• Clinical and Experimental Pediatrics
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• v.57 no.8
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• pp.337-344
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• 2014

Inherited bone marrow failure syndrome (IBMFS) encompasses a heterogeneous and complex group of genetic disorders characterized by physical malformations, insufficient blood cell production, and increased risk of malignancies. They often have substantial phenotype overlap, and therefore, genotyping is often a critical means of establishing a diagnosis. Current advances in the field of IBMFSs have identified multiple genes associated with IBMFSs and their pathways: genes involved in ribosome biogenesis, such as those associated with Diamond-Blackfan anemia and Shwachman-Diamond syndrome; genes involved in telomere maintenance, such as dyskeratosis congenita genes; genes encoding neutrophil elastase or neutrophil adhesion and mobility associated with severe congenital neutropenia; and genes involved in DNA recombination repair, such as those associated with Fanconi anemia. Early and adequate genetic diagnosis is required for proper management and follow-up in clinical practice. Recent advances using new molecular technologies, including next generation sequencing (NGS), have helped identify new candidate genes associated with the development of bone marrow failure. Targeted NGS using panels of large numbers of genes is rapidly gaining potential for use as a cost-effective diagnostic tool for the identification of mutations in newly diagnosed patients. In this review, we have described recent insights into IBMFS and how they are advancing our understanding of the disease's pathophysiology; we have also discussed the possible implications they will have in clinical practice for Korean patients.

• Design & Manufacturing
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• v.14 no.1
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• pp.63-68
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• 2020

Ultra-high brightness and thin displays need to optical micro-patterns which can uniformly diffuse the lights and low loss. The micro random patterns have characteristics to rise the optical efficiency such as light extraction, uniform diffusion. For this reason, various fabrication processes are studied for random patterns. In this study, the micro random patterns were machined by diamond turning which used a controlled cutting tool path with random cutting depth. The machined patterns had random shape and directionality along the circumferential direction. The average width and length of machined random pattern according to rotation radius were 40.13㎛~55.51㎛ and 37.25㎛~59.49㎛, and these results were compared with the designed result. Also, the machining error according to rotation radius in diamond turning using randomly controlled cutting depth was discussed.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.05a
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• pp.687-691
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• 2000

Diamond turning machines for manufacture of precision optics require deliberate diagnosis to ensure that all the machine elements are properly operating, kinematically, dynamically and thermally, to produce demanded work qualities. One effective way is to directly inspect topographical features of work surfaces that have been carefully generated with prescribed machining conditions intended to exaggerate faulty consequences of any ill-operating machine elements. In this research, a very-large-scale Phase measuring interferometric system that has been developed for years at Korea Advanced Institute of Science and Technology is used to fulfill the metrological requirements fur the surface analysis. A special stitching technique is used to extend the measuring range, which integrates all the patches that are separately sampled over the whole surface while moving the stage. Then, the measured surface profile is analyzed to releated the machine error sources. For this, zernike polynomial fitting is used together with the wavelet filter and the fourier transform. Experimental results showed that the suggested technique in this study is very effective in diagnosing actual diamond turning machines

• Journal of the Korean Society for Precision Engineering
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• v.20 no.6
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• pp.20-26
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• 2003

This study proposes the construction of attractor quadrant method for high-precision cutting characteristics evaluation of non-ferrous metals. Also this paper aims to find the optimal cutting conditions of diamond turning machine by measuring surface form and roughness to perform the cutting experiment of non-ferrous metals, which are aluminum, with diamond tool. As well, according to change cutting conditions such as feed rate, using diamond turning machine to Perform cutting Processing, by measuring cutting force and surface roughness and according to cutting conditions the aluminum about cutting properties. Trajectory changes in the attractor indicated a substantial difference in fractal characteristics and attractor quadrant characteristics. In quantitative quadrant feature extraction, 1,309 point in the case of A17075 (one quadrant) and 1,406 point (one quadrant) in the case of brass were proposed on the basis of attractor reconstruction. Proposed attractor quadrant method can be used for high-precision cutting characteristics evaluation of non-ferrous metals.

• Journal of the Korean institute of surface engineering
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• v.53 no.6
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• pp.360-368
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• 2020

Wear resistance of cutting tools is one of the most important requirements in terms of the durability of cutting tool itself as well as the machining accuracy of the workpiece. Generally, tungsten carbide ball end mills have been processed with hard coatings for high durability and wear resistance such as diamond coating and tetrahedral amorphous carbon(ta-C) coating. In this study, we developed multilayer ta-C coatings whose wear resistance is comparable to that of diamond coating. First, we prepared single layer ta-C coatings according to the substrate bias voltage and Ar gas flow, and the surface microstructure, raman characteristics, hardness and wear characteristics were evaluated. Then, considering the hardness and wear resistance of the single layer ta-C, we fabricated multilayer coatings consisting of hard and soft layers. As a result, it was confirmed that the wear resistance of the multilayer ta-C coating with hardness of 51 GPa, and elastic recovery rate of 85% improved to 97% compared to that of the diamond coated ball end mill.

• Korean Journal of Materials Research
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• v.34 no.2
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• pp.105-110
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• 2024

Scanning probe microscopy (SPM) has become an indispensable tool in efforts to develop the next generation of nanoelectronic devices, given its achievable nanometer spatial resolution and highly versatile ability to measure a variety of properties. Recently a new scanning probe microscope was developed to overcome the tip degradation problem of the classic SPM. The main advantage of this new method, called Reverse tip sample (RTS) SPM, is that a single tip can be replaced by a chip containing hundreds to thousands of tips. Generally for use in RTS SPM, pyramid-shaped diamond tips are made by molding on a silicon substrate. Combining RTS SPM with Scanning spreading resistance microscopy (SSRM) using the diamond tip offers the potential to perform 3D profiling of semiconductor materials. However, damage frequently occurs to the completed tips because of the complex manufacturing process. In this work, we design, fabricate, and evaluate an RTS tip chip prototype to simplify the complex manufacturing process, prevent tip damage, and shorten manufacturing time.

• The Korean Journal of Ceramics
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• v.2 no.4
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• pp.216-220
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• 1996

In the present paper, a new type of DC arc plasma torch is disclosed. The principles of the new magnetic and fluid dynamic controlled large orifice long discharge tunnel plasma torch is discussed. Two series of DC Plasma Jet diamond film deposition equipment have been developed. The 20kW Jet equipped with a $\Phi$70 mm orifice torch is capable of deposition diamond films at a growth rate as high as 40$\mu\textrm{m}$/h over a substrate area of $\Phi$65 mm. The 100kW high power Jet which is newly developed based on the experience of the low power model is equipped with a $\Phi$120 mm orifice torch, and is capable of depositing diamond films over a substrate area of $\Phi$110 mm at growth rate as high as 40 $\mu\textrm{m}$/h, and can be operated at gas recycling mode, which allows 95% of the gases be recycled. It is demonstrated that the new type DC plasma torch can be easily scaled up to even higher power Jet. It is estimated that even by the 100kW Jet, the cost for tool grade diamond films can be as low as less than ＄4/carat.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2002.10a
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• pp.203-208
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• 2002

This paper deals with turning experiments of aluminium alloy using a single crystal diamond with round cutting edge. A face cutting was conducted using a special precision machine to study the characteristic phenomena in heavy cutting of aluminium alloy. In many cases, one of the most important matter on the surface integrity is about a damaged layer remaining just under the surface after machining. A machined surface roughness can be improved at a small geometrical surface roughness under special cutting conditions, even if a steady vibration exists between a tool and a workpiece.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2011.06a
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• pp.195-196
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• 2011

• Transactions of the Korean Society of Machine Tool Engineers
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• v.16 no.1
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• pp.80-85
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• 2007

High speed cutting is a machining process which cuts materials with the fast movement and rotation of a spindle in a machine tool. High speed cutting leaves a plastically deformed layer on the machined surface. This deformed layer affects in various forms to the surface roughness of machined parts such as the dimensional instability, the micro crack. The surface roughness is called surface integrity which is very important in precision cutting. This paper aims to study on the machined surfaces characteristics of aluminum alloy and brass by AFM(Atomic force microscope) measurement. The objective is contribution to ultra- precision cutting by exhibit foundation data of surface roughness and tool wear when parts are cutting with diamond tool at the factory.