• BMB Reports
• /
• v.40 no.5
• /
• pp.765-772
• /
• 2007

Eosinophils act as effectors in the inflammatory reactions of allergic diseases including atopic dermatitis. Atopic dermatitis patients and others with allergic disorders suffer from eosinophilia, an accumulation of eosinophils due to increased survival or decreased apoptosis of eosinophils. In this study, a differential phosphoproteome analysis of AML14.3D10 eosinophil cell line after treatment with IL-5 or dexamethasone was conducted in an effort to identify the phosphoproteins involved in the proliferation or apoptosis of eosinophils. Proteins were separated by 2-DE and alterations in phosphoproteins were then detected by Pro-Q Diamond staining. The significant quantitative changes were shown in nineteen phosphoproteins including retinoblastoma binding protein 7, MTHSP75, and lymphocyte cytosolic protein 1. In addition, seven phosphoproteins including galactokinase I, and proapolipoprotein, were appeared after treatment with IL-5 or dexamethasone. Especially, the phospho-APOE protein was down-regulated in IL-5 treated AML14.3D10, while the more heavily phosphorylated APOE form was induced after dexamethasone treatment. These phosphoproteome data for the AML14.3D10 cell line may provide clues to understand the mechanism of eosinophilia as well as allergic disorders including atopic dermatitis.

• The Journal of Korean Academy of Prosthodontics
• /
• v.26 no.1
• /
• pp.153-169
• /
• 1988

There is a little scientific documentation reporting the stress, distribution to the edentulous mandible by different concepts of occlusal scheme. So, this study was to investigate the hypothesis that the magnitude and distribution of the occlusal stresses, transmitted through a mandibular complete denture base to the edentulous mandible, would be influenced by the lingualized occlusion. This investigation was performed to analyze the stresses induced in a three-dimensional photoelastic edentulous mandible, when a load is applied to the denture arranged into lingualized occlusion in centric relation, lateral and protrusive functional position. The mounted denture on a Dentatus Type ARO articulator was loaded in a pure vertical direction with 15kgs on the center of articulator in each case and the stresses were frozen into epoxy edentulous model at $127^{\circ}C$ in the stress freezing furnace. The stress-frozen epoxy models were sliced with diamond disc saw into 4mm thick. The slices were examined with a circular polariscope. The results were as follows: 1. In centric relation, the stresses were low at anteriors, and gradually increase to the premolar, molar area and highest at the first molar and gradually decrease from the second molar and lowest at the retromolar pad region. The lingual side showed higher stresses than labiobuccal side. 2. In lateral functional position, the working side showed higher stresses than the balancing side. In working side, the lingual side showed higher stresses than the buccal side and in balancing side, the buccal side showed higher stresses than the lingual side. 3. In protrusive position, stress distribution was symmetrical on the posteriors and the stresses were concentrated at the labial side of the anteriors.

• The Journal of Information Systems
• /
• v.26 no.4
• /
• pp.379-400
• /
• 2017

Purpose The purpose of this study is to investigate the effects of ICT on multilevel marketing organizations (MLMs) whose members are both salespeople and consumers. This study explores the effects of the latest ICT convergence on the direct selling, which is the oldest sales method, and suggests the direction for the development of network marketing. Therefore, we will propose the changes in direct sales brought by ICT and predict the future direction of network marketing in preparation for the 4th Industrial Revolution era. Design/methodology/approach Exploratory case study was the methodology selected for this paper. The case study enables the use of multiple methods for data collection and analysis. This study applies qualitative case-study methodology on Amway Korea, which is the top seller of MLM organizations, to better understand the impact of ICT. This study conducted an in-depth interview with four different levels of MLM members (e.g. membership, ruby, emerald, diamond) which are based on the qualification system of MLM organizations and observed their behaviors. Findings This study revealed that the ICT impact on network marketing organizations(MLMs) could be summarized as follows : new membership growth, easier communication with customers, increase in work efficiency, increase in organizational trust, change in educational environment, and increase in the use of social media. Based on the interview, we propose the changes of network marketing organizations in the fourth industrial revolution era and the future strategy of Amway Korea as follows: (1) retention of royal ABOs, (2) harmony with SMEs, (3) utilization of Big Data, (4) creation of IoT business model, and (5) construction of successful O2O business platform.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.21 no.4
• /
• pp.663-671
• /
• 2017

This study analyzed the determinants influencing competitiveness of artificial intelligence industry of Korea. Analysis showed that the factors having the greatest influence on the national competitiveness of the artificial intelligence industry were, in decreasing order of importance, R&D, capital, and ICT competitiveness. Given the capital-intensive characteristic of the artificial intelligence technology, it is important to enhance the national R&D capacity in artificial intelligence technology and ICT, and to make substantial investments in the establishment of related infrastructure. Considering that the development and utilization of ICT infrastructure serves as the basis for artificial intelligence technology, the high standards of Korean consumers are expected to have a positive catalytic effect on the acquisition of national competitiveness for the artificial intelligence industry. For companies to respond in a timely manner to the rapid dissemination and high impact of artificial intelligence technology, they must prepare for such advancements by improving their competencies.

• Proceedings of the KIEE Conference
• /
• 1996.07c
• /
• pp.1446-1449
• /
• 1996

Thin films of diamond-like carbon(DLC) have been deposited using a magnetron plasma-enhanced chemical vapor deposition(PECVD) method with an rf(13.56 MHz) plasma of $C_{3}H_{8}$. From the Langmuir probe I-V characteristics, it can be observed that increasing the magnetic field yields an increase of the temperature($T_e$) and density($N_e$) of electron. At a magnetic field of 82 Gauss, the estimated values of $T_e$ and $N_e$ are approximately $1.5\;{\times}\;10^5$ K(13.5 eV) and $1.3\;{\times}\;10^{11}\;cm^{-3}$, respectively. Such a highly dense plasma can be attributed to the enhanced ionization caused by the cyclotron motion of electrons in the presence of a magnetic field. On the other hand, the negative dc self-bias voltage($-V_{sb}$) decreases with an increasing magnetic field, which is irrespective of gas pressure in the range of $1{\sim}7$ mTorr. This result is well explained by a theoretical model considering the variation of $T_e$. Deposition rates of DLC films increases with a magnetic field. This may be due to the increased mean free path of electrons in the magnetron plasma. Structures of DLC films are examined by using various techniques such as FTIR and Raman spectroscopy. Most of hydrocarbon bonds in DLC films prepared consist of $sp^3$ tetrahedral bonds. Increasing the rf power leads to an enhancement of cross-linking of carbon atoms in DLC films. At approximately 140 W, the maximum film density obtained is about 2.4 $g/cm^3$.

• Journal of Korean Ophthalmic Optics Society
• /
• v.5 no.2
• /
• pp.127-138
• /
• 2000

Differential equations and their solutions were formulated to describe the deflection of both temples and front frames and the pressure exerted by them varying parameters such as elastic modulus, thickness, length, width and shape of crosssection. The effect of such parameters on the deflections of both temples and front frames was illustrated by plotting the solutions of the derived equations. Deflection of temples was found to be maximum where the cross section was diamond-shaped and to be minimum with the rectangular cross section while thickness and cross section area of temples remain constant. The effect of parameters consisting of front frame on the deflection of front frames are very similar to those on temples. The central deflection and pressure of front frame initiated by the temple decreases as the length of temple increases. Detailed analysis of stresses at various parts of the temple will help design custom made spectacle frame as well as most comfortable frames.

• Steel and Composite Structures
• /
• v.37 no.2
• /
• pp.175-191
• /
• 2020

In this article, for the first time, the seismic behavior of elliptic-braced moment resisting frame (ELBRF) is assessed through a laboratory program and numerical analyses of FEM specifically focused on the development of global- and local-type failure mechanisms. The ELBRF as a new lateral braced system, when installed in the middle bay of the frames in the facade of a building, not only causes no problem to the opening space of the facade, but also improves the structural behavior. Quantitative and qualitative investigations were pursued to find out how elliptic braces would affect the failure mechanism of ELBRF structures exposed to seismic action as a nonlinear process. To this aim, an experimental test of a ½ scale single-story single-bay ELBRF specimen under cyclic quasi-static loading was run and the results were compared with those for X-bracing, knee-bracing, K-bracing, and diamond-bracing systems in a story base model. Nonlinear FEM analyses were carried out to evaluate failure mechanism, yield order of components, distribution of plasticity, degradation of structural nonlinear stiffness, distribution of internal forces, and energy dissipation capacity. The test results indicated that the yield of elliptic braces would delay the failure mode of adjacent elliptic columns and thus, help tolerate a significant nonlinear deformation to the point of ultimate failure. Symmetrical behavior, high energy absorption, appropriate stiffness, and high ductility in comparison with the conventional systems are some of the advantages of the proposed system.

• Journal of Digital Convergence
• /
• v.15 no.7
• /
• pp.367-373
• /
• 2017

The study aims to suggests mobile application service that helps to reduce physical and mental suffering after surgery for breast cancer patients constantly increasing. At first, I analyze literature research to understand the breast cancer and similar services for achieving study purposes. After I finally design a mobile application that offers to customed one-to-one specialist coaching service focused on post-treatment management by using a double diamond design process model. In detail, first, I analyze the current program and comprehend user needs through interviews with the person such as breast patient, protector, nurse, salesperson in cancer center. Second, I specify the entire scenario, concept and keyword based on the persona and the customer journey map representing user. Third, I propose the mobile application for the ultimate goal by producing prototype to effectively communicate with specific functional descriptions. I hope this service will improve the quality of their lives.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.14 no.3
• /
• pp.1081-1089
• /
• 2013

The purpose of this paper is to suggest the formation plan of green cluster for the enhancement of green industry competitiveness in Korea. For this reason, this paper has the analysis to find out regional competitiveness and effective factors in the green industry. The major findings are as follows. First, the renewable energy industry was competitive at Gyeonggi, Gyeongnam, Chungbuk, Chungnam, Ulsan, Jeonnam, and the carbon reduction industry was competitive at Ulsan, Gyeonggi, Gyeongbuk,, Chungnam, Seoul, Chungbuk, Inchon. Second, the most important factors of the renewable energy industry was factor condition, such as business, labor, research and development; while in the carbon reduction industry was sector of structure and rivalry, such as performance, policy and institution, market share, industry specialization. Third, it showed that the green industry was more competitive at the local area with the better industrial infrastructure. So, we need to focus on the green of existing industry-infrastructure, and the strategy of selection and concentration, for the enhancement of green industry competitiveness in Korea.

• The Korean Journal of Health Service Management
• /
• v.5 no.2
• /
• pp.209-226
• /
• 2011

The purpose of this study is to analyze and find out key success factors and marketing strategies of Bumrungrad Hospital in Bangkok, Thailand. The major success factors of Bumrungrad Hospital are as follows; First, Bumrungrad Hospital had professional medical team and board of directors who had the international career. Second, Bumrungrad was supported by Thai government and they were in a cooperative relationship with each other for the development of the medical industry. Third, Bumrungrad appropriately handled the internal and external changes including Asia Financial Crises in 1997 and others. Fourth, Bumrungrad diversified and broaden its business field such as global medical investing and management, medical technology, anti-age medicine and wellness. Marketing strategies of Bumrungrad analyzed are the following four factors. First, Bumrungrad focused on the quality of services by employing professional medical staffs, who have the international certification, and by constructing IT system for hospital management. Second, Bumrungrad has maintained an equalized price policy to attract the customers bothin the domestic and foreign markets. The cost for care has appealed the foreign customers for its comparatively low price, but it focused mainly on the upper middle class in Thailand. Third, it established, managed, and consulted hospitals in the foreign countries including the Philippines and the Arab Emirates. Fourth, it adopted differentiated promotion strategies suitable for the special needs of domestic and foreign customers, and put emphasis on the buzz marketing.