourea (NMU) on female rats was analyzed. In the present experiment, we compared the effexts of ages on the chemical mammary carcinogenesis by studying the metabolic system of the carcinogenic activation, detoxification or DNA damage and repair. The breast tumor incidence was significantly higher in the young rats of 50 days old than in those of one year old rats. As an index of organospecific DNA damage or repair, the in vivo covalent binding index(CBI) of the specific organs by the specific chemical carcinogens was monitored. And for the analysis of carcinogenic activation, the quantity of cytochrome P450`s was determined with the respective type-specific monoclonal antibody, while the detoxication capacity was deduced by the activity monitoring of glutathione S-transferase (GST) and peroxidase. The skin tissues of the mammary region had the highest CBI with both of DMBA and NMU at 50 days of age. And there were contrasting differences in the contents of carcinogenic activation and detoxication system: that is, the content of T.C.D.D.-inducible cytochrome P450 was high, while the activities of GST and peroxidase was low in the mammary skin tissues at tumor prevalent age. These results led us to conclude that the molecular organospecific carcinogenesis, as illustrated with mammary carcinoge-nesis by DMBA and NMU, is operated probably through the differential capacity of the target tissues in the high carcinogenic activation, low detoxication and the low DNA repair function.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.1
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• pp.69-82
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• 2015

This Research is based on the theory of the prior researches that have demonstrated a positive impact of the entrepreneurship and competitive advantages on business performance. And the purpose of this research which approaches in the viewpoint of combining a entrepreneurial attribute including two factors(entrepreneurship and commercialization capabilities) and the differentiated competitive advantage as a role of core competence is to examine how the combined competence affects the business performance. In order to achieve this purpose, we conduct a survey for CEO of 250 small firms which belong to the start-up phase and are located in the 6 administrative region with the assistance of Small & Medium Business Administration representatives and analyze empirically the survey data by utilizing statistical program(Spss 18.0). As the results, we conclude that the entrepreneurial attributes of small firms' CEO and DFCA have a positive impact on business performance respectively and the entrepreneurship, one of the two entrepreneurial factors, has a positive impact on choosing DFCA. Also we report that DFCA plays a mediating role with regards to relationship between entrepreneurial attributes and business performance. Therefore, this research suggests the followings: First, the CEO of start-up business should focus on building a differential competitive advantage which is the basis for creating competitiveness from the initial point. Secondly, he should make a alignment for core competencies, in order to reach the stable growth phase in the shortest period, through which the entrepreneurial attributes is to be inherent as a discriminatory competitive competence. Third, he should promote to establish a business strategy based on strengthening of entrepreneurship and discriminatory competitive as a growth strategy during start-up phase.

• Journal of the Korean Society for Nondestructive Testing
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• v.32 no.1
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• pp.64-70
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• 2012

Two kinds of eddy current probes are mainly used to perform the steam generator tube integrity assesment in NPPs. The first one is the bobbin probe using for inspection of volumetric defect like a fretting wear. The second one is the rotating probe using for inspection of non-volumetric defect like a crack. The eddy current probe is one of the essential components which consist of the whole eddy current examination system, and provides a decisive data for the tube integrity in accordance with acceptance criteria described in specific procedures. The design of ECT probe is especially important to improve examination results because the quality of acquired ECT data is depended on the probe design characteristics, such as coil geometry, electrical properties, operation frequency. In this study, it is analyzed that the coil winding number of differential bobbin probe affects the electrical properties of the probe. Eddy current bobbin probes for the steam generator tubes in NPPs are designed and fabricated according to the results. Experiment shows that the change in coil winding number has much effects on the optimum inspection frequency determined by the tube geometry and material. Therefore, the coil winding number in bobbin probe is very important in the probe design. In this study, a basis of the coil winding number for the eddy current bobbin probe design for steam generator tubes in NPPs is established.

• 모자간호학회지
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• v.2 no.1
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• pp.5-20
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• 1992

This study was undertaken to identify the levels and affecting factors of the maternal role attainment(MRA) in the primipara during the postpartum period. The healthy ninety primiparous from the one university hospital and two local clinics in KwangJu city were selected and two Semantic Differential Scales (SD-Myself as Mothers, SD-My Baby) and the Pharis Self Confidence Scale were used in this study. Questionnaires were distributed at the 3rd days and the 4-6 weeks of the primiparous not showing any complication after normal delivery. The data collected were analysed statistically using t-test, Pearson's Product Moment Correlation Coefficient and ANOVA. The results obtained were summarized as follows; 1) On the 3rd day after the delivery, the scores of SD-myself as mother, SD-baby and Pharis Self Confidence were 70.6 points, 73.6 points and 78.6 points, respectively, showing the low level of MRA. 2) On the 4-6 weeks after delivery, the score of SD-myself as mother, SD-baby and Pharis Self Confidence were 72.8 points, 77.9 points, and 86.9 points, respectively, indicating the moderate level of MRA. 3) The mean scores of the SD scale and the Pharis Self Confidence during the postpartum periods were higher than those of the 3rd days, showing the SD-myself as mother (t=-2.09, P<.05), SD-baby(t=-4.12, P<.001), Pharis Self Confidence(t=-6.59, P<.001), respectively. 4) Positive correlations (r=.24$\sim$.69) were shown in the concepts related to the MRA and the cognitive-motor skill components and cognitive-affective skill components of the MRA became harmonious over time. 5) The relationships between the score of the MRA and the demographic and obstetric variables were as follows ; a) the score of the MRA in the twenties was higher than those of the thirties. b) the group with higher educational background showed higher MRA socres than the group with lower one. c) those who wanted pregnancy sustenance had higher MRA scores than those who did not. d) the group that did think of festus-feature represented higher MRA scores than those who did not. e) the group of mothers who have the daughters showed higher MRA scores than those who have boys. It can be concluded from the results that the MRA in the primiparous increased gradually, and that the cognitive-motor skills and cognitive-affective skills became harmonious over time. The level of the MRA was affected partly by the mothers general, obstetrical variables. Following suggestion were made oil the basis of the present study ; a) The longitudinal study on the MRA is needed. b) Multivariate analyses should be done for the identification of the factors influcening on the MRA. c) Education program for primiparous mother should be designed and developed to improve the MRA.

• Korean Journal of Poultry Science
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• v.19 no.4
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• pp.187-195
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• 1992

This study carried out to investigate selection response of pure line population of layer chicken. Data for two layer pure line of Single Comb White Leghorn were collected from 1986 to 1991. Primary selection criteria were egg number to 270 days of age (EN270), egg weight(BW270), body weight (BW270) at 270 days of age and the days of the 1st egg(SM). The results obtained in this study are summarized as follows ; 1. Mean phenotypic values of two strains were decreased by 1.94 day(K), 1.320ay(F) for SM and increased by 0.09g(K), -0.05g(F) for EW 270 and 0.56(K), -0.78(F) for EN270. 2. The ratio of a realized selection differential to expected selection differentials for SM (sexual maturity), EW 270, and BW 270 were not significantly decreased during 5 generations. 3. Heritability were estimated from sib analysis. The means of estimates were 0.28(F), 0.39(K) for BW270, and 0.25(F), 0.29(K) for EN270 and 0.51(F), 0.48(K) for EW270. 4. The genetic gains were estimated by method of selection index in retrospect on the basis of selection differentials. EN270 and EW270 were found to increase by 2.01(F), 2.25(K) and 0.54 (F), 0.65(K) per generation.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.45 no.3
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• pp.68-79
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• 2008

Aortic AIx(augmentation index) has been used to measure aortic stiffness quantitatively and even to evaluate ventricular load. However, in order to calculate aortic AIx catheters should be inserted to the subjects' artery, which hampers its clinical usage. To overcome such limitation, aortic AIx has been indirectly calculated by estimating aortic pressure wave from the peripheral arterial pulse by applying transfer functions. In this study, central aortic pressure waves using Millar catheter and radial artery pulse waves using tonometry pressure sensor were measured to establish transfer functions for an estimation of central aortic pressure waves from radial artery pulse waves. Also, an algorithm which detects augmentation point for the calculation of AIx were developed. Developed algorithm for the detection of augmentation point gradually increases the differential order to detect inflection point rather than detects the distinctive point that appears after a specific time. Transfer functions were established using 10th order ARX model and were verified for the stability of the transfer function through residual analysis. Evaluation of an algorithm for the detection of augmentation point were performed by comparing the augmentation points obtained from developed algorithm with the known augmentation points synthesized in various conditions. In addition, developed algorithm for the AIx is proved to provide more accurate results than the ones developed by previous studies. The significance of the study was in two folds. Firstly, the results could provide the basis for the measurement of aortic stiffness using easily-measurable radial artery pulse waves, and secondly, extension of the study may enable the early diagnosis of various vascular diseases.

• Journal of the Korean earth science society
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• v.22 no.1
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• pp.65-74
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• 2001

To evaluate the influence of meteorological conditions on the performance of DOAS (Differential Optical Absorption Spectroscopy) system, we analyzed the concentrations of three criteria pollutants and relevant environmental parameters measured during 14 month periods between Jun. 1999 and Oct. 2000. According to our study, the performance of DOAS can be sensitively influenced via various manners (such as among different chemicals and/or between different time periods). It turns out that O$_3$ exhibits most frequently the weakest agreement between two systems. When comparison was made among different meteorological parameters, the strongest variability was seen from such ones as windspeed, wind direction, and irradiance. In addition, the absolute differences in measured concentrations between two systems were compared against various environmental parameters by means of linear regression analysis. Results of this analysis indicated that the differences between the two tend to decrease with the increase of such parameters as windspeed. It is thus concluded on the basis of our study that the simultaneous evaluation of meteorological data should be an essential step toward the accurate assessment of pollutant concentration data obtained by DOAS measurement system.