• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7497-7500
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• 2015

Background: Tumor markers, designated as a broad group of substances produced by malignancies, could be in the form of biochemical substances, immunological substances, cell surface changes and genetic alterations. Cancer, a disorder of cellular behavior is characterized by alteration of serum glycoproteins. L-fucose, a hexose, which is the terminal sugar in most of the plasma glycoproteins, may be useful as a tumor marker for the detection, monitoring and prognostic assessment of malignancies. The aim of the study was to ascertain the role of serum fucose as a biomarker for early detection of oral cancer and to compare serum fucose levels in healthy controls, leukoplakia and oral cancer patients. Materials and Methods: The study included 60 (100.0%) subjects, who were grouped as 20 (33.3%) control subjects, 20 (33.3%) squamous cell carcinoma patients and 20 (33.3%) leukoplakia patients. Fucose estimation was done using UV-visible spectrophotometry based on the method as adopted by Winzler using cysteine reagent. The results were analyzed statistically using ANOVA with Bonferroni post hoc tests. Results: Results showed a high significance in serum fucose in oral squamous cell carcinoma (OSCC) and leukoplakia subjects compared to normal controls. There was a gradual increase in the values noted from control to leukoplakia and to squamous cell carcinoma. Conclusions: Estimation of serum fucose may be a reliable marker and can be used as an effective diagnostic biomarker in oral squamous cell carcinoma patients.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제2권1호
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• pp.66-75
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• 1991

자폐장애의 유전적 요소를 조사하기 위하여 DSM-III-R의 진단기준으로 자폐장애에 부합한 38명의 아동에서 염색체 검사를 실시하였다. 본 연구의 대상은 남아 28명과 여아 10명이었으며, 평균 연령은 $108.8{\pm}28.5개월(70{\sim}156개월)$이었다. 염색체 핵형검사 결과 모든 대상 아동에서 46XX 혹은 46XY로서 염색체 수에는 이상이 없었다. Fragile X는 한 명에서도 발견되지 않았다. Fragile X 이외의 염색체 구조의 이상은 14명(36.8%)에서 발견되었으며, 그 양상은 breakage 11명, gap 2명, breakage와 gap이 공존하는 경우 1명이었다. Denver의 염색체 분류에 의한 이상 염색체 군은 A군 4명, C군 3명, 두 군 이상의 이상은 A군과 B군 동시에 발견된 경우가 1명, A군과 C군 동시 발견이 3명, A군과 E군 동시 발견이 1명, C군과 E군 동시 발견이 1명, A군 B군과 C군 동시 발견이 1명이었다. 염색체 구조에 이상이 있는 집단과 이상이 없는 집단을 DSM-III-R에 의한 자폐장애 증상 항목별로 비교하여 본 바, 모든 증상의 빈도는 양 집단간에 통계적으로 유의한 차이가 없었다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제29권2호
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• pp.73-79
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• 2018

Objectives: The overuse of the Internet among adolescents has increased dramatically in recent years, leading to pathological or problematic Internet use. Cognitive behavioral therapy (CBT) is known to be effective for the treatment of problematic Internet use, particularly for adolescents. The aim of the present study was to evaluate the therapeutic efficacy of group CBT for problematic Internet use in adolescents. Methods: A total of 17 patients aged 12-17 years who met Young's diagnostic questionnaire criteria of problematic Internet use participated in a school-based eight-session group CBT program. The level of problematic Internet use among participating students was measured using Young's Internet Addiction Scale (IAS). Depression and anxiety levels were evaluated using the Children's Depression Inventory (CDI) and the State-Trait Anxiety Inventory (STAI), respectively. Each construct was assessed at baseline, immediately after the intervention, and at a one-month follow-up visit. Statistical significance was based on a p-value of <0.05. Results: Immediately after the program, the IAS, CDI, and State Anxiety Inventory (SAI) scores were significantly lower than before the program. At the one-month follow-up assessment, the IAS scores remained low, and the CDI and SAI scores were even lower than immediately after the program. Conclusion: Group CBT was effective for adolescents with problematic Internet use, and was also demonstrated to improve depression and anxiety.

• 사상체질의학회지
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• 제15권3호
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• pp.11-21
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• 2003

Purpose: This study had focused on evaluating the QSCC II for the elevating accuracy and the designing new Questionnaire. Methods : QSCC II was administered to 1051 patients who had been treated in Hospital and Kyung Hee Oriental Medical Hospital during 19 months from sept. 2000 to mar. 2002. We analyzed all subjects of the QSCC II. Result: 1. In the analysis with all subjects of the QSCC II , 1-1. 75 subjects had a significance between the Sasang Constitution groups. 1-2. In each Sasang Constitution group, we was able to select some significant subjects. I had selected 34 subjects in the Taeyang scale, 33 subjects in the Soyang scale, 28 subjects in the Taeeum scale, and 23 subjects in the Soeum scale. 1-3. When I applied the new intensifying value and calculation, the diagnostic discrimination abilities of the QSCCII was 61.8% about Taeyangin, 55.9% about Soyangin, 63.8% about Taeeumin, 63.6% about Soeumin, and total average was 61.8%. the Dong Eui Oriental Medical from sept. 2000 to mar. 2002.

• 사상체질의학회지
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• 제15권3호
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• pp.1-10
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• 2003

Purpose: This study had focused on evaluating the QSCC II for the elevating accuracy and the designing new Questionnaire. Methods : QSCC II was administered to 1051 patients who had been treated in the Dong Eui Oriental Medical Hospital and Kyung Hee Oriental Medical Hospital during 19 months from sept. 2000 to mar. 2002. We analyzed all subjects of the QSCC II. Result: 1. In the analysis with all subjects of the QSCC II ,1-1. 75 subjects had a significance between the Sasang Constitution groups. 1-2. In each Sasang Constitution group, we was able to select some significant subjects. I had selected 34 subjects in the Taeyang scale, 33 subjects in the Soyang scale, 28 subjects in the Taeeum scale, and 23 subjects in the Soeum scale. 1-3. When I applied the new intensifying value and calculation, the diagnostic discrimination abilities of the QSCC II was 61.8% about Taeyangin, 55.9% about Soyangin, 63.8% about Taeeumin, 63.6% about Soeumin, and total average was 61.8%.

• 한국방사선학회논문지
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• 제14권6호
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• pp.819-825
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• 2020

전산화단층촬영장비 테이블로 인한 화질 저하의 경감을 위하여 개발한 에어 매트리스(Air mattress)의 유용성을 평가하고자 하였다. 5, 10 cm 두께의 에어 매트리스(Air mattress)를 개발하여 적용 유무와 두께에 따른 AAPM 팬텀을 스캔한 영상을 통하여 화질을 측정하였으며 일원배치 분산분석으로 통계적 유의성을 확인하였다. AAPM 팬텀을 표준 방식으로 스캔한 영상과 비교했을 때 에어 매트리스를 적용한 영상은 차이가 나타나지 않았으나, 에어 매트리스를 적용하지 않았을 때의 영상은 CT Number와 균일도가 낮아지고 노이즈가 높게 나타났으며 공간분해능이 낮아지는 것으로 나타났다. 개발된 에어 매트리스는 진단 영상에 아무런 해가 없을 뿐만 아니라, 화질을 높이는 데에 매우 효과적이며 최신, 고가 장비에 적용되는 기술을 이용하지 않고도 기존의 장비에 단순히 에어 매트리스를 적용함으로써 화질을 증가시킬 수 있다.

• Advances in pediatric surgery
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• 제17권1호
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• pp.35-44
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• 2011

Thyroglossal duct cysts (TGDC) are the most common type of congenital developmental anomaly encountered in the anterior midline of the neck in childhood. The aim of the study was to evaluate the clinical characteristics of TGDC and identify any factors that could be related to recurrence after surgery. This study consisted of a retrospective chart review of 45 patients treated at Kyungpook National University Hospital for TGDC between 1990 and 2008. All records were reviewed for age and sex, length of history, presentation, diagnostic methods, sizes and locations of cyst, surgical management, histopathology of the lesion and recurrences. The statistical analysis of risk factors for recurrence was made using the Fisher's exact test with a significance level of p (0.05. The male to female ratio was 2.2:1 with a male preponderance. The mean age at operation was 5 years and 2 months (4 months - 17 years). The most common presenting symptom was a nontender cervical mass (78 %). Most TGDC were found in the midline position. Twenty four were infrahyold, 17 were hyoid, and 4 were suprahyoid level. Forty one (91 %) patients received the Sistrunk operation, and 4(9 %) patients received Cyst excision. Postoperative a seroma developed in six patients in the early postoperative days. There were a total of 3(6.6 %) recurrences, 2 in patients who had excision only and in one patient who had the Sistrunk operation. Univariate analysis for risk factors with recurrence showed that there was no statistical relationship between the presence of preoperative infection and the development of recurrence. The removal of hyoid bone along with TGDC was a statistically significant risk factor for recurrent disease. This study suggests that the Sistrunk operation Is the treatment of choice for TGDC in order to reduce recurrence.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.95-100
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• 2016

Background: Survival time of lymphoma patients can be estimated with the help of microarray technology. In this study, with the use of iterative Bayesian Model Averaging (BMA) method, survival time of Mantle Cell Lymphoma patients (MCL) was estimated and in reference to the findings, patients were divided into two high-risk and low-risk groups. Materials and Methods: In this study, gene expression data of MCL patients were used in order to select a subset of genes for survival analysis with microarray data, using the iterative BMA method. To evaluate the performance of the method, patients were divided into high-risk and low-risk based on their scores. Performance prediction was investigated using the log-rank test. The bioconductor package "iterativeBMAsurv" was applied with R statistical software for classification and survival analysis. Results: In this study, 25 genes associated with survival for MCL patients were identified across 132 selected models. The maximum likelihood estimate coefficients of the selected genes and the posterior probabilities of the selected models were obtained from training data. Using this method, patients could be separated into high-risk and low-risk groups with high significance (p<0.001). Conclusions: The iterative BMA algorithm has high precision and ability for survival analysis. This method is capable of identifying a few predictive variables associated with survival, among many variables in a set of microarray data. Therefore, it can be used as a low-cost diagnostic tool in clinical research.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3461-3464
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• 2014

Background: To determine the frequency of dysplastic lesions in the endocervical curettage (ECC) specimens of women with ASC-US and LSIL Pap and to evaluate the possible factors associated with high grade dysplasia in those ECC specimens. Materials and Methods: Two hundred and sixty patients with ASC-US and LSIL cytologic smears who underwent an ECC at the time of colposcopic examination during January 2010 and December 2012 were reviewed. Demographic and clinicopathologic data were collected. Multivariate analysis using binary logistic regression was used to identify factors that might be associated with high grade endocervical dysplasia. Results: The frequency of endocervical dysplasia was 7.7% (20 out of 260 patients). Cervical intraepithelial neoplasia (CIN) 1 and CIN 2-3 lesions in the endocervical canal were observed in 12 and 8 patients, respectively. No microinvasive or invasive cervical cancers were identified. There was no difference in the frequency of high grade endocervical dysplasia between the patients with satisfactory and unsatisfactory colposcopic examinations (1.4% vs 5.1%, respectively, p=0.087). A multivariate logistic regression analysis demonstrated a significant association between high grade CIN on ectocervical biopsy as well as LSIL cytologic smears and high grade dysplasia in endocervical canal (OR=0.046, 95%CI=0.007-0.288; p=0.001 and OR=0.154, 95%CI=0.025-0.942; p=0.043, respectively). Conclusions: The frequency of high grade endocervical dysplasia in women with ASC-US and LSIL cytologic smears was low. Therefore, routine performance of ECC in those women is debatable. High grade ectocervical dysplasia and LSIL cytologic smears may be used as predictors for high grade dysplasia in endocervical canal and ECC in these patients is reasonable.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5483-5486
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• 2014

Recently, the transcription factor SOX11 has gained extensive attention as a diagnostic marker in a series of cancers. However, to date, the possible roles of SOX11 in breast cancer has not been investigated. In this study, immunohistochemical staining for SOX11 was performed for 116 cases of breast cancer. Nuclear SOX11 was observed in 42 (36.2%) and cytoplasmic SOX11 in 52 (44.8%) of breast cancer samples. Moreover, high expression of cytoplasmic and nuclear SOX11 was associated with clinicopathological factors, including earlier tumor grade, absence of lymph node metastasis and smaller tumor size. Kaplan-Meier survival curves demonstrated high nuclear SOX11 expression to be associated with more prolonged overall survival than those with low expression and it could be an independent predictor of survival for breast cancer patients. It is worthwhile to note that cytoplasmic SOX11 was not correlated with prognosis of breast cancer patients. These data suggest the possibility that nuclear SOX11 could be as a potential target for breast cancer therapy.