• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.12
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• pp.5972-5989
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• 2019

With the onset of the big data age, data is growing exponentially, and the issue of how to optimize large-scale data processing is especially significant. Large-scale global optimization (LSGO) is a research topic with great interest in academia and industry. Spark is a popular cloud computing framework that can cluster large-scale data, and it can effectively support the functions of iterative calculation through resilient distributed datasets (RDD). In this paper, we propose a hybrid mechanism of particle swarm optimization (PSO) and differential evolution (DE) algorithms based on Spark (SparkPSODE). The SparkPSODE algorithm is a parallel algorithm, in which the RDD and island models are employed. The island model is used to divide the global population into several subpopulations, which are applied to reduce the computational time by corresponding to RDD's partitions. To preserve population diversity and avoid premature convergence, the evolutionary strategy of DE is integrated into SparkPSODE. Finally, SparkPSODE is conducted on a set of benchmark problems on LSGO and show that, in comparison with several algorithms, the proposed SparkPSODE algorithm obtains better optimization performance through experimental results.

• BMB Reports
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• v.48 no.10
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• pp.549-558
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• 2015

Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest. It is commonly believed to underlie organismal aging and age-associated diseases. However, the mechanism by which cellular senescence contributes to aging and age-associated pathologies remains unclear. Recent studies showed that senescent cells exert detrimental effects on the tissue microenvironment, generating pathological facilitators or aggravators. The most significant environmental effector resulting from senescent cells is the senescence-associated secretory phenotype (SASP), which is constituted by a strikingly increased expression and secretion of diverse pro-inflammatory cytokines. Careful investigation into the components of SASPs and their mechanism of action, may improve our understanding of the pathological backgrounds of age-associated diseases. In this review, we focus on the differential expression of SASP-related genes, in addition to SASP components, during the progress of senescence. We also provide a perspective on the possible action mechanisms of SASP components, and potential contributions of SASP-expressing senescent cells, to age-associated pathologies.

• Mycobiology
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• v.30 no.2
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• pp.88-92
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• 2002

Rehmannia glutinosa is a perennial medicinal plant belonging to the family Scrophulariaceae with more than 300 species known in the world, especially in temperate regions. Its roots have been used widely in Korea for medicinal purposes. However, it is commonly infected by various pathogens during storage, causing great damage to the roots, and impedes the intensive farming of the crop. Therefore, an attempt has been made to isolate and screen a resistance gene against the pathogen Fusarium oxysporum using differential display. We treated salicylic acid(SA), and isolated a resistance gene that responds to SA. As a result, we found that SA was involved in plant defense mechanism in pathogenicity tests with SA treated and non-treted plants, and we isolated a partial PR-la gene through differential display polymerase chain reaction(DD-PCR) method.

• Smart Structures and Systems
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• v.15 no.3
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• pp.735-749
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• 2015

The major difficulty of using Bayesian probabilistic inference for system identification is to obtain the posterior probability density of parameters conditioned by the measured response. The posterior density of structural parameters indicates how plausible each model is when considering the uncertainty of prediction errors. The Markov chain Monte Carlo (MCMC) method is a widespread medium for posterior inference but its convergence is often slow. The differential evolution adaptive Metropolis-Hasting (DREAM) algorithm boasts a population-based mechanism, which nms multiple different Markov chains simultaneously, and a global optimum exploration ability. This paper proposes an improved differential evolution adaptive Metropolis-Hasting algorithm (IDREAM) strategy to estimate the posterior density of structural parameters. The main benefit of IDREAM is its efficient MCMC simulation through its use of the adaptive Metropolis (AM) method with a mutation strategy for ensuring quick convergence and robust solutions. Its effectiveness was demonstrated in simulations on identifying the structural parameters with limited output data and noise polluted measurements.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.31 no.2 s.257
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• pp.151-158
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• 2007

The mechanism of power transmission from motor torque to stem thrust and the operation characteristic of each stroke position are analyzed using the diagnostic signal, and effects of differential pressure on the performance of motor operated flexible wedge gate valve are investigated. Test facility consists of 76 mm motor operated valve(flexible wedge type), pump and pipe system. Static and dynamic test are performed separately, and two differential pressure conditions are applied in the dynamic test. To evaluate the performance of valve, test signals for the torque, thrust, current, voltage and stroke length are acquired by using UDS which is diagnosis device for motor operated valve, and each diagnostic signal is analyzed and compared. The characteristic of valve performance factors such as stem factor, rate of loading, valve factor, are evaluated, and these factors are found to be severely influenced by the fluid differential pressure.

• Journal of Korean Society of Water and Wastewater
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• v.9 no.3
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• pp.65-77
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• 1995

The kinetics of flocculation of heterodisperse suspension like those in water treatment plants and natural water system are usually described by the Smoluchowski equation, which incorporates collision frequency functions for particle collisions by Brownian motion, fluid shear, and differential sedimentation. These collisionfrequeney functions have been based on a rectilinear view of collisions, i.e., one that ignores short-range forces and changes in fluid motion as particles approach one another. In this research, a curvilinear approach, i.e., one that accounts for hydrodynamic forces and particle interaction in the collision of two different size particles is developed. Collision efficiency factors of each mechanism can be calculated by trajectory analysis (fluid shear and differential sedimentation) or the solution of diffusion equation (Brownian motion). The results are presented as a set of corrections to the rectilinear collision frequency functions for each mechanism.

• Advances in Computational Design
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• v.4 no.3
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• pp.197-210
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• 2019

Motion generation of a four-bar linkage is a type of mechanism synthesis that has a wide range of applications such as a pick-and-place operation in manufacturing. In this research, the use of meta-heuristics for motion generation of a four-bar linkage is demonstrated. Three problems of motion generation were posed as a constrained optimization probably using the weighted sum technique to handle two types of tracking errors. A simple penalty function technique was used to deal with design constraints while three meta-heuristics including differential evolution (DE), self-adaptive differential evolution (JADE) and teaching learning based optimization (TLBO) were employed to solve the problems. Comparative results and the effect of the constraint handling technique are illustrated and discussed.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2013.05a
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• pp.389-390
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• 2013

• The Korean Journal of Physiology and Pharmacology
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• v.11 no.4
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• pp.149-154
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• 2007

Kainic acid (KA) causes neurodegeneration, but no consensus has been reached concerning its mechanism. Nitric oxide may be a regulator of the mechanism. We identified differentially expressed genes in the hippocampus of mice treated with kainic acid, together with or without L-NAME, a nonselective nitric oxide synthase inhibitor, using a new differential display PCR method based on annealing control primers. Eight genes were identified, including clathrin light polypeptide, TATA element modulatory factor 1, neurexin III, ND4, ATPase, $H^+$ transporting, V1 subunit E isoform 1, and N-myc downstream regulated gene 2. Although the functions of these genes and their products remain to be determined, their identification provides insight into the molecular mechanism(s) involved in KA-induced neuronal cell death in the hippocampal CA3 area.

• Journal of the Korean Ceramic Society
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• v.21 no.4
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• pp.349-354
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• 1984

The purpose of present study is to find the structure crystallization mechanism and physical properties in $TiO_2$ containing lead zinc borosilicate glass system. The experiments such as differential thermal analysis infrared spectral analysis. X-ray diffraction analysis and thermal expansion measurements have been done. Differential thermal analysis of coarse and fine glass powder showed bulk nucleating mechanism for high $TiO_2$ containing glasses and surface nucleation mechanism for low $TiO_2$ containing glasses. The prepared glasses crystallized to crystalline mixture of PbO.2ZnO. $B_2O_3$ .4PbO.2ZnO.$5B_2O_3$and 2PbO.ZnO.$B_2O_3$ when heat-treated in the range of 480 and 51$0^{\circ}C$ and crystallized to PbTiO3 when heat-treated at $600^{\circ}C$. Obtained crystalline phase of $PbTiO_3$ in glass matrix strongly affects to thermal expansion coefficient and the value of crystallized glass varied 68.0 to $107.1{\times}10-7$/$^{\circ}C$ depending on the amount of $TiO_2$added. Infrared spectral analysis showed that [$BO_3$] triangle and [$BO_3$] tetrahedral units were coexisted in the glass with high content of PbO.