• Title/Summary/Keyword: diagnostic technique

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Oral Lichen Planus and Oral Lichenoid Lesion: Diagnosis and Assessment of Direct Immunofluorescence

  • Lee, Kyung-Eun
    • Journal of Oral Medicine and Pain
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    • v.41 no.3
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    • pp.91-98
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    • 2016
  • Purpose: Oral lichen planus (OLP) has generated many discussions and been associated with much controversy for a long time. A reliable diagnosis of OLP has proven challenging and significant disagreements concerning its diagnosis has continued. Therefore, the aim of this study was to apprehend newly proposed diagnostic criteria of OLP and oral lichenoid lesion (OLL) and to evaluate difference of final diagnosis of OLP and OLL in accordance with type of diagnostic criteria. Also, direct immunofluorescence (DIF) was compared to evaluate the value of DIF between two groups. Methods: Fifty-two patients with DIF result were retrospectively reviewed. The selected patients were classified by the modified World Health Organization (WHO) diagnostic criteria of OLP and OLL and by criteria proposed by American Academy of Oral and Maxillofacial Pathology (AAOMP). Results of DIF in OLP and OLL were classified by deposition intensity or pattern of fibrinogen. The classification of fluorescence pattern in each specimen was graded as positive, possibly positive or negative. Results: Patients diagnosed as OLP were a few more when the modified WHO diagnostic criteria were used than when criteria proposed by AAOMP were used. There was no statistical difference of DIF between OLP and OLL by applying the WHO modification criteria or criteria proposed by AAOMP. Conclusions: The final diagnosis of OLP could be changed in accordance with type of diagnostic criteria and difference of DIF between OLP and OLL was not found.

Evaluation of Chest Density in Insight Film (Insight film을 이용한 농도측정 평가)

  • Kwon, Lee-Seon;Park, Jang-Hwan;Lim, Oh-Soo;Jung, Kyong-Mo;Cheung, Hwan
    • Journal of radiological science and technology
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    • v.15 no.2
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    • pp.17-23
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    • 1992
  • Simple chest radiography is the most frequently performed examination in radiologic practice. However, with transmitted dose through chest which has the problem of wide variations in absorption, conventional Film/Screen Combinations Method make it difficult to delineate lung field mediastinum & cardia portion and subdiaphragmatic structures. In order to overcome this problem, we have been tried several methods as follows. High Kilovoltage Technique, Rare Earth Screen/Wide Lattitude Film, Use of Compensating Filter and Digital Beam Attenuator and recently Insigh System has been developed. In this paper, we'd like to discuss Insight film through apperciation by measuring the difference of contrast. In order to evaluate insight film. We have done experiments using Insight System with Simple Phase, Picker 550. We could get an result which was able to overcome the limitted dynamic range of conventional Film/Screen System remarkably.

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Diagnostics for Heteroscedasticity in Mixed Linear Models

  • Ahn, Chul-Hwan
    • Journal of the Korean Statistical Society
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    • v.19 no.2
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    • pp.171-175
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    • 1990
  • A diagnostic test for detecting nonconstant variance in mixed linear models based on the score statistic is derived through the technique of model expansion, and compared to the log likelihood ratio test.

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Ultrasound Breast Elastographic Evaluation of Mass-Forming Ductal Carcinoma-in-situ with Histological Correlation - New Findings for a Toothpaste Sign

  • Leong, Lester Chee Hao;Sim, Llewellyn Shao-Jen;Jara-Lazaro, Ana Richelia;Tan, Puay Hoon
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.5
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    • pp.2673-2678
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    • 2016
  • Background: It is unclear as to whether the size ratio elastographic technique is useful for assessing ultrasound-detected ductal carcinoma-in-situ (DCIS) masses since they commonly lack a significant desmoplastic reaction. The objectives of this study were to determine the accuracy of this elastographic technique in DCIS and examine if there was any histopathological correlation with the grey-scale strain patterns. Materials and Methods: Female patients referred to the radiology department for image-guided breast biopsy were prospectively evaluated by ultrasound elastography prior to biopsy. Histological diagnosis was the gold standard. An elastographic size ratio of more than 1.1 was considered malignant. Elastographic strain patterns were assessed for correlation with the DCIS histological architectural patterns and nuclear grade. Results: There were 30 DCIS cases. Elastographic sensitivity for detection of malignancy was 86.7% (26/30). 10/30 (33.3%) DCIS masses demonstrated predominantly white elastographic strain patterns while 20/30 (66.7%) were predominantly black. There were 3 (10.0%) DCIS masses that showed had a co-existent bull's-eye sign and 7 (23.3%) other masses had a co-existent toothpaste sign, a strain pattern that has never been reported in the literature. Four out of 4/5 comedo DCIS showed a predominantly white strain pattern (p=0.031) while 6/7 cases with the toothpaste sign were papillary DCIS (p=0.031). There was no relationship between the strain pattern and the DCIS nuclear grade. Conclusions: The size ratio elastographic technique was found to be very sensitive for ultrasound-detected DCIS masses. While the elastographic grey-scale strain pattern should not be used for diagnostic purposes, it correlated well with the DCIS architecture.

Research about pulse diagnostic technique out of "Nan Jing hoeju jeonjung" ("난경회주전정(難經滙注箋正)"중(中) 맥진(脈診)에 관한 연구(硏究))

  • Park, Keun-Jung;Yoon, Chang-Yeol
    • Journal of Haehwa Medicine
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    • v.15 no.2
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    • pp.39-52
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    • 2006
  • We came to the conclusion as follows from the research about pulse diagnostic technique (脈診) out of "Nan Jinghoeju jeonjung" (難經滙注箋正). 1. "Nan Jing" is practical medical book for clinician and holds different opinions about three portions and nine takings(三部九候脈法) from Huang Di Nei Jing's Taking the pulse of Bu Jung Chim Chon Kwan Chuk((浮中沈 寸關尺) is a quite creative means which has been a important role to future generation. 2. We pointed the differences between western medical science and traditional medical science. And can explain the pulse in western medicine divided from twelve channels of Oriental Medicine. We can explain special connection between heart and lungs using the theory of systemic & pulmonary circulation in western medicine. And this can be a basement of Lung controls every pulse theory in oriental medicine. 3. We have negative assertion about viewing the human body using theory of Yin and Yang-Five Elements. And have poor opinion of explaining about the matching internal organs to Chon Kwan Chuk using the theory of Yin and Yang-Five Elements. 4. We pointed out the mistake that Porak & Sang hwa act for heart. We took pulses considering heart is a real actual internal organ as others. 5. We denied the theory of Man's Chuk pulse is always weak(男子尺脈恒弱) & Woman's Chuk pulse is always strong(女子尺脈恒盛). The physical form of man and woman is not different from each other considering their inheritances from forefather & same shape of organs. So, we cannot insist on the theory.

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New Diagnostic Technique and Device for Lightning Arresters by Analyzing the Wave Height Distribution of Leakage Currents (누설전류의 파고분포 분석에 의한 새로운 피뢰기 진단기술 및 장치)

  • 길경석;한주섭;송재영;조한구;한문섭
    • The Transactions of the Korean Institute of Electrical Engineers C
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    • v.52 no.12
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    • pp.562-567
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    • 2003
  • Lightning arresters are deteriorated by repetition of protective operation against overvoltages or impulse currents in environments of its use. If a deteriorated arrester is left in power lines, it can lead to an accident such as a line to ground fault even in a normal system. Therefore, it is necessary to eliminate the deteriorated arrester in advance by checking the soundness of arresters on a regular basis, and to ensure the reliability of power systems by preventing accidents. Various deterioration diagnostic techniques and devices are suggested, and most of which measure leakage current components as an indicator of arrester ageing. However, the techniques based on the magnitude of leakage current measure simply RMS or peak value of leakage current components and do not provide detailed information needed in the diagnosis. In this study, we found that the wave height distributions of the total leakage currents are remarkably changed or a new wave height are produced with the progress of arrester deterioration. To propose a new technique for the diagnosis, we designed a leakage current detection unit and an analysis program which can measure leakage current magnitudes and analyze wave height distributions. From the experimental results, we confirmed that the proposed technique by analyzing the wave height distribution can simply diagnose the mode of defects such as a partial damage and an existence of punctures in arresters as well as deterioration of arresters.

Monoclonal Antibody-Based Dipstick Assay: A Reliable Field Applicable Technique for Diagnosis of Schistosoma mansoni Infection Using Human Serum and Urine Samples

  • Demerdash, Zeinab;Mohamed, Salwa;Hendawy, Mohamed;Rabia, Ibrahim;Attia, Mohy;Shaker, Zeinab;Diab, Tarek M.
    • Parasites, Hosts and Diseases
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    • v.51 no.1
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    • pp.93-98
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    • 2013
  • A field applicable diagnostic technique, the dipstick assay, was evaluated for its sensitivity and specificity in diagnosing human Schistosoma mansoni infection. A monoclonal antibody (mAb) against S. mansoni adult worm tegumental antigen (AWTA) was employed in dipstick and sandwich ELISA for detection of circulating schistosome antigen (CSA) in both serum and urine samples. Based on clinical and parasitological examinations, 60 S. mansoni-infected patients, 30 patients infected with parasites other than schistosomiasis, and 30 uninfected healthy individuals were selected. The sensitivity and specificity of dipstick assay in urine samples were 86.7% and 90.0%, respectively, compared to 90.0% sensitivity and 91.7% specificity of sandwich ELISA. In serum samples, the sensitivity and specificity were 88.3% and 91.7% for dipstick assay vs. 91.7% and 95.0% for sandwich ELISA, respectively. The diagnostic efficacy of dipstick assay in urine and serum samples was 88.3% and 90.0%, while it was 90.8% and 93.3% for sandwich ELISA, respectively. The diagnostic indices of dipstick assay and ELISA either in serum or in urine were statistically comparable (P>0.05). In conclusion, the dipstick assay offers an alternative simple, rapid, non-invasive technique in detecting CSA or complement to stool examinations especially in field studies.

Diagnostics and Prognostics Based on Adaptive Time-Frequency Feature Discrimination

  • Oh, Jae-Hyuk;Kim, Chang-Gu;Cho, Young-Man
    • Journal of Mechanical Science and Technology
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    • v.18 no.9
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    • pp.1537-1548
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    • 2004
  • This paper presents a novel diagnostic technique for monitoring the system conditions and detecting failure modes and precursors based on wavelet-packet analysis of external noise/vibration measurements. The capability is based on extracting relevant features of noise/vibration data that best discriminate systems with different noise/vibration signatures by analyzing external measurements of noise/vibration in the time-frequency domain. By virtue of their localized nature both in time and frequency, the identified features help to reveal faults at the level of components in a mechanical system in addition to the existence of certain faults. A prima-facie case is made via application of the proposed approach to fault detection in scroll and rotary compressors, although the methods and algorithms are very general in nature. The proposed technique has successfully identified the existence of specific faults in the scroll and rotary compressors. In addition, its capability of tracking the severity of specific faults in the rotary compressors indicates that the technique has a potential to be used as a prognostic tool.

A suggestion of Aortic wall Stiffness Evaluation Technique Independent on Changeable Blood Pressure : Aortic Distensibility Index (변화하는 혈압의 영향을 받지 않는 동맥 벽의 강화도 측정 방법 제안 : 대동맥 확장지수)

  • Seo, Jee-Hye;Choi, Dong-Ho;Wu, Zhuqing;Rienmueller, Rainer;Lee, Jong-Min
    • Journal of Biomedical Engineering Research
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    • v.29 no.2
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    • pp.151-158
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    • 2008
  • To evaluate aortic wall stiffness without influence of different background blood pressure, a new technique was developed and verified. At eight swine descending aortae, volume-pressure measurement was performed using custom-made system. Based on averaged pressure-volume curve, aortic distensibility index was formulated to evaluate aortic wall stiffness regardless of variable blood pressure and aortic size. The variability of aortic distensibility index by pressure change was compared with other parameters for wall stiffness evaluation. Subsequently, the aortic distensibility index was calculated at 100 contrast-enhanced EBCT data sets of normal volunteers in regular health screening program. The measured aortic distensibility index was compared with age, coronary calcium score, and aortic calcium score. Between 50 and 360 mmHg of blood pressure, the coefficient of variance of aortic distensibility index was 22.00% as comparing with 88.99% of classical compliance. Based on age, aortic distensibility index showed correlation coefficient of 0.55, whereas classical compliance showed 0.26. The correlation coefficient with modified aortic calcification was 0.43. Linear regression study revealed statistical significance of correlation coefficients. The aortic distensibility index, the method to evaluate aortic wall stiffness free from variable blood pressure and aortic size, was developed and verified with significant practical feasibility.

Performance Evaluation of Biozentech Malaria Scanner in Plasmodium knowlesi and P. falciparum as a New Diagnostic Tool

  • Firdaus, Egy Rahman;Park, Ji-Hoon;Muh, Fauzi;Lee, Seong-Kyun;Han, Jin-Hee;Lim, Chae-Seung;Na, Sung-Hun;Park, Won Sun;Park, Jeong-Hyun;Han, Eun-Taek
    • Parasites, Hosts and Diseases
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    • v.59 no.2
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    • pp.113-119
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    • 2021
  • The computer vision diagnostic approach currently generates several malaria diagnostic tools. It enhances the accessible and straightforward diagnostics that necessary for clinics and health centers in malaria-endemic areas. A new computer malaria diagnostics tool called the malaria scanner was used to investigate living malaria parasites with easy sample preparation, fast and user-friendly. The cultured Plasmodium parasites were used to confirm the sensitivity of this technique then compared to fluorescence-activated cell sorting (FACS) analysis and light microscopic examination. The measured percentage of parasitemia by the malaria scanner revealed higher precision than microscopy and was similar to FACS. The coefficients of variation of this technique were 1.2-6.7% for Plasmodium knowlesi and 0.3-4.8% for P. falciparum. It allowed determining parasitemia levels of 0.1% or higher, with coefficient of variation smaller than 10%. In terms of the precision range of parasitemia, both high and low ranges showed similar precision results. Pearson's correlation test was used to evaluate the correlation data coming from all methods. A strong correlation of measured parasitemia (r2=0.99, P<0.05) was observed between each method. The parasitemia analysis using this new diagnostic tool needs technical improvement, particularly in the differentiation of malaria species.