• 약학회지
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• 제49권2호
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• pp.151-155
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• 2005

For decades, the demand for new antiviral strategies, especially in hepatitis, has increased markedly due to its devastating pathogenic outcome, In the present study, we examin ed the antiviral effect of the combination of amantadine and biphenyl dimethyl dicarboxylate (DDB) in HepG2 2.2.15, which is transfected with HBV DNA. The study demonstrated that the combination not the single treatment may have an anti-HBV effect through a synergism of antiviral, anti-inflammatory and cytoprotective activities in STAT1 ${\alpha}$, 6-16 gene, and pro-inflammatory components such as nitric oxide and IL-1${\beta}$ expression. In addition, hepatitis B surface and core gene expression were examined as a final end point for the anti-HBV activities, which was also significantly suppressed comparing to normal control (p<0.01).

• Archives of Pharmacal Research
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• 제22권2호
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• pp.124-129
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• 1999

The present study was undertaken to investigate the effect of biphenyl dimethyl idcarboxylate (PMC) on the humoral immunosuppression by ketoconazole (KCZ) in ICR mice. PMC at a dose of 6 mg/kg was administered orally to mice daily for 14 consecutive days. KCZ was suspended in RPMI 1640 medium and orally administered at 160 mg/kg/day 2 hrs after the administration of PMC. Mice were immunized an challenged with challenged red blood cells (SRBC). The results of the present study are summarized as follows; a gain of body weight and relative weights of spleen and liver were significantly increased by combination of PMC and KCZ, as compared with those in mice treated with KCZ alone. Splenic plaque forming cells (PFC) and hemagglutination (HA) titers to SRBC were greatly enhanced by the combination of PMC and KCZ, compared with treatment of KCZ alone. The elevation of serum glutamicpyruvic transminase (S-GPT) and total protein levels caused by KCZ were reduced to normal level by the combination of PMC and KCZ. In addition, lower serum albumin and A/G ratio were also increased to normal level. These findings indicate that PMC has a protective effect against KCZ-induced humoral immunosuppression.

• 한국식품위생안전성학회지
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• 제28권1호
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• pp.56-62
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• 2013

연구에서는 PEN 수지 안전관리를 위하여 HPLC-UV 검출기를 이용한 2,6-NDC 및 2,6-NDA 분석법을 확립하였다. 분석법 검증 결과, 2,6-NDC 및 2,6-NDA 모두 $0.002{\mu}g/mL$ 검출한계, $0.005{\mu}g/mL$ 정량한계 및 $0.05{\sim}1{\mu}g/mL$의 농도 범위에서 $r^2$= 0.999 이상의 직선성을 확인할 수 있었다. 또한 회수율도 90~110%임을 확인할 수 있었다.

• Journal of Pharmaceutical Investigation
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• 제29권3호
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• pp.227-234
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• 1999

Solid dispersions were prepared to increase the dissolution rate of biphenyl dimethyl dicarboxylate (DDB) using water-soluble carriers such as povidone, copolyvidone, $2-hydroxypropyl-{\beta}-cyclodextrin (HPCD)$, sodium salicylate or sodium benzoate by solvent evaporation method. Solid dispersions were characterized by infrared spectrometry, differential scanning calorimetry (DSC) and powder X-ray diffractometry, dissolution and permeation studies. DDB tablets (7.5 mg) were prepared by compressing the powder mixtures composed of solid dispersions, lactose, com starch, crospovidone and magnesium stearate using a single-punch press. DDB capsules (7.5 mg) were also prepared by filling the mixtures in empty hard gelatin capsules (size No.1). From the DSC and powder x-ray diffractometric studies, it was found that DDB was amorphous in the HPCD or copolyvidone solid dispersions. Dissolution rates after 10 min of DDB alone and solid dispersions (1 : 10) in sodium benzoate, sodium salicylate and copolyvidone were 11.8, 23.5, 22.8 and 82.5%, respectively. Dissolution rates of DDB after 30 min from 1 : 10 and 1 : 20 copolyvidone solid dispersions were 80.5 and 95.0%, respectively. For the DDB tablets prepared using solid dispersions (1 : 20), the initial dissolution rate was dependent on carrier material, and was ranked in order, $Kollidon\;30\;{\ll}$ copolyvidone < HPCD. For the HPCD solid dispersion tablets, dissolution rate reached 97.4% after 15 min, but thereafter slowly decreased to 80.7% after 2 hr due to the precipitation of DDB. However, in the case of copolyvidone solid dispersion tablets, dissolution increased linearly and reached 93.4% after 2 hr. Reducing the volume of test medium from 900 to 300 ml markedly decreased the dissolution rate of the tablets containing 1 : 20 HPCD solid dispersions and 1 : 10 copolyvidone solid dispersion. For 1 : 20 copolyvidone solid dispersion tablets, there was no significant change in dissolution rate up to 1 hr with different volumes of test medium. Preparation of the copolyvidone solid dispersion (1 : 20) in capsules markedly delayed the dissolution (31.2 % after 2hr) due to the limited diffusion within capsules. The permeation rate $(13.4\;g/cm^2\;after\;8\;hr)$ of DDB through rabbit duodenal mucosa from copolyvidone solid dispersion (1 : 10) was markedly enhanced, when compared with drug alone or physical mixtures. From overall findings, DDB formulations containing copolyvidone solid dispersions (1 : 20) could be used to remarkably improve the dissolution rate in dosage form of powders and tablets.

• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 2003년도 봄 학술발표회 논문집
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• pp.341-342
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• 2003

Poly(trimethylene 2,6-naphthalate)(PTN)은 dimethyl-2,6-naphthalene dicarboxylate(NDC)와 1,3-propanediol(PDO)로 합성된 polyester이다. 비록 PTN은 아직 상업화된 resin은 아니지만 Poly(trimethylene terephthalate)(PTT)와 비슷한 화학적 구조를 가지며 PTT 보다 높은 유리전이 온도(72$^{\circ}C$)를 나타내고 있으므로 다양한 분야에 응용될 수 있다. 특히 최근에 1,3-propanediol based polyester는 가스 차탄 특성이 우수하다는 것이 보고되었으며 PTN의 산소, 이산화탄소 등 가스 차단 특성은 poly(ethylene 2,6-naphthalete)(PEN)보다 우수한 것으로 보고되었다. (중략)

• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 2002년도 봄 학술발표회 논문집
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• pp.247-250
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• 2002

Poly(ethylene 2,6-naphthalene dicarboxylate)(PEN)은 그 주사슬에 PET의 벤젠고리 대신 나프탈렌 고리로 치환된 구조로 인하여 PEN섬유는 내열성, 탄성계수(modulus), 형태안정성(dimensional stability), 내화학성 등에서 PET에 비해 우수한 장점을 갖고 있으며, 따라서 고온, 고습한 환경에서도 기계적 성질을 오랫동안 유지할 수 있다. 그리고 중합 및 방사 등의 제조 공정이 PET와 유사하여 향후 고강력, 고형 태안정성 산업용사에서 획기적인 변화를 가져올 것으로 기대된다. (중략)

• Archives of Pharmacal Research
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• 제15권4호
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• pp.336-342
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• 1992

Ten [$Pd^{II}$(dicarboxylato)(1, 2-diaminocyclohexane)] complexes were prepared after the antitumor-active Pt(II)1, 2-diaminocyclohexane complexes as the cisplatin analogues of palladium series. They were characterized by means of elemental analysis, IR and NMR spectroscopy. As a result, the dicarboxylate ligands were conformed to be chelated with Pd(II) within the scope studied. The stability differences beween the dicarboxylato complexes according to the chelate ring size could not be differentiated due to generally lower thermodynamic stability of the dicarboxylato Pd(II) complexes.

• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 2001년도 가을 학술발표회 논문집
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• pp.91-94
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• 2001

Poly(ethylene 2,6-naphthalene dicarboxylate)(PEN)은 그 주사슬에 PET의 벤젠고리 대신 나프탈렌 고리로 치환된 구조로 인하여 PEN섬유는 내열성, 탄성계수(modulus), 형태안정성(dimensional stability), 내화학성 등에서 PET에 비해 우수한 장점을 갖고 있으며, 따라서 고온, 고습한 환경에서도 기계적 성질을 오랫동안 유지할 수 있다. (중략)

• Bulletin of the Korean Chemical Society
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• 제29권12호
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• pp.2383-2389
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• 2008

• Bulletin of the Korean Chemical Society
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• 제34권5호
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• pp.1583-1585
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• 2013