• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1137-1144
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• 2012

Introduction: Recent studies have shown that circulating tumor cells (CTCs) play potential roles as diagnostic and prognostic biomarkers with various cancer types. The aim of this study was to comprehensively and quantitatively summarize the evidence for the use of CTCs to predict the survival outcome of lung cancer patients. Materials and Methods: Relevant literature was identified using Medline and EMBASE. Patients' clinical characteristics, overall survival (OS) and progression-free survival (PFS) together with CTC positive rates at different time points (before, during and after treatment) were extracted. A meta-analysis was performed to clarify the prognostic role of CTCs and the correlation between the CTC appearance and clinical characteristics. Results: A total of 12 articles containing survival outcomes and clinical characteristics and 15 articles containing only clinical characteristics were included for the global meta-analysis. The hazard ratio (HR) for OS predicted by pro-treatment CTCs was 2.61 [1.82, 3.74], while the HR for PFS was 2.37 [1.41, 3.99]. The HR for OS predicted by post-treatment CTCs was 4.19 [2.92, 6.00], while the HR for PFS was 4.97 [3.05, 8.11]. Subgroup analyses were conducted according to histological classification and detection method. Odds ratio (OR) showed the appearance of pro-treatment CTCs correlated with the lymph node status, distant metastasis, and TNM staging, while post-treatment CTCs correlated with TNM staging only. Conclusion: Detection of CTCs in the peripheral blood indicates a poor prognosis in patients with lung cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6411-6414
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• 2014

Background: A dense breast not only reduces the sensitivity of mammography but also is a moderate independent risk factor for breast cancer. The percentage of Western women with fat breast tissue is higher aged 40 years or older. To a certain extent, mammography as a first choice of screening imaging method for Western women of this group is reasonable. Hitherto, the frequency and age distribution of mammographic breast density patterns among Chinese women had not been characterized. The purpose of this study was to investigate the frequency and age distribution of mammographic breast density patterns among a group of Chinese screening women and breast cancer patients in order to provide useful information for age-specific guidelines for breast cancer screening in Chinese women. Methods: A retrospective review of a total of 3,394 screening women between August and December 2009 and 2,527 breast cancer patients between July 2011 and June 2012 was conducted. Descriptive analyses were used to examine the association between age and breast density. The significance of differences of breast density between the screening women and the breast cancer patients was examined using nonparametric tests. Results: There was a significant inverse relationship between age and breast density overall (r=-0.37, p< 0.01). Breast density of the breast cancer patients in the subgroups of 40-49 years old was greater compared with that of the screening women, the same in those aged 50-54 years and in those 55 years old or older, less than in the screening group. Conclusions: With regard to the Chinese women younger than 55 years old, the diagnostic efficiency of breast cancer screening imaging examinations may be potentially improved by combining screening mammography with ultrasound.

• Journal of Korean Academy of Nursing
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• v.43 no.5
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• pp.579-586
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• 2013

Purpose: This article provides an update and overview of a nursing research program focused on understanding the pathophysiology and management of irritable bowel syndrome (IBS). Methods: This review includes English language papers from the United States, Europe, and Asia (e.g., South Korea) from 1999 to 2013. We addressed IBS as a health problem, emerging etiologies, diagnostic and treatment approaches and the importance of a biopsychosocial model. Results: IBS is a chronic, functional gastrointestinal disorder characterized by recurrent episodes of abdominal pain and alterations in bowel habit (diarrhea, constipation, mixed). It is a condition for which adults, particularly women ages 20-45, seek health care services in both the United States and South Korea. Clinically, nurses play key roles in symptom prevention and management including designing and implementing approaches to enhance the patients' self-management strategies. Multiple mechanisms are believed to participate in the development and maintenance of IBS symptoms including autonomic nervous system dysregulation, intestinal inflammation, intestinal dysbiosis, dietary intolerances, alterations in emotion regulation, heightened visceral pain sensitivity, hypothalamic-pituitary-adrenal dysregulation, and dysmotility. Because IBS tends to occur in families, genetic factors may also contribute to the pathophysiology. Patients with IBS often report a number of co-morbid disorders and/or symptoms including poor sleep. Conclusion: The key to planning effective management strategies is to understand the heterogeneity of this disorder. Interventions for IBS include non-pharmacological strategies such as cognitive behavior therapy, relaxation strategies, and exclusion diets.

• Land and Housing Review
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• v.10 no.1
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• pp.1-7
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• 2019

This article assumes that the first newtown has declined in Korea. Urban regeneration projects should be implemented for regeneration for CBD in Newtown as well as small local cities. The purpose of this article is to analyze the character of the subway area and to suggest the key issues for regeneartion in the subway area. Especially focussing on the local important commercial function in 5 subway areas. As a result of analyzing 5 subway areas according to basic statistical data, field interviews, and legal decline diagnostic index, all five commercial districts showed decline. In particular, the decline of Baekseok Station area appears to be serious, and there is a key factor that attracts the decline of the commercial area such as the long - term building or the closure rate of each commercial area. In addition, the vacancy rate is increasing due to large distribution facilities in new cities, the entry of new floating facilities on the outskirts, and unsold new stores, and the recession is accelerating. In this way, the signs of decline in the core of the new city are enriched, but the current Urban Regeneration Act is a legal system with a policy goal of regeneration of small and medium cities in the provinces as a system to promote the function of core bases rather than the overall redevelopment of new cities. Therefore, preemptive response is needed for the regeneration in those areas.

• Korean journal of applied entomology
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• v.57 no.3
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• pp.137-141
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• 2018

Neanastatinae Kalina, 1984 is reported for the first time from South Korea with two newly recognized species of Metapelma Westwood, 1835: M. beijingensis Yang and M. pacificum Nikol'skaya. Also, male of M. pacificum is discovered and diagnosed for the first time. Key to South Korean species of Metapelma, diagnoses and photographs of the diagnostic characters are provided along with a key to species of the genus.

• Mycobiology
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• v.44 no.4
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• pp.202-216
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• 2016

Arthonia coreana, Arthonia superpallens, and Arthonia zelkovae are new species from South Korea. All new species are in the Euarthonia tribe, based on the key characteristics of colorless hypothecium and multi-cellular spores. A. coreana has a dull brownish hypophloedal thallus without bleaching and rounded or curved big apothecia in comparison with those of Arthonia punctiformis. A. coreana consistently exhibits 4-septate ascospores, which is a distinctive characteristic that distinguishes it from other Arthonia species. A. superpallens has a white-greenish thallus, pale yellowish apothecia, and a trentepohlioid alga. However, A. superpallens has no distinct prothallus, adnate, and convex apothecia, no pycnidia, and is UV-, in contrast with related species in the Arthonia antillarum group. A. zelkovae has a white, epiphloedal thallus, brownish-black epruinose apothecia covered with a whitish bark layer, and smaller ascospores in comparison with those of A. punctiformis. A. zelkovae consists of a chlorococcoid alga, which differs from related Arthonia species such as A. punctiformis, Arthonia pinastri, and Arthonia glaucella. Although A. zelkovae is similar to Arthonia dispersa in its white-colored thallus, blackish apothecia, and the presence of a chlorococcoid photobiont, A. zelkovae differs from the latter in having larger-sized 3-septate ascospores. Arthonia cinnabarina f. marginata, A. glaucella, Arthonia ilicinella, Arthonia lapidicola, Arthonia leioplacella, Arthonia pertabescens, A. pinastri, Arthonia spadicea, and Arthonia stellaris are newly described in Korea. The diagnostic characteristics of these species are discussed and presented. An artificial key is provided to facilitate identification of Arthonia species from Northeast Asia.

• Parasites, Hosts and Diseases
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• v.57 no.1
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• pp.61-67
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• 2019

Cystic echinococcosis (CE) in sheep is a hazardous zoonotic parasitic disease that is caused by Echinococcus granulosus (Eg). At present, serological test is an important diagnostic method for Eg infection in domestic animals. Here, a fusion protein Eg mefAg-1 harboring 8 dominant B-cell epitopes of Eg such as antigen B, tetraspanin 1, tetraspanin 6, reticulon and Eg95 was produced in E. coli and evaluated for CE in sheep by indirect ELISA. Eg mefAg-1 showed in ELISA a high sensitivity (93.41%) and specificity (99.31%), with a coincidence rate of 97.02%. Overall, it is suggested that the Eg mefAg-1 could be a potential antigen candidate for CE serodiagnosis in sheep.

• Nuclear Engineering and Technology
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• v.51 no.7
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• pp.1860-1865
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• 2019

The confinement degradation of the energetic particles during RMP would be a key issue in success of realizing the successful energy production using fusion plasma, because a 3.5 MeV energetic alpha particle should be able to sustain the burning plasma after the ignition. As KSTAR recent results indicate the generation of high-performance plasma(${\beta}_p{\sim}3$), the confinement of the energetic particles is also an important key aspect in neutral beam driven plasma. In general, the measured absolute value of the neutron intensity is generally used for to estimating the confinement time of energetic particles by comparing it with the theoretical value based on transport calculations. However, the availability of, but for its calculation process, many accurate diagnostic data of plasma parameters such as thermal and incident fast ion density, are essential to the calculation process. In this paper, the time evolution of the neutron signal from an He3 counter during the beam blank has permitted to facilitate the estimation of the slowing down time of energetic particles and the method is applied to investigate the fast ion effect on ELM suppressed KSTAR plasma which is heated by high energy deuterium neutral beams.

• Journal of Species Research
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• v.11 no.3
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• pp.169-173
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• 2022

Three species belonging to the genus Trapania Pruvot-Fol, 1931 are redescribed from Korea in this paper: Trapania euryeia Gosliner & Fahey, 2008, T. japonica (Baba, 1935), and T. toddi Rudman, 1987. Among these species, T. japonica is newly added to Korean fauna. The genus Trapania is characterized by a pair of extra-rhinophoral appendages on each side of the head, tentacular foot corners, a pair of extra-branchial appendages present around the gill, radula formula N×1.0.1. and consists of denticulated teeth, triaulic reproductive system, and minute spines on the armed penis. Herein, synonyms of the genus Trapania are summarized through a detailed literature review and the diagnostic characters of the genus Trapania are provided. Three species of the genus Trapania from Korea are distinguished from each other based on the color of extra-rhinoporal appendages and extra-branchial appendages, ground color, and distribution range of the brown markings on the dorsal surface. A taxonomic key to the genus Trapania in Korea is provided. In addition, the morphological characteristics of three trapanian nudibranchs in Korea are described and detailed photos of living animal are provided.

• Journal of Service Research and Studies
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• v.5 no.2
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• pp.71-81
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• 2015

The RSA public key encryption algorithm, a few, key generation, factoring, the Euler function, key setup, a joint expression law, the application process are serial indexes. The foundation of such algorithms are mathematical principles. The first concept from mathematics principle is applied from how to obtain a minority. It is to obtain a product of two very large prime numbers, but readily tracking station the original two prime number, the product are used in a very hard principles. If a very large prime numbers p and q to obtain, then the product is the two $n=p{\times}q$ easy station, a method for tracking the number of p and q from n synthesis and it is substantially impossible. The RSA encryption algorithm, the number of digits in order to implement the inverse calculation is difficult mathematical one-way function and uses the integer factorization problem of a large amount. Factoring the concept of the calculation of the mod is difficult to use in addition to the problem in the reverse direction. But the interests of the encryption algorithm implementation usually are focused on introducing the film the first time you use encryption algorithm but we have to know how to go through some process applied to the field work This study presents a field force applied encryption process scheme based on public key algorithms attribute diagnosis.