• The Korean Journal of Nuclear Medicine
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• v.30 no.3
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• pp.299-314
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• 1996

The purpose of the present study was to validate the use of tissue radioactivity ratios instead of regional metabolic rates for the assessment of regional metabolic changes in Alzheimer's disease(AD) with [$^{18}F$]FDG PET and to examine the correlation of ratio indices with the severity of cognitive impairment in AD. Thirty-seven AD Patients(age $68{\pm}9 yrs$, $mean{\pm}s.d.$; 36 probable and 1 definite AD), 28 patients with dementia of non-Alzheimer type(age $66{\pm}7 yrs$), and 17 healthy controls(age $66{\pm}4 yrs$) underwent [$^{18}F$]FDG PET imaging. Two simplified radioactivity ratio indices were calculated from 37-66 min image: region-to-cerebellar radioactivity ratio(RCR) and a composite radioactivity ratio(a ratio of radioactivity in the most typically affected regions over the least typically affected regions: CRR). Local cerebral metabolic rate for glucose(LCMRglu) was also measured using a three-compartment, five-parameter tracer kinetic model. The ratio indices were significantly lower in AD patients than in controls(RCR in temporoparietal cortex, $0.949{\pm}0.136$ vs. $1.238{\pm}0.129$, p=0.0004; RCR in frontal cortex, $1.027{\pm}0.128$ vs. $1.361{\pm}0.151$, p<0.0001; CRR, $0.886{\pm}0.096$ vs. $1.032{\pm}0.042$. p=0.0024). On the RCR analysis, 86% of AD patients showed a pattern of bilateral temporoparietal hypometabolism with or without frontal involvement; hypometabolism was unilateral in 11% of the patients. When bilateral temporoparietal hypometabolism was considered to be suggestive of AD, the sensitivity and specificity of the RCR analysis for the differential diagnosis of AD were 86% and 73%, respectively. The RCR was correlated significantly with the macroparameter K [$K_1k_3/(k_2+k_3)$] (r=0.775, p<0.0001) and LCMRglu(r=0.633, p=0.0002) measured using the kinetic model. In patients with AD, both average RCR of cortical association areas and CRR were correlated with Mini-Mental Status Examination(r=0.565, p=0.0145; r=0.642, p=0.0031, respectively), Clinical Dementia Rating(r=-0.576, p=0.0124; r=-0.591, p=0.0077), and total score of Mattis Dementia Rating Scale (r=0.574, p=0.0648; r=0.737, p=0.0096). There were also significant correlations between memory and language impairments and corresponding regional RCRs. The results suggest that the [$^{18}F$]FDG PET ratio indices, RCR and CRR, reflect global and regional metabolic rates and correlate with the severity of cognitive impairment in AD. The simplified ratio analysis may be clinically useful for the differential diagnosis and serial monitoring of the disease.

• Asian-Australasian Journal of Animal Sciences
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• v.29 no.11
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• pp.1653-1663
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• 2016

Meat quality is a complex trait influenced by many factors, including genetics, nutrition, feeding environment, animal handling, and their interactions. To elucidate relevant factors affecting pork quality associated with oxidative stress and muscle development, we analyzed protein expression in high quality longissimus dorsi muscles (HQLD) and low quality longissimus dorsi muscles (LQLD) from Duroc pigs by liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomic analysis. Between HQLD (n = 20) and LQLD (n = 20) Duroc pigs, 24 differentially expressed proteins were identified by LC-MS/MS. A total of 10 and 14 proteins were highly expressed in HQLD and LQLD, respectively. The 24 proteins have putative functions in the following seven categories: catalytic activity (31%), ATPase activity (19%), oxidoreductase activity (13%), cytoskeletal protein binding (13%), actin binding (12%), calcium ion binding (6%), and structural constituent of muscle (6%). Silver-stained image analysis revealed significant differential expression of lactate dehydrogenase A (LDHA) between HQLD and LQLD Duroc pigs. LDHA was subjected to in vitro study of myogenesis under oxidative stress conditions and LDH activity assay to verification its role in oxidative stress. No significant difference of mRNA expression level of LDHA was found between normal and oxidative stress condition. However, LDH activity was significantly higher under oxidative stress condition than at normal condition using in vitro model of myogenesis. The highly expressed LDHA was positively correlated with LQLD. Moreover, LDHA activity increased by oxidative stress was reduced by antioxidant resveratrol. This paper emphasizes the importance of differential expression patterns of proteins and their interaction for the development of meat quality traits. Our proteome data provides valuable information on important factors which might aid in the regulation of muscle development and the improvement of meat quality in longissimus dorsi muscles of Duroc pigs under oxidative stress conditions.

• Korean Chemical Engineering Research
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• v.50 no.4
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• pp.749-753
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• 2012

In present work, anode support for micro-tubular SOFC was fabricated with outer diameter of 3 mm and characterized with microstructure, mechanical properties and gas permeability. The microstructure of surface and cross section of a porous anode support were analyzed by using SEM (Scanning Electron Microscope) image. The gas permeability and the mechanical strength of anode support was measured and analysed by using differential pressure at the flow rates of 50, 100, 150 cc/min. and using universal testing machine respectively. The unit cell composed of NiO-YSZ, YSZ, YSZ-LSM/LSM/LSCF was fabricated and operated with reaction temperature and fuel flow rate and showed maximum power density of $1095mW/cm^2$ on the condition of $800^{\circ}C$. The performance of single cell for micro-tubular SOFC increased with the increasing the reaction temperature due to the decrement of ohmic resistance of cell by the increment of the ionic conductivity of electrolyte through the evaluation of electrochemical impedance analysis for single cell with reaction temperature.

• Journal of Acupuncture Research
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• v.27 no.4
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• pp.19-28
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• 2010

Objectives : To demonstrate the need for differential diagnosis between discogenic pain and lumbar sprain and strain in acute low-back pain patients. Methods : Outpatients who made their first visits during May 1, 2009 to Oct. 30, 2009(n=53) were examined by history taking, physical examination, X-rays, and CT imaging. Disorders found on lumbosacral spine X-ray cuts and those on lumbosacral spine CT images were separately recorded. The relationship between treatment period, disc space narrowing and disc degeneration on X-rays, and HIVD on CT images was examined. Results : 1. Correlation between disc space narrowing on X-rays and HIVD found on CT images was analyzed. 21(72.41%) out of 29 patients having disc space narrowing on X-rays and HIVD on CT at the same level required treatment for over 8 weeks. 2. 2(50%) out of 4 Lawrence classification grade I patients, 8(66.67%) out of 12 grade II patients, and 14(70%) out of 20 grade III patients needed treatment for over 8 weeks. Conclusions : Disc space narrowing on X-ray and HIVD on CT at the same level, or disc space narrowing and disc degeneration on X-ray image alone indicate a tendency for treatment periods over 8 weeks, which is longer than the conventional treatment period for lumbar strain and sprain.

• Archives of design research
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• v.19 no.1 s.63
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• pp.225-234
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• 2006

Product designers sketch various ideas of foreground figures(detail design) onto background figures(basic form) and evaluate numerous combinations of them in the late stages of design process. Designers have to test their ideas elaborately with a high-fidelity physical model that looks like a real product. However, due to the requirements of time and expense in making high-fidelity design models, it is impossible to evaluate such a number of combinatorial solutions of background and foreground figures. Contrary to digital models, physical design models are not easily modifiable and so designers cannot easily develope ideas through iterative design-evaluation process. To address these problems, we proposed a new concept 'Augmented Plasticity' that gives morphological editability to a rigid physical object using Augmented Reality technology and implemented the idea as Digital Skin system. Digital Skin system figures out the position and orientation of object surface with ARToolKit visual marker and superimposes a deformed surface image seamlessly using differential rendering method. We tried to apply Digital Skin system to detail design, redesign of product, and material exploration task. In consequence, it was found that Digital Skin system has potential to allow designers to implement and test their ideas very efficiently in the late stages of design process.

• The Journal of the Korea Contents Association
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• v.13 no.5
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• pp.303-310
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• 2013

Thyroid nodular disease is the most frequently appeared in thyroid disease. Thyroid ultrasonography offers location of nodules, size, the number, information of internal echo characteristic. Thus, it makes possible to sort high-risk nodule containing high possibility about thyroid cancer and to induct precisely when take a Fine Needle Biopsy Aspiration. On thyroid nodule, the case which is diagnosed as malignant is less than 5% but screening test is very important on ultrasound and also must be reduced unnecessary procedure. Therefore, in this study an approach for describing a region is to quantity its texture content. We applied TFA algorithm on case which has been pathologically diagnosed as papillary thyroid cancer. we obtained experiment image which set the ROI on ultrasound and cut the $50{\times}50$ pixel size, histogram equalization. Consequently, Disease recognition detection efficiency of GLavg, SKEW, UN, ENT parameter were high as 91~100%. It is suggestion about possibility on CAD which distinguishes thyroid nodule. In addition, it will be helpful to differential diagnosis of thyroid nodule. If the study on additional parameter algorithm is continuously progressed from now on, it is able to arrange practical base on CAD and it is possible to apply various disease in the thyroid US.

• Proceedings of the Korean DIstribution Association Conference
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• 2007.08a
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• pp.3-26
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• 2007

Recently, both scholars and marketers have asserted the importance of boundary spanning behaviors, such as external representation, being vocal advocates to outsiders of the organization's image, goods, and services, internal influence, taking individual initiative in communications to the firm and co-workers to improve service delivery by the organization, co-workers, and oneself, and service delivery, serving customers in a conscientious, responsive, flexible, and courteous manner. However, there is lack of study dealing with bourdary spanning behaviors bewteen organizational dyads, in which boundary spanning behaviors are expected to have important roles. The objectives of this paper is to investigate these important concerns with prior research by developing a theoretical model predicting how distinct buyer's boundary spanning behaviors occur. To be concrete, this paper develops a seller characteristics-based model of the attitudinal antecedents of three conceptually distinct forms of boundary spanning behaviors, and tests the hypothesized differential effects of seller characteristics on the three forms of boundary spanning behaviors, and investigates the extent to which these relationships are mediated by relationship satisfaction and organizational commitment. For the purpose of empirical testing, 420 respondents of leading automobile dealers, dining franchisees, industrial material retailers in Korea were surveyed and the analysis utilizing structural equation model indicated that communication quality, fairness, and marketing program dynamism had positive effects on buyer's boundary spanning behaviors via relationship satisfaction and organizational commitment. In addition, boundary spanning behaviors occurred more in contractural and corporate distribution channel than in conventional distribution channel.

• Tunnel and Underground Space
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• v.26 no.1
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• pp.24-31
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• 2016

Recently, many studies have been conducted to use fixed-wing and rotary-wing unmanned aerial vehicles (UAVs, Drones) for topographic surveying in open-pit mines. Because the fixed-wing and rotary-wing UAVs have different characteristics such as flight height, speed, time and performance of mounted cameras, their results of topographic surveying at a same site need to be compared. This study selected a construction site in Yangsan-si, Gyeongsangnam-do, Korea as a study area and compared the topographic surveying results from a fixed-wing UAV (SenseFly eBee) and a popular rotary-wing UAV (DJI Phantom2 Vision+). As results of data processing for aerial photos taken from eBee and Phantom2 Vision+, orthomosaic images and digital surface models with about 4 cm grid spacing could be generated. Comparisons of the X, Y, Z-coordinates of 7 ground control points measured by differential global positioning system and those determined by eBee and Phantom2 Vision+ revealed that the root mean squared errors of X, Y, Z-coordinates were around 10 cm, respectively.

• Economic and Environmental Geology
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• v.17 no.3
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• pp.215-230
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• 1984

Petrological, paleomagnetic, geomorphological and structural studies on the southern part of, so called, Chugaryeong rift valley, have been carried out in order to clarify the nature of the rift valley. Three stages of volcanic activities characterized by Jijangbong acidic volcanic rocks and tholeiitic and andesitic basalt of Cretaceous age(?), and Jongok Quaternary olivine basalt occurred along the Dongducheon fault line. Jijangbong acidic volcanic rocks distributed in the central part of the studied area consist of rhyodacite, acidic tuff and tuff breccia, which are bounded by Dongsong fault on the east and Daegwangri fault on the west. The Jongok basalt differs from those of Ulrung and Jeju islands in mineralogy, chemical composition and differentiation. Jongok basalt distributed along the Hantan river dilineates the vesicles curved toward downstream direction and increment of numbers and thickness of lava flow toward upstream direction. These facts suggest that lava flowed from upstream side of the river. Rectangular drainage patterns also support the presence of the Dongducheon, Pocheon, Wangsukcheon and Kyonggang faults which were previously known. LANDSAT image, however, does not show any lineaments which could be counted as a graben or rift valley. Displacement of Precambrian quartzite and Jurassic Daedong supergroup along the southwestern extension of the Dongducheon fault shows the right lateral movement. The Paleomagnetic study of the tholeiitic and andesitic basalts from Baegeuri, Jangtanri and Tonghyeonri located at 2. 3km east, 0km east, and 1.5km west of Dongducheon fault respectively shows that their VGP(Virtual Geomagnetic Pole) being to intermediate geomagnetic field of short duration which suggests that they formed in almost same period. Mean VGP of Jongok basalt is located 82.4N and 80.6E. This is in good coincidence with worldwide VGP of Plio-Pleistocene indicating that Jongok basalt was extruded during Plio-Pleistocene epoch, and suggesting that the studied area has been tectonically stable since then. From the present study, the tectonic episode of the region is concluded as following three stages. 1. The 1st period is worked by the Daebo orogeny of Jurassic during which granodiorite was intruded in Precambrian basement. 2. The 2nd period is the time when right lateral strike-slip fault of NNE-SSW direction was formed probably during late Cretaceous to Paleogene and the Jijangbong acidic volcanic rocks and the older basalts were extruded. 3. The 3rd period is the time when the fault was rejuvenated during Pliocene or Pleistocene accompanied by the eruption of Jongok basalt. As a conclusion, geologic structure of the studied area is rather fault line valley than graben or rift valley, which is formed by differential erosion along the Dongducheon fault suggesting a continuation of the Sikhote-Alin fault. The volcanic rocks including the Jijangbong acidic rocks, tholeiitic-andesitic basalt and olivine basalt are associated with this fault line.

• Journal of Korean Society for Geospatial Information Science
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• v.17 no.3
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• pp.23-31
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• 2009

The border of the shorelines in a nation is an important factor in determining the border of a national territory, but Korea's shorelines are rapidly changing due to the recent rise in sea level from global warming and growth-centered economic policy over the decades of years. This research was done centering on the areas having well-preserved shorelines as they naturally are and other areas having damaged shorelines in their vicinities due to artificial structures at the two beaches located at the neighboring areas and having mutually homogeneous ocean conditions with each other. First, this research derived the shorelines using the aerial photographies taken from 1947 until 2007 and revised the tidal levels sounding data obtained from a hydrographical survey automation system consisting of Echosounder[Echotrac 3100] and Differential Global Positioning System[Beacon]by using topographical data and ships on land obtained by applying post-processing Kinematic GPS measuring method. In addition, this research evaluated the changes and dimensional variations for the last 60 years by dividing these determined shorelines into 5 sections. As a result, the Haewundae Beach showed a total of 29% decrease rate in dimension as of the year 2007 in comparison with the year 1947 due to a rapid dimensional decline centering on its west areas, while the dimension of the Gwanganri Beach showed an increase in its dimension amounting to a total of 69% due to the decrease in flow velocity by artificial structures built on both ends of the beach-forming accumulation; thus, it was found that there existed a big difference in deposition & accumulation tendency depending on neighboring environment in spite of the homogeneous ocean conditions.